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DCTD protein (dCMP deaminase)

 A6QQC3_BOVIN            Unreviewed;       178 AA.
A6QQC3; F1MQM8;
21-AUG-2007, integrated into UniProtKB/TrEMBL.
21-AUG-2007, sequence version 1.
25-OCT-2017, entry version 85.
SubName: Full=DCTD protein {ECO:0000313|EMBL:AAI49762.1};
SubName: Full=dCMP deaminase {ECO:0000313|Ensembl:ENSBTAP00000027028};
Name=DCTD {ECO:0000313|EMBL:AAI49762.1,
ECO:0000313|Ensembl:ENSBTAP00000027028};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI49762.1};
[1] {ECO:0000313|EMBL:AAI49762.1}
NUCLEOTIDE SEQUENCE.
STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI49762.1};
TISSUE=Uterus {ECO:0000313|EMBL:AAI49762.1};
Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
Siddiqui A., Holt R., Jones S.J., Marra M.A.;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSBTAP00000027028, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027028,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[3] {ECO:0000313|Ensembl:ENSBTAP00000027028}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027028};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|PIRSR:PIRSR006019-2};
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EMBL; DAAA02060140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; DAAA02060141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC149761; AAI49762.1; -; mRNA.
RefSeq; NP_001094762.1; NM_001101292.1.
UniGene; Bt.64698; -.
STRING; 9913.ENSBTAP00000027028; -.
Ensembl; ENSBTAT00000027028; ENSBTAP00000027028; ENSBTAG00000020282.
GeneID; 784292; -.
KEGG; bta:784292; -.
CTD; 1635; -.
eggNOG; KOG3127; Eukaryota.
eggNOG; COG2131; LUCA.
GeneTree; ENSGT00390000000501; -.
HOGENOM; HOG000015715; -.
HOVERGEN; HBG025823; -.
KO; K01493; -.
OMA; YITASPC; -.
OrthoDB; EOG091G0JEC; -.
TreeFam; TF105971; -.
Reactome; R-BTA-499943; Interconversion of nucleotide di- and triphosphates.
Proteomes; UP000009136; Chromosome 27.
Bgee; ENSBTAG00000020282; -.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0004132; F:dCMP deaminase activity; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006231; P:dTMP biosynthetic process; IBA:GO_Central.
GO; GO:0006226; P:dUMP biosynthetic process; IBA:GO_Central.
CDD; cd01286; deoxycytidylate_deaminase; 1.
InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
InterPro; IPR002125; CMP_dCMP_dom.
InterPro; IPR016193; Cytidine_deaminase-like.
InterPro; IPR016473; dCMP_deaminase.
InterPro; IPR015517; dCMP_deaminase-rel.
InterPro; IPR035105; Deoxycytidylate_deaminase_dom.
PANTHER; PTHR11086; PTHR11086; 1.
Pfam; PF00383; dCMP_cyt_deam_1; 1.
PIRSF; PIRSF006019; dCMP_deaminase; 1.
SUPFAM; SSF53927; SSF53927; 1.
PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1.
PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Metal-binding {ECO:0000256|PIRSR:PIRSR006019-2};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Zinc {ECO:0000256|PIRSR:PIRSR006019-2}.
DOMAIN 14 151 CMP/dCMP-type deaminase.
{ECO:0000259|PROSITE:PS51747}.
ACT_SITE 86 86 Proton donor.
{ECO:0000256|PIRSR:PIRSR006019-1}.
METAL 84 84 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR006019-2}.
METAL 110 110 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR006019-2}.
METAL 113 113 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR006019-2}.
SEQUENCE 178 AA; 20039 MW; 720FCCB2ED90710B CRC64;
MSEVPCRKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNAENKIVG IGYNGMPNGC
SDDLLPWRRT AENILDTKYP YVCHAELNAI MNKNSADVKG CTMYVALFPC NECAKLIIQA
GIKEVIFMSD KYHDSNETTA ARLLFEMAGV SFRKFTPKCS QIVIDFDSIN SRPSQKLQ


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