Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

DNA repair protein RAD51 homolog 1 (Rad51-like protein 1) (AtRAD51)

 RAD51_ARATH             Reviewed;         342 AA.
P94102;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
25-OCT-2017, entry version 135.
RecName: Full=DNA repair protein RAD51 homolog 1 {ECO:0000303|PubMed:9520262};
AltName: Full=Rad51-like protein 1 {ECO:0000303|PubMed:9520262};
Short=AtRAD51 {ECO:0000303|PubMed:9520262};
Name=RAD51 {ECO:0000303|PubMed:9520262};
OrderedLocusNames=At5g20850 {ECO:0000312|Araport:AT5G20850};
ORFNames=F22D1.20 {ECO:0000312|EMBL:AF296834};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Landsberg erecta;
PubMed=8980505; DOI=10.1007/BF00019108;
Urban C., Smith K.N., Beier H.;
"Nucleotide sequences of nuclear tRNA(Cys) genes from Nicotiana and
Arabidopsis and expression in HeLa cell extract.";
Plant Mol. Biol. 32:549-552(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, DEVELOPMENTAL STAGE, AND
TISSUE SPECIFICITY.
STRAIN=cv. Columbia;
PubMed=9520262; DOI=10.1007/s004380050649;
Doutriaux M.P., Couteau F., Bergounioux C., White C.;
"Isolation and characterisation of the RAD51 and DMC1 homologs from
Arabidopsis thaliana.";
Mol. Gen. Genet. 257:283-291(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130714; DOI=10.1038/35048507;
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
"Sequence and analysis of chromosome 5 of the plant Arabidopsis
thaliana.";
Nature 408:823-826(2000).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[5]
INDUCTION.
PubMed=10894550; DOI=10.1038/35017595;
Ries G., Heller W., Puchta H., Sandermann H., Seidlitz H.K., Hohn B.;
"Elevated UV-B radiation reduces genome stability in plants.";
Nature 406:98-101(2000).
[6]
INDUCTION, SUBUNIT, TISSUE SPECIFICITY, AND INTERACTION WITH XRCC3.
STRAIN=cv. Columbia; TISSUE=Flower bud;
PubMed=12139010; DOI=10.1023/A:1016047231597;
Osakabe K., Yoshioka T., Ichikawa H., Toki S.;
"Molecular cloning and characterization of RAD51-like genes from
Arabidopsis thaliana.";
Plant Mol. Biol. 50:71-81(2002).
[7]
INDUCTION.
PubMed=12509526; DOI=10.1105/tpc.006577;
Garcia V., Bruchet H., Camescasse D., Granier F., Bouchez D.,
Tissier A.;
"AtATM is essential for meiosis and the somatic response to DNA damage
in plants.";
Plant Cell 15:119-132(2003).
[8]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=15249667; DOI=10.1073/pnas.0404110101;
Li W., Chen C., Markmann-Mulisch U., Timofejeva L., Schmelzer E.,
Ma H., Reiss B.;
"The Arabidopsis AtRAD51 gene is dispensable for vegetative
development but required for meiosis.";
Proc. Natl. Acad. Sci. U.S.A. 101:10596-10601(2004).
[9]
INTERACTION WITH RAD54/CHR25, AND TISSUE SPECIFICITY.
STRAIN=cv. Columbia; TISSUE=Flower bud;
PubMed=17227544; DOI=10.1111/j.1365-313X.2006.02927.x;
Osakabe K., Abe K., Yoshioka T., Osakabe Y., Todoriki S., Ichikawa H.,
Hohn B., Toki S.;
"Isolation and characterization of the RAD54 gene from Arabidopsis
thaliana.";
Plant J. 48:827-842(2006).
[10]
INTERACTION WITH BRCA2A AND BRCA2B.
PubMed=16415210; DOI=10.1104/pp.105.075838;
Dray E., Siaud N., Dubois E., Doutriaux M.P.;
"Interaction between Arabidopsis Brca2 and its partners Rad51, Dmc1,
and Dss1.";
Plant Physiol. 140:1059-1069(2006).
-!- FUNCTION: Binds to single and double-stranded DNA and exhibits
DNA-dependent ATPase activity. Unwinds duplex DNA (By similarity).
Component of the meiotic recombination pathway. Seems to play a
role in mediating chromosome homology search, chromosome pairing
and synapsis at early stages and probably chromosome crossing-over
at later stages in meiosis. Probably is involved in the repair of
meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in
homologous recombination. Its function is dispensable for
vegetative growth and root mitosis. {ECO:0000250|UniProtKB:Q06609,
ECO:0000269|PubMed:15249667}.
-!- SUBUNIT: Self-associates and interacts with XRCC3
(PubMed:12139010). Binds to RAD54/CHR25 (PubMed:17227544).
Interacts with BRCA2A and BRCA2B (PubMed:16415210). Can form a
tripartite complex with both BRCA2B and DSS1(I) (PubMed:16415210).
{ECO:0000269|PubMed:12139010, ECO:0000269|PubMed:16415210,
ECO:0000269|PubMed:17227544}.
-!- INTERACTION:
Q7Y1C5:BRCA2A; NbExp=5; IntAct=EBI-307687, EBI-307680;
Q7Y1C4:BRCA2B; NbExp=5; IntAct=EBI-307687, EBI-307707;
Q0PCS3:CHR25; NbExp=3; IntAct=EBI-307687, EBI-1768899;
Q39009:DMC1; NbExp=4; IntAct=EBI-307687, EBI-307715;
Q8GYD2:MND1; NbExp=2; IntAct=EBI-307687, EBI-1554720;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: Detected in various tissues. Higher expression
in reproductive tissues than in vegetative tissues, with the
highest expression level in young flower buds. At cellular level,
is expressed at low levels in flower primordia, then at higher
levels in young anthers and at highest levels in both females and
males meiocytes. Not detected in gametophytes.
{ECO:0000269|PubMed:12139010, ECO:0000269|PubMed:15249667,
ECO:0000269|PubMed:17227544, ECO:0000269|PubMed:9520262}.
-!- DEVELOPMENTAL STAGE: Cell cycle regulated, peaking at the S phase.
It is also expressed at high levels in exponentially growing cells
in suspension cultures. {ECO:0000269|PubMed:9520262}.
-!- INDUCTION: By genotoxic stress and by DNA damage (gamma-radiation,
UV-B). Regulated by ATM in response to DNA double strand breaks
(DSBs). {ECO:0000269|PubMed:10894550, ECO:0000269|PubMed:12139010,
ECO:0000269|PubMed:12509526, ECO:0000269|PubMed:9520262}.
-!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U43652; AAC49555.1; -; Genomic_DNA.
EMBL; AJ001100; CAA04529.1; -; Genomic_DNA.
EMBL; U43528; AAB37762.1; -; mRNA.
EMBL; AF296834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CP002688; AED92897.1; -; Genomic_DNA.
RefSeq; NP_568402.1; NM_122092.3.
UniGene; At.110; -.
ProteinModelPortal; P94102; -.
SMR; P94102; -.
BioGrid; 17483; 7.
DIP; DIP-31780N; -.
IntAct; P94102; 11.
STRING; 3702.AT5G20850.1; -.
PaxDb; P94102; -.
EnsemblPlants; AT5G20850.1; AT5G20850.1; AT5G20850.
GeneID; 832208; -.
Gramene; AT5G20850.1; AT5G20850.1; AT5G20850.
KEGG; ath:AT5G20850; -.
Araport; AT5G20850; -.
TAIR; locus:2147092; AT5G20850.
eggNOG; KOG1433; Eukaryota.
eggNOG; COG0468; LUCA.
HOGENOM; HOG000227426; -.
InParanoid; P94102; -.
KO; K04482; -.
OMA; FRPQRLI; -.
OrthoDB; EOG09360EJO; -.
PhylomeDB; P94102; -.
Reactome; R-ATH-5693616; Presynaptic phase of homologous DNA pairing and strand exchange.
PRO; PR:P94102; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; P94102; baseline and differential.
Genevisible; P94102; AT.
GO; GO:0005694; C:chromosome; IDA:TAIR.
GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:GO_Central.
GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
GO; GO:0000400; F:four-way junction DNA binding; IBA:GO_Central.
GO; GO:0000150; F:recombinase activity; IBA:GO_Central.
GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IBA:GO_Central.
GO; GO:0006259; P:DNA metabolic process; IDA:TAIR.
GO; GO:0000730; P:DNA recombinase assembly; IBA:GO_Central.
GO; GO:0006302; P:double-strand break repair; IMP:TAIR.
GO; GO:0045003; P:double-strand break repair via synthesis-dependent strand annealing; IDA:TAIR.
GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:InterPro.
GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:TAIR.
GO; GO:0010332; P:response to gamma radiation; IEP:TAIR.
GO; GO:0009314; P:response to radiation; NAS:TAIR.
GO; GO:0042148; P:strand invasion; IBA:GO_Central.
CDD; cd01123; Rad51_DMC1_radA; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR011941; DNA_recomb/repair_Rad51.
InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
InterPro; IPR016467; DNA_recomb/repair_RecA-like.
InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033925; Rad51_DMC1_RadA.
InterPro; IPR020588; RecA_ATP-bd.
InterPro; IPR020587; RecA_monomer-monomer_interface.
Pfam; PF08423; Rad51; 1.
PIRSF; PIRSF005856; Rad51; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF47794; SSF47794; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR02239; recomb_RAD51; 1.
PROSITE; PS50162; RECA_2; 1.
PROSITE; PS50163; RECA_3; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; DNA damage; DNA recombination;
DNA repair; DNA-binding; Nucleotide-binding; Nucleus;
Reference proteome.
CHAIN 1 342 DNA repair protein RAD51 homolog 1.
/FTId=PRO_0000122926.
DOMAIN 51 80 HhH.
DOMAIN 100 314 FtsK. {ECO:0000255|PROSITE-
ProRule:PRU00289}.
NP_BIND 130 137 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00289}.
SEQUENCE 342 AA; 37304 MW; 08067F8D85A2E77D CRC64;
MTTMEQRRNQ NAVQQQDDEE TQHGPFPVEQ LQAAGIASVD VKKLRDAGLC TVEGVAYTPR
KDLLQIKGIS DAKVDKIVEA ASKLVPLGFT SASQLHAQRQ EIIQITSGSR ELDKVLEGGI
ETGSITELYG EFRSGKTQLC HTLCVTCQLP MDQGGGEGKA MYIDAEGTFR PQRLLQIADR
FGLNGADVLE NVAYARAYNT DHQSRLLLEA ASMMIETRFA LLIVDSATAL YRTDFSGRGE
LSARQMHLAK FLRSLQKLAD EFGVAVVITN QVVAQVDGSA LFAGPQFKPI GGNIMAHATT
TRLALRKGRA EERICKVISS PCLPEAEARF QISTEGVTDC KD


Related products :

Catalog number Product name Quantity
EIAAB33413 DNA repair protein RAD51 homolog 4,Homo sapiens,Human,R51H3,RAD51 homolog D,RAD51D,RAD51L3,RAD51-like protein 3,TRAD
EIAAB33411 DNA repair protein RAD51 homolog 3,Homo sapiens,Human,R51H3,RAD51 homolog C,RAD51C,RAD51L2,RAD51-like protein 2
EIAAB33408 DNA repair protein RAD51 homolog 2,Mouse,Mus musculus,R51H2,RAD51 homolog B,Rad51b,Rad51l1,RAD51-like protein 1,Rec2
EIAAB33660 DNA repair protein RAD51 homolog 1,Homo sapiens,hRAD51,HsRAD51,Human,RAD51,RAD51 homolog A,RAD51A,RECA
EIAAB33414 Bos taurus,Bovine,DNA repair protein RAD51 homolog 4,R51H3,RAD51 homolog D,RAD51D,RAD51L3,RAD51-like protein 3
EIAAB33410 DNA repair protein RAD51 homolog 3,Mouse,Mus musculus,R51H3,RAD51 homolog C,Rad51c,Rad51l2,RAD51-like protein 2
EIAAB33661 DNA repair protein RAD51 homolog 1,Mouse,Mus musculus,Rad51,RAD51 homolog A,Rad51a,Reca
EIAAB33409 DNA repair protein RAD51 homolog 2,Homo sapiens,Human,R51H2,RAD51 homolog B,Rad51B,RAD51B,RAD51L1,RAD51-like protein 1,REC2
EIAAB33412 DNA repair protein RAD51 homolog 4,Mouse,Mus musculus,R51H3,R51h3,RAD51 homolog D,Rad51d,Rad51l3,RAD51-like protein 3
CSB-EL019263MO Mouse DNA repair protein RAD51 homolog 1(RAD51) ELISA kit SpeciesMouse 96T
CSB-EL019263HU Human DNA repair protein RAD51 homolog 1(RAD51) ELISA kit SpeciesHuman 96T
Y050646 Anti-Phospho-RAD51(DNA repair protein RAD51 homolog 1) Antibody 100ug
CSB-EL019263RB Rabbit DNA repair protein RAD51 homolog 1(RAD51) ELISA kit SpeciesRabbit 96T
EIAAB33662 DNA repair protein RAD51 homolog 1,Oryctolagus cuniculus,Rabbit,RAD51
CSB-EL019263BO Bovine DNA repair protein RAD51 homolog 1(RAD51) ELISA kit SpeciesBovine 96T
YHB1034Hu Human DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 96T
E0050Rb Rabbit DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 96T
CSB-EL019263BO Bovine DNA repair protein RAD51 homolog 1(RAD51) ELISA kit 96T
YHB0059Bo Bovine DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 48T
E0050Rb Rabbit DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 48T
YHB0029Ca Canine DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 48T
E0049Rb Rabbit DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 48T
E1034Mo Mouse DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 96T
CK-E90454 Human DNA repair protein RAD51 homolog 1 (RAD51)ELISA Kit 96T
E0083Bo Bovine DNA repair protein RAD51 homolog 1(RAD51) ELISA Kit 48T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur