GENTAUR Molecular Products.

 Q7KUL1_DROME            Unreviewed;       764 AA.
 Q7KUL1;
 05-JUL-2004, integrated into UniProtKB/TrEMBL.
 26-JUN-2013, sequence version 2.
 12-SEP-2018, entry version 127.
 SubName: Full=Dally-like, isoform C {ECO:0000313|EMBL:AAS65005.2};
 Name=dlp {ECO:0000313|EMBL:AAS65005.2,
 ECO:0000313|FlyBase:FBgn0041604};
 Synonyms=CG17703 {ECO:0000313|EMBL:AAS65005.2},
 CG32146 {ECO:0000313|EMBL:AAS65005.2},
 CG5031 {ECO:0000313|EMBL:AAS65005.2},
 CT16138 {ECO:0000313|EMBL:AAS65005.2},
 D-gpcB {ECO:0000313|EMBL:AAS65005.2},
 Dally-like {ECO:0000313|EMBL:AAS65005.2},
 DLP {ECO:0000313|EMBL:AAS65005.2}, Dlp {ECO:0000313|EMBL:AAS65005.2},
 Dly {ECO:0000313|EMBL:AAS65005.2}, dly {ECO:0000313|EMBL:AAS65005.2},
 Dmel\CG32146 {ECO:0000313|EMBL:AAS65005.2};
 ORFNames=CG32146 {ECO:0000313|FlyBase:FBgn0041604},
 Dmel_CG32146 {ECO:0000313|EMBL:AAS65005.2};
 Drosophila melanogaster (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
 Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
 Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7227 {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803};
 [1] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=10731132; DOI=10.1126/science.287.5461.2185;
 Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
 Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
 George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
 Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
 Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
 Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
 Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
 Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
 Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
 Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
 Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
 Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
 de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
 Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
 Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
 Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
 Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
 Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
 Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
 Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
 Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
 Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
 Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
 Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
 Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
 Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
 Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
 Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
 Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
 Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
 Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
 Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
 Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
 Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
 Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
 Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
 "The genome sequence of Drosophila melanogaster.";
 Science 287:2185-2195(2000).
 [2] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537568;
 Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
 Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
 George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
 Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
 Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
 Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
 "Finishing a whole-genome shotgun: release 3 of the Drosophila
 melanogaster euchromatic genome sequence.";
 Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
 [3] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 GENOME REANNOTATION.
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
 Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
 Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
 Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
 Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
 Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
 Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
 Lewis S.E.;
 "Annotation of the Drosophila melanogaster euchromatic genome: a
 systematic review.";
 Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
 [4] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537573;
 Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
 Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
 Ashburner M., Celniker S.E.;
 "The transposable elements of the Drosophila melanogaster euchromatin:
 a genomics perspective.";
 Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
 [5] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=12537574;
 Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
 Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
 Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
 Karpen G.H.;
 "Heterochromatic sequences in a Drosophila whole-genome shotgun
 assembly.";
 Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
 [6] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
 Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
 Ashburner M., Anxolabehere D.;
 "Combined evidence annotation of transposable elements in genome
 sequences.";
 PLoS Comput. Biol. 1:166-175(2005).
 [7] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=17569856; DOI=10.1126/science.1139815;
 Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
 "The Release 5.1 annotation of Drosophila melanogaster
 heterochromatin.";
 Science 316:1586-1591(2007).
 [8] {ECO:0000313|EMBL:AAS65005.2, ECO:0000313|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
 PubMed=17569867; DOI=10.1126/science.1139816;
 Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
 Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
 Dimitri P., Karpen G.H., Celniker S.E.;
 "Sequence finishing and mapping of Drosophila melanogaster
 heterochromatin.";
 Science 316:1625-1628(2007).
 -!- FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
     {ECO:0000256|RuleBase:RU003519}.
 -!- SUBCELLULAR LOCATION: Cell membrane
     {ECO:0000256|RuleBase:RU003519}; Lipid-anchor, GPI-anchor
     {ECO:0000256|RuleBase:RU003519}.
 -!- SIMILARITY: Belongs to the glypican family.
     {ECO:0000256|RuleBase:RU003518}.
 -----------------------------------------------------------------------
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 EMBL; AE014296; AAS65005.2; -; Genomic_DNA.
 RefSeq; NP_996075.2; NM_206353.2.
 UniGene; Dm.2840; -.
 ProteinModelPortal; Q7KUL1; -.
 SMR; Q7KUL1; -.
 IntAct; Q7KUL1; 3.
 PRIDE; Q7KUL1; -.
 EnsemblMetazoa; FBtr0333032; FBpp0305246; FBgn0041604.
 GeneID; 39596; -.
 UCSC; CG32146-RB; d. melanogaster.
 CTD; 39596; -.
 FlyBase; FBgn0041604; dlp.
 eggNOG; KOG3821; Eukaryota.
 eggNOG; ENOG410XST2; LUCA.
 GeneTree; ENSGT00550000074430; -.
 InParanoid; Q7KUL1; -.
 OMA; QCPSEFE; -.
 OrthoDB; EOG091G06T6; -.
 Reactome; R-DME-1971475; A tetrasaccharide linker sequence is required for GAG synthesis.
 Reactome; R-DME-2022928; HS-GAG biosynthesis.
 Reactome; R-DME-2024096; HS-GAG degradation.
 Reactome; R-DME-376176; Signaling by ROBO receptors.
 ChiTaRS; dlp; fly.
 GenomeRNAi; 39596; -.
 Proteomes; UP000000803; Chromosome 3L.
 Bgee; FBgn0041604; Expressed in 66 organ(s), highest expression level in embryo.
 ExpressionAtlas; Q7KUL1; baseline and differential.
 Genevisible; Q7KUL1; DM.
 GO; GO:0046658; C:anchored component of plasma membrane; IEA:InterPro.
 GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase.
 GO; GO:0098595; C:perivitelline space; HDA:FlyBase.
 GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
 GO; GO:0045202; C:synapse; IDA:FlyBase.
 GO; GO:0007411; P:axon guidance; IMP:FlyBase.
 GO; GO:0048749; P:compound eye development; IMP:FlyBase.
 GO; GO:0050908; P:detection of light stimulus involved in visual perception; IMP:FlyBase.
 GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase.
 GO; GO:0007528; P:neuromuscular junction development; IMP:FlyBase.
 GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:FlyBase.
 GO; GO:0045570; P:regulation of imaginal disc growth; IMP:FlyBase.
 GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:FlyBase.
 GO; GO:0007367; P:segment polarity determination; IMP:FlyBase.
 GO; GO:0007224; P:smoothened signaling pathway; IMP:FlyBase.
 InterPro; IPR001863; Glypican.
 PANTHER; PTHR10822; PTHR10822; 2.
 Pfam; PF01153; Glypican; 2.
 1: Evidence at protein level;
 Coiled coil {ECO:0000256|SAM:Coils};
 Complete proteome {ECO:0000313|Proteomes:UP000000803};
 Glycoprotein {ECO:0000256|RuleBase:RU003519};
 GPI-anchor {ECO:0000256|RuleBase:RU003519};
 Heparan sulfate {ECO:0000256|RuleBase:RU003519};
 Lipoprotein {ECO:0000256|RuleBase:RU003519};
 Membrane {ECO:0000256|RuleBase:RU003519, ECO:0000256|SAM:Phobius};
 Proteoglycan {ECO:0000256|RuleBase:RU003519};
 Proteomics identification {ECO:0000213|PeptideAtlas:Q7KUL1};
 Reference proteome {ECO:0000313|Proteomes:UP000000803};
 Transmembrane {ECO:0000256|SAM:Phobius};
 Transmembrane helix {ECO:0000256|SAM:Phobius}.
 TRANSMEM     21     41       Helical. {ECO:0000256|SAM:Phobius}.
 COILED      473    495       {ECO:0000256|SAM:Coils}.
 SEQUENCE   764 AA;  85194 MW;  C5C6DF5A7189F8F2 CRC64;
 MLHQQQQQQH LHCRRKATAT TTARLVIFSS PLLLLLLTTH LPPTLQADNG PAPQVAALAA
 PNPAGGVAGS SIIDQFSPNC SAVTHIFQAR GIDAIEIPQK PSNERVLRYC ESPSVGTCCT
 YNMETRMAMQ SRQQLEGHTK DQISRMSGIL GSKATKFKDI FTALLKESRT QFNSMFIRTY
 GVIYERNSYV FSDLFKELET YFANGRVDLL EVMDKFFNTL YQKMFTVLNT QYTFDENYMR
 CVSEHMKELK PFGDVPDKLS VQIKRSFVAT RTYGQALTTA SEVAKKVLNV RLNADCTGAL
 TKMQHCGACK GYTEKPCTNY CVNVIKGCLH YQHEFDSEWE NFAMAMDKVA ERLLGSFNIV
 MVVEPLNIKI SEAIMNFQDS GQDITNRVFQ GCGRPKLKKM KRSISPKLQG VQILNARSPV
 EADTLDIDET LDEAIVLRER RAAEPGSQET SAQQSQEQGV GKSGNGGGGG GGNNRRQQQR
 RKQQQQRRKQ QNNRDDNDDD DNESGGGREP ILDRIVRDIR QRVKDYKKFW SNLPHSVCSN
 EDIASSSDVD GMCWNGHTID RYMHSITTEH GSNPEFTGNP ASTKQTAQMA SQLSHLKNAI
 VHLRNAYNGQ DVEWSEQELP YAGSGAGSGS GSEDDEDDDE GSGLGPFEPS HKPDVERPSV
 DADNDDDEDA GGRGHMPTHT SRPTSGVDDK NPLIHTTHFD QDHNDLDEDH RQLDEDEDTD
 AGHDGANDNR SSDAPEKMTL RRALVVYLLP LYMAWFGGVC ADLL

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