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D-lactate dehydrogenase VanH-A (Dehydrogenase) (Dehydrogenase VanH) (Pyruvate dehydrogenase) (VanH) (VanH protein) (VanH protein, D-specific alpha-keto acid dehydrogenase) (EC 1.1.1.-) (Vancomycin resistance protein VanH / D-lactate dehydrogenase) (EC 1.1.1.28)

 Q7B609_ENTFC            Unreviewed;       322 AA.
Q7B609;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
20-JUN-2018, entry version 110.
SubName: Full=D-lactate dehydrogenase VanH-A {ECO:0000313|EMBL:AQY33698.1};
SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:AAM77884.1};
SubName: Full=Vancomycin resistance protein VanH / D-lactate dehydrogenase {ECO:0000313|EMBL:ADA62244.1};
Name=vanH {ECO:0000313|EMBL:AAM77884.1};
Synonyms=vanHB {ECO:0000313|EMBL:SAM54142.1};
ORFNames=B1P95_18720 {ECO:0000313|EMBL:OOL76091.1},
B4W81_17375 {ECO:0000313|EMBL:AQY33698.1},
BTA13_00015 {ECO:0000313|EMBL:PHL89746.1},
BU181_13530 {ECO:0000313|EMBL:OUK20407.1},
BU182_12485 {ECO:0000313|EMBL:OUK07100.1},
BU183_03140 {ECO:0000313|EMBL:OUK43297.1},
BU184_09560 {ECO:0000313|EMBL:OUK34963.1},
BU185_04510 {ECO:0000313|EMBL:OUK10442.1},
BU187_14560 {ECO:0000313|EMBL:OUK12909.1},
BU189_06920 {ECO:0000313|EMBL:OUK16490.1},
BU190_07870 {ECO:0000313|EMBL:OUK42559.1},
BU192_08230 {ECO:0000313|EMBL:OUK28406.1},
BU194_15315 {ECO:0000313|EMBL:OUK39334.1},
BXT96_15020 {ECO:0000313|EMBL:AUO62971.1},
CX663_16365 {ECO:0000313|EMBL:AUH49308.1},
DTPHA_602991 {ECO:0000313|EMBL:SAM54142.1},
Efm04900tn_00005 {ECO:0000313|EMBL:AKE81062.1},
EFM1CSP_09205 {ECO:0000313|EMBL:OSP79560.1},
Efm32007tn_0005 {ECO:0000313|EMBL:AKL90234.1},
SAP083A_023 {ECO:0000313|EMBL:ADA62244.1};
Enterococcus faecium (Streptococcus faecium).
Plasmid p2 {ECO:0000313|EMBL:AUH49308.1,
ECO:0000313|Proteomes:UP000234558},
Plasmid p268-3 {ECO:0000313|EMBL:AQY33698.1},
Plasmid p268-3 sequence {ECO:0000313|Proteomes:UP000190755},
Plasmid p5753cA {ECO:0000313|EMBL:ADA62244.1},
Plasmid pEFA-790c {ECO:0000313|EMBL:AUO62971.1},
Plasmid pF856 {ECO:0000313|EMBL:AFV27320.1},
Plasmid pIP816 {ECO:0000313|EMBL:CAP70013.1},
Plasmid pRUM {ECO:0000313|EMBL:ABY85811.1},
Plasmid pS177 {ECO:0000313|EMBL:ADV60063.1},
Plasmid pUW786 {ECO:0000313|EMBL:AAM77884.1},
Plasmid pVEF1 {ECO:0000313|EMBL:CAL36535.1},
Plasmid pVEF2 {ECO:0000313|EMBL:CAL90941.1},
Plasmid pVEF3 {ECO:0000313|EMBL:CAP62632.1},
Plasmid pVEF4 {ECO:0000313|EMBL:CAZ67070.1},
Plasmid pefa-790c {ECO:0000313|Proteomes:UP000235573}, and
Plasmid unnamed {ECO:0000313|EMBL:AFC95873.1}.
Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
Enterococcus.
NCBI_TaxID=1352 {ECO:0000313|EMBL:AAM77884.1};
[1] {ECO:0000313|EMBL:AAM77884.1}
NUCLEOTIDE SEQUENCE.
STRAIN=UW786 {ECO:0000313|EMBL:AAM77884.1};
PLASMID=pUW786 {ECO:0000313|EMBL:AAM77884.1};
Werner G., Klare I., Witte W.;
"Multi-resistance gene cluster on a plasmid in a clinical isolate of
Enterococcus faecium.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:CAL36535.1}
NUCLEOTIDE SEQUENCE.
STRAIN=399/F99/A9 {ECO:0000313|EMBL:CAL90941.1}, and
399/F99/H8 {ECO:0000313|EMBL:CAL36535.1};
PLASMID=pVEF1 {ECO:0000313|EMBL:CAL36535.1}, and
pVEF2 {ECO:0000313|EMBL:CAL90941.1};
PubMed=17116680; DOI=10.1128/AAC.00557-06;
Sletvold H., Johnsen P.J., Simonsen G.S., Aasnaes B., Sundsfjord A.,
Nielsen K.M.;
"Comparative DNA analysis of two vanA plasmids from Enterococcus
faecium strains isolated from poultry and a poultry farmer in
Norway.";
Antimicrob. Agents Chemother. 51:736-739(2007).
[3] {ECO:0000313|EMBL:ACC93632.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ZP2298 {ECO:0000313|EMBL:ACC93632.1};
PubMed=17951264; DOI=10.1093/jac/dkm399;
Qu T.T., Chen Y.G., Yu Y.S., Lv H.X., Dong X.Q., Xiao Z., Gu H.Q.,
Li L.J.;
"Molecular characterization of vancomycin-resistant enterococci in
Hangzhou, China.";
J. Antimicrob. Chemother. 60:1403-1405(2007).
[4] {ECO:0000313|EMBL:ABY85811.1}
NUCLEOTIDE SEQUENCE.
STRAIN=VRE3 {ECO:0000313|EMBL:ABY85811.1};
PLASMID=pRUM {ECO:0000313|EMBL:ABY85811.1};
PubMed=18462926; DOI=10.1016/j.ijantimicag.2008.01.030;
Sung K., Khan S.A., Nawaz M.S.;
"Genetic diversity of Tn1546-like elements in clinical isolates of
vancomycin-resistant enterococci.";
Int. J. Antimicrob. Agents 31:549-554(2008).
[5] {ECO:0000313|EMBL:CAP62632.1}
NUCLEOTIDE SEQUENCE.
STRAIN=399/S99/A7 {ECO:0000313|EMBL:CAP62632.1};
PLASMID=pVEF3 {ECO:0000313|EMBL:CAP62632.1};
PubMed=18511120; DOI=10.1016/j.plasmid.2008.04.002;
Sletvold H., Johnsen P.J., Simonsen G.S., Sundsfjord A., Nielsen K.M.;
"The toxin-antitoxin system w-e-z ensures stable maintenance of vanA
plasmids in an antibiotic-free environment.";
Plasmid 60:75-85(2008).
[6] {ECO:0000313|EMBL:ACC93632.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ZP2298 {ECO:0000313|EMBL:ACC93632.1};
PubMed=19846656; DOI=10.1128/JCM.01802-09;
Qu T.T., Zhang J.L., Zhou Z.H., Wei Z.Q., Yu Y.S., Chen Y.G., Li L.J.;
"Heteroresistance to teicoplanin in Enterococcus faecium harboring the
vanA gene.";
J. Clin. Microbiol. 47:4194-4196(2009).
[7] {ECO:0000313|EMBL:ADA62244.1}
NUCLEOTIDE SEQUENCE.
STRAIN=5753c {ECO:0000313|EMBL:ADA62244.1};
PLASMID=p5753cA {ECO:0000313|EMBL:ADA62244.1};
Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B.;
Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:ADA62244.1}
NUCLEOTIDE SEQUENCE.
STRAIN=5753c {ECO:0000313|EMBL:ADA62244.1};
PLASMID=p5753cA {ECO:0000313|EMBL:ADA62244.1};
Summers A.O., Shearer J., Wireman J.;
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:ACP19235.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C864 {ECO:0000313|EMBL:ACP19235.1};
PubMed=20519356; DOI=10.1093/jac/dkq192;
Lopez M., Saenz Y., Alvarez-Martinez M.J., Marco F., Robredo B.,
Rojo-Bezares B., Ruiz-Larrea F., Zarazaga M., Torres C.;
"Tn1546 structures and multilocus sequence typing of vanA-containing
enterococci of animal, human and food origin.";
J. Antimicrob. Chemother. 65:1570-1575(2010).
[10] {ECO:0000313|EMBL:CAP70013.1}
NUCLEOTIDE SEQUENCE.
STRAIN=399/F98/A4 {ECO:0000313|EMBL:CAZ67070.1}, and
BM4147 {ECO:0000313|EMBL:CAP70013.1};
PLASMID=pIP816 {ECO:0000313|EMBL:CAP70013.1}, and
pVEF4 {ECO:0000313|EMBL:CAZ67070.1};
Sletvold H., Johnsen P.J., Wikmark O.G., Simonsen G.S., Sundsfjord A.,
Nielsen K.M.;
"Tn1546 is part of a larger plasmid-encoded genetic unit horizontally
disseminated among clonal Enterococcus faecium lineages.";
J. Antimicrob. Chemother. 65:1894-1906(2010).
[11] {ECO:0000313|EMBL:ADV60063.1}
NUCLEOTIDE SEQUENCE.
STRAIN=S177 {ECO:0000313|EMBL:ADV60063.1};
PLASMID=pS177 {ECO:0000313|EMBL:ADV60063.1};
PubMed=21030436; DOI=10.1099/mic.0.045492-0;
Halvorsen E.M., Williams J.J., Bhimani A.J., Billings E.A.,
Hergenrother P.J.;
"Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin
system, cleaves mRNA and inhibits protein synthesis.";
Microbiology 157:387-397(2011).
[12] {ECO:0000313|EMBL:AFC95873.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A94 {ECO:0000313|EMBL:AFC95873.1};
PLASMID=unnamed {ECO:0000313|EMBL:AFC95873.1};
Qu T.-T., Yang Q., Shen P., Wei Z.-Q., Yu Y.-S.;
"Novel vancomycin resistance transposon, plasmid replicon types and
virulence factors of vancomycin-resistant Enterococci in Zhejiang,
China.";
Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
[13] {ECO:0000313|EMBL:AFC95873.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A94 {ECO:0000313|EMBL:AFC95873.1};
PLASMID=unnamed {ECO:0000313|EMBL:AFC95873.1};
PubMed=22867881; DOI=10.1016/j.ijantimicag.2012.06.010;
Wang R., Lou J., Liu J., Zhang L., Li J., Kan B.;
"Antibiotic resistance of Vibrio cholerae O1 El Tor strains from the
seventh pandemic in China, 1961-2010.";
Int. J. Antimicrob. Agents 40:361-364(2012).
[14] {ECO:0000313|EMBL:AFV27320.1}
NUCLEOTIDE SEQUENCE.
PLASMID=pF856 {ECO:0000313|EMBL:AFV27320.1};
PubMed=24523464; DOI=10.1128/JCM.03563-13;
Szakacs T.A., Kalan L., McConnell M.J., Eshaghi A., Shahinas D.,
McGeer A., Wright G.D., Low D.E., Patel S.N.;
"Outbreak of Vancomycin-Susceptible Enterococcus faecium Containing
the Wild-Type vanA Gene.";
J. Clin. Microbiol. 52:1682-1686(2014).
[15] {ECO:0000313|EMBL:AKE81062.1}
NUCLEOTIDE SEQUENCE.
STRAIN=TIES/04900 {ECO:0000313|EMBL:AKE81062.1};
PLASMID=unnamed {ECO:0000313|EMBL:AKE81062.1};
Sacramento A.G., Cerdeira L.T., de Almeida L.M., Pires C.,
Oliveira T.G., Zanella R.C., Lincopan N., Mamizuka E.M.;
"Tn1546 structures of vanA-type Enterococcus faecium TIES/04900
isolated from urban river.";
Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
[16] {ECO:0000313|EMBL:AKL90234.1}
NUCLEOTIDE SEQUENCE.
STRAIN=VREfm 320/07 {ECO:0000313|EMBL:AKL90234.1};
Sacramento A.G., Cerdeira L.T., de Almeida L.M., Pires C.,
Mamizuka E.M., Liconpan N.;
"Genome sequence of Enterococcus faecium strain EFP6CSP.";
Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
[17] {ECO:0000313|EMBL:SAM54142.1, ECO:0000313|Proteomes:UP000183509}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Isolate 22 {ECO:0000313|EMBL:SAM54142.1};
Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K.,
Barbian K., Babar A., Rosenke K.;
Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
[18] {ECO:0000313|Proteomes:UP000195317, ECO:0000313|Proteomes:UP000195596, ECO:0000313|Proteomes:UP000195616}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IHC1 {ECO:0000313|EMBL:OUK07100.1,
ECO:0000313|Proteomes:UP000196332},
IHC11 {ECO:0000313|EMBL:OUK34963.1,
ECO:0000313|Proteomes:UP000195680},
IHC12 {ECO:0000313|EMBL:OUK42559.1,
ECO:0000313|Proteomes:UP000195596},
IHC13 {ECO:0000313|EMBL:OUK39334.1,
ECO:0000313|Proteomes:UP000195760}, IHC2 {ECO:0000313|EMBL:OUK10442.1,
ECO:0000313|Proteomes:UP000195730}, IHC3 {ECO:0000313|EMBL:OUK43297.1,
ECO:0000313|Proteomes:UP000195945}, IHC4 {ECO:0000313|EMBL:OUK16490.1,
ECO:0000313|Proteomes:UP000195625}, IHC5 {ECO:0000313|EMBL:OUK12909.1,
ECO:0000313|Proteomes:UP000195317}, IHC6 {ECO:0000313|EMBL:OUK20407.1,
ECO:0000313|Proteomes:UP000196144}, and
IHC8 {ECO:0000313|EMBL:OUK28406.1, ECO:0000313|Proteomes:UP000195616};
Gazdik M.A., Burr Z., Coombs J., Webb B., Lopansri B., Ford C.;
"Molecular epidemiology of vancomycin-resistant Enterococcus faecium
from patients with hematological malignancy.";
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
[19] {ECO:0000313|EMBL:PHL89746.1, ECO:0000313|Proteomes:UP000225744}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=11_Efcm_HA-DE {ECO:0000313|EMBL:PHL89746.1,
ECO:0000313|Proteomes:UP000225744};
PubMed=29051750; DOI=.3389/fmicb.2017.01914;
Zhou X., Garcia-Cobos S., Ruijs G.J.H.M., Kampinga G.A., Arends J.P.,
Borst D.M., Moller L.V., Holman N.D., Schuurs T.A.,
Bruijnesteijn van Coppenraet L.E., Weel J.F., van Zeijl J.H., Kock R.,
Rossen J.W.A., Friedrich A.W.;
"Epidemiology of Extended-Spectrum ?-Lactamase-Producing E. coli and
Vancomycin-Resistant Enterococci in the Northern Dutch-German Cross-
Border Region.";
Front. Microbiol. 8:1914-1914(2017).
[20] {ECO:0000313|EMBL:OOL76091.1, ECO:0000313|Proteomes:UP000191171}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LIM1759 {ECO:0000313|EMBL:OOL76091.1,
ECO:0000313|Proteomes:UP000191171};
Marchi A.P., Martins R.C., Marie S.K., Levin A.S., Costa S.F.;
"Clonality and virulence of isolates of VRE in Hematopoietic Stem Cell
Transplanted (HSCT) patients.";
Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
[21] {ECO:0000313|EMBL:AQY33698.1, ECO:0000313|Proteomes:UP000190755}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2014-VREF-268 {ECO:0000313|EMBL:AQY33698.1};
PLASMID=p268-3 {ECO:0000313|EMBL:AQY33698.1};
Kim H.M.;
"Non-typeable vancomycin-resistant E. faecium.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[22] {ECO:0000313|EMBL:OSP79560.1, ECO:0000313|Proteomes:UP000192991}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=EFM1CSP {ECO:0000313|EMBL:OSP79560.1,
ECO:0000313|Proteomes:UP000192991};
Sacramento A., Cerdeira L., Lincopan N.;
"Draft genome sequence of an Enterococcus faecium strain EFM1CSP.";
Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
[23] {ECO:0000313|EMBL:AUH49308.1, ECO:0000313|Proteomes:UP000234558}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC4 {ECO:0000313|EMBL:AUH49308.1,
ECO:0000313|Proteomes:UP000234558};
PLASMID=p2 {ECO:0000313|EMBL:AUH49308.1};
Li N.;
"First report of the horizontal transfer of vanA during soybean meal
fermentation.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
[24] {ECO:0000313|EMBL:AUO62971.1, ECO:0000313|Proteomes:UP000235573}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AALTL {ECO:0000313|EMBL:AUO62971.1,
ECO:0000313|Proteomes:UP000235573};
PLASMID=pEFA-790c {ECO:0000313|EMBL:AUO62971.1};
Conlan S., Palmore T.N., Frank K.M., Segre J.A.;
"Whole genome sequencing of Enterococcus faecium strain AALTL.";
Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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EMBL; AF516335; AAM77884.1; -; Genomic_DNA.
EMBL; EU376117; ABY85811.1; -; Genomic_DNA.
EMBL; EU599211; ACC93632.1; -; Genomic_DNA.
EMBL; FJ866609; ACP19235.1; -; Genomic_DNA.
EMBL; GQ900435; ADA62244.1; -; Genomic_DNA.
EMBL; HQ115078; ADV60063.1; -; Genomic_DNA.
EMBL; JN982328; AFC95873.1; -; Genomic_DNA.
EMBL; JQ663598; AFV27320.1; -; Genomic_DNA.
EMBL; KR047792; AKE81062.1; -; Genomic_DNA.
EMBL; KR349520; AKL90234.1; -; Genomic_DNA.
EMBL; CP019995; AQY33698.1; -; Genomic_DNA.
EMBL; CP025427; AUH49308.1; -; Genomic_DNA.
EMBL; CP025755; AUO62971.1; -; Genomic_DNA.
EMBL; AM296544; CAL36535.1; -; Genomic_DNA.
EMBL; AM410096; CAL90941.1; -; Genomic_DNA.
EMBL; AM931300; CAP62632.1; -; Genomic_DNA.
EMBL; AM932524; CAP70013.1; -; Genomic_DNA.
EMBL; FN424376; CAZ67070.1; -; Genomic_DNA.
EMBL; MVGJ01000665; OOL76091.1; -; Genomic_DNA.
EMBL; NBVQ01000081; OSP79560.1; -; Genomic_DNA.
EMBL; MSHS01000160; OUK07100.1; -; Genomic_DNA.
EMBL; MSHR01000036; OUK10442.1; -; Genomic_DNA.
EMBL; MSHV01000152; OUK12909.1; -; Genomic_DNA.
EMBL; MSHU01000085; OUK16490.1; -; Genomic_DNA.
EMBL; MSHW01000176; OUK20407.1; -; Genomic_DNA.
EMBL; MSHY01000092; OUK28406.1; -; Genomic_DNA.
EMBL; MSIB01000092; OUK34963.1; -; Genomic_DNA.
EMBL; MSID01000238; OUK39334.1; -; Genomic_DNA.
EMBL; MSIC01000099; OUK42559.1; -; Genomic_DNA.
EMBL; MSHT01000262; OUK43297.1; -; Genomic_DNA.
EMBL; NXPI01000001; PHL89746.1; -; Genomic_DNA.
EMBL; FKLM01000120; SAM54142.1; -; Genomic_DNA.
RefSeq; WP_001059542.1; NZ_PPCL01000141.1.
RefSeq; YP_001019036.1; NC_008821.1.
RefSeq; YP_001974797.1; NC_010980.1.
RefSeq; YP_002128398.1; NC_011140.1.
RefSeq; YP_004172616.1; NC_014959.1.
RefSeq; YP_006937549.1; NC_013317.1.
RefSeq; YP_007908269.1; NC_021170.1.
RefSeq; YP_976078.1; NC_008768.1.
EnsemblBacteria; KWY81475; KWY81475; AS252_02500.
GeneID; 10164670; -.
GeneID; 13874696; -.
GeneID; 15383085; -.
GeneID; 4670245; -.
GeneID; 4783157; -.
GeneID; 6385882; -.
GeneID; 6779649; -.
PATRIC; fig|1352.1358.peg.3011; -.
BioCyc; MetaCyc:MONOMER-15467; -.
Proteomes; UP000183509; Unassembled WGS sequence.
Proteomes; UP000190755; Plasmid p268-3 sequence.
Proteomes; UP000191171; Unassembled WGS sequence.
Proteomes; UP000192991; Unassembled WGS sequence.
Proteomes; UP000195317; Unassembled WGS sequence.
Proteomes; UP000195596; Unassembled WGS sequence.
Proteomes; UP000195616; Unassembled WGS sequence.
Proteomes; UP000195625; Unassembled WGS sequence.
Proteomes; UP000195680; Unassembled WGS sequence.
Proteomes; UP000195730; Unassembled WGS sequence.
Proteomes; UP000195760; Unassembled WGS sequence.
Proteomes; UP000195945; Unassembled WGS sequence.
Proteomes; UP000196144; Unassembled WGS sequence.
Proteomes; UP000196332; Unassembled WGS sequence.
Proteomes; UP000225744; Unassembled WGS sequence.
Proteomes; UP000234558; Plasmid p2.
Proteomes; UP000235573; Plasmid pefa-790c.
GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
InterPro; IPR029753; D-isomer_DH_CS.
InterPro; IPR029752; D-isomer_DH_CS1.
InterPro; IPR006140; D-isomer_DH_NAD-bd.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF00389; 2-Hacid_dh; 1.
Pfam; PF02826; 2-Hacid_dh_C; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000183509,
ECO:0000313|Proteomes:UP000190755, ECO:0000313|Proteomes:UP000191171,
ECO:0000313|Proteomes:UP000192991};
DNA-directed DNA polymerase {ECO:0000313|EMBL:CAP62632.1};
Nucleotidyltransferase {ECO:0000313|EMBL:CAP62632.1};
Oxidoreductase {ECO:0000256|RuleBase:RU003719,
ECO:0000313|EMBL:ADA62244.1}; Plasmid {ECO:0000313|EMBL:AAM77884.1};
Pyruvate {ECO:0000313|EMBL:AAM77884.1};
RNA-directed DNA polymerase {ECO:0000313|EMBL:CAP62632.1};
Transferase {ECO:0000313|EMBL:CAP62632.1}.
DOMAIN 38 319 2-Hacid_dh. {ECO:0000259|Pfam:PF00389}.
DOMAIN 112 294 2-Hacid_dh_C. {ECO:0000259|Pfam:PF02826}.
SEQUENCE 322 AA; 35795 MW; 07CC31611C459D12 CRC64;
MNNIGITVYG CEQDEADAFH ALSPRFGVMA TIINANVSES NAKSAPFNQC ISVGHKSEIS
ASILLALKRA GVKYISTRSI GCNHIDTTAA KRMGITVDNV AYSPDSVADY TMMLILMAVR
NVKSIVRSVE KHDFRLDSDR GKVLSDMTVG VVGTGQIGKA VIERLRGFGC KVLAYSRSRS
IEVNYVPFDE LLQNSDIVTL HVPLNTDTHY IISHEQIQRM KQGAFLINTG RGPLVDTYEL
VKALENGKLG GAALDVLEGE EEFFYSDCTQ KPIDNQFLLK LQRMPNVIIT PHTAYYTEQA
LRDTVEKTIK NCLDFERRQE HE


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