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Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD)

 DHRS4_RAT               Reviewed;         279 AA.
Q8VID1; Q6IRD4;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 2.
20-JUN-2018, entry version 112.
RecName: Full=Dehydrogenase/reductase SDR family member 4;
EC=1.1.1.184;
AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase;
Short=CR;
Short=PHCR;
AltName: Full=NADPH-dependent retinol dehydrogenase/reductase;
Short=NDRD;
AltName: Full=Peroxisomal short-chain alcohol dehydrogenase;
Short=PSCD;
Name=Dhrs4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 20-279.
STRAIN=Wistar; TISSUE=Heart;
Hara A., Imamura Y., Abe H., Inoue S., Ishikura S.;
"Molecular characterization of mammalian carbonyl/retinal
reductases.";
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Reduces all-trans-retinal and 9-cis retinal. Can also
catalyze the oxidation of all-trans-retinol with NADP as co-
factor, but with much lower efficiency. Reduces alkyl phenyl
ketones and alpha-dicarbonyl compounds with aromatic rings, such
as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine,
menadione and 4-hexanoylpyridine. Has no activity towards
aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
-!- MISCELLANEOUS: Inhibited by kaempferol, quercetin, genistein and
myristic acid. {ECO:0000250}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAB78529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; CH474049; EDM14225.1; -; Genomic_DNA.
EMBL; BC070961; AAH70961.1; -; mRNA.
EMBL; AB062758; BAB78529.1; ALT_INIT; mRNA.
RefSeq; NP_695227.2; NM_153315.2.
UniGene; Rn.12783; -.
ProteinModelPortal; Q8VID1; -.
SMR; Q8VID1; -.
BioGrid; 251774; 1.
STRING; 10116.ENSRNOP00000024782; -.
iPTMnet; Q8VID1; -.
PhosphoSitePlus; Q8VID1; -.
PaxDb; Q8VID1; -.
PRIDE; Q8VID1; -.
Ensembl; ENSRNOT00000024782; ENSRNOP00000024782; ENSRNOG00000018239.
GeneID; 266686; -.
KEGG; rno:266686; -.
UCSC; RGD:708482; rat.
CTD; 10901; -.
RGD; 708482; Dhrs4.
eggNOG; KOG0725; Eukaryota.
eggNOG; COG1028; LUCA.
GeneTree; ENSGT00920000148965; -.
HOVERGEN; HBG105779; -.
InParanoid; Q8VID1; -.
KO; K11147; -.
OMA; FELLGAY; -.
OrthoDB; EOG091G0G3R; -.
PhylomeDB; Q8VID1; -.
TreeFam; TF315405; -.
Reactome; R-RNO-5365859; RA biosynthesis pathway.
Reactome; R-RNO-9033241; Peroxisomal protein import.
PRO; PR:Q8VID1; -.
Proteomes; UP000002494; Chromosome 15.
Bgee; ENSRNOG00000018239; -.
Genevisible; Q8VID1; RN.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0005777; C:peroxisome; IDA:RGD.
GO; GO:0004090; F:carbonyl reductase (NADPH) activity; IEA:UniProtKB-EC.
GO; GO:0001758; F:retinal dehydrogenase activity; IEA:Ensembl.
GO; GO:0042574; P:retinal metabolic process; IEA:Ensembl.
InterPro; IPR029511; DHRS4-like.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
PANTHER; PTHR43943:SF8; PTHR43943:SF8; 1.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00061; ADH_SHORT; 1.
2: Evidence at transcript level;
Acetylation; Complete proteome; NADP; Oxidoreductase; Peroxisome;
Phosphoprotein; Reference proteome.
CHAIN 1 279 Dehydrogenase/reductase SDR family member
4.
/FTId=PRO_0000054652.
NP_BIND 37 61 NADP. {ECO:0000250}.
MOTIF 277 279 Microbody targeting signal.
ACT_SITE 183 183 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10001}.
BINDING 170 170 Substrate. {ECO:0000250}.
MOD_RES 93 93 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 93 93 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 106 106 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 217 217 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 217 217 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 221 221 Phosphoserine.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 228 228 N6-succinyllysine.
{ECO:0000250|UniProtKB:Q99LB2}.
MOD_RES 235 235 N6-succinyllysine.
{ECO:0000250|UniProtKB:Q99LB2}.
SEQUENCE 279 AA; 29822 MW; ED38F20A7B720FEF CRC64;
MQKAGLLLRG WTRAWKSVRM ASSGLTRQNP LANKVALVTA STDGIGLAIA RRLAEDGAHV
VISSRKQQNV DRAVATLQGE GLSVTGVVCH VGKAEDREKL VNMALKLHQG IDILVSNAAV
NPFFGNLMDV TEEVWNKVLS INVTASAMMI KAVVPAMEKR GGGSVVIVSS VAGFVLFPSL
GPYNVSKTAL LGLTKNFAAE LAPKNIRVNC LAPGLIKTHF SSVLWKEKAR EEMIKETMQI
RRLGKPEDCV GIVSFLCSED ASYINGETVV VGGGTPSRL


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