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DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3)

 RA51D_MOUSE             Reviewed;         329 AA.
O55230;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
23-MAY-2018, entry version 141.
RecName: Full=DNA repair protein RAD51 homolog 4;
AltName: Full=R51H3;
AltName: Full=RAD51 homolog D;
AltName: Full=RAD51-like protein 3;
Name=Rad51d; Synonyms=R51h3, Rad51l3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
PubMed=9570954; DOI=10.1006/geno.1998.5226;
Pittman D.L., Weinberg L.R., Schimenti J.C.;
"Identification, characterization, and genetic mapping of Rad51d, a
new mouse and human RAD51/RecA-related gene.";
Genomics 49:103-111(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9512535; DOI=10.1093/nar/26.7.1653;
Cartwright R., Dunn A.M., Simpson P.J., Tambini C.E., Thacker J.;
"Isolation of novel human and mouse genes of the recA/RAD51
recombination-repair gene family.";
Nucleic Acids Res. 26:1653-1659(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Kawabata M.;
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
DISRUPTION PHENOTYPE.
PubMed=10705376;
DOI=10.1002/(SICI)1526-968X(200003)26:3<167::AID-GENE1>3.0.CO;2-M;
Pittman D.L., Schimenti J.C.;
"Midgestation lethality in mice deficient for the RecA-related gene,
Rad51d/Rad51l3.";
Genesis 26:167-173(2000).
[7]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15109494; DOI=10.1016/S0092-8674(04)00337-X;
Tarsounas M., Munoz P., Claas A., Smiraldo P.G., Pittman D.L.,
Blasco M.A., West S.C.;
"Telomere maintenance requires the RAD51D recombination/repair
protein.";
Cell 117:337-347(2004).
[8]
INTERACTION WITH RAD51C AND XRCC2.
PubMed=14704354; DOI=10.1093/nar/gkg925;
Miller K.A., Sawicka D., Barsky D., Albala J.S.;
"Domain mapping of the Rad51 paralog protein complexes.";
Nucleic Acids Res. 32:169-178(2004).
-!- FUNCTION: Involved in the homologous recombination repair (HRR)
pathway of double-stranded DNA breaks arising during DNA
replication or induced by DNA-damaging agents. Bind to single-
stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part
of the Rad21 paralog protein complex BCDX2 which acts in the
BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts
downstream of BRCA2 recruitment and upstream of RAD51 recruitment.
BCDX2 binds predominantly to the intersection of the four duplex
arms of the Holliday junction and to junction of replication
forks. The BCDX2 complex was originally reported to bind single-
stranded DNA, single-stranded gaps in duplex DNA and specifically
to nicks in duplex DNA. Involved in telomere maintenance. The
BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction
resolution by BLM (By similarity). {ECO:0000250,
ECO:0000269|PubMed:15109494}.
-!- SUBUNIT: Part of the BCDX2 complex consisting of RAD51B, RAD51C,
RAD51D and XRCC2; the complex has a ring-like structure arranged
into a flat disc around a central channel. In the absence of DNA,
the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring
structure; in the presence of single-stranded DNA it formed a
filamentous structure with the ssDNA. Interacts with SWSAP1 and
ZSWIM7; involved in homologous recombination repair. Interacts
with BLM; required for stimulation of BLM activity by the BCDX2
subcomplex XRCC2:RAD51D (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
{ECO:0000269|PubMed:15109494}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=1;
Comment=At least 2 isoforms are produced.;
Name=1;
IsoId=O55230-1; Sequence=Displayed;
-!- TISSUE SPECIFICITY: Highly expressed in brain followed by testis.
Also expressed in heart, liver, kidney, spleen, lung and skeletal
muscle.
-!- DISRUPTION PHENOTYPE: Midgestation lethal.
{ECO:0000269|PubMed:10705376}.
-!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
{ECO:0000305}.
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EMBL; AB007040; BAA24010.1; -; mRNA.
EMBL; AF034955; AAC40093.1; -; mRNA.
EMBL; Y15570; CAA75679.1; -; mRNA.
EMBL; AK017835; BAB30965.1; -; mRNA.
EMBL; BC049136; AAH49136.1; -; mRNA.
CCDS; CCDS36250.1; -. [O55230-1]
RefSeq; NP_035365.1; NM_011235.4. [O55230-1]
UniGene; Mm.441571; -.
UniGene; Mm.9286; -.
ProteinModelPortal; O55230; -.
SMR; O55230; -.
BioGrid; 202567; 3.
IntAct; O55230; 1.
MINT; O55230; -.
STRING; 10090.ENSMUSP00000018985; -.
PhosphoSitePlus; O55230; -.
EPD; O55230; -.
PaxDb; O55230; -.
PRIDE; O55230; -.
Ensembl; ENSMUST00000018985; ENSMUSP00000018985; ENSMUSG00000018841. [O55230-1]
GeneID; 19364; -.
KEGG; mmu:19364; -.
UCSC; uc007knm.2; mouse. [O55230-1]
CTD; 5892; -.
MGI; MGI:1261809; Rad51d.
eggNOG; KOG1433; Eukaryota.
eggNOG; COG0468; LUCA.
GeneTree; ENSGT00860000133731; -.
HOGENOM; HOG000049134; -.
HOVERGEN; HBG057455; -.
InParanoid; O55230; -.
KO; K10871; -.
OMA; CSLSYKA; -.
OrthoDB; EOG091G0SEJ; -.
PhylomeDB; O55230; -.
TreeFam; TF101219; -.
Reactome; R-MMU-5685942; HDR through Homologous Recombination (HRR).
Reactome; R-MMU-5693568; Resolution of D-loop Structures through Holliday Junction Intermediates.
Reactome; R-MMU-5693579; Homologous DNA Pairing and Strand Exchange.
Reactome; R-MMU-5693616; Presynaptic phase of homologous DNA pairing and strand exchange.
PRO; PR:O55230; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000018841; -.
CleanEx; MM_RAD51L3; -.
ExpressionAtlas; O55230; baseline and differential.
Genevisible; O55230; MM.
GO; GO:0005813; C:centrosome; ISS:UniProtKB.
GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IDA:BHF-UCL.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; ISS:UniProtKB.
GO; GO:0005657; C:replication fork; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008094; F:DNA-dependent ATPase activity; ISS:UniProtKB.
GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
GO; GO:0000400; F:four-way junction DNA binding; IBA:GO_Central.
GO; GO:0043015; F:gamma-tubulin binding; ISS:UniProtKB.
GO; GO:0000150; F:recombinase activity; IBA:GO_Central.
GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI.
GO; GO:0051276; P:chromosome organization; IMP:MGI.
GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
GO; GO:0036297; P:interstrand cross-link repair; IMP:MGI.
GO; GO:0000707; P:meiotic DNA recombinase assembly; IBA:GO_Central.
GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
GO; GO:0006289; P:nucleotide-excision repair; IMP:MGI.
GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
GO; GO:0051726; P:regulation of cell cycle; IMP:MGI.
GO; GO:0010212; P:response to ionizing radiation; IBA:GO_Central.
GO; GO:0042148; P:strand invasion; ISS:UniProtKB.
GO; GO:0000723; P:telomere maintenance; IGI:BHF-UCL.
GO; GO:0000722; P:telomere maintenance via recombination; IC:BHF-UCL.
CDD; cd01123; Rad51_DMC1_radA; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
InterPro; IPR016467; DNA_recomb/repair_RecA-like.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033925; Rad51_DMC1_RadA.
InterPro; IPR020588; RecA_ATP-bd.
Pfam; PF08423; Rad51; 1.
PIRSF; PIRSF005856; Rad51; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50162; RECA_2; 1.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Chromosome; Complete proteome;
DNA damage; DNA recombination; DNA repair; DNA-binding;
Nucleotide-binding; Nucleus; Reference proteome; Telomere.
CHAIN 1 329 DNA repair protein RAD51 homolog 4.
/FTId=PRO_0000122943.
NP_BIND 107 114 ATP. {ECO:0000255}.
REGION 1 83 preferentially binds ssDNA.
{ECO:0000250}.
REGION 4 77 Interaction with XRCC2.
{ECO:0000269|PubMed:14704354}.
REGION 77 328 Interaction with RAD51C.
{ECO:0000269|PubMed:14704354}.
SEQUENCE 329 AA; 35260 MW; 6E463822408EF484 CRC64;
MGMLRAGLCP GLTEETVQLL RGRKIKTVAD LAAADLEEVA QKCGLSYKAL VALRRVLLAQ
FSAFPLNGAD LYEELKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCV
AANVAHSLQQ NVLYVDSNGG MTASRLLQLL QARTQDEEKQ ASALQRIQVV RSFDIFRMLD
MLQDLRGTIA QQEATSSGAV KVVIVDSVTA VVAPLLGGQQ REGLALMMQL ARELKILARD
LGVAVVVTNH LTRDWDGRRF KPALGRSWSF VPSTRILLDV TEGAGTLGSS QRTVCLTKSP
RQPTGLQEMI DIGTLGTEEQ SPELPGKQT


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