Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

DNA mismatch repair protein Msh2 (MutS protein homolog 2)

 MSH2_MOUSE              Reviewed;         935 AA.
P43247;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
20-JUN-2018, entry version 153.
RecName: Full=DNA mismatch repair protein Msh2;
AltName: Full=MutS protein homolog 2;
Name=Msh2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ;
PubMed=7838728; DOI=10.1093/nar/22.25.5723;
Varlet I., Pallard C., Radman M., Moreau J., de Wind N.;
"Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch
repair genes.";
Nucleic Acids Res. 22:5723-5728(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Lipford J.R., Kane M.F., Kolodner R.D.;
"Mouse MutS homolog 2 (mMSH2) c-DNA sequence from -56.";
Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-567, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z.,
Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
-!- FUNCTION: Component of the post-replicative DNA mismatch repair
system (MMR). Forms two different heterodimers: MutS alpha (MSH2-
MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which
binds to DNA mismatches thereby initiating DNA repair. When bound,
heterodimers bend the DNA helix and shields approximately 20 base
pairs. MutS alpha recognizes single base mismatches and
dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta
recognizes larger insertion-deletion loops up to 13 nucleotides
long. After mismatch binding, MutS alpha or beta forms a ternary
complex with the MutL alpha heterodimer, which is thought to be
responsible for directing the downstream MMR events, including
strand discrimination, excision, and resynthesis. ATP binding and
hydrolysis play a pivotal role in mismatch repair functions. The
ATPase activity associated with MutS alpha regulates binding
similar to a molecular switch: mismatched DNA provokes ADP-->ATP
exchange, resulting in a discernible conformational transition
that converts MutS alpha into a sliding clamp capable of
hydrolysis-independent diffusion along the DNA backbone. This
transition is crucial for mismatch repair. MutS alpha may also
play a role in DNA homologous recombination repair. In melanocytes
may modulate both UV-B-induced cell cycle regulation and apoptosis
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2-
MSH3 (MutS beta). Both heterodimer form a ternary complex with
MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1-
associated genome surveillance complex (BASC), which contains
BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1
protein complex. This association could be a dynamic process
changing throughout the cell cycle and within subnuclear domains.
Interacts with ATR. Interacts with SLX4/BTBD12; this interaction
is direct and links MutS beta to SLX4, a subunit of different
structure-specific endonucleases (By similarity). Interacts with
SMARCAD1 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X81143; CAA57049.1; -; mRNA.
EMBL; U21011; AAA75027.1; -; mRNA.
EMBL; BC047117; AAH47117.1; -; mRNA.
CCDS; CCDS29019.1; -.
PIR; S53608; S53608.
RefSeq; NP_032654.1; NM_008628.2.
UniGene; Mm.4619; -.
ProteinModelPortal; P43247; -.
SMR; P43247; -.
BioGrid; 201525; 6.
ComplexPortal; CPX-78; DNA mismatch repair MutSbeta complex.
ComplexPortal; CPX-81; DNA mismatch repair MutSalpha complex.
CORUM; P43247; -.
DIP; DIP-57027N; -.
IntAct; P43247; 3.
STRING; 10090.ENSMUSP00000024967; -.
iPTMnet; P43247; -.
PhosphoSitePlus; P43247; -.
EPD; P43247; -.
PaxDb; P43247; -.
PeptideAtlas; P43247; -.
PRIDE; P43247; -.
Ensembl; ENSMUST00000024967; ENSMUSP00000024967; ENSMUSG00000024151.
GeneID; 17685; -.
KEGG; mmu:17685; -.
UCSC; uc008dva.1; mouse.
CTD; 4436; -.
MGI; MGI:101816; Msh2.
eggNOG; KOG0219; Eukaryota.
eggNOG; COG0249; LUCA.
GeneTree; ENSGT00550000074867; -.
HOGENOM; HOG000196498; -.
HOVERGEN; HBG006399; -.
InParanoid; P43247; -.
KO; K08735; -.
OMA; GDFYTAH; -.
OrthoDB; EOG091G03SA; -.
PhylomeDB; P43247; -.
TreeFam; TF351780; -.
Reactome; R-MMU-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
Reactome; R-MMU-5358606; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
PRO; PR:P43247; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000024151; -.
CleanEx; MM_MSH2; -.
ExpressionAtlas; P43247; baseline and differential.
Genevisible; P43247; MM.
GO; GO:0032301; C:MutSalpha complex; IDA:MGI.
GO; GO:0032302; C:MutSbeta complex; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0043531; F:ADP binding; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016887; F:ATPase activity; IMP:MGI.
GO; GO:0019237; F:centromeric DNA binding; IDA:MGI.
GO; GO:0003684; F:damaged DNA binding; IMP:MGI.
GO; GO:0032181; F:dinucleotide repeat insertion binding; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; IMP:MGI.
GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:GO_Central.
GO; GO:0000406; F:double-strand/single-strand DNA junction binding; IBA:GO_Central.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0000400; F:four-way junction DNA binding; IBA:GO_Central.
GO; GO:0032137; F:guanine/thymine mispair binding; ISO:MGI.
GO; GO:0000404; F:heteroduplex DNA loop binding; IBA:GO_Central.
GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
GO; GO:0030983; F:mismatched DNA binding; IMP:MGI.
GO; GO:0032405; F:MutLalpha complex binding; IEA:Ensembl.
GO; GO:0032357; F:oxidized purine DNA binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0032138; F:single base insertion or deletion binding; IBA:GO_Central.
GO; GO:0032142; F:single guanine insertion binding; IEA:Ensembl.
GO; GO:0032143; F:single thymine insertion binding; IEA:Ensembl.
GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
GO; GO:0000403; F:Y-form DNA binding; IBA:GO_Central.
GO; GO:0030183; P:B cell differentiation; IMP:MGI.
GO; GO:0019724; P:B cell mediated immunity; IMP:MGI.
GO; GO:0007050; P:cell cycle arrest; IMP:MGI.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI.
GO; GO:0008340; P:determination of adult lifespan; IMP:MGI.
GO; GO:0006281; P:DNA repair; IMP:MGI.
GO; GO:0006302; P:double-strand break repair; IMP:MGI.
GO; GO:0007281; P:germ cell development; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
GO; GO:0031573; P:intra-S DNA damage checkpoint; IGI:MGI.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:MGI.
GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IGI:MGI.
GO; GO:0045190; P:isotype switching; IMP:MGI.
GO; GO:0043570; P:maintenance of DNA repeat elements; ISO:MGI.
GO; GO:0008584; P:male gonad development; IMP:MGI.
GO; GO:0006311; P:meiotic gene conversion; IBA:GO_Central.
GO; GO:0006298; P:mismatch repair; IDA:MGI.
GO; GO:0045910; P:negative regulation of DNA recombination; IMP:MGI.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
GO; GO:0045128; P:negative regulation of reciprocal meiotic recombination; IBA:GO_Central.
GO; GO:0006119; P:oxidative phosphorylation; IMP:MGI.
GO; GO:0051096; P:positive regulation of helicase activity; ISO:MGI.
GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IMP:CAFA.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IMP:CAFA.
GO; GO:0006301; P:postreplication repair; IMP:MGI.
GO; GO:0010224; P:response to UV-B; IMP:MGI.
GO; GO:0010165; P:response to X-ray; IMP:MGI.
GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IMP:MGI.
GO; GO:0016447; P:somatic recombination of immunoglobulin gene segments; IMP:MGI.
GO; GO:0002204; P:somatic recombination of immunoglobulin genes involved in immune response; IGI:MGI.
Gene3D; 3.30.420.110; -; 1.
Gene3D; 3.40.1170.10; -; 1.
InterPro; IPR011184; DNA_mismatch_repair_Msh2.
InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
InterPro; IPR032642; Msh2.
InterPro; IPR036678; MutS_con_dom_sf.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR11361:SF35; PTHR11361:SF35; 1.
Pfam; PF01624; MutS_I; 1.
Pfam; PF05188; MutS_II; 1.
Pfam; PF05192; MutS_III; 1.
Pfam; PF05190; MutS_IV; 1.
Pfam; PF00488; MutS_V; 1.
PIRSF; PIRSF005813; MSH2; 1.
SMART; SM00534; MUTSac; 1.
SMART; SM00533; MUTSd; 1.
SUPFAM; SSF48334; SSF48334; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF53150; SSF53150; 2.
PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
1: Evidence at protein level;
Acetylation; ATP-binding; Cell cycle; Complete proteome; DNA damage;
DNA repair; DNA-binding; Nucleotide-binding; Nucleus; Phosphoprotein;
Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P43246}.
CHAIN 2 935 DNA mismatch repair protein Msh2.
/FTId=PRO_0000115184.
NP_BIND 669 676 ATP. {ECO:0000255}.
REGION 601 671 Interaction with EXO1. {ECO:0000250}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P43246}.
MOD_RES 567 567 N6-acetyllysine.
{ECO:0000244|PubMed:23806337}.
MOD_RES 921 921 Phosphoserine.
{ECO:0000250|UniProtKB:P43246}.
CONFLICT 733 733 A -> S (in Ref. 2; AAA75027).
{ECO:0000305}.
SEQUENCE 935 AA; 104151 MW; 2111E9D5E3A8548A CRC64;
MAVQPKETLQ LEGAAEAGFV RFFEGMPEKP STTVRLFDRG DFYTAHGEDA LLAAREVFKT
QGVIKYMGPA GSKTLQSVVL SKMNFESFVK DLLLVRQYRV EVYKNKAGNK ASKENEWYLA
FKASPGNLSQ FEDILFGNND MSASVGVMGI KMAVVDGQRH VGVGYVDSTQ RKLGLCEFPE
NDQFSNLEAL LIQIGPKECV LPGGETTGDM GKLRQVIQRG GILITERKRA DFSTKDIYQD
LNRLLKGKKG EQINSAALPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LATFDFSQYM
KLDMAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTAQGQR LVNQWIKQPL MDRNRIEERL
NLVEAFVEDS ELRQSLQEDL LRRFPDLNRL AKKFQRQAAN LQDCYRLYQG INQLPSVIQA
LEKYEGRHQA LLLAVFVTPL IDLRSDFSKF QEMIETTLDM DQVENHEFLV KPSFDPNLSE
LREVMDGLEK KMQSTLINAA RGLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS
TVDIQKNGVK FTNSELSSLN EEYTKNKGEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
HLDAIVSFAH VSNAAPVPYV RPVILEKGKG RIILKASRHA CVEVQDEVAF IPNDVHFEKD
KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA EVSIVDCILA RVGAGDSQLK
GVSTFMAEML ETASILRSAT KDSLIIIDEL GRGTSTYDGF GLAWAISDYI ATKIGAFCMF
ATHFHELTAL ANQIPTVNNL HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPRHV
IACAKQKALE LEEFQNIGTS LGCDEAEPAA KRRCLEREQG EKIILEFLSK VKQVPFTAMS
EESISAKLKQ LKAEVVAKNN SFVNEIISRI KAPAP


Related products :

Catalog number Product name Quantity
EIAAB25479 DNA mismatch repair protein Msh2,hMSH2,Homo sapiens,Human,MSH2,MutS protein homolog 2
EIAAB25478 DNA mismatch repair protein Msh2,Msh2,MutS protein homolog 2,Rat,Rattus norvegicus
EIAAB25480 DNA mismatch repair protein Msh2,Mouse,Msh2,Mus musculus,MutS protein homolog 2
EIAAB25477 Bos taurus,Bovine,DNA mismatch repair protein Msh2,MSH2,MutS protein homolog 2
29-555 MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consis 0.1 mg
CSB-EL015028MO Mouse DNA mismatch repair protein Msh2(MSH2) ELISA kit SpeciesMouse 96T
CSB-EL015028HU Human DNA mismatch repair protein Msh2(MSH2) ELISA kit SpeciesHuman 96T
CSB-EL015028BO Bovine DNA mismatch repair protein Msh2(MSH2) ELISA kit SpeciesBovine 96T
CSB-EL015028HU Human DNA mismatch repair protein Msh2(MSH2) ELISA kit 96T
CSB-EL015028RA Rat DNA mismatch repair protein Msh2(MSH2) ELISA kit SpeciesRat 96T
CSB-EL015028MO Mouse DNA mismatch repair protein Msh2(MSH2) ELISA kit 96T
CSB-EL015028BO Bovine DNA mismatch repair protein Msh2(MSH2) ELISA kit 96T
MSH2_BOVIN ELISA Kit FOR DNA mismatch repair protein Msh2; organism: Bovine; gene name: MSH2 96T
MSH2_MOUSE ELISA Kit FOR DNA mismatch repair protein Msh2; organism: Mouse; gene name: Msh2 96T
MSH2_HUMAN ELISA Kit FOR DNA mismatch repair protein Msh2; organism: Human; gene name: MSH2 96T
CSB-EL015028RA Rat DNA mismatch repair protein Msh2(MSH2) ELISA kit 96T
GWB-B80BFC DNA Mismatch Repair Protein Msh2 (MSH2) Rabbit anti-Human Polyclonal (aa550-600) Antibody
EIAAB25488 DNA mismatch repair protein Msh6,G_T mismatch-binding protein,GTBP,GTBP,GTMBP,hMSH6,Homo sapiens,Human,MSH6,MutS-alpha 160 kDa subunit,p160
EIAAB25489 DNA mismatch repair protein Msh6,G_T mismatch-binding protein,GTBP,GTMBP,Gtmbp,Mouse,Msh6,Mus musculus,MutS-alpha 160 kDa subunit,p160
32-196 MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replica 0.1 mL
EIAAB31664 DNA mismatch repair protein PMS2,Homo sapiens,Human,Mismatch repair endonuclease PMS2,PMS1 protein homolog 2,PMS2,PMSL2
EH2384 DNA mismatch repair protein Msh2 Elisa Kit 96T
25-693 MSH5 is a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that particip 0.05 mg
25-692 MSH5 is a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that particip 0.05 mg
EIAAB31663 DNA mismatch repair protein PMS2,Mismatch repair endonuclease PMS2,Mouse,Mus musculus,PMS1 protein homolog 2,Pms2


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur