Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Decorin (Bone proteoglycan II) (Dermatan sulfate proteoglycan II) (DS-PGII) (PG-S2)

 PGS2_HORSE              Reviewed;         360 AA.
O46542;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
23-MAY-2018, entry version 116.
RecName: Full=Decorin;
AltName: Full=Bone proteoglycan II;
AltName: Full=Dermatan sulfate proteoglycan II;
Short=DS-PGII;
AltName: Full=PG-S2;
Flags: Precursor;
Name=DCN;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Richardson D.W., Dodge G.R.;
"Effects of interleukin-1 beta and tumor necrosis factor-alpha on the
expression of matrix related genes in cultured equine articular
chondrocytes.";
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: May affect the rate of fibrils formation. {ECO:0000250}.
-!- SUBUNIT: Binds to type I and type II collagen, fibronectin and
TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts
with DPT (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000250}.
-!- PTM: The attached glycosaminoglycan chain can be either
chondroitin sulfate or dermatan sulfate depending upon the tissue
of origin. {ECO:0000250}.
-!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
family. SLRP class I subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF038127; AAB92652.1; -; mRNA.
RefSeq; NP_001075394.1; NM_001081925.2.
RefSeq; XP_005606524.1; XM_005606467.2.
UniGene; Eca.4010; -.
ProteinModelPortal; O46542; -.
SMR; O46542; -.
STRING; 9796.ENSECAP00000017861; -.
PaxDb; O46542; -.
PeptideAtlas; O46542; -.
PRIDE; O46542; -.
Ensembl; ENSECAT00000021671; ENSECAP00000017861; ENSECAG00000020413.
GeneID; 100034120; -.
KEGG; ecb:100034120; -.
CTD; 1634; -.
VGNC; VGNC:17046; DCN.
eggNOG; KOG0619; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00760000118969; -.
HOGENOM; HOG000261690; -.
HOVERGEN; HBG016052; -.
InParanoid; O46542; -.
KO; K04660; -.
OMA; PLGPVCP; -.
OrthoDB; EOG091G044B; -.
TreeFam; TF334562; -.
Proteomes; UP000002281; Chromosome 28.
Bgee; ENSECAG00000020413; -.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
GO; GO:0005518; F:collagen binding; IEA:InterPro.
GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0046426; P:negative regulation of JAK-STAT cascade; IBA:GO_Central.
GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
GO; GO:1900747; P:negative regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
GO; GO:0019800; P:peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; IEA:Ensembl.
GO; GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
GO; GO:0051901; P:positive regulation of mitochondrial depolarization; IEA:Ensembl.
GO; GO:0090141; P:positive regulation of mitochondrial fission; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR028549; Decorin.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000372; LRRNT.
InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
PANTHER; PTHR44053:SF2; PTHR44053:SF2; 1.
Pfam; PF13855; LRR_8; 3.
Pfam; PF01462; LRRNT; 1.
PIRSF; PIRSF002490; SLRP_I; 1.
SMART; SM00369; LRR_TYP; 7.
SMART; SM00013; LRRNT; 1.
PROSITE; PS51450; LRR; 8.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein;
Leucine-rich repeat; Proteoglycan; Reference proteome; Repeat;
Secreted; Signal.
SIGNAL 1 16 {ECO:0000250|UniProtKB:Q01129}.
PROPEP 17 30 {ECO:0000250|UniProtKB:Q01129}.
/FTId=PRO_0000032707.
CHAIN 31 360 Decorin.
/FTId=PRO_0000032708.
REPEAT 74 94 LRR 1.
REPEAT 95 118 LRR 2.
REPEAT 119 142 LRR 3.
REPEAT 143 163 LRR 4.
REPEAT 164 187 LRR 5.
REPEAT 188 213 LRR 6.
REPEAT 214 234 LRR 7.
REPEAT 235 258 LRR 8.
REPEAT 259 282 LRR 9.
REPEAT 283 305 LRR 10.
REPEAT 306 335 LRR 11.
REPEAT 336 360 LRR 12.
COMPBIAS 55 68 Cys-rich.
CARBOHYD 34 34 O-linked (Xyl...) (glycosaminoglycan)
serine. {ECO:0000250}.
CARBOHYD 212 212 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 263 263 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 304 304 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 55 61 {ECO:0000250}.
DISULFID 59 68 {ECO:0000250}.
DISULFID 314 347 {ECO:0000250}.
SEQUENCE 360 AA; 39939 MW; 2DAE97CDE16F7C45 CRC64;
MKATIIFLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPED RIHEVLDLEP LGPVCPFRCQ
CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG DFKNLKNLHA LILVNNKISK
ISPGAFTPLV KLERLYLSKN HLKELPEKMP KTLQELRVHE NEITKVRKAV FNGLNQMIVV
ELGTNPLKSS GIENGAFQGM KKLSYIRIAD TNITTIPPGL PPSLTELHLD GNKITKVDAA
SLRGLNNLAK LGLSFNSISA VDNGSLANTP HLRELHLDNN KLIKVPGGLA DHKYIQVVYL
HNNNISAVGS NDFCPPGYNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RSAIQLGNYK


Related products :

Catalog number Product name Quantity
EIAAB30782 Bone proteoglycan II,Dcn,Decorin,Dermatan sulfate proteoglycan-II,DSPG,PG40,PG-S2,Rat,Rattus norvegicus
EIAAB13151 Dermatan sulfate proteoglycan 3,Dspg3,Epiphycan,Epyc,Mouse,Mus musculus,Pglb,PG-Lb,Proteoglycan-Lb,Small chondroitin_dermatan sulfate proteoglycan
EIAAB13149 Bos taurus,Bovine,Dermatan sulfate proteoglycan 3,DSPG3,Epiphycan,EPYC,PGLB,PG-Lb,Proteoglycan-Lb,Small chondroitin_dermatan sulfate proteoglycan
EIAAB13150 Dermatan sulfate proteoglycan 3,DSPG3,Epiphycan,EPYC,Homo sapiens,Human,PGLB,PG-Lb,Proteoglycan-Lb,SLRR3B,Small chondroitin_dermatan sulfate proteoglycan
EIAAB13148 Chicken,Dermatan sulfate proteoglycan 3,DSPG3,Epiphycan,EPYC,Gallus gallus,PGLB,PG-Lb,Proteoglycan-Lb,Small chondroitin_dermatan sulfate proteoglycan
EIAAB09627 Chondroitin sulfate proteoglycan 4,Chondroitin sulfate proteoglycan NG2,CSPG4,Homo sapiens,Human,MCSP,Melanoma chondroitin sulfate proteoglycan,Melanoma-associated chondroitin sulfate proteoglycan
E1817b ELISA kit Bos taurus,Bovine,Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,VCAN,Ver 96T
U1817r CLIA kit Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,Rat,Rattus norvegicus,Vcan, 96T
E1817r ELISA kit Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,Rat,Rattus norvegicus,Vcan 96T
E1817r ELISA Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,Rat,Rattus norvegicus,Vcan,Vers 96T
E1817h ELISA kit Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Homo sapiens,Human,Large fibroblast proteoglycan,PG-M,VCAN,Ve 96T
U1817h CLIA kit Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Homo sapiens,Human,Large fibroblast proteoglycan,PG-M,VCAN,Ver 96T
U1817r CLIA Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,Rat,Rattus norvegicus,Vcan,Versi 96T
E1817b ELISA Bos taurus,Bovine,Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,VCAN,Versican 96T
U1817b CLIA Bos taurus,Bovine,Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,VCAN,Versican 96T
U1817b CLIA kit Bos taurus,Bovine,Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Large fibroblast proteoglycan,PG-M,VCAN,Vers 96T
U1817h CLIA Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Homo sapiens,Human,Large fibroblast proteoglycan,PG-M,VCAN,Versican 96T
E1817h ELISA Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,CSPG2,GHAP,Glial hyaluronate-binding protein,Homo sapiens,Human,Large fibroblast proteoglycan,PG-M,VCAN,Versica 96T
EIAAB09628 An2,Chondroitin sulfate proteoglycan 4,Chondroitin sulfate proteoglycan NG2,Cspg4,Kiaa4232,Mouse,Mus musculus,Ng2,Proteoglycan AN2
U1817m CLIA Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,Large fibroblast proteoglycan,Mouse,Mus musculus,PG-M,Vcan,Versican core protein 96T
E1817m ELISA kit Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,Large fibroblast proteoglycan,Mouse,Mus musculus,PG-M,Vcan,Versican core protein 96T
E1817m ELISA Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,Large fibroblast proteoglycan,Mouse,Mus musculus,PG-M,Vcan,Versican core protein 96T
U1817m CLIA kit Chondroitin sulfate proteoglycan 2,Chondroitin sulfate proteoglycan core protein 2,Cspg2,Large fibroblast proteoglycan,Mouse,Mus musculus,PG-M,Vcan,Versican core protein 96T
EIAAB30783 Bone proteoglycan II,DCN,Decorin,PG-S2,Pig,Sus scrofa
U1908h CLIA ACAN,AGC1,Aggrecan core protein,Cartilage-specific proteoglycan core protein,Chondroitin sulfate proteoglycan 1,Chondroitin sulfate proteoglycan core protein 1,CSPCP,CSPG1,Homo sapiens,Human,MSK1 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur