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D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302)

 DBP_HUMAN               Reviewed;         325 AA.
Q10586; A2I2P4;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
25-OCT-2017, entry version 147.
RecName: Full=D site-binding protein;
AltName: Full=Albumin D box-binding protein;
AltName: Full=Albumin D-element-binding protein;
AltName: Full=Tax-responsive enhancer element-binding protein 302;
Short=TaxREB302;
Name=DBP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7835883; DOI=10.1006/geno.1994.1510;
Khatib Z.A., Inaba T., Valentine M., Look A.T.;
"Chromosomal localization and cDNA cloning of the human DBP and TEF
genes.";
Genomics 23:344-351(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8786133; DOI=10.1006/geno.1996.0295;
Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.;
"Genomic structure of the human D-site binding protein (DBP) gene.";
Genomics 34:334-339(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=9110174;
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
"Large-scale concatenation cDNA sequencing.";
Genome Res. 7:353-358(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
PubMed=8482542; DOI=10.1016/0378-1119(93)90375-D;
Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.;
"Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is
specific for the tax-responsive enhancer of HTLV-I.";
Gene 126:251-255(1993).
[9]
SEQUENCE REVISION.
Nyunoya H.;
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
[10]
REVIEW.
PubMed=10508692; DOI=10.1016/S0959-437X(99)00009-X;
Brown S.A., Schibler U.;
"The ins and outs of circadian timekeeping.";
Curr. Opin. Genet. Dev. 9:588-594(1999).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
-!- FUNCTION: This transcriptional activator recognizes and binds to
the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such
as albumin, CYP2A4 and CYP2A5. It is not essential for circadian
rhythm generation, but modulates important clock output genes. May
be a direct target for regulation by the circadian pacemaker
component clock. May affect circadian period and sleep regulation.
-!- SUBUNIT: Binds DNA as a homodimer or a heterodimer. Can form a
heterodimer with TEF.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in the
suprachiasmatic nuclei (SCN) and in most peripheral tissues, with
a strong circadian rhythmicity.
-!- SIMILARITY: Belongs to the bZIP family. PAR subfamily.
{ECO:0000305}.
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EMBL; U06936; AAA81374.1; -; mRNA.
EMBL; U48213; AAB18668.1; -; Genomic_DNA.
EMBL; U48212; AAB18668.1; JOINED; Genomic_DNA.
EMBL; EF015902; ABM64213.1; -; Genomic_DNA.
EMBL; U79283; AAB50219.1; -; mRNA.
EMBL; BT006836; AAP35482.1; -; mRNA.
EMBL; CH471177; EAW52374.1; -; Genomic_DNA.
EMBL; BC011965; AAH11965.1; -; mRNA.
EMBL; D28468; BAA05833.1; -; mRNA.
CCDS; CCDS12728.1; -.
PIR; A55558; A55558.
RefSeq; NP_001343.2; NM_001352.4.
UniGene; Hs.414480; -.
UniGene; Hs.528006; -.
ProteinModelPortal; Q10586; -.
SMR; Q10586; -.
BioGrid; 107996; 11.
IntAct; Q10586; 3.
STRING; 9606.ENSP00000222122; -.
iPTMnet; Q10586; -.
PhosphoSitePlus; Q10586; -.
BioMuta; DBP; -.
DMDM; 1706312; -.
EPD; Q10586; -.
PaxDb; Q10586; -.
PeptideAtlas; Q10586; -.
PRIDE; Q10586; -.
DNASU; 1628; -.
Ensembl; ENST00000222122; ENSP00000222122; ENSG00000105516.
GeneID; 1628; -.
KEGG; hsa:1628; -.
UCSC; uc002pjx.5; human.
CTD; 1628; -.
DisGeNET; 1628; -.
EuPathDB; HostDB:ENSG00000105516.10; -.
GeneCards; DBP; -.
HGNC; HGNC:2697; DBP.
MIM; 124097; gene.
neXtProt; NX_Q10586; -.
OpenTargets; ENSG00000105516; -.
PharmGKB; PA27165; -.
eggNOG; KOG3119; Eukaryota.
eggNOG; ENOG410YJ8G; LUCA.
GeneTree; ENSGT00440000039070; -.
HOGENOM; HOG000234383; -.
HOVERGEN; HBG004983; -.
InParanoid; Q10586; -.
KO; K09056; -.
OMA; DSCESPS; -.
OrthoDB; EOG091G0EO0; -.
PhylomeDB; Q10586; -.
TreeFam; TF315869; -.
Reactome; R-HSA-1368108; BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLink; Q10586; -.
SIGNOR; Q10586; -.
GeneWiki; DBP_(gene); -.
GenomeRNAi; 1628; -.
PRO; PR:Q10586; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000105516; -.
CleanEx; HS_DBP; -.
ExpressionAtlas; Q10586; baseline and differential.
Genevisible; Q10586; HS.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:BHF-UCL.
GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
InterPro; IPR004827; bZIP.
InterPro; IPR029830; DBP.
PANTHER; PTHR11988:SF7; PTHR11988:SF7; 1.
Pfam; PF07716; bZIP_2; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
1: Evidence at protein level;
Activator; Biological rhythms; Complete proteome; DNA-binding;
Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 325 D site-binding protein.
/FTId=PRO_0000076507.
DOMAIN 255 318 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 257 279 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 283 297 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
COMPBIAS 129 135 Poly-Pro.
COMPBIAS 188 239 Pro-rich (proline/acidic region (PAR)).
MOD_RES 86 86 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:24275569}.
CONFLICT 179 179 S -> T (in Ref. 1; AAA81374).
{ECO:0000305}.
CONFLICT 245 245 R -> K (in Ref. 8; BAA05833).
{ECO:0000305}.
SEQUENCE 325 AA; 34349 MW; A6933CE21399ECF3 CRC64;
MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA
ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD
AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG
HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI
MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
VVAVRQELSH YRAVLSRYQA QHGAL


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