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DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (RAD51-like protein 1)

 RA51B_MOUSE             Reviewed;         350 AA.
O35719; Q8BSH6; Q9D555;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
07-NOV-2003, sequence version 2.
10-OCT-2018, entry version 137.
RecName: Full=DNA repair protein RAD51 homolog 2;
Short=R51H2;
AltName: Full=RAD51 homolog B;
AltName: Full=RAD51-like protein 1;
Name=Rad51b; Synonyms=Rad51l1, Rec2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=9207106; DOI=10.1073/pnas.94.14.7417;
Rice M.C., Smith S.T., Bullrich F., Havre P., Kmiec E.B.;
"Isolation of human and mouse genes based on homology to REC2, a
recombinational repair gene from the fungus Ustilago maydis.";
Proc. Natl. Acad. Sci. U.S.A. 94:7417-7422(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J; TISSUE=Mesonephros;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
-!- FUNCTION: Involved in the homologous recombination repair (HRR)
pathway of double-stranded DNA breaks arising during DNA
replication or induced by DNA-damaging agents. May promote the
assembly of presynaptic RAD51 nucleoprotein filaments. Binds
single-stranded DNA and double-stranded DNA and has DNA-dependent
ATPase activity. Part of the RAD21 paralog protein complex BCDX2
which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA
damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of
RAD51 recruitment. BCDX2 binds predominantly to the intersection
of the four duplex arms of the Holliday junction and to junction
of replication forks. The BCDX2 complex was originally reported to
bind single-stranded DNA, single-stranded gaps in duplex DNA and
specifically to nicks in duplex DNA. The BCDX2 subcomplex
RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase
activity suggesting an involvement in early stages of the HR
pathway (By similarity). {ECO:0000250}.
-!- SUBUNIT: Part of the BCDX2 complex consisting of RAD51B, RAD51C,
RAD51D and XRCC2; the complex has a ring-like structure arranged
into a flat disc around a central channel. The BCDX2 subcomplex
RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1;
involved in homologous recombination repair (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O35719-1; Sequence=Displayed;
Name=2;
IsoId=O35719-2; Sequence=VSP_008869, VSP_008870;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in a wide range of tissues.
-!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
{ECO:0000305}.
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EMBL; U92068; AAB63359.1; -; mRNA.
EMBL; AK015771; BAB29970.1; -; mRNA.
EMBL; AK032913; BAC28084.1; -; mRNA.
CCDS; CCDS56845.1; -. [O35719-2]
RefSeq; NP_001239491.1; NM_001252562.1. [O35719-2]
RefSeq; NP_033040.2; NM_009014.3. [O35719-1]
RefSeq; XP_011242347.1; XM_011244045.1. [O35719-2]
UniGene; Mm.341756; -.
ProteinModelPortal; O35719; -.
BioGrid; 202566; 1.
STRING; 10090.ENSMUSP00000078490; -.
PhosphoSitePlus; O35719; -.
MaxQB; O35719; -.
PaxDb; O35719; -.
PeptideAtlas; O35719; -.
PRIDE; O35719; -.
Ensembl; ENSMUST00000079533; ENSMUSP00000078490; ENSMUSG00000059060. [O35719-2]
Ensembl; ENSMUST00000171210; ENSMUSP00000128357; ENSMUSG00000059060. [O35719-1]
Ensembl; ENSMUST00000218039; ENSMUSP00000152105; ENSMUSG00000059060. [O35719-1]
GeneID; 19363; -.
KEGG; mmu:19363; -.
UCSC; uc007oai.1; mouse. [O35719-1]
UCSC; uc007oaj.1; mouse. [O35719-2]
CTD; 5890; -.
MGI; MGI:1099436; Rad51b.
eggNOG; KOG1433; Eukaryota.
eggNOG; COG0468; LUCA.
GeneTree; ENSGT00860000133731; -.
HOGENOM; HOG000154062; -.
HOVERGEN; HBG061476; -.
InParanoid; O35719; -.
KO; K10869; -.
OMA; RKEFDTQ; -.
PhylomeDB; O35719; -.
TreeFam; TF101219; -.
Reactome; R-MMU-5685942; HDR through Homologous Recombination (HRR).
Reactome; R-MMU-5693568; Resolution of D-loop Structures through Holliday Junction Intermediates.
Reactome; R-MMU-5693579; Homologous DNA Pairing and Strand Exchange.
Reactome; R-MMU-5693616; Presynaptic phase of homologous DNA pairing and strand exchange.
Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
ChiTaRS; Rad51b; mouse.
PRO; PR:O35719; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000059060; Expressed in 31 organ(s), highest expression level in dorsal root ganglion.
CleanEx; MM_RAD51L1; -.
Genevisible; O35719; MM.
GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; ISS:UniProtKB.
GO; GO:0005657; C:replication fork; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008094; F:DNA-dependent ATPase activity; ISO:MGI.
GO; GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
GO; GO:0000400; F:four-way junction DNA binding; IBA:GO_Central.
GO; GO:0000150; F:recombinase activity; IBA:GO_Central.
GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO; GO:0001832; P:blastocyst growth; IMP:MGI.
GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:0000707; P:meiotic DNA recombinase assembly; IBA:GO_Central.
GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
GO; GO:0010212; P:response to ionizing radiation; IBA:GO_Central.
GO; GO:0061053; P:somite development; IMP:MGI.
GO; GO:0042148; P:strand invasion; IBA:GO_Central.
CDD; cd01123; Rad51_DMC1_radA; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
InterPro; IPR016467; DNA_recomb/repair_RecA-like.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033925; Rad51_DMC1_RadA.
InterPro; IPR030548; RAD51B.
InterPro; IPR020588; RecA_ATP-bd.
PANTHER; PTHR22942:SF15; PTHR22942:SF15; 1.
Pfam; PF08423; Rad51; 1.
PIRSF; PIRSF005856; Rad51; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50162; RECA_2; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Complete proteome; DNA damage;
DNA recombination; DNA repair; DNA-binding; Nucleotide-binding;
Nucleus; Reference proteome.
CHAIN 1 350 DNA repair protein RAD51 homolog 2.
/FTId=PRO_0000122940.
NP_BIND 108 115 ATP. {ECO:0000255}.
REGION 1 75 Interaction with RAD51C. {ECO:0000250}.
VAR_SEQ 254 258 ILTNQ -> TFQPI (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_008869.
VAR_SEQ 259 350 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_008870.
CONFLICT 23 23 Q -> L (in Ref. 1; AAB63359).
{ECO:0000305}.
SEQUENCE 350 AA; 38152 MW; 2DB79F8D60C0529D CRC64;
MSSKKLRRVG LSPELCDRLS RYQIVNCQHF LSLSPLELMK VTGLSYRGVH ELLHTVSKAC
APQMQTAYEL KTRRSAHLSP AFLSTTLCAL DEALHGGVPC GSLTEITGPP GCGKTQFCIM
MSVLATLPTS LGGLEGAVVY IDTESAFTAE RLVEIAESRF PQYFNTEEKL LLTSSRVHLC
RELTCEGLLQ RLESLEEEII SKGVKLVIVD SIASVVRKEF DPKLQGNIKE RNKFLGKGAS
LLKYLAGEFS IPVILTNQIT THLSGALPSQ ADLVSPADDL SLSEGTSGSS CLVAALGNTW
GHCVNTRLIL QYLDSERRQI LIAKSPLAAF TSFVYTIKGE GLVLQGHERP


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