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D(3) dopamine receptor (Dopamine D3 receptor)

 DRD3_RAT                Reviewed;         446 AA.
P19020; P70647;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 1.
30-AUG-2017, entry version 155.
RecName: Full=D(3) dopamine receptor;
AltName: Full=Dopamine D3 receptor;
Name=Drd3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
PubMed=1975644; DOI=10.1038/347146a0;
Sokoloff P., Giros B., Martres M.-P., Bouthenet M.-L., Schwartz J.-C.;
"Molecular cloning and characterization of a novel dopamine receptor
(D3) as a target for neuroleptics.";
Nature 347:146-151(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
PubMed=2039532; DOI=10.1016/0006-291X(91)90469-N;
Giros B., Martres M.-P., Pilon C., Sokoloff P., Schwartz J.-C.;
"Shorter variants of the D3 dopamine receptor produced through various
patterns of alternative splicing.";
Biochem. Biophys. Res. Commun. 176:1584-1592(1991).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-106.
PubMed=8333859; DOI=10.1006/bbrc.1993.1842;
Pagliusi S., Chollet-Daemerius A., Losberger C., Mills A.,
Kawashima E.;
"Characterization of a novel exon within the D3 receptor gene giving
rise to an mRNA isoform expressed in rat brain.";
Biochem. Biophys. Res. Commun. 194:465-471(1993).
[4]
INTERACTION WITH CLIC6.
PubMed=14499480; DOI=10.1016/S0169-328X(03)00283-3;
Griffon N., Jeanneteau F., Prieur F., Diaz J., Sokoloff P.;
"CLIC6, a member of the intracellular chloride channel family,
interacts with dopamine D(2)-like receptors.";
Brain Res. Mol. Brain Res. 117:47-57(2003).
[5]
3D-STRUCTURE MODELING.
TISSUE=Brain;
PubMed=1358063; DOI=10.1042/bj2870277;
Livingstone C.D., Strange P.G., Naylor L.H.;
"Molecular modelling of D2-like dopamine receptors.";
Biochem. J. 287:277-282(1992).
-!- FUNCTION: Dopamine receptor whose activity is mediated by G
proteins which inhibit adenylyl cyclase. Promotes cell
proliferation (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with CLIC6 (PubMed:14499480). Interacts with
GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat
21); increases PKA-mediated phosphorylation of FLNA (By
similarity). {ECO:0000250|UniProtKB:P35462,
ECO:0000269|PubMed:14499480}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P19020-1; Sequence=Displayed;
Name=D3(TM3-del);
IsoId=P19020-2; Sequence=VSP_001874, VSP_001875;
Name=D3(O2-DEL);
IsoId=P19020-3; Sequence=VSP_001876;
-!- TISSUE SPECIFICITY: Mainly in limbic areas of brain.
-!- PTM: Phosphorylated by GRK4. {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; X53944; CAA37887.1; -; mRNA.
EMBL; M69194; AAA41076.1; ALT_SEQ; Genomic_DNA.
EMBL; M69189; AAA41076.1; JOINED; Genomic_DNA.
EMBL; M69190; AAA41076.1; JOINED; Genomic_DNA.
EMBL; M69191; AAA41076.1; JOINED; Genomic_DNA.
EMBL; M69192; AAA41076.1; JOINED; Genomic_DNA.
EMBL; M69193; AAA41076.1; JOINED; Genomic_DNA.
EMBL; S63847; AAB27545.1; -; Genomic_DNA.
EMBL; S63846; AAB27545.1; JOINED; Genomic_DNA.
PIR; S11565; DYRTD3.
RefSeq; NP_058836.1; NM_017140.2. [P19020-1]
UniGene; Rn.10356; -.
ProteinModelPortal; P19020; -.
STRING; 10116.ENSRNOP00000031550; -.
BindingDB; P19020; -.
ChEMBL; CHEMBL3138; -.
GuidetoPHARMACOLOGY; 216; -.
iPTMnet; P19020; -.
PhosphoSitePlus; P19020; -.
PaxDb; P19020; -.
PRIDE; P19020; -.
Ensembl; ENSRNOT00000089057; ENSRNOP00000073117; ENSRNOG00000060806. [P19020-1]
GeneID; 29238; -.
KEGG; rno:29238; -.
UCSC; RGD:2521; rat. [P19020-1]
CTD; 1814; -.
RGD; 2521; Drd3.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00760000118795; -.
HOGENOM; HOG000239242; -.
HOVERGEN; HBG106962; -.
InParanoid; P19020; -.
KO; K04146; -.
OMA; QNSQCIS; -.
OrthoDB; EOG091G06VI; -.
PhylomeDB; P19020; -.
TreeFam; TF334382; -.
Reactome; R-RNO-390651; Dopamine receptors.
Reactome; R-RNO-418594; G alpha (i) signalling events.
PRO; PR:P19020; -.
Proteomes; UP000002494; Chromosome 11.
Bgee; ENSRNOG00000060806; -.
Genevisible; P19020; RN.
GO; GO:0045177; C:apical part of cell; IDA:RGD.
GO; GO:0042995; C:cell projection; IDA:RGD.
GO; GO:0030139; C:endocytic vesicle; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0016020; C:membrane; IDA:BHF-UCL.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0031748; F:D1 dopamine receptor binding; IPI:RGD.
GO; GO:0035240; F:dopamine binding; IMP:RGD.
GO; GO:0004952; F:dopamine neurotransmitter receptor activity; IMP:RGD.
GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:BHF-UCL.
GO; GO:0008144; F:drug binding; IDA:BHF-UCL.
GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
GO; GO:0046717; P:acid secretion; IDA:BHF-UCL.
GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl.
GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IEA:Ensembl.
GO; GO:0050482; P:arachidonic acid secretion; IEA:Ensembl.
GO; GO:0048148; P:behavioral response to cocaine; IMP:RGD.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
GO; GO:0007212; P:dopamine receptor signaling pathway; IMP:RGD.
GO; GO:0002031; P:G-protein coupled receptor internalization; IDA:RGD.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.
GO; GO:0035483; P:gastric emptying; IMP:RGD.
GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IEA:Ensembl.
GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:BHF-UCL.
GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IEA:Ensembl.
GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0050709; P:negative regulation of protein secretion; IEA:Ensembl.
GO; GO:0032416; P:negative regulation of sodium:proton antiporter activity; IMP:RGD.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
GO; GO:0032467; P:positive regulation of cytokinesis; IEA:Ensembl.
GO; GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IEA:Ensembl.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IMP:BHF-UCL.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IDA:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
GO; GO:0060134; P:prepulse inhibition; IEA:Ensembl.
GO; GO:0002016; P:regulation of blood volume by renin-angiotensin; IEA:Ensembl.
GO; GO:0030814; P:regulation of cAMP metabolic process; IDA:BHF-UCL.
GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IMP:RGD.
GO; GO:0014059; P:regulation of dopamine secretion; IEA:Ensembl.
GO; GO:0019216; P:regulation of lipid metabolic process; IEA:Ensembl.
GO; GO:0040012; P:regulation of locomotion; IMP:RGD.
GO; GO:0090325; P:regulation of locomotion involved in locomotory behavior; IMP:RGD.
GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IDA:BHF-UCL.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0034776; P:response to histamine; IEA:Ensembl.
GO; GO:0043278; P:response to morphine; IEA:Ensembl.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IMP:RGD.
GO; GO:0008542; P:visual learning; IEA:Ensembl.
CDD; cd15310; 7tmA_D3_dopamine_R; 1.
InterPro; IPR001620; Dopamine_D3_rcpt.
InterPro; IPR000929; Dopamine_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
PANTHER; PTHR24249:SF341; PTHR24249:SF341; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00568; DOPAMINED3R.
PRINTS; PR00242; DOPAMINER.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome;
Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 446 D(3) dopamine receptor.
/FTId=PRO_0000069400.
TOPO_DOM 1 32 Extracellular. {ECO:0000250}.
TRANSMEM 33 55 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 56 65 Cytoplasmic. {ECO:0000250}.
TRANSMEM 66 88 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 89 104 Extracellular. {ECO:0000250}.
TRANSMEM 105 126 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 127 149 Cytoplasmic. {ECO:0000250}.
TRANSMEM 150 170 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 171 187 Extracellular. {ECO:0000250}.
TRANSMEM 188 212 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 213 375 Cytoplasmic. {ECO:0000250}.
TRANSMEM 376 397 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 398 412 Extracellular. {ECO:0000250}.
TRANSMEM 413 434 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 435 446 Cytoplasmic. {ECO:0000250}.
REGION 189 196 Agonist binding. {ECO:0000250}.
REGION 388 396 Agonist binding. {ECO:0000250}.
BINDING 110 110 Agonist. {ECO:0000250}.
CARBOHYD 12 12 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 19 19 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 173 173 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 103 181 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 401 404 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VAR_SEQ 92 100 TGGVWNFSR -> HSGGHASSL (in isoform
D3(TM3-del)). {ECO:0000305}.
/FTId=VSP_001874.
VAR_SEQ 101 446 Missing (in isoform D3(TM3-del)).
{ECO:0000305}.
/FTId=VSP_001875.
VAR_SEQ 176 193 Missing (in isoform D3(O2-DEL)).
{ECO:0000305}.
/FTId=VSP_001876.
CONFLICT 71 71 L -> M (in Ref. 3). {ECO:0000305}.
CONFLICT 139 139 Q -> E (in Ref. 2; AAA41076).
{ECO:0000305}.
SEQUENCE 446 AA; 49516 MW; 180E36AFF217E9DB CRC64;
MAPLSQISTH LNSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV CAAVLRERAL
QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN
LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPSI
CSISNPDFVI YSSVVSFYVP FGVTVLVYAR IYIVLRQRQR KRILTRQNSQ CISIRPGFPQ
QSSCLRLHPI RQFSIRARFL SDATGQMEHI EDKQYPQKCQ DPLLSHLQPP SPGQTHGGLK
RYYSICQDTA LRHPSLEGGA GMSPVERTRN SLSPTMAPKL SLEVRKLSNG RLSTSLRLGP
LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH CQACHVSPEL YRATTWLGYV
NSALNPVIYT TFNVEFRKAF LKILSC


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