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DNA polymerase lambda (OsPolL) (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-)

 DPOLL_ORYSJ             Reviewed;         549 AA.
Q67VC8; Q0DDB2; Q6L9M0;
02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
23-MAY-2018, entry version 75.
RecName: Full=DNA polymerase lambda;
Short=OsPolL {ECO:0000303|PubMed:15206945};
Short=Pol Lambda {ECO:0000305};
EC=2.7.7.7 {ECO:0000269|PubMed:15206945};
EC=4.2.99.- {ECO:0000305};
Name=POLL {ECO:0000305};
OrderedLocusNames=Os06g0237200 {ECO:0000312|EMBL:BAS96965.1},
LOC_Os06g13020 {ECO:0000305};
ORFNames=OSJNBa0068B06.5 {ECO:0000312|EMBL:BAD18976.1};
Oryza sativa subsp. japonica (Rice).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
NCBI_TaxID=39947;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR,
INTERACTION WITH PCNA, TISSUE SPECIFICITY, INDUCTION, AND MUTAGENESIS
OF ASP-397 AND ASP-399.
STRAIN=cv. Nipponbare;
PubMed=15206945; DOI=10.1111/j.1432-1033.2004.04214.x;
Uchiyama Y., Kimura S., Yamamoto T., Ishibashi T., Sakaguchi K.;
"Plant DNA polymerase lambda, a DNA repair enzyme that functions in
plant meristematic and meiotic tissues.";
Eur. J. Biochem. 271:2799-2807(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=16100779; DOI=10.1038/nature03895;
International rice genome sequencing project (IRGSP);
"The map-based sequence of the rice genome.";
Nature 436:793-800(2005).
[3]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=18089549; DOI=10.1093/nar/gkm978;
The rice annotation project (RAP);
"The rice annotation project database (RAP-DB): 2008 update.";
Nucleic Acids Res. 36:D1028-D1033(2008).
[4]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=24280374; DOI=10.1186/1939-8433-6-4;
Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
Buell C.R., Matsumoto T.;
"Improvement of the Oryza sativa Nipponbare reference genome using
next generation sequence and optical map data.";
Rice 6:4-4(2013).
-!- FUNCTION: Repair polymerase involved in base excision repair (BER)
and responsible for repair of lesions that give rise to abasic
(AP) sites in DNA. Has both DNA polymerase and terminal
transferase activities. Has a 5'-deoxyribose-5-phosphate lyase
(dRP lyase) activity. {ECO:0000269|PubMed:15206945}.
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1). {ECO:0000269|PubMed:15206945}.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000269|PubMed:15206945};
-!- SUBUNIT: Interacts with PCNA. {ECO:0000269|PubMed:15206945}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in proliferating tissues. Expressed
in roots, root apex, young leaves, shoot apical meristem (SAM),
flag leaves and panicles. {ECO:0000269|PubMed:15206945}.
-!- INDUCTION: By UV treatment and methyl methanesulfonate (MMS).
{ECO:0000269|PubMed:15206945}.
-!- SIMILARITY: Belongs to the DNA polymerase type-X family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAF19161.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=BAS96965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB099525; BAD18976.1; -; mRNA.
EMBL; AP004995; BAD37891.1; -; Genomic_DNA.
EMBL; AP008212; BAF19161.1; ALT_SEQ; Genomic_DNA.
EMBL; AP014962; BAS96965.1; ALT_SEQ; Genomic_DNA.
RefSeq; XP_015643819.1; XM_015788333.1.
UniGene; Os.23526; -.
ProteinModelPortal; Q67VC8; -.
SMR; Q67VC8; -.
STRING; 39947.LOC_Os06g13020.1; -.
EnsemblPlants; Os06t0237200-00; Os06t0237200-00; Os06g0237200.
GeneID; 4340604; -.
Gramene; Os06t0237200-00; Os06t0237200-00; Os06g0237200.
KEGG; osa:4340604; -.
eggNOG; KOG2534; Eukaryota.
eggNOG; COG1796; LUCA.
InParanoid; Q67VC8; -.
KO; K03512; -.
OrthoDB; EOG0936076R; -.
Proteomes; UP000059680; Chromosome 6.
ExpressionAtlas; Q67VC8; differential.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0051575; F:5'-deoxyribose-5-phosphate lyase activity; IDA:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003887; F:DNA-directed DNA polymerase activity; IDA:UniProtKB.
GO; GO:0030145; F:manganese ion binding; IDA:UniProtKB.
GO; GO:0097510; P:base-excision repair, AP site formation via deaminated base removal; IDA:UniProtKB.
GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblPlants.
GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblPlants.
GO; GO:0010224; P:response to UV-B; IEA:EnsemblPlants.
CDD; cd00141; NT_POLXc; 1.
Gene3D; 1.10.150.110; -; 1.
Gene3D; 3.30.210.10; -; 1.
Gene3D; 3.40.50.10190; -; 1.
InterPro; IPR001357; BRCT_dom.
InterPro; IPR036420; BRCT_dom_sf.
InterPro; IPR002054; DNA-dir_DNA_pol_X.
InterPro; IPR019843; DNA_pol-X_BS.
InterPro; IPR010996; DNA_pol_b-like_N.
InterPro; IPR028207; DNA_pol_B_palm_palm.
InterPro; IPR018944; DNA_pol_lambd_fingers_domain.
InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
InterPro; IPR037160; DNA_Pol_thumb_sf.
InterPro; IPR022312; DNA_pol_X.
InterPro; IPR002008; DNA_pol_X_beta-like.
InterPro; IPR029398; PolB_thumb.
Pfam; PF14792; DNA_pol_B_palm; 1.
Pfam; PF14791; DNA_pol_B_thumb; 1.
Pfam; PF10391; DNA_pol_lambd_f; 1.
Pfam; PF14716; HHH_8; 1.
PRINTS; PR00869; DNAPOLX.
PRINTS; PR00870; DNAPOLXBETA.
SMART; SM00483; POLXc; 1.
SUPFAM; SSF47802; SSF47802; 1.
SUPFAM; SSF52113; SSF52113; 1.
PROSITE; PS50172; BRCT; 1.
PROSITE; PS00522; DNA_POLYMERASE_X; 1.
1: Evidence at protein level;
Complete proteome; DNA damage; DNA repair; DNA replication;
DNA synthesis; DNA-binding; DNA-directed DNA polymerase; Lyase;
Manganese; Metal-binding; Nucleotidyltransferase; Nucleus;
Reference proteome; Transferase.
CHAIN 1 549 DNA polymerase lambda.
/FTId=PRO_0000438213.
DOMAIN 17 116 BRCT. {ECO:0000255|PROSITE-
ProRule:PRU00033}.
NP_BIND 387 390 dCTP binding.
{ECO:0000250|UniProtKB:Q9UGP5}.
NP_BIND 396 399 dCTP binding.
{ECO:0000250|UniProtKB:Q9UGP5}.
REGION 233 247 DNA binding.
{ECO:0000250|UniProtKB:Q9UGP5}.
REGION 315 318 DNA binding.
{ECO:0000250|UniProtKB:Q9UGP5}.
REGION 390 399 Involved in primer binding.
{ECO:0000250}.
REGION 438 479 DNA binding.
{ECO:0000250|UniProtKB:Q9UGP5}.
ACT_SITE 280 280 {ECO:0000305}.
METAL 397 397 Manganese.
{ECO:0000250|UniProtKB:Q9UGP5}.
METAL 399 399 Manganese.
{ECO:0000250|UniProtKB:Q9UGP5}.
METAL 464 464 Manganese.
{ECO:0000250|UniProtKB:Q9UGP5}.
BINDING 356 356 dCTP. {ECO:0000250|UniProtKB:Q9UGP5}.
BINDING 487 487 dCTP. {ECO:0000250|UniProtKB:Q9UGP5}.
MUTAGEN 397 397 D->A: Loss of polymerase activity; when
associated with A-399.
{ECO:0000269|PubMed:15206945}.
MUTAGEN 399 399 D->A: Loss of polymerase activity; when
associated with A-397.
{ECO:0000269|PubMed:15206945}.
CONFLICT 11 11 A -> AAAA (in Ref. 1; BAD18976).
{ECO:0000305}.
CONFLICT 423 423 G -> D (in Ref. 1; BAD18976).
{ECO:0000305}.
SEQUENCE 549 AA; 60628 MW; CBDEBE99CA6BEF46 CRC64;
MAPKRKPPAR AAAAKLDPDG MFRGVSAFVV PHAVQSRRLE VWKQRLAQMG GRVQEKLAAK
GGGGAVTHVL AADAKALLRE LDAAWLHRFR GSVVSFEWLE ECLKSGERLP EHKFAINYEE
EFKPKKEGGA AGSGVLQSAK RSKISSDGPE NRKETAGGNR ESRDAIAHPN EDSDVVKGPS
TCTSSQSASG DSKETIASQN AFKAEEASSG ESSTYAPPDL NRNITEIFGK LINIYRALGD
DRRSFSYYKA IPVIEKLPFK IESADQVKDL PAIGKSLKDH INEIVNTGKL SKLEHFENDE
KVRTVSLFGE VWGVGPATAL KLYDKGHRTL DDLQKDDSLT SAQRIGLKFF DDIKQRIPRH
EVSEMEKLLQ EVGTDILPGV IIVCGGSYRR GKSSCGDMDI IITHPDGESH VGFLPKFVQR
LKGINFLRED LIFSIHSIEG TDCGVDTYFG LCTYPGRELR HRIDLKVYPR NRHAFGLLAW
TGNDVLNRRL RILADSKGYI LDDTGLYLAT PGSGGKRGGR SDAIINCDTE KDVFDTLGFP
WLEPHERNL


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