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DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (C/EBP-homologous protein 10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)

 A0A2J8KW39_PANTR        Unreviewed;       192 AA.
A0A2J8KW39; H2R2A8;
25-APR-2018, integrated into UniProtKB/TrEMBL.
25-APR-2018, sequence version 1.
07-NOV-2018, entry version 5.
RecName: Full=DNA damage-inducible transcript 3 protein {ECO:0000256|PIRNR:PIRNR016571};
Short=DDIT-3 {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=C/EBP zeta {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=C/EBP-homologous protein {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=C/EBP-homologous protein 10 {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=CCAAT/enhancer-binding protein homologous protein {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=Growth arrest and DNA-damage-inducible protein GADD153 {ECO:0000256|PIRNR:PIRNR016571};
Name=DDIT3 {ECO:0000313|Ensembl:ENSPTRP00000043666,
ECO:0000313|VGNC:VGNC:12914};
ORFNames=CK820_G0035462 {ECO:0000313|EMBL:PNI39246.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI39246.1};
[1] {ECO:0000313|Ensembl:ENSPTRP00000043666, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000043666}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:PNI39246.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI39246.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI39246.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Multifunctional transcription factor in ER stress
response. Plays an essential role in the response to a wide
variety of cell stresses and induces cell cycle arrest and
apoptosis in response to ER stress. Plays a dual role both as an
inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and
as an activator of other genes. Acts as a dominant-negative
regulator of C/EBP-induced transcription: dimerizes with members
of the C/EBP family, impairs their association with C/EBP binding
sites in the promoter regions, and inhibits the expression of
C/EBP regulated genes. Positively regulates the transcription of
TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA,
BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2
and MYOD1, ATF4-dependent transcriptional activation of asparagine
synthetase (ASNS), CEBPA-dependent transcriptional activation of
hepcidin (HAMP) and CEBPB-mediated expression of peroxisome
proliferator-activated receptor gamma (PPARG). Inhibits the
canonical Wnt signaling pathway by binding to TCF7L2/TCF4,
impairing its DNA-binding properties and repressing its
transcriptional activity. Plays a regulatory role in the
inflammatory response through the induction of caspase-11
(CASP4/CASP11) which induces the activation of caspase-1 (CASP1)
and both these caspases increase the activation of pro-IL1B to
mature IL1B which is involved in the inflammatory response.
{ECO:0000256|PIRNR:PIRNR016571}.
-!- SUBUNIT: Heterodimer. {ECO:0000256|PIRNR:PIRNR016571}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR016571}.
Nucleus {ECO:0000256|PIRNR:PIRNR016571}. Note=Present in the
cytoplasm under non-stressed conditions and ER stress leads to its
nuclear accumulation. {ECO:0000256|PIRNR:PIRNR016571}.
-!- PTM: Phosphorylation at serine residues by MAPK14 enhances its
transcriptional activation activity while phosphorylation at
serine residues by CK2 inhibits its transcriptional activation
activity. {ECO:0000256|PIRNR:PIRNR016571}.
-!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
{ECO:0000256|PIRNR:PIRNR016571}.
-!- SIMILARITY: Belongs to the bZIP family.
{ECO:0000256|PIRNR:PIRNR016571}.
-----------------------------------------------------------------------
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EMBL; AC191734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; NBAG03000333; PNI39246.1; -; Genomic_DNA.
EMBL; NBAG03000333; PNI39248.1; -; Genomic_DNA.
RefSeq; XP_009423339.1; XM_009425064.2.
RefSeq; XP_009423340.1; XM_009425065.2.
STRING; 9598.ENSPTRP00000043666; -.
Ensembl; ENSPTRT00000047450; ENSPTRP00000043666; ENSPTRG00000022781.
GeneID; 452017; -.
KEGG; ptr:452017; -.
CTD; 1649; -.
VGNC; VGNC:12914; DDIT3.
eggNOG; ENOG410ISXY; Eukaryota.
eggNOG; ENOG41127XB; LUCA.
GeneTree; ENSGT00390000006305; -.
KO; K04452; -.
OMA; MVNLHQA; -.
OrthoDB; EOG091G0UKC; -.
TreeFam; TF105006; -.
Proteomes; UP000002277; Chromosome 12.
Bgee; ENSPTRG00000022781; Expressed in 6 organ(s), highest expression level in liver.
GO; GO:1990622; C:CHOP-ATF3 complex; IEA:Ensembl.
GO; GO:1990617; C:CHOP-ATF4 complex; IEA:Ensembl.
GO; GO:0036488; C:CHOP-C/EBP complex; IEA:Ensembl.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
GO; GO:0008140; F:cAMP response element binding protein binding; IEA:Ensembl.
GO; GO:0043522; F:leucine zipper domain binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0001077; F:proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001955; P:blood vessel maturation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:1990442; P:intrinsic apoptotic signaling pathway in response to nitrosative stress; IEA:Ensembl.
GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IEA:Ensembl.
GO; GO:2000016; P:negative regulation of determination of dorsal identity; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
GO; GO:0044324; P:regulation of transcription involved in anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR004827; bZIP.
InterPro; IPR016670; DNA_damage_induc_transcript_3.
PANTHER; PTHR16833; PTHR16833; 1.
Pfam; PF07716; bZIP_2; 1.
PIRSF; PIRSF016571; C/EBPzeta_CHOP_DDIT3; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
3: Inferred from homology;
Activator {ECO:0000256|PIRNR:PIRNR016571};
Apoptosis {ECO:0000256|PIRNR:PIRNR016571};
Cell cycle {ECO:0000256|PIRNR:PIRNR016571};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Cytoplasm {ECO:0000256|PIRNR:PIRNR016571};
DNA-binding {ECO:0000256|PIRNR:PIRNR016571};
Growth arrest {ECO:0000256|PIRNR:PIRNR016571};
Nucleus {ECO:0000256|PIRNR:PIRNR016571};
Phosphoprotein {ECO:0000256|PIRNR:PIRNR016571};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Repressor {ECO:0000256|PIRNR:PIRNR016571};
Stress response {ECO:0000256|PIRNR:PIRNR016571};
Transcription {ECO:0000256|PIRNR:PIRNR016571};
Transcription regulation {ECO:0000256|PIRNR:PIRNR016571};
Ubl conjugation {ECO:0000256|PIRNR:PIRNR016571};
Unfolded protein response {ECO:0000256|PIRNR:PIRNR016571};
Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR016571}.
DOMAIN 122 185 BZIP. {ECO:0000259|PROSITE:PS50217}.
COILED 140 181 {ECO:0000256|SAM:Coils}.
SEQUENCE 192 AA; 21681 MW; 46569DBC24760231 CRC64;
MELVPATPHY PADVLFQTDP TAEMAAESLP FSFGTLSSWE LEAWYEDLQE VLSSDENGGT
YVSPPGNEEE ESKIFTTLDP ASLAWLTEEE PEPAEVTSTS QSPHSPDSSQ SSLAQEEEEE
DQGRTRKRKQ SGHSPARAGK QRMKEKEQEN ERKVAQLAEE NERLKQEIEH LTREVEATRR
ALIDRMVNLH QA


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