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Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) (Short chain dehydrogenase/reductase family 46C member 1) (Short chain dehydrogenase/reductase family 7C member 6)

 DHRSX_HUMAN             Reviewed;         330 AA.
Q8N5I4; Q6UWC7; Q8WUS4; Q96GR8; Q9NTF6;
03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 2.
25-OCT-2017, entry version 136.
RecName: Full=Dehydrogenase/reductase SDR family member on chromosome X;
EC=1.1.-.-;
AltName: Full=DHRSXY;
AltName: Full=Short chain dehydrogenase/reductase family 46C member 1;
AltName: Full=Short chain dehydrogenase/reductase family 7C member 6;
Name=DHRSX; Synonyms=CXorf11, DHRS5X, SDR46C1, SDR7C6;
ORFNames=UNQ6508/PRO21433;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS LEU-247
AND ARG-292.
TISSUE=Teratocarcinoma;
PubMed=11731500; DOI=10.1101/gr.197001;
Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E.,
Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.;
"Differential divergence of three human pseudoautosomal genes and
their mouse homologs: implications for sex chromosome evolution.";
Genome Res. 11:2095-2100(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-292 AND
LYS-297.
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15772651; DOI=10.1038/nature03440;
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-247; ARG-292
AND LYS-297.
TISSUE=Brain, Duodenum, and Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-330, AND VARIANTS
LEU-247 AND ARG-292.
TISSUE=Testis;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[6]
PROTEIN SEQUENCE OF 2-11, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=25076851; DOI=10.7150/ijms.9529;
Zhang G., Luo Y., Li G., Wang L., Na D., Wu X., Zhang Y., Mo X.,
Wang L.;
"DHRSX, a novel non-classical secretory protein associated with
starvation induced autophagy.";
Int. J. Med. Sci. 11:962-970(2014).
-!- FUNCTION: Involved in the positive regulation of starvation-
induced autophagy (PubMed:25076851).
{ECO:0000269|PubMed:25076851}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25076851}.
Note=Secreted in a non-classical form. A signal peptide sequence
at position 1-31 is predicted.
-!- TISSUE SPECIFICITY: Widely expressed. Highly expressed in the
pancreas. {ECO:0000269|PubMed:11731500,
ECO:0000269|PubMed:25076851}.
-!- MISCELLANEOUS: The gene coding for this protein is located in the
pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
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EMBL; AJ293620; CAC82170.1; -; mRNA.
EMBL; AY358849; AAQ89208.1; -; mRNA.
EMBL; AC079176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BX119919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BX649443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR381696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CR856018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC019696; AAH19696.2; ALT_SEQ; mRNA.
EMBL; BC032340; AAH32340.1; -; mRNA.
EMBL; AL137300; CAB70685.1; -; mRNA.
CCDS; CCDS35195.1; -.
PIR; T46363; T46363.
RefSeq; NP_660160.2; NM_145177.2.
UniGene; Hs.131452; -.
ProteinModelPortal; Q8N5I4; -.
SMR; Q8N5I4; -.
BioGrid; 128508; 4.
IntAct; Q8N5I4; 2.
MINT; MINT-5003345; -.
STRING; 9606.ENSP00000334113; -.
BioMuta; DHRSX; -.
DMDM; 229462837; -.
EPD; Q8N5I4; -.
MaxQB; Q8N5I4; -.
PaxDb; Q8N5I4; -.
PeptideAtlas; Q8N5I4; -.
PRIDE; Q8N5I4; -.
DNASU; 207063; -.
Ensembl; ENST00000334651; ENSP00000334113; ENSG00000169084.
GeneID; 207063; -.
KEGG; hsa:207063; -.
UCSC; uc004cqf.5; human.
CTD; 207063; -.
EuPathDB; HostDB:ENSG00000169084.13; -.
GeneCards; DHRSX; -.
H-InvDB; HIX0016629; -.
H-InvDB; HIX0177589; -.
HGNC; HGNC:18399; DHRSX.
HPA; HPA003035; -.
neXtProt; NX_Q8N5I4; -.
OpenTargets; ENSG00000169084; -.
PharmGKB; PA27330; -.
eggNOG; KOG1208; Eukaryota.
eggNOG; COG1028; LUCA.
GeneTree; ENSGT00760000119068; -.
HOVERGEN; HBG078800; -.
InParanoid; Q8N5I4; -.
KO; K11170; -.
OMA; PAKCEQL; -.
OrthoDB; EOG091G0FGA; -.
PhylomeDB; Q8N5I4; -.
TreeFam; TF105429; -.
GeneWiki; DHRSX; -.
GenomeRNAi; 207063; -.
PRO; PR:Q8N5I4; -.
Proteomes; UP000005640; Chromosome X.
Bgee; ENSG00000169084; -.
CleanEx; HS_DHRSX; -.
ExpressionAtlas; Q8N5I4; baseline and differential.
Genevisible; Q8N5I4; HS.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO; GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
Pfam; PF00106; adh_short; 1.
PRINTS; PR00081; GDHRDH.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00061; ADH_SHORT; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Oxidoreductase;
Polymorphism; Reference proteome; Secreted.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:25076851}.
CHAIN 2 330 Dehydrogenase/reductase SDR family member
on chromosome X.
/FTId=PRO_0000031974.
NP_BIND 47 71 NAD or NADP. {ECO:0000250}.
ACT_SITE 208 208 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10001}.
BINDING 183 183 Substrate. {ECO:0000250}.
VARIANT 247 247 V -> L (in dbSNP:rs1127915).
{ECO:0000269|PubMed:11731500,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:17974005}.
/FTId=VAR_055354.
VARIANT 292 292 H -> R (in dbSNP:rs3210910).
{ECO:0000269|PubMed:11731500,
ECO:0000269|PubMed:12975309,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:17974005}.
/FTId=VAR_055355.
VARIANT 297 297 E -> K (in dbSNP:rs12010).
{ECO:0000269|PubMed:12975309,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_016100.
SEQUENCE 330 AA; 36443 MW; 0191EC6B0B98F56F CRC64;
MSPLSAARAA LRVYAVGAAV ILAQLLRRCR GGFLEPVFPP RPDRVAIVTG GTDGIGYSTA
KHLARLGMHV IIAGNNDSKA KQVVSKIKEE TLNDKVEFLY CDLASMTSIR QFVQKFKMKK
IPLHVLINNA GVMMVPQRKT RDGFEEHFGL NYLGHFLLTN LLLDTLKESG SPGHSARVVT
VSSATHYVAE LNMDDLQSSA CYSPHAAYAQ SKLALVLFTY HLQRLLAAEG SHVTANVVDP
GVVNTDVYKH VFWATRLAKK LLGWLLFKTP DEGAWTSIYA AVTPELEGVG GHYLYNEKET
KSLHVTYNQK LQQQLWSKSC EMTGVLDVTL


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