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DASH complex subunit ask1 (Associated with spindles and kinetochores protein 1) (Meiotically up-regulated gene 181 protein) (Outer kinetochore protein ask1)

 ASK1_SCHPO              Reviewed;         307 AA.
Q9P6S5; P78949;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
31-JAN-2018, entry version 98.
RecName: Full=DASH complex subunit ask1;
AltName: Full=Associated with spindles and kinetochores protein 1;
AltName: Full=Meiotically up-regulated gene 181 protein;
AltName: Full=Outer kinetochore protein ask1;
Name=ask1; Synonyms=mug181; ORFNames=SPBC27.02c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=972 / ATCC 24843;
Kohnosu A., Niwa O., Yano M., Saitoh S., Katayama T., Nagao K.,
Yanagida M.;
"S.pombe chromosome II cosmid 1228 sequence.";
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
FUNCTION IN MEIOSIS.
PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L.,
San-Segundo P., Smith G.R., Moreno S.;
"A large-scale screen in S. pombe identifies seven novel genes
required for critical meiotic events.";
Curr. Biol. 15:2056-2062(2005).
[4]
FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
"Molecular analysis of kinetochore architecture in fission yeast.";
EMBO J. 24:2919-2930(2005).
[5]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-136, AND IDENTIFICATION
BY MASS SPECTROMETRY.
PubMed=18257517; DOI=10.1021/pr7006335;
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
-!- FUNCTION: Component of the DASH complex, a microtubule-binding
subcomplex of the outer kinetochore that is essential for proper
chromosome segregation. The DASH complex mediates the formation
and maintenance of bipolar kinetochore-microtubule attachments by
forming closed rings around spindle microtubules and establishing
interactions with proteins from the central kinetochore. Plays a
role in meiosis. {ECO:0000269|PubMed:16079914,
ECO:0000269|PubMed:16303567}.
-!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle
the microtubules. {ECO:0000269|PubMed:16079914}.
-!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle.
Chromosome, centromere, kinetochore. Note=Associates with the
mitotic spindle and the kinetochore. Kinetochore association
occurs only during mitosis.
-!- SIMILARITY: Belongs to the DASH complex ASK1 family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAA12199.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; D83993; BAA12199.1; ALT_SEQ; Genomic_DNA.
EMBL; CU329671; CAB89002.1; -; Genomic_DNA.
RefSeq; NP_595657.1; NM_001021551.2.
BioGrid; 277026; 362.
MINT; MINT-4704736; -.
STRING; 4896.SPBC27.02c.1; -.
iPTMnet; Q9P6S5; -.
MaxQB; Q9P6S5; -.
PaxDb; Q9P6S5; -.
PRIDE; Q9P6S5; -.
EnsemblFungi; SPBC27.02c.1; SPBC27.02c.1:pep; SPBC27.02c.
GeneID; 2540498; -.
KEGG; spo:SPBC27.02c; -.
EuPathDB; FungiDB:SPBC27.02c; -.
PomBase; SPBC27.02c; ask1.
InParanoid; Q9P6S5; -.
KO; K11566; -.
OMA; RTESCHT; -.
OrthoDB; EOG092C5NUZ; -.
PhylomeDB; Q9P6S5; -.
PRO; PR:Q9P6S5; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:PomBase.
GO; GO:0005829; C:cytosol; IDA:PomBase.
GO; GO:0042729; C:DASH complex; IDA:PomBase.
GO; GO:1990941; C:mitotic spindle kinetochore microtubule; IDA:PomBase.
GO; GO:1990537; C:mitotic spindle polar microtubule; IDA:PomBase.
GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
GO; GO:0005880; C:nuclear microtubule; IDA:PomBase.
GO; GO:0005634; C:nucleus; IDA:PomBase.
GO; GO:0051010; F:microtubule plus-end binding; IBA:GO_Central.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0043622; P:cortical microtubule organization; IGI:PomBase.
GO; GO:0071963; P:establishment or maintenance of cell polarity regulating cell shape; IGI:PomBase.
GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
GO; GO:1990758; P:mitotic sister chromatid biorientation; TAS:PomBase.
InterPro; IPR013964; DASH_Ask1.
Pfam; PF08655; DASH_Ask1; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome;
Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton;
Kinetochore; Meiosis; Microtubule; Mitosis; Nucleus; Phosphoprotein;
Reference proteome.
CHAIN 1 307 DASH complex subunit ask1.
/FTId=PRO_0000211316.
MOD_RES 136 136 Phosphothreonine.
{ECO:0000269|PubMed:18257517}.
SEQUENCE 307 AA; 34593 MW; 6C0A1C7A765C96F3 CRC64;
MNNLEQLERL EQSITLALYE IDANFSKCHR TVTTKILPIV EKYAKNCNTI WDSSKFWKQF
FEASANVSLS GVEEPVPVES NPSDQDVMSN STEADLQLHT KNEHLEKRHS FVGKSDFPDA
AVQGDNTKNE DFVQSTPKKM DVSLEDISLD DAALTPIPAR MQTPLRKPEN NPHTGRSALL
HRVLDTNWQV QVTPREPKNL QSQEVMDIDS SPFVSPSPIS MKMDMPSLND RNSSHALSLF
AEFEHESYDS INPSGMSPPK TIQFSPHTMG VGSSQQANER SLSLQRKLET LNDSNDSFVK
EEDSWEL


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