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D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase)

 F4APE7_GLAS4            Unreviewed;       326 AA.
F4APE7;
28-JUN-2011, integrated into UniProtKB/TrEMBL.
28-JUN-2011, sequence version 1.
22-NOV-2017, entry version 52.
RecName: Full=D-alanine--D-alanine ligase {ECO:0000256|HAMAP-Rule:MF_00047, ECO:0000256|SAAS:SAAS00910572};
EC=6.3.2.4 {ECO:0000256|HAMAP-Rule:MF_00047, ECO:0000256|SAAS:SAAS00910572};
AltName: Full=D-Ala-D-Ala ligase {ECO:0000256|HAMAP-Rule:MF_00047};
AltName: Full=D-alanylalanine synthetase {ECO:0000256|HAMAP-Rule:MF_00047};
Name=ddl {ECO:0000256|HAMAP-Rule:MF_00047};
OrderedLocusNames=Glaag_0847 {ECO:0000313|EMBL:AEE21810.1};
Glaciecola sp. (strain 4H-3-7+YE-5).
Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
Alteromonadaceae; Glaciecola.
NCBI_TaxID=983545 {ECO:0000313|EMBL:AEE21810.1, ECO:0000313|Proteomes:UP000006544};
[1] {ECO:0000313|EMBL:AEE21810.1, ECO:0000313|Proteomes:UP000006544}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=4H-3-7+YE-5 {ECO:0000313|EMBL:AEE21810.1,
ECO:0000313|Proteomes:UP000006544};
PubMed=21705587; DOI=10.1128/JB.05468-11;
US DOE Joint Genome Institute;
Klippel B., Lochner A., Bruce D.C., Davenport K.W., Detter C.,
Goodwin L.A., Han J., Han S., Land M.L., Mikhailova N., Nolan M.,
Pennacchio L., Pitluck S., Tapia R., Woyke T., Wiebusch S., Basner A.,
Abe F., Horikoshi K., Keller M., Antranikian G.;
"Complete genome sequence of the marine, cellulose and xylan degrading
bacterium Glaciecola sp. 4H-3-7+YE-5.";
J. Bacteriol. 193:4547-4548(2011).
[2]
NUCLEOTIDE SEQUENCE.
STRAIN=4H-3-7+YE-5;
US DOE Joint Genome Institute;
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I.,
Piela B., Lochner A., Antranikian F.I., Woyke T.;
"Complete sequence of chromosome of Glaciecola sp. 4H-3-7+YE-5.";
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Cell wall formation. {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00910576}.
-!- CATALYTIC ACTIVITY: ATP + 2 D-alanine = ADP + phosphate + D-
alanyl-D-alanine. {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00910566}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|PIRSR:PIRSR039102-3};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|PIRSR:PIRSR039102-3};
Note=Binds 2 magnesium or manganese ions per subunit.
{ECO:0000256|PIRSR:PIRSR039102-3};
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|SAAS:SAAS00910564};
-!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
{ECO:0000256|HAMAP-Rule:MF_00047, ECO:0000256|SAAS:SAAS00910582}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00644680}.
-!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
{ECO:0000256|HAMAP-Rule:MF_00047, ECO:0000256|SAAS:SAAS00910642}.
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EMBL; CP002526; AEE21810.1; -; Genomic_DNA.
RefSeq; WP_013752979.1; NC_015497.1.
STRING; 983545.Glaag_0847; -.
EnsemblBacteria; AEE21810; AEE21810; Glaag_0847.
KEGG; gag:Glaag_0847; -.
eggNOG; ENOG4105CPF; Bacteria.
eggNOG; COG1181; LUCA.
KO; K01921; -.
OrthoDB; POG091H00GT; -.
UniPathway; UPA00219; -.
Proteomes; UP000006544; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
Gene3D; 3.30.1490.20; -; 1.
HAMAP; MF_00047; Dala_Dala_lig; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR000291; D-Ala_lig_Van_CS.
InterPro; IPR005905; D_ala_D_ala.
InterPro; IPR011095; Dala_Dala_lig_C.
InterPro; IPR011127; Dala_Dala_lig_N.
InterPro; IPR016185; PreATP-grasp_dom_sf.
Pfam; PF07478; Dala_Dala_lig_C; 1.
Pfam; PF01820; Dala_Dala_lig_N; 1.
PIRSF; PIRSF039102; Ddl/VanB; 2.
SUPFAM; SSF52440; SSF52440; 1.
TIGRFAMs; TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE; PS50975; ATP_GRASP; 1.
PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
PROSITE; PS00844; DALA_DALA_LIGASE_2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
ECO:0000256|SAAS:SAAS00644673};
Cell shape {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00644714};
Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00644792};
Complete proteome {ECO:0000313|Proteomes:UP000006544};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00910562};
Ligase {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00644741, ECO:0000313|EMBL:AEE21810.1};
Magnesium {ECO:0000256|PIRSR:PIRSR039102-3,
ECO:0000256|SAAS:SAAS00910568};
Manganese {ECO:0000256|PIRSR:PIRSR039102-3,
ECO:0000256|SAAS:SAAS00910578};
Metal-binding {ECO:0000256|PIRSR:PIRSR039102-3,
ECO:0000256|SAAS:SAAS00910590};
Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
ECO:0000256|SAAS:SAAS00644673};
Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_00047,
ECO:0000256|SAAS:SAAS00644714}.
DOMAIN 124 323 ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
METAL 277 277 Magnesium or manganese 1.
{ECO:0000256|PIRSR:PIRSR039102-3}.
METAL 290 290 Magnesium or manganese 1.
{ECO:0000256|PIRSR:PIRSR039102-3}.
METAL 290 290 Magnesium or manganese 2.
{ECO:0000256|PIRSR:PIRSR039102-3}.
METAL 292 292 Magnesium or manganese 2.
{ECO:0000256|PIRSR:PIRSR039102-3}.
SEQUENCE 326 AA; 34866 MW; D9D6E29567056C20 CRC64;
MTSINATNTN AIDVDAIESK DPAGFGKVAV MFGGRSAERE VSLRSGQAVL NALVGAGVNA
HGFDPADRQL HELVEQKFDR VLIMLHGRGG EDGSLQGALQ QMNMPYTGTG VLGSALCMDK
IRSKQVWQSL GLPTANYEIA DKRDFNAANC GDIMTRLGDL VMVKPAQEGS SIGMAKVSNA
HQLAAAIQQA FEYDDKVLLE QFIQGSEYTV SLLNGIALPS ISMSTPRDFY DYEAKYQSNS
TEYFCPSGLS DEQETDLAQL ALNAFDAVAG TGWGRIDFMQ DAQGQFYLLE ANTVPGMTEK
SLVPLAAKQA GLSFAQLSLA VLATAG


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