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D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein)

 DBP_BOVIN               Reviewed;         325 AA.
Q32PF6;
07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
20-DEC-2005, sequence version 2.
25-OCT-2017, entry version 79.
RecName: Full=D site-binding protein;
AltName: Full=Albumin D box-binding protein;
AltName: Full=Albumin D-element-binding protein;
Name=DBP;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Ascending colon;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: This transcriptional activator recognizes and binds to
the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such
as albumin, CYP2A4 and CYP2A5. It is not essential for circadian
rhythm generation, but modulates important clock output genes. May
be a direct target for regulation by the circadian pacemaker
component clock. May affect circadian period and sleep regulation
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Binds DNA as a homodimer or a heterodimer. Can form a
heterodimer with TEF (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the bZIP family. PAR subfamily.
{ECO:0000305}.
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EMBL; BC108134; AAI08135.2; -; mRNA.
RefSeq; NP_001032522.1; NM_001037445.1.
UniGene; Bt.38784; -.
STRING; 9913.ENSBTAP00000008883; -.
PaxDb; Q32PF6; -.
PRIDE; Q32PF6; -.
Ensembl; ENSBTAT00000008883; ENSBTAP00000008883; ENSBTAG00000006754.
GeneID; 503577; -.
KEGG; bta:503577; -.
CTD; 1628; -.
eggNOG; ENOG410ISXS; Eukaryota.
eggNOG; ENOG410YAPB; LUCA.
GeneTree; ENSGT00440000039070; -.
HOGENOM; HOG000234383; -.
HOVERGEN; HBG004983; -.
InParanoid; Q32PF6; -.
KO; K09056; -.
OMA; DSCESPS; -.
OrthoDB; EOG091G0EO0; -.
TreeFam; TF315869; -.
Proteomes; UP000009136; Chromosome 18.
Bgee; ENSBTAG00000006754; -.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
InterPro; IPR004827; bZIP.
InterPro; IPR029830; DBP.
PANTHER; PTHR11988:SF7; PTHR11988:SF7; 1.
Pfam; PF07716; bZIP_2; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
2: Evidence at transcript level;
Activator; Biological rhythms; Complete proteome; DNA-binding;
Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 325 D site-binding protein.
/FTId=PRO_0000226720.
DOMAIN 255 318 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 257 279 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 283 297 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
COMPBIAS 129 135 Poly-Pro.
COMPBIAS 188 239 Pro-rich (proline/acidic region (PAR)).
MOD_RES 86 86 Phosphoserine.
{ECO:0000250|UniProtKB:Q10586}.
SEQUENCE 325 AA; 34322 MW; 59C3A8D4F54D00CB CRC64;
MARPVSERTP APLLLGGPTG APPGGGALLG LRSLLQGTSK PKEPTSCLLK EKERKASPPA
ATVPGPGLET AGPADASAGA VVGGGSPRGR PGAAPGPGLL APLLWERTLP FGDVEYVDLD
AFLLEHGLPP SPPPPGGPSP APSPVRTPAP SPRPGSCGSA SPRSSPGHAP ARAALGAAGG
HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI
MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
VVAVRQELSH YRAVLSRYQA QHGAL


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