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DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)

 DDIT3_BOVIN             Reviewed;         168 AA.
Q0IIB6;
01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
03-OCT-2006, sequence version 1.
30-AUG-2017, entry version 82.
RecName: Full=DNA damage-inducible transcript 3 protein;
Short=DDIT-3;
AltName: Full=C/EBP zeta;
AltName: Full=C/EBP-homologous protein;
Short=CHOP;
AltName: Full=C/EBP-homologous protein 10;
Short=CHOP-10;
AltName: Full=CCAAT/enhancer-binding protein homologous protein;
AltName: Full=Growth arrest and DNA-damage-inducible protein GADD153;
Name=DDIT3; Synonyms=CHOP, CHOP10, GADD153;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Hypothalamus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Multifunctional transcription factor in ER stress
response. Plays an essential role in the response to a wide
variety of cell stresses and induces cell cycle arrest and
apoptosis in response to ER stress. Plays a dual role both as an
inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and
as an activator of other genes. Acts as a dominant-negative
regulator of C/EBP-induced transcription: dimerizes with members
of the C/EBP family, impairs their association with C/EBP binding
sites in the promoter regions, and inhibits the expression of
C/EBP regulated genes. Positively regulates the transcription of
TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA,
BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2
and MYOD1, ATF4-dependent transcriptional activation of asparagine
synthetase (ASNS), CEBPA-dependent transcriptional activation of
hepcidin (HAMP) and CEBPB-mediated expression of peroxisome
proliferator-activated receptor gamma (PPARG). Inhibits the
canonical Wnt signaling pathway by binding to TCF7L2/TCF4,
impairing its DNA-binding properties and repressing its
transcriptional activity. Plays a regulatory role in the
inflammatory response through the induction of caspase-11
(CASP4/CASP11) which induces the activation of caspase-1 (CASP1)
and both these caspases increase the activation of pro-IL1B to
mature IL1B which is involved in the inflammatory response (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer (By similarity). Interacts with TCF7L2/TCF4,
EP300/P300, HDAC1, HDAC5 and HDAC6. Interacts with TRIB3 which
blocks its association with EP300/P300. Interacts with FOXO3,
CEBPB and ATF4 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000255|PROSITE-ProRule:PRU00978}. Note=Present in the
cytoplasm under non-stressed conditions and ER stress leads to its
nuclear accumulation. {ECO:0000250}.
-!- DOMAIN: The N-terminal region is necessary for its proteasomal
degradation, transcriptional activity and interaction with
EP300/P300. {ECO:0000250}.
-!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
{ECO:0000250}.
-!- PTM: Phosphorylation at serine residues by MAPK14 enhances its
transcriptional activation activity while phosphorylation at
serine residues by CK2 inhibits its transcriptional activation
activity. {ECO:0000250}.
-!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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EMBL; BC122721; AAI22722.1; -; mRNA.
RefSeq; NP_001071631.1; NM_001078163.1.
UniGene; Bt.65257; -.
STRING; 9913.ENSBTAP00000042185; -.
PaxDb; Q0IIB6; -.
PRIDE; Q0IIB6; -.
Ensembl; ENSBTAT00000044712; ENSBTAP00000042185; ENSBTAG00000031544.
GeneID; 777788; -.
KEGG; bta:777788; -.
CTD; 1649; -.
eggNOG; ENOG410ISXY; Eukaryota.
eggNOG; ENOG41127XB; LUCA.
GeneTree; ENSGT00390000006305; -.
HOGENOM; HOG000089934; -.
HOVERGEN; HBG051328; -.
InParanoid; Q0IIB6; -.
KO; K04452; -.
OMA; WELEAWY; -.
OrthoDB; EOG091G0UKC; -.
TreeFam; TF105006; -.
Proteomes; UP000009136; Chromosome 5.
Bgee; ENSBTAG00000031544; -.
GO; GO:1990622; C:CHOP-ATF3 complex; IBA:GO_Central.
GO; GO:1990617; C:CHOP-ATF4 complex; IBA:GO_Central.
GO; GO:0036488; C:CHOP-C/EBP complex; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO; GO:0035976; C:transcription factor AP-1 complex; IEA:Ensembl.
GO; GO:0008140; F:cAMP response element binding protein binding; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0043522; F:leucine zipper domain binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IBA:GO_Central.
GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
GO; GO:0001955; P:blood vessel maturation; ISS:UniProtKB.
GO; GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISS:UniProtKB.
GO; GO:1990442; P:intrinsic apoptotic signaling pathway in response to nitrosative stress; IEA:Ensembl.
GO; GO:0042789; P:mRNA transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IEA:Ensembl.
GO; GO:2000016; P:negative regulation of determination of dorsal identity; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0032757; P:positive regulation of interleukin-8 production; ISS:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO; GO:0051259; P:protein oligomerization; IEA:Ensembl.
GO; GO:0044324; P:regulation of transcription involved in anterior/posterior axis specification; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.
GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
GO; GO:0042594; P:response to starvation; ISS:UniProtKB.
GO; GO:0006986; P:response to unfolded protein; ISS:UniProtKB.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR004827; bZIP.
InterPro; IPR016670; DNA_damage_induc_transcript_3.
PANTHER; PTHR16833; PTHR16833; 1.
PIRSF; PIRSF016571; C/EBPzeta_CHOP_DDIT3; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
2: Evidence at transcript level;
Activator; Apoptosis; Cell cycle; Complete proteome; Cytoplasm;
DNA-binding; Growth arrest; Nucleus; Phosphoprotein;
Reference proteome; Repressor; Stress response; Transcription;
Transcription regulation; Ubl conjugation; Unfolded protein response;
Wnt signaling pathway.
CHAIN 1 168 DNA damage-inducible transcript 3
protein.
/FTId=PRO_0000285215.
DOMAIN 98 161 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 10 26 N-terminal. {ECO:0000250}.
REGION 10 18 Interaction with TRIB3. {ECO:0000250}.
REGION 100 129 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 133 147 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
COMPBIAS 92 96 Poly-Glu.
MOD_RES 14 14 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:P35639}.
MOD_RES 15 15 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:P35639}.
MOD_RES 30 30 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:P35639}.
MOD_RES 31 31 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:P35639}.
MOD_RES 78 78 Phosphoserine; by MAPK14.
{ECO:0000250|UniProtKB:P35639}.
MOD_RES 81 81 Phosphoserine; by MAPK14.
{ECO:0000250|UniProtKB:P35639}.
SEQUENCE 168 AA; 19003 MW; D178D4EC04980AD5 CRC64;
MAAESLPFSF GALSSWELEA WYEDLQEVLS SDENRGTCVS PPGNKEEESK SFTTLDPASL
AWLTEEPGPP EVTHTSQSPC SPESSQSSLA QEEEEEDQGR TRKRKQSGQS PARAGKQRMK
EKEQENERKV AQLAEENERL KQEIERLTRE VEATRRALID RMVNLHQA


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