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DNA mismatch repair protein Mlh3 (MutL protein homolog 3)

 MLH3_HUMAN              Reviewed;        1453 AA.
Q9UHC1; P49751; Q56DK9; Q9P292; Q9UHC0;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
11-JAN-2011, sequence version 3.
12-SEP-2018, entry version 164.
RecName: Full=DNA mismatch repair protein Mlh3;
AltName: Full=MutL protein homolog 3;
Name=MLH3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, AND
VARIANTS ASP-826 AND LEU-844.
PubMed=10615123; DOI=10.1038/71643;
Lipkin S.M., Wang V., Jacoby R., Banerjee-Basu S., Baxevanis A.D.,
Lynch H.T., Elliott R.M., Collins F.S.;
"MLH3: a DNA mismatch repair gene associated with mammalian
microsatellite instability.";
Nat. Genet. 24:27-35(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MLH1, AND VARIANT
ASP-826.
PubMed=11292842; DOI=10.1093/nar/29.8.1695;
Kondo E., Horii A., Fukushige S.;
"The interacting domains of three MutL heterodimers in man: hMLH1
interacts with 36 homologous amino acid residues within hMLH3, hPMS1
and hPMS2.";
Nucleic Acids Res. 29:1695-1702(2001).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-93; SER-120;
GLN-231; ILE-420; VAL-492; GLN-600; PRO-606; GLN-624; CYS-647;
CYS-720; ILE-723; PHE-741; HIS-797; ASP-826; LEU-844; GLY-845;
ILE-942; PRO-966; ASN-1073; GLU-1105; ASP-1163 AND ARG-1319.
NIEHS SNPs program;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12508121; DOI=10.1038/nature01348;
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
Quetier F., Waterston R., Hood L., Weissenbach J.;
"The DNA sequence and analysis of human chromosome 14.";
Nature 421:601-607(2003).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 1189-1453.
TISSUE=Brain;
PubMed=7596406; DOI=10.1038/375754a0;
Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G.,
Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L.,
Foncin J.-F., Bruni A.C., Montesi M.P., Sorbi S., Rainero I.,
Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P.,
Polinsky R.J., Wasco W., da Silva H.A.R., Haines J.L.,
Pericak-Vance M.A., Tanzi R.E., Roses A.D., Fraser P.E., Rommens J.M.,
St George-Hyslop P.H.;
"Cloning of a gene bearing missense mutations in early-onset familial
Alzheimer's disease.";
Nature 375:754-760(1995).
[6]
INVOLVEMENT IN SOMATIC COLORECTAL CANCER.
PubMed=11317354; DOI=10.1002/humu.1114;
Lipkin S.M., Wang V., Stoler D.L., Anderson G.R., Kirsch I.,
Hadley D., Lynch H.T., Collins F.S.;
"Germline and somatic mutation analyses in the DNA mismatch repair
gene MLH3: evidence for somatic mutation in colorectal cancers.";
Hum. Mutat. 17:389-396(2001).
[7]
INTERACTION WITH MTMR15.
PubMed=20603073; DOI=10.1016/j.molcel.2010.06.023;
Smogorzewska A., Desetty R., Saito T.T., Schlabach M., Lach F.P.,
Sowa M.E., Clark A.B., Kunkel T.A., Harper J.W., Colaiacovo M.P.,
Elledge S.J.;
"A genetic screen identifies FAN1, a Fanconi anemia-associated
nuclease necessary for DNA interstrand crosslink repair.";
Mol. Cell 39:36-47(2010).
[8]
VARIANTS HNPCC7 GLU-24; SER-499; GLN-624; CYS-647; GLY-817; SER-981;
SER-1007; THR-1394 AND LYS-1451.
PubMed=11586295; DOI=10.1038/ng1001-137;
Wu Y., Berends M.J.W., Sijmons R.H., Mensink R.G.J., Verlind E.,
Kooi K.A., van der Sluis T., Kempinga C., van der Zee A.G.J.,
Hollema H., Buys C.H.C.M., Kleibeuker J.H., Hofstra R.M.W.;
"A role for MLH3 in hereditary nonpolyposis colorectal cancer.";
Nat. Genet. 29:137-138(2001).
-!- FUNCTION: Probably involved in the repair of mismatches in DNA.
-!- SUBUNIT: Heterodimer of MLH1 and MLH3. Interacts with MTMR15/FAN1.
{ECO:0000269|PubMed:11292842, ECO:0000269|PubMed:20603073}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9UHC1-1; Sequence=Displayed;
Name=2;
IsoId=Q9UHC1-2; Sequence=VSP_003290;
-!- TISSUE SPECIFICITY: Ubiquitous.
-!- DISEASE: Hereditary non-polyposis colorectal cancer 7 (HNPCC7)
[MIM:614385]: An autosomal dominant disease associated with marked
increase in cancer susceptibility. It is characterized by a
familial predisposition to early-onset colorectal carcinoma (CRC)
and extra-colonic tumors of the gastrointestinal, urological and
female reproductive tracts. HNPCC is reported to be the most
common form of inherited colorectal cancer in the Western world.
Clinically, HNPCC is often divided into two subgroups. Type I is
characterized by hereditary predisposition to colorectal cancer, a
young age of onset, and carcinoma observed in the proximal colon.
Type II is characterized by increased risk for cancers in certain
tissues such as the uterus, ovary, breast, stomach, small
intestine, skin, and larynx in addition to the colon. Diagnosis of
classical HNPCC is based on the Amsterdam criteria: 3 or more
relatives affected by colorectal cancer, one a first degree
relative of the other two; 2 or more generation affected; 1 or
more colorectal cancers presenting before 50 years of age;
exclusion of hereditary polyposis syndromes. The term 'suspected
HNPCC' or 'incomplete HNPCC' can be used to describe families who
do not or only partially fulfill the Amsterdam criteria, but in
whom a genetic basis for colon cancer is strongly suspected.
{ECO:0000269|PubMed:11586295}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease
characterized by malignant lesions arising from the inner wall of
the large intestine (the colon) and the rectum. Genetic
alterations are often associated with progression from
premalignant lesion (adenoma) to invasive adenocarcinoma. Risk
factors for cancer of the colon and rectum include colon polyps,
long-standing ulcerative colitis, and genetic family history.
{ECO:0000269|PubMed:11317354}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC42005.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Sequence=AAC42005.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/mlh3/";
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EMBL; AF195657; AAF23904.1; -; mRNA.
EMBL; AF195658; AAF23905.1; -; Genomic_DNA.
EMBL; AB039667; BAA92353.1; -; mRNA.
EMBL; AY963685; AAX59030.1; -; Genomic_DNA.
EMBL; AL049780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; L40399; AAC42005.1; ALT_SEQ; mRNA.
CCDS; CCDS32123.1; -. [Q9UHC1-1]
CCDS; CCDS9837.1; -. [Q9UHC1-2]
RefSeq; NP_001035197.1; NM_001040108.1. [Q9UHC1-1]
RefSeq; XP_006720179.1; XM_006720116.3. [Q9UHC1-1]
RefSeq; XP_016876708.1; XM_017021219.1. [Q9UHC1-2]
UniGene; Hs.436650; -.
ProteinModelPortal; Q9UHC1; -.
SMR; Q9UHC1; -.
BioGrid; 117961; 7.
IntAct; Q9UHC1; 41.
MINT; Q9UHC1; -.
STRING; 9606.ENSP00000348020; -.
CarbonylDB; Q9UHC1; -.
iPTMnet; Q9UHC1; -.
PhosphoSitePlus; Q9UHC1; -.
BioMuta; MLH3; -.
DMDM; 317373417; -.
EPD; Q9UHC1; -.
PaxDb; Q9UHC1; -.
PeptideAtlas; Q9UHC1; -.
PRIDE; Q9UHC1; -.
ProteomicsDB; 84305; -.
ProteomicsDB; 84306; -. [Q9UHC1-2]
DNASU; 27030; -.
Ensembl; ENST00000355774; ENSP00000348020; ENSG00000119684. [Q9UHC1-1]
Ensembl; ENST00000380968; ENSP00000370355; ENSG00000119684. [Q9UHC1-2]
Ensembl; ENST00000556740; ENSP00000452316; ENSG00000119684. [Q9UHC1-1]
GeneID; 27030; -.
KEGG; hsa:27030; -.
UCSC; uc001xrd.1; human. [Q9UHC1-1]
CTD; 27030; -.
DisGeNET; 27030; -.
EuPathDB; HostDB:ENSG00000119684.15; -.
GeneCards; MLH3; -.
GeneReviews; MLH3; -.
HGNC; HGNC:7128; MLH3.
HPA; HPA060570; -.
MalaCards; MLH3; -.
MIM; 114500; phenotype.
MIM; 604395; gene.
MIM; 614385; phenotype.
neXtProt; NX_Q9UHC1; -.
OpenTargets; ENSG00000119684; -.
Orphanet; 144; Hereditary nonpolyposis colon cancer.
PharmGKB; PA30845; -.
eggNOG; KOG1977; Eukaryota.
eggNOG; COG0323; LUCA.
GeneTree; ENSGT00800000124176; -.
HOGENOM; HOG000140944; -.
HOVERGEN; HBG006375; -.
InParanoid; Q9UHC1; -.
KO; K08739; -.
OMA; CEYDVCM; -.
OrthoDB; EOG091G08LH; -.
PhylomeDB; Q9UHC1; -.
TreeFam; TF329597; -.
Reactome; R-HSA-912446; Meiotic recombination.
ChiTaRS; MLH3; human.
GeneWiki; MLH3; -.
GenomeRNAi; 27030; -.
PRO; PR:Q9UHC1; -.
Proteomes; UP000005640; Chromosome 14.
Bgee; ENSG00000119684; Expressed in 217 organ(s), highest expression level in lung.
CleanEx; HS_MLH3; -.
ExpressionAtlas; Q9UHC1; baseline and differential.
Genevisible; Q9UHC1; HS.
GO; GO:0005712; C:chiasma; IBA:GO_Central.
GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0016887; F:ATPase activity; IBA:GO_Central.
GO; GO:0019237; F:centromeric DNA binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
GO; GO:0003696; F:satellite DNA binding; TAS:ProtInc.
GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
GO; GO:0007144; P:female meiosis I; IEA:Ensembl.
GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
GO; GO:0008104; P:protein localization; IEA:Ensembl.
GO; GO:0007131; P:reciprocal meiotic recombination; NAS:UniProtKB.
GO; GO:0007130; P:synaptonemal complex assembly; IEA:Ensembl.
CDD; cd00075; HATPase_c; 1.
Gene3D; 3.30.230.10; -; 1.
Gene3D; 3.30.565.10; -; 1.
InterPro; IPR014762; DNA_mismatch_repair_CS.
InterPro; IPR013507; DNA_mismatch_S5_2-like.
InterPro; IPR003594; HATPase_C.
InterPro; IPR036890; HATPase_C_sf.
InterPro; IPR028830; Mlh3.
InterPro; IPR038973; MutL/Mlh/Pms.
InterPro; IPR014790; MutL_C.
InterPro; IPR037198; MutL_C_sf.
InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
PANTHER; PTHR10073; PTHR10073; 1.
PANTHER; PTHR10073:SF7; PTHR10073:SF7; 1.
Pfam; PF01119; DNA_mis_repair; 1.
Pfam; PF08676; MutL_C; 1.
SMART; SM01340; DNA_mis_repair; 1.
SMART; SM00853; MutL_C; 1.
SUPFAM; SSF118116; SSF118116; 1.
SUPFAM; SSF54211; SSF54211; 1.
SUPFAM; SSF55874; SSF55874; 1.
PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disease mutation; DNA damage;
DNA repair; Hereditary nonpolyposis colorectal cancer; Nucleus;
Polymorphism; Reference proteome.
CHAIN 1 1453 DNA mismatch repair protein Mlh3.
/FTId=PRO_0000178003.
VAR_SEQ 1215 1238 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_003290.
VARIANT 24 24 Q -> E (in HNPCC7; dbSNP:rs28937870).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012946.
VARIANT 93 93 R -> G (in dbSNP:rs28756978).
{ECO:0000269|Ref.3}.
/FTId=VAR_023338.
VARIANT 120 120 F -> S (in dbSNP:rs28756979).
{ECO:0000269|Ref.3}.
/FTId=VAR_023339.
VARIANT 231 231 K -> Q (in dbSNP:rs28756981).
{ECO:0000269|Ref.3}.
/FTId=VAR_023340.
VARIANT 420 420 V -> I (in dbSNP:rs28756982).
{ECO:0000269|Ref.3}.
/FTId=VAR_023341.
VARIANT 492 492 L -> V (in dbSNP:rs28756983).
{ECO:0000269|Ref.3}.
/FTId=VAR_023342.
VARIANT 494 494 H -> R (in dbSNP:rs760778201).
/FTId=VAR_010790.
VARIANT 499 499 N -> S (in HNPCC7; dbSNP:rs28937871).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012947.
VARIANT 600 600 R -> Q (in dbSNP:rs28756984).
{ECO:0000269|Ref.3}.
/FTId=VAR_023343.
VARIANT 606 606 T -> P (in dbSNP:rs28756985).
{ECO:0000269|Ref.3}.
/FTId=VAR_023344.
VARIANT 624 624 E -> Q (in HNPCC7; dbSNP:rs28756986).
{ECO:0000269|PubMed:11586295,
ECO:0000269|Ref.3}.
/FTId=VAR_012948.
VARIANT 647 647 R -> C (in HNPCC7; dbSNP:rs28756987).
{ECO:0000269|PubMed:11586295,
ECO:0000269|Ref.3}.
/FTId=VAR_012949.
VARIANT 720 720 Y -> C (in dbSNP:rs28756988).
{ECO:0000269|Ref.3}.
/FTId=VAR_023345.
VARIANT 723 723 V -> I (in dbSNP:rs28756989).
{ECO:0000269|Ref.3}.
/FTId=VAR_023346.
VARIANT 741 741 V -> F (in dbSNP:rs28756990).
{ECO:0000269|Ref.3}.
/FTId=VAR_023347.
VARIANT 797 797 R -> H (in dbSNP:rs28756991).
{ECO:0000269|Ref.3}.
/FTId=VAR_023348.
VARIANT 817 817 S -> G (in HNPCC7; dbSNP:rs143278116).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012950.
VARIANT 826 826 N -> D (in dbSNP:rs175081).
{ECO:0000269|PubMed:10615123,
ECO:0000269|PubMed:11292842,
ECO:0000269|Ref.3}.
/FTId=VAR_036781.
VARIANT 844 844 P -> L (in dbSNP:rs175080).
{ECO:0000269|PubMed:10615123,
ECO:0000269|Ref.3}.
/FTId=VAR_023349.
VARIANT 845 845 S -> G (in dbSNP:rs28756992).
{ECO:0000269|Ref.3}.
/FTId=VAR_023350.
VARIANT 942 942 T -> I (in dbSNP:rs17102999).
{ECO:0000269|Ref.3}.
/FTId=VAR_023351.
VARIANT 966 966 S -> P (in dbSNP:rs17782839).
{ECO:0000269|Ref.3}.
/FTId=VAR_023352.
VARIANT 981 981 G -> S (in HNPCC7; dbSNP:rs377337763).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012951.
VARIANT 1007 1007 N -> S (in HNPCC7; dbSNP:rs776639203).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012952.
VARIANT 1073 1073 D -> N (in dbSNP:rs28756993).
{ECO:0000269|Ref.3}.
/FTId=VAR_023353.
VARIANT 1105 1105 D -> E (in dbSNP:rs28757008).
{ECO:0000269|Ref.3}.
/FTId=VAR_023354.
VARIANT 1163 1163 G -> D (in dbSNP:rs28757011).
{ECO:0000269|Ref.3}.
/FTId=VAR_023355.
VARIANT 1319 1319 G -> R. {ECO:0000269|Ref.3}.
/FTId=VAR_023356.
VARIANT 1394 1394 A -> T (in HNPCC7; dbSNP:rs138006166).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012953.
VARIANT 1451 1451 E -> K (in HNPCC7; dbSNP:rs28939071).
{ECO:0000269|PubMed:11586295}.
/FTId=VAR_012954.
SEQUENCE 1453 AA; 163711 MW; 3D063427457DB033 CRC64;
MIKCLSVEVQ AKLRSGLAIS SLGQCVEELA LNSIDAEAKC VAVRVNMETF QVQVIDNGFG
MGSDDVEKVG NRYFTSKCHS VQDLENPRFY GFRGEALANI ADMASAVEIS SKKNRTMKTF
VKLFQSGKAL KACEADVTRA SAGTTVTVYN LFYQLPVRRK CMDPRLEFEK VRQRIEALSL
MHPSISFSLR NDVSGSMVLQ LPKTKDVCSR FCQIYGLGKS QKLREISFKY KEFELSGYIS
SEAHYNKNMQ FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGPTSRQM NSSLRHRSTP
ELYGIYVINV QCQFCEYDVC MEPAKTLIEF QNWDTLLFCI QEGVKMFLKQ EKLFVELSGE
DIKEFSEDNG FSLFDATLQK RVTSDERSNF QEACNNILDS YEMFNLQSKA VKRKTTAENV
NTQSSRDSEA TRKNTNDAFL YIYESGGPGH SKMTEPSLQN KDSSCSESKM LEQETIVASE
AGENEKHKKS FLEHSSLENP CGTSLEMFLS PFQTPCHFEE SGQDLEIWKE STTVNGMAAN
ILKNNRIQNQ PKRFKDATEV GCQPLPFATT LWGVHSAQTE KEKKKESSNC GRRNVFSYGR
VKLCSTGFIT HVVQNEKTKS TETEHSFKNY VRPGPTRAQE TFGNRTRHSV ETPDIKDLAS
TLSKESGQLP NKKNCRTNIS YGLENEPTAT YTMFSAFQEG SKKSQTDCIL SDTSPSFPWY
RHVSNDSRKT DKLIGFSKPI VRKKLSLSSQ LGSLEKFKRQ YGKVENPLDT EVEESNGVTT
NLSLQVEPDI LLKDKNRLEN SDVCKITTME HSDSDSSCQP ASHILNSEKF PFSKDEDCLE
QQMPSLRESP MTLKELSLFN RKPLDLEKSS ESLASKLSRL KGSERETQTM GMMSRFNELP
NSDSSRKDSK LCSVLTQDFC MLFNNKHEKT ENGVIPTSDS ATQDNSFNKN SKTHSNSNTT
ENCVISETPL VLPYNNSKVT GKDSDVLIRA SEQQIGSLDS PSGMLMNPVE DATGDQNGIC
FQSEESKARA CSETEESNTC CSDWQRHFDV ALGRMVYVNK MTGLSTFIAP TEDIQAACTK
DLTTVAVDVV LENGSQYRCQ PFRSDLVLPF LPRARAERTV MRQDNRDTVD DTVSSESLQS
LFSEWDNPVF ARYPEVAVDV SSGQAESLAV KIHNILYPYR FTKGMIHSMQ VLQQVDNKFI
ACLMSTKTEE NGEAGGNLLV LVDQHAAHER IRLEQLIIDS YEKQQAQGSG RKKLLSSTLI
PPLEITVTEE QRRLLWCYHK NLEDLGLEFV FPDTSDSLVL VGKVPLCFVE REANELRRGR
STVTKSIVEE FIREQLELLQ TTGGIQGTLP LTVQKVLASQ ACHGAIKFND GLSLQESCRL
IEALSSCQLP FQCAHGRPSM LPLADIDHLE QEKQIKPNLT KLRKMAQAWR LFGKAECDTR
QSLQQSMPPC EPP


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EIAAB25480 DNA mismatch repair protein Msh2,Mouse,Msh2,Mus musculus,MutS protein homolog 2
EIAAB25482 DNA mismatch repair protein Msh3,Mouse,Msh3,Mus musculus,Protein repair-1,Protein repair-3,REP-1,REP-3,Rep-3
EIAAB31662 DNA mismatch repair protein PMS1,Homo sapiens,Human,PMS1,PMS1 protein homolog 1,PMSL1
EIAAB25488 DNA mismatch repair protein Msh6,G_T mismatch-binding protein,GTBP,GTBP,GTMBP,hMSH6,Homo sapiens,Human,MSH6,MutS-alpha 160 kDa subunit,p160
EIAAB25489 DNA mismatch repair protein Msh6,G_T mismatch-binding protein,GTBP,GTMBP,Gtmbp,Mouse,Msh6,Mus musculus,MutS-alpha 160 kDa subunit,p160
CSB-EL014625HU Human mutL homolog 3 (E. coli) (MLH3) ELISA kit, Species Human, Sample Type serum, plasma 96T
EIAAB13183 DNA excision repair protein ERCC-5,DNA repair protein complementing XP-G cells homolog,Ercc5,Ercc-5,Mouse,Mus musculus,Xeroderma pigmentosum group G-complementing protein homolog,Xpg
MC-308 Mismatch Repair Protein 2 mAb 500 uL
MC-308 Mismatch Repair Protein 2 mAb 500 uL
MC-308 Mismatch Repair Protein 2 mAb 2MSH01 500 uL
MC-308 Mismatch Repair Protein 2 mAb Clone 2MSH01 500 uL


 

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