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DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)

 DDT4L_HUMAN             Reviewed;         193 AA.
Q96D03; B2R7C3;
23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
18-JUL-2018, entry version 120.
RecName: Full=DNA damage-inducible transcript 4-like protein;
AltName: Full=HIF-1 responsive protein RTP801-like;
AltName: Full=Protein regulated in development and DNA damage response 2;
Short=REDD-2;
Name=DDIT4L; Synonyms=REDD2, RTP801L;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cerebellum, and Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lymph node;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION.
PubMed=12453409; DOI=10.1016/S1097-2765(02)00706-2;
Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H.,
Minda K., Oliner J.D., McKeon F., Haber D.A.;
"REDD1, a developmentally regulated transcriptional target of p63 and
p53, links p63 to regulation of reactive oxygen species.";
Mol. Cell 10:995-1005(2002).
[6]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=15308555; DOI=10.1161/01.ATV.0000142366.69080.c3;
Cuaz-Perolin C., Furman C., Larigauderie G., Legedz L., Lasselin C.,
Copin C., Jaye M., Searfoss G., Yu K.T., Duverger N.,
Negre-Salvayre A., Fruchart J.-C., Rouis M.;
"REDD2 gene is upregulated by modified LDL or hypoxia and mediates
human macrophage cell death.";
Arterioscler. Thromb. Vasc. Biol. 24:1830-1835(2004).
[7]
FUNCTION.
PubMed=15545625; DOI=10.1101/gad.1256804;
Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H.,
Hafen E., Witters L.A., Ellisen L.W., Kaelin W.G. Jr.;
"Regulation of mTOR function in response to hypoxia by REDD1 and the
TSC1/TSC2 tumor suppressor complex.";
Genes Dev. 18:2893-2904(2004).
[8]
FUNCTION.
PubMed=15632201; DOI=10.1074/jbc.C400557200;
Corradetti M.N., Inoki K., Guan K.-L.;
"The stress-inducted proteins RTP801 and RTP801L are negative
regulators of the mammalian target of rapamycin pathway.";
J. Biol. Chem. 280:9769-9772(2005).
-!- FUNCTION: Inhibits cell growth by regulating the TOR signaling
pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
{ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}.
-!- INTERACTION:
Q13137:CALCOCO2; NbExp=3; IntAct=EBI-742054, EBI-739580;
Q9UK45:LSM7; NbExp=7; IntAct=EBI-742054, EBI-348372;
Q15014:MORF4L2; NbExp=5; IntAct=EBI-742054, EBI-399257;
Q8WY64:MYLIP; NbExp=4; IntAct=EBI-742054, EBI-6952711;
P62308:SNRPG; NbExp=8; IntAct=EBI-742054, EBI-624585;
A0A024R4Q5:TFPT; NbExp=4; IntAct=EBI-742054, EBI-11527449;
P22217:TRX1 (xeno); NbExp=3; IntAct=EBI-742054, EBI-19607;
P22803:TRX2 (xeno); NbExp=3; IntAct=EBI-742054, EBI-19598;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- TISSUE SPECIFICITY: Up-regulated in atherosclerotic plaques
relative to healthy segments of the same artery.
{ECO:0000269|PubMed:15308555}.
-!- INDUCTION: Up-regulated by oxidized LDL and hypoxia in
macrophages. {ECO:0000269|PubMed:15308555}.
-!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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EMBL; AK094236; BAC04315.1; -; mRNA.
EMBL; AK312926; BAG35770.1; -; mRNA.
EMBL; AL832277; CAI46176.1; -; mRNA.
EMBL; CH471057; EAX06119.1; -; Genomic_DNA.
EMBL; BC013592; AAH13592.1; -; mRNA.
CCDS; CCDS34036.1; -.
RefSeq; NP_660287.1; NM_145244.3.
UniGene; Hs.480378; -.
ProteinModelPortal; Q96D03; -.
SMR; Q96D03; -.
BioGrid; 125421; 9.
IntAct; Q96D03; 607.
STRING; 9606.ENSP00000354830; -.
MoonDB; Q96D03; Predicted.
iPTMnet; Q96D03; -.
PhosphoSitePlus; Q96D03; -.
BioMuta; DDIT4L; -.
DMDM; 74731396; -.
PaxDb; Q96D03; -.
PeptideAtlas; Q96D03; -.
PRIDE; Q96D03; -.
ProteomicsDB; 76241; -.
DNASU; 115265; -.
Ensembl; ENST00000273990; ENSP00000354830; ENSG00000145358.
GeneID; 115265; -.
KEGG; hsa:115265; -.
UCSC; uc003hvq.4; human.
CTD; 115265; -.
DisGeNET; 115265; -.
EuPathDB; HostDB:ENSG00000145358.6; -.
GeneCards; DDIT4L; -.
HGNC; HGNC:30555; DDIT4L.
HPA; HPA050903; -.
MIM; 607730; gene.
neXtProt; NX_Q96D03; -.
OpenTargets; ENSG00000145358; -.
PharmGKB; PA128394749; -.
eggNOG; ENOG410J0CV; Eukaryota.
eggNOG; ENOG4111V50; LUCA.
GeneTree; ENSGT00530000063652; -.
HOGENOM; HOG000060250; -.
HOVERGEN; HBG104439; -.
InParanoid; Q96D03; -.
OMA; LVFKQDG; -.
OrthoDB; EOG091G0LVJ; -.
PhylomeDB; Q96D03; -.
TreeFam; TF105007; -.
GenomeRNAi; 115265; -.
PRO; PR:Q96D03; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000145358; -.
CleanEx; HS_DDIT4L; -.
ExpressionAtlas; Q96D03; baseline and differential.
Genevisible; Q96D03; HS.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
Gene3D; 1.10.490.100; -; 1.
InterPro; IPR012918; RTP801-like.
InterPro; IPR038281; RTP801-like_C_sf.
PANTHER; PTHR12478; PTHR12478; 1.
Pfam; PF07809; RTP801_C; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Polymorphism; Reference proteome.
CHAIN 1 193 DNA damage-inducible transcript 4-like
protein.
/FTId=PRO_0000307204.
VARIANT 161 161 S -> F (in dbSNP:rs11553154).
/FTId=VAR_053971.
SEQUENCE 193 AA; 21740 MW; 3BEEB3D0530C5BFF CRC64;
MVATGSLSSK NPASISELLD CGYHPESLLS DFDYWDYVVP EPNLNEVIFE ESTCQNLVKM
LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK
LDRIVCDSSV VPTFELTLVF KQENCSWTSF RDFFFSRGRF SSGFRRTLIL SSGFRLVKKK
LYSLIGTTVI EGS


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