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D(3) dopamine receptor (Dopamine D3 receptor)

 DRD3_MOUSE              Reviewed;         446 AA.
P30728;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
25-OCT-2017, entry version 151.
RecName: Full=D(3) dopamine receptor;
AltName: Full=Dopamine D3 receptor;
Name=Drd3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D3LONG AND D3SHORT).
STRAIN=BALB/cJ;
PubMed=8449953;
Fishburn C.S., Belleli D., David C., Carmon S., Fuchs S.;
"A novel short isoform of the D3 dopamine receptor generated by
alternative splicing in the third cytoplasmic loop.";
J. Biol. Chem. 268:5872-5878(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7598803; DOI=10.1089/dna.1995.14.485;
Fu D., Skryabin B.V., Brosius J., Robakis N.K.;
"Molecular cloning and characterization of the mouse dopamine D3
receptor gene: an additional intron and an mRNA variant.";
DNA Cell Biol. 14:485-492(1995).
-!- FUNCTION: Dopamine receptor whose activity is mediated by G
proteins which inhibit adenylyl cyclase. Promotes cell
proliferation (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with CLIC6 (By similarity). Interacts with
GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat
21); increases PKA-mediated phosphorylation of FLNA (By
similarity). {ECO:0000250|UniProtKB:P19020,
ECO:0000250|UniProtKB:P35462}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=D3Long;
IsoId=P30728-1; Sequence=Displayed;
Name=D3Short;
IsoId=P30728-2; Sequence=VSP_001873;
-!- PTM: Phosphorylated by GRK4. {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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EMBL; X67274; CAA47691.1; -; mRNA.
EMBL; S78580; AAB35066.2; -; Genomic_DNA.
EMBL; S78574; AAB35066.2; JOINED; Genomic_DNA.
EMBL; S78638; AAB35066.2; JOINED; Genomic_DNA.
EMBL; S78577; AAB35066.2; JOINED; Genomic_DNA.
EMBL; S78578; AAB35066.2; JOINED; Genomic_DNA.
EMBL; S78579; AAB35066.2; JOINED; Genomic_DNA.
EMBL; S78639; AAB35066.2; JOINED; Genomic_DNA.
CCDS; CCDS28179.1; -. [P30728-1]
PIR; I48322; I48322.
RefSeq; NP_031903.1; NM_007877.2. [P30728-1]
UniGene; Mm.439735; -.
ProteinModelPortal; P30728; -.
SMR; P30728; -.
BioGrid; 199307; 1.
CORUM; P30728; -.
STRING; 10090.ENSMUSP00000023390; -.
BindingDB; P30728; -.
ChEMBL; CHEMBL2111359; -.
PhosphoSitePlus; P30728; -.
PaxDb; P30728; -.
PRIDE; P30728; -.
Ensembl; ENSMUST00000023390; ENSMUSP00000023390; ENSMUSG00000022705. [P30728-1]
GeneID; 13490; -.
KEGG; mmu:13490; -.
UCSC; uc007zgi.1; mouse. [P30728-1]
CTD; 1814; -.
MGI; MGI:94925; Drd3.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00890000139331; -.
HOGENOM; HOG000239242; -.
HOVERGEN; HBG106962; -.
InParanoid; P30728; -.
KO; K04146; -.
OMA; QNSQCIS; -.
OrthoDB; EOG091G06VI; -.
PhylomeDB; P30728; -.
TreeFam; TF334382; -.
Reactome; R-MMU-390651; Dopamine receptors.
Reactome; R-MMU-418594; G alpha (i) signalling events.
PRO; PR:P30728; -.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000022705; -.
CleanEx; MM_DRD3; -.
ExpressionAtlas; P30728; baseline and differential.
Genevisible; P30728; MM.
GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
GO; GO:0042995; C:cell projection; IEA:Ensembl.
GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0031748; F:D1 dopamine receptor binding; IEA:Ensembl.
GO; GO:0035240; F:dopamine binding; IEA:Ensembl.
GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:MGI.
GO; GO:0008144; F:drug binding; ISO:MGI.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:MGI.
GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; ISO:MGI.
GO; GO:0050482; P:arachidonic acid secretion; ISO:MGI.
GO; GO:0048148; P:behavioral response to cocaine; IMP:BHF-UCL.
GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:MGI.
GO; GO:0032922; P:circadian regulation of gene expression; IMP:MGI.
GO; GO:0002031; P:G-protein coupled receptor internalization; ISO:MGI.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISO:MGI.
GO; GO:0035483; P:gastric emptying; IEA:Ensembl.
GO; GO:0007626; P:locomotory behavior; IMP:MGI.
GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IMP:MGI.
GO; GO:0007194; P:negative regulation of adenylate cyclase activity; ISO:MGI.
GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IGI:MGI.
GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IDA:MGI.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IMP:MGI.
GO; GO:0050709; P:negative regulation of protein secretion; ISO:MGI.
GO; GO:0032416; P:negative regulation of sodium:proton antiporter activity; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
GO; GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:MGI.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0060134; P:prepulse inhibition; ISO:MGI.
GO; GO:0002016; P:regulation of blood volume by renin-angiotensin; IMP:MGI.
GO; GO:0030814; P:regulation of cAMP metabolic process; ISO:MGI.
GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IEA:Ensembl.
GO; GO:0014059; P:regulation of dopamine secretion; IMP:MGI.
GO; GO:0019216; P:regulation of lipid metabolic process; IMP:MGI.
GO; GO:0090325; P:regulation of locomotion involved in locomotory behavior; IEA:Ensembl.
GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
GO; GO:0001975; P:response to amphetamine; IGI:MGI.
GO; GO:0042220; P:response to cocaine; IMP:MGI.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0045471; P:response to ethanol; IMP:MGI.
GO; GO:0034776; P:response to histamine; ISO:MGI.
GO; GO:0043278; P:response to morphine; IMP:MGI.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO; GO:0008542; P:visual learning; IMP:MGI.
CDD; cd15310; 7tmA_D3_dopamine_R; 1.
InterPro; IPR001620; Dopamine_D3_rcpt.
InterPro; IPR000929; Dopamine_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00568; DOPAMINED3R.
PRINTS; PR00242; DOPAMINER.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome;
Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 446 D(3) dopamine receptor.
/FTId=PRO_0000069398.
TOPO_DOM 1 32 Extracellular. {ECO:0000250}.
TRANSMEM 33 55 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 56 65 Cytoplasmic. {ECO:0000250}.
TRANSMEM 66 88 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 89 104 Extracellular. {ECO:0000250}.
TRANSMEM 105 126 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 127 149 Cytoplasmic. {ECO:0000250}.
TRANSMEM 150 170 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 171 187 Extracellular. {ECO:0000250}.
TRANSMEM 188 212 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 213 375 Cytoplasmic. {ECO:0000250}.
TRANSMEM 376 397 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 398 412 Extracellular. {ECO:0000250}.
TRANSMEM 413 434 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 435 446 Cytoplasmic. {ECO:0000250}.
REGION 189 196 Agonist binding. {ECO:0000250}.
REGION 388 396 Agonist binding. {ECO:0000250}.
BINDING 110 110 Agonist. {ECO:0000250}.
CARBOHYD 12 12 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 19 19 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 173 173 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 103 181 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 401 404 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VAR_SEQ 268 288 Missing (in isoform D3Short).
{ECO:0000303|PubMed:8449953}.
/FTId=VSP_001873.
SEQUENCE 446 AA; 49669 MW; B391C2D493B58242 CRC64;
MAPLSQISSH INSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV CAAVLRERAL
QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN
LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPSI
CSISNPDFVI YSSVVSFYVP FGVTVLVYAR IYMVLRQRRR KRILTRQNSQ CISIRPGFPQ
QSSCLRLHPI RQFSIRARFL SDATGQMEHI EDKPYPQKCQ DPLLSHLQPL SPGQTHGELK
RYYSICQDTA LRHPNFEGGG GMSQVERTRN SLSPTMAPKL SLEVRKLSNG RLSTSLKLGP
LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH CQACHVSPEL YRATTWLGYV
NSALNPVIYT TFNIEFRKAF LKILSC


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