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DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (C/EBP-homologous protein 10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)

 M1PEQ4_CAPHI            Unreviewed;       168 AA.
M1PEQ4;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
20-JUN-2018, entry version 21.
RecName: Full=DNA damage-inducible transcript 3 protein {ECO:0000256|PIRNR:PIRNR016571};
Short=DDIT-3 {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=C/EBP zeta {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=C/EBP-homologous protein {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=C/EBP-homologous protein 10 {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=CCAAT/enhancer-binding protein homologous protein {ECO:0000256|PIRNR:PIRNR016571};
AltName: Full=Growth arrest and DNA-damage-inducible protein GADD153 {ECO:0000256|PIRNR:PIRNR016571};
Name=DDIT3 {ECO:0000313|EMBL:AGF87123.1};
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925 {ECO:0000313|EMBL:AGF87123.1};
[1] {ECO:0000313|EMBL:AGF87123.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Ovary {ECO:0000313|EMBL:AGF87123.1};
Lin P., Liu Y., Sun J., Jin Y., Wang A.;
"Cloning and bioinformatics analysis of goat CHOP gene.";
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Multifunctional transcription factor in ER stress
response. Plays an essential role in the response to a wide
variety of cell stresses and induces cell cycle arrest and
apoptosis in response to ER stress. Plays a dual role both as an
inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and
as an activator of other genes. Acts as a dominant-negative
regulator of C/EBP-induced transcription: dimerizes with members
of the C/EBP family, impairs their association with C/EBP binding
sites in the promoter regions, and inhibits the expression of
C/EBP regulated genes. Positively regulates the transcription of
TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA,
BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2
and MYOD1, ATF4-dependent transcriptional activation of asparagine
synthetase (ASNS), CEBPA-dependent transcriptional activation of
hepcidin (HAMP) and CEBPB-mediated expression of peroxisome
proliferator-activated receptor gamma (PPARG). Inhibits the
canonical Wnt signaling pathway by binding to TCF7L2/TCF4,
impairing its DNA-binding properties and repressing its
transcriptional activity. Plays a regulatory role in the
inflammatory response through the induction of caspase-11
(CASP4/CASP11) which induces the activation of caspase-1 (CASP1)
and both these caspases increase the activation of pro-IL1B to
mature IL1B which is involved in the inflammatory response.
{ECO:0000256|PIRNR:PIRNR016571}.
-!- SUBUNIT: Heterodimer. {ECO:0000256|PIRNR:PIRNR016571}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR016571}.
Nucleus {ECO:0000256|PIRNR:PIRNR016571}. Note=Present in the
cytoplasm under non-stressed conditions and ER stress leads to its
nuclear accumulation. {ECO:0000256|PIRNR:PIRNR016571}.
-!- PTM: Phosphorylation at serine residues by MAPK14 enhances its
transcriptional activation activity while phosphorylation at
serine residues by CK2 inhibits its transcriptional activation
activity. {ECO:0000256|PIRNR:PIRNR016571}.
-!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
{ECO:0000256|PIRNR:PIRNR016571}.
-!- SIMILARITY: Belongs to the bZIP family.
{ECO:0000256|PIRNR:PIRNR016571}.
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EMBL; KC188779; AGF87123.1; -; mRNA.
RefSeq; NP_001274160.1; NM_001287231.1.
RefSeq; XP_005680342.1; XM_005680285.3.
UniGene; Chi.14674; -.
Ensembl; ENSCHIT00000016605; ENSCHIP00000008843; ENSCHIG00000011897.
GeneID; 102175557; -.
KEGG; chx:102175557; -.
CTD; 1649; -.
KO; K04452; -.
OrthoDB; EOG091G0UKC; -.
GO; GO:1990622; C:CHOP-ATF3 complex; IEA:Ensembl.
GO; GO:1990617; C:CHOP-ATF4 complex; IEA:Ensembl.
GO; GO:0036488; C:CHOP-C/EBP complex; IEA:Ensembl.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
GO; GO:0008140; F:cAMP response element binding protein binding; IEA:Ensembl.
GO; GO:0043522; F:leucine zipper domain binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001955; P:blood vessel maturation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:1990442; P:intrinsic apoptotic signaling pathway in response to nitrosative stress; IEA:Ensembl.
GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IEA:Ensembl.
GO; GO:2000016; P:negative regulation of determination of dorsal identity; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
GO; GO:0044324; P:regulation of transcription involved in anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR004827; bZIP.
InterPro; IPR016670; DNA_damage_induc_transcript_3.
PANTHER; PTHR16833; PTHR16833; 1.
Pfam; PF07716; bZIP_2; 1.
PIRSF; PIRSF016571; C/EBPzeta_CHOP_DDIT3; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
2: Evidence at transcript level;
Activator {ECO:0000256|PIRNR:PIRNR016571};
Apoptosis {ECO:0000256|PIRNR:PIRNR016571};
Cell cycle {ECO:0000256|PIRNR:PIRNR016571};
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|PIRNR:PIRNR016571};
DNA-binding {ECO:0000256|PIRNR:PIRNR016571};
Growth arrest {ECO:0000256|PIRNR:PIRNR016571};
Nucleus {ECO:0000256|PIRNR:PIRNR016571};
Phosphoprotein {ECO:0000256|PIRNR:PIRNR016571};
Repressor {ECO:0000256|PIRNR:PIRNR016571};
Stress response {ECO:0000256|PIRNR:PIRNR016571};
Transcription {ECO:0000256|PIRNR:PIRNR016571};
Transcription regulation {ECO:0000256|PIRNR:PIRNR016571};
Ubl conjugation {ECO:0000256|PIRNR:PIRNR016571};
Unfolded protein response {ECO:0000256|PIRNR:PIRNR016571};
Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR016571}.
DOMAIN 98 161 BZIP. {ECO:0000259|PROSITE:PS50217}.
COILED 116 157 {ECO:0000256|SAM:Coils}.
SEQUENCE 168 AA; 19018 MW; 6B779F1969BA43E9 CRC64;
MAAESLPFSF GALSSWELEA WYEDLQEVLS SDENRGTCVS PPGNKEEESK TFTTLDPASL
AWLTEEPGPP EVTRTSQSPC SPESSQSSLA QEEEEEDQGR PRKRKQSGQS PARAGKQRMK
EKEQENERKV AQLAEENDRL KQEIERLTRE VEATRRALID RMVNLHQA


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