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DNA repair protein RAD51 homolog 1

 RAD51_RABIT             Reviewed;         339 AA.
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
16-JAN-2019, entry version 123.
RecName: Full=DNA repair protein RAD51 homolog 1;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
PubMed=9634474; DOI=10.1007/s002510050410;
Schiaffella E., Fuschiotti P., Bensinger S.J., Mage R.G.;
"High RAD51 mRNA levels in young rabbit appendix. A role in B-cell
gene conversion?";
Immunogenetics 48:108-115(1998).
-!- FUNCTION: Plays an important role in homologous strand exchange, a
key step in DNA repair through homologous recombination (HR).
Binds to single and double-stranded DNA and exhibits DNA-dependent
ATPase activity. Catalyzes the recognition of homology and strand
exchange between homologous DNA partners to form a joint molecule
between a processed DNA break and the repair template. Binds to
single-stranded DNA in an ATP-dependent manner to form
nucleoprotein filaments which are essential for the homology
search and strand exchange. Part of a PALB2-scaffolded HR complex
containing BRCA2 and RAD51C and which is thought to play a role in
DNA repair by HR. Plays a role in regulating mitochondrial DNA
copy number under conditions of oxidative stress in the presence
of RAD51C and XRCC3. Also involved in interstrand cross-link
repair. {ECO:0000250|UniProtKB:Q06609}.
-!- SUBUNIT: Forms linear homooligomers, giving rise to a RAD51
nucleoprotein filament, which is essential for strand-pairing
reactions during DNA recombination. Interacts with BRCA1 and
either directly or indirectly with p53. Interacts with XRCC3,
RAD54L and RAD54B. Interacts with the BCDX2 subcomplex
RAD51C:RAD51B. Interacts directly with PALB2 which may serve as a
scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51
and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with
CHEK1, and this may require prior phosphorylation of CHEK1.
Interacts with the MND1-PSMC3IP heterodimer. Found in a complex,
at least composed of BLM, RAD51 and SPIDR; the complex formation
is mediated by SPIDR. Interacts with SPIDR; the interaction is
direct and recruits RAD51 to DNA damage sites. Interacts with
FIGNL1 (via N-terminal one-half region); the interaction is
direct. Interacts with RAD51AP1 (via C-terminal region); the
interaction is direct. Interacts with NABP2, RPA1, PALB2 and
RAD51. Interacts with SWI5/C9orf119, and at lower level with
SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this
interaction is necessary for efficient recruitment to chromatin in
response to DNA damage. Interacts with SWSAP1; involved in
homologous recombination repair. Interacts with PARPBP, BRCA2 and
RECQL5; these interactions interfere with the formation of the
RAD51-DNA homologous recombination structure. Interacts with POLQ;
POLQ acts as an inhibitor of homology-recombination repair (HR)
pathway by limiting RAD51 accumulation at resected ends. Interacts
with FBH1. Interacts with POLN. Interacts with RFWD3. Interacts
with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA
damage sites. {ECO:0000250|UniProtKB:Q06609}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q06609}.
Cytoplasm {ECO:0000250|UniProtKB:Q06609}. Cytoplasm, perinuclear
region {ECO:0000250|UniProtKB:Q06609}. Mitochondrion matrix
{ECO:0000250|UniProtKB:Q06609}. Chromosome
{ECO:0000250|UniProtKB:Q06609}. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome
{ECO:0000250|UniProtKB:Q06609}. Note=Colocalizes with RAD51AP1 and
RPA2 to multiple nuclear foci upon induction of DNA damage. DNA
damage induces an increase in nuclear levels. Together with
FIGNL1, redistributed in discrete nuclear DNA damage-induced foci
after ionizing radiation (IR) or camptothecin (CPT) treatment.
Accumulated at sites of DNA damage in a SPIDR-dependent manner.
Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner.
-!- PTM: Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex,
regulating RAD51 subcellular location and preventing its
association with DNA. Ubiquitinated by RFWD3 in response to DNA
damage: ubiquitination leads to degradation by the proteasome,
promoting homologous recombination.
-!- PTM: Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may
enhance association with chromatin at sites of DNA damage and
promote DNA repair by homologous recombination. Phosphorylation by
ABL1 inhibits function. {ECO:0000250|UniProtKB:Q06609}.
-!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AF017729; AAC28561.1; -; mRNA.
RefSeq; NP_001075493.1; NM_001082024.1.
UniGene; Ocu.2212; -.
ProteinModelPortal; O77507; -.
SMR; O77507; -.
STRING; 9986.ENSOCUP00000014527; -.
GeneID; 100008661; -.
KEGG; ocu:100008661; -.
CTD; 5888; -.
eggNOG; KOG1433; Eukaryota.
eggNOG; COG0468; LUCA.
HOGENOM; HOG000227426; -.
HOVERGEN; HBG001504; -.
InParanoid; O77507; -.
KO; K04482; -.
OrthoDB; 877394at2759; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO; GO:0000228; C:nuclear chromosome; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO; GO:0000150; F:recombinase activity; IEA:InterPro.
GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO; GO:0043142; F:single-stranded DNA-dependent ATPase activity; ISS:UniProtKB.
GO; GO:0072757; P:cellular response to camptothecin; ISS:UniProtKB.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.
GO; GO:0000730; P:DNA recombinase assembly; ISS:UniProtKB.
GO; GO:0006268; P:DNA unwinding involved in DNA replication; ISS:UniProtKB.
GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
GO; GO:0036297; P:interstrand cross-link repair; ISS:UniProtKB.
GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:InterPro.
GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
CDD; cd01123; Rad51_DMC1_radA; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR011941; DNA_recomb/repair_Rad51.
InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
InterPro; IPR016467; DNA_recomb/repair_RecA-like.
InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033925; Rad51_DMC1_RadA.
InterPro; IPR020588; RecA_ATP-bd.
InterPro; IPR020587; RecA_monomer-monomer_interface.
Pfam; PF08423; Rad51; 1.
PIRSF; PIRSF005856; Rad51; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF47794; SSF47794; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR02239; recomb_RAD51; 1.
PROSITE; PS50162; RECA_2; 1.
PROSITE; PS50163; RECA_3; 1.
2: Evidence at transcript level;
Acetylation; ATP-binding; Chromosome; Complete proteome; Cytoplasm;
Cytoskeleton; DNA damage; DNA recombination; DNA repair; DNA-binding;
Isopeptide bond; Mitochondrion; Nucleotide-binding; Nucleus;
Phosphoprotein; Reference proteome; Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q06609}.
CHAIN 2 339 DNA repair protein RAD51 homolog 1.
DOMAIN 48 77 HhH.
NP_BIND 127 134 ATP. {ECO:0000250}.
REGION 184 257 Interaction with PALB2. {ECO:0000250}.
MOTIF 245 260 Nuclear export signal; masked by the
interaction with BRCA2.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 54 54 Phosphotyrosine; by ABL1.
MOD_RES 309 309 Phosphothreonine; by CHEK1.
CROSSLNK 58 58 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
CROSSLNK 64 64 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
SEQUENCE 339 AA; 37028 MW; 0B7A2C6621FAF84D CRC64;

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