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DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (C/EBP-homologous protein 10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)

 M3VXV5_FELCA            Unreviewed;       167 AA.
M3VXV5;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 2.
05-DEC-2018, entry version 42.
SubName: Full=DNA damage inducible transcript 3 {ECO:0000313|Ensembl:ENSFCAP00000001926};
Name=DDIT3 {ECO:0000313|Ensembl:ENSFCAP00000001926};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000001926, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000001926, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001926,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000001926}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001926};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000001926}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000001926};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
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EMBL; AANG04003655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_006933910.1; XM_006933848.3.
STRING; 9685.ENSFCAP00000001926; -.
Ensembl; ENSFCAT00000002084; ENSFCAP00000001926; ENSFCAG00000002084.
GeneID; 101081819; -.
KEGG; fca:101081819; -.
CTD; 1649; -.
eggNOG; ENOG410ISXY; Eukaryota.
eggNOG; ENOG41127XB; LUCA.
GeneTree; ENSGT00390000006305; -.
InParanoid; M3VXV5; -.
KO; K04452; -.
OrthoDB; EOG091G0UKC; -.
Proteomes; UP000011712; Chromosome B4.
Bgee; ENSFCAG00000002084; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:1990622; C:CHOP-ATF3 complex; IBA:GO_Central.
GO; GO:1990617; C:CHOP-ATF4 complex; IBA:GO_Central.
GO; GO:0036488; C:CHOP-C/EBP complex; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
GO; GO:0008140; F:cAMP response element binding protein binding; IEA:Ensembl.
GO; GO:0043522; F:leucine zipper domain binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0001077; F:proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001955; P:blood vessel maturation; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IBA:GO_Central.
GO; GO:1990442; P:intrinsic apoptotic signaling pathway in response to nitrosative stress; IEA:Ensembl.
GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IEA:Ensembl.
GO; GO:2000016; P:negative regulation of determination of dorsal identity; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
GO; GO:0044324; P:regulation of transcription involved in anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
InterPro; IPR004827; bZIP.
InterPro; IPR016670; DNA_damage_induc_transcript_3.
PANTHER; PTHR16833; PTHR16833; 1.
PIRSF; PIRSF016571; C/EBPzeta_CHOP_DDIT3; 1.
PROSITE; PS50217; BZIP; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Reference proteome {ECO:0000313|Proteomes:UP000011712}.
DOMAIN 97 160 BZIP. {ECO:0000259|PROSITE:PS50217}.
COILED 115 156 {ECO:0000256|SAM:Coils}.
SEQUENCE 167 AA; 18876 MW; 22FE814D583CA434 CRC64;
MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGATYVS PPGNEEESKT FTTLDPASLA
WLTEEPGPAE VTNTSQSPHS PDSIQSSLAQ EEEEEDQERP RKRKQSGQSL AGAGKQRMKE
KEQENERKVA QLAEENERLK QEIERLTREV EATRRALIDR MVNLHKA


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