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DASH complex subunit ASK1 (Associated with spindles and kinetochores protein 1) (Outer kinetochore protein ASK1)

 ASK1_ASHGO              Reviewed;         181 AA.
Q75DE8;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
23-MAY-2018, entry version 79.
RecName: Full=DASH complex subunit ASK1;
AltName: Full=Associated with spindles and kinetochores protein 1;
AltName: Full=Outer kinetochore protein ASK1;
Name=ASK1; OrderedLocusNames=ABR079C;
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
Y-1056) (Yeast) (Eremothecium gossypii).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
NCBI_TaxID=284811;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
PubMed=15001715; DOI=10.1126/science.1095781;
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient
Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
PubMed=23749448; DOI=10.1534/g3.112.002881;
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
"Genomes of Ashbya fungi isolated from insects reveal four mating-type
loci, numerous translocations, lack of transposons, and distinct gene
duplications.";
G3 (Bethesda) 3:1225-1239(2013).
-!- FUNCTION: Component of the DASH complex, a microtubule-binding
subcomplex of the outer kinetochore that is essential for proper
chromosome segregation. The DASH complex mediates the formation
and maintenance of bipolar kinetochore-microtubule attachments by
forming closed rings around spindle microtubules and establishing
interactions with proteins from the central kinetochore (By
similarity). {ECO:0000250}.
-!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle
the microtubules. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm,
cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere,
kinetochore {ECO:0000250}. Note=Associates with the mitotic
spindle and the kinetochore. {ECO:0000250}.
-!- SIMILARITY: Belongs to the DASH complex ASK1 family.
{ECO:0000305}.
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EMBL; AE016815; AAS50849.1; -; Genomic_DNA.
RefSeq; NP_983025.1; NM_208378.1.
STRING; 33169.AAS50849; -.
EnsemblFungi; AAS50849; AAS50849; AGOS_ABR079C.
GeneID; 4619129; -.
KEGG; ago:AGOS_ABR079C; -.
HOGENOM; HOG000034102; -.
InParanoid; Q75DE8; -.
KO; K11566; -.
OMA; CEDITNS; -.
OrthoDB; EOG092C5NUZ; -.
Proteomes; UP000000591; Chromosome II.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0042729; C:DASH complex; IBA:GO_Central.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:InterPro.
GO; GO:0044732; C:mitotic spindle pole body; IBA:GO_Central.
GO; GO:0051010; F:microtubule plus-end binding; IBA:GO_Central.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:1990758; P:mitotic sister chromatid biorientation; IBA:GO_Central.
InterPro; IPR013964; DASH_Ask1.
Pfam; PF08655; DASH_Ask1; 1.
3: Inferred from homology;
Cell cycle; Cell division; Centromere; Chromosome;
Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton;
Kinetochore; Microtubule; Mitosis; Nucleus; Reference proteome.
CHAIN 1 181 DASH complex subunit ASK1.
/FTId=PRO_0000211313.
SEQUENCE 181 AA; 19596 MW; 874FD9D56779F627 CRC64;
MARQPPAPEP TLEQLDQEIT LQLQKIDANL SACFSKITKD IIPAVARYGA VCDDALSACS
WLRELFQKSS DIQLATEPAA PAPAAESLFP QAPAPRAPEV TTEGHVLAVP VSSDDEPDDG
STLQRQHKRR KLSLQLQQRY GSSSSSSFVS RSPTLRTRPA SSPLRAPDDP DPPAVLRFAA
R


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