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Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (mouNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD)

 DHRS4_MOUSE             Reviewed;         279 AA.
Q99LB2; G3X8V7; Q9EQU4;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 3.
20-JUN-2018, entry version 132.
RecName: Full=Dehydrogenase/reductase SDR family member 4;
EC=1.1.1.184;
AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase;
Short=CR;
Short=PHCR;
AltName: Full=NADPH-dependent retinol dehydrogenase/reductase;
Short=NDRD;
Short=mouNRDR;
AltName: Full=Peroxisomal short-chain alcohol dehydrogenase;
Short=PSCD;
Name=Dhrs4; Synonyms=D14Ucla2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Liver;
Furukawa A., Ohnishi T., Huang D., Araki N., Ichikawa Y.;
"cDNA cloning and characterization of peroxisomal short-chain
dehydrogenase / reductase that reduce all-trans retinal to retinol.";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas,
and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[6]
SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-93; LYS-217; LYS-228 AND
LYS-235, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Liver;
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z.,
Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
[7]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-93; LYS-106 AND LYS-217, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=23576753; DOI=10.1073/pnas.1302961110;
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J.,
Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
"Label-free quantitative proteomics of the lysine acetylome in
mitochondria identifies substrates of SIRT3 in metabolic pathways.";
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
-!- FUNCTION: Reduces all-trans-retinal and 9-cis retinal. Can also
catalyze the oxidation of all-trans-retinol with NADP as co-
factor, but with much lower efficiency. Reduces alkyl phenyl
ketones and alpha-dicarbonyl compounds with aromatic rings, such
as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine,
menadione and 4-hexanoylpyridine. Has no activity towards
aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
-!- MISCELLANEOUS: Inhibited by kaempferol, quercetin, genistein and
myristic acid. {ECO:0000250}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH03484.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAB18776.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AB045132; BAB18776.1; ALT_INIT; mRNA.
EMBL; AC159002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466535; EDL36299.1; -; Genomic_DNA.
EMBL; BC003484; AAH03484.1; ALT_INIT; mRNA.
EMBL; BC054361; AAH54361.1; -; mRNA.
CCDS; CCDS27111.1; -.
RefSeq; NP_001033027.2; NM_001037938.2.
UniGene; Mm.27427; -.
ProteinModelPortal; Q99LB2; -.
SMR; Q99LB2; -.
BioGrid; 205827; 1.
IntAct; Q99LB2; 5.
MINT; Q99LB2; -.
STRING; 10090.ENSMUSP00000022821; -.
iPTMnet; Q99LB2; -.
PhosphoSitePlus; Q99LB2; -.
SwissPalm; Q99LB2; -.
EPD; Q99LB2; -.
MaxQB; Q99LB2; -.
PaxDb; Q99LB2; -.
PRIDE; Q99LB2; -.
Ensembl; ENSMUST00000022821; ENSMUSP00000022821; ENSMUSG00000022210.
GeneID; 28200; -.
KEGG; mmu:28200; -.
UCSC; uc007tym.2; mouse.
CTD; 10901; -.
MGI; MGI:90169; Dhrs4.
eggNOG; KOG0725; Eukaryota.
eggNOG; COG1028; LUCA.
GeneTree; ENSGT00920000148965; -.
HOVERGEN; HBG105779; -.
InParanoid; Q99LB2; -.
KO; K11147; -.
OMA; FELLGAY; -.
OrthoDB; EOG091G0G3R; -.
TreeFam; TF315405; -.
Reactome; R-MMU-5365859; RA biosynthesis pathway.
Reactome; R-MMU-9033241; Peroxisomal protein import.
PRO; PR:Q99LB2; -.
Proteomes; UP000000589; Chromosome 14.
Bgee; ENSMUSG00000022210; -.
CleanEx; MM_DHRS4; -.
ExpressionAtlas; Q99LB2; baseline and differential.
Genevisible; Q99LB2; MM.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005778; C:peroxisomal membrane; ISO:MGI.
GO; GO:0005777; C:peroxisome; IDA:MGI.
GO; GO:0000253; F:3-keto sterol reductase activity; ISO:MGI.
GO; GO:0018455; F:alcohol dehydrogenase [NAD(P)+] activity; ISO:MGI.
GO; GO:0004090; F:carbonyl reductase (NADPH) activity; ISO:MGI.
GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; ISO:MGI.
GO; GO:0001758; F:retinal dehydrogenase activity; IDA:MGI.
GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
GO; GO:0006066; P:alcohol metabolic process; ISO:MGI.
GO; GO:0042180; P:cellular ketone metabolic process; ISO:MGI.
GO; GO:0055114; P:oxidation-reduction process; ISO:MGI.
GO; GO:0051262; P:protein tetramerization; ISO:MGI.
GO; GO:0042574; P:retinal metabolic process; IDA:MGI.
GO; GO:0008202; P:steroid metabolic process; ISO:MGI.
InterPro; IPR029511; DHRS4-like.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
PANTHER; PTHR43943:SF8; PTHR43943:SF8; 1.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00061; ADH_SHORT; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; NADP; Oxidoreductase; Peroxisome;
Phosphoprotein; Reference proteome.
CHAIN 1 279 Dehydrogenase/reductase SDR family member
4.
/FTId=PRO_0000054648.
NP_BIND 37 61 NADP. {ECO:0000250}.
MOTIF 277 279 Microbody targeting signal.
ACT_SITE 183 183 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10001}.
BINDING 170 170 Substrate. {ECO:0000250}.
MOD_RES 93 93 N6-acetyllysine; alternate.
{ECO:0000244|PubMed:23576753}.
MOD_RES 93 93 N6-succinyllysine; alternate.
{ECO:0000244|PubMed:23806337}.
MOD_RES 106 106 N6-acetyllysine.
{ECO:0000244|PubMed:23576753}.
MOD_RES 217 217 N6-acetyllysine; alternate.
{ECO:0000244|PubMed:23576753}.
MOD_RES 217 217 N6-succinyllysine; alternate.
{ECO:0000244|PubMed:23806337}.
MOD_RES 221 221 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 228 228 N6-succinyllysine.
{ECO:0000244|PubMed:23806337}.
MOD_RES 235 235 N6-succinyllysine.
{ECO:0000244|PubMed:23806337}.
CONFLICT 109 109 Q -> R (in Ref. 4; AAH03484/AAH54361).
{ECO:0000305}.
SEQUENCE 279 AA; 29885 MW; 985668BDE2935072 CRC64;
MQKAGRLLGG WTQAWMSVRM ASSGLTRRNP LSNKVALVTA STDGIGFAIA RRLAEDGAHV
VVSSRKQQNV DRAVATLQGE GLSVTGIVCH VGKAEDREKL ITTALKRHQG IDILVSNAAV
NPFFGNLMDV TEEVWDKVLS INVTATAMMI KAVVPEMEKR GGGSVVIVGS VAGFTRFPSL
GPYNVSKTAL LGLTKNFAAE LAPKNIRVNC LAPGLIKTRF SSVLWEEKAR EDFIKEAMQI
RRLGKPEDCA GIVSFLCSED ASYINGETVV VGGGTPSRL


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