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Delta(6)-fatty-acid desaturase fat-3 (EC 1.14.19.-) (Fatty acid desaturase 3)

 FAT3_CAEEL              Reviewed;         443 AA.
Q23221; E9P867; E9P868; O61388;
18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 2.
05-DEC-2018, entry version 133.
RecName: Full=Delta(6)-fatty-acid desaturase fat-3;
EC=1.14.19.-;
AltName: Full=Fatty acid desaturase 3;
Name=fat-3; ORFNames=W08D2.4;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, AND PATHWAY.
PubMed=9480865; DOI=10.1042/bj3300611;
Napier J.A., Hey S.J., Lacey D.J., Shewry P.R.;
"Identification of a caenorhabditis elegans Delta6-fatty-acid-
desaturase by heterologous expression in saccharomyces cerevisiae.";
Biochem. J. 330:611-614(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION, AND PATHWAY.
PubMed=11972048; DOI=10.1073/pnas.092064799;
Watts J.L., Browse J.;
"Genetic dissection of polyunsaturated fatty acid synthesis in
Caenorhabditis elegans.";
Proc. Natl. Acad. Sci. U.S.A. 99:5854-5859(2002).
[4]
FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF SER-186.
PubMed=18094048; DOI=10.1091/mbc.E07-07-0719;
Marza E., Long T., Saiardi A., Sumakovic M., Eimer S., Hall D.H.,
Lesa G.M.;
"Polyunsaturated fatty acids influence synaptojanin localization to
regulate synaptic vesicle recycling.";
Mol. Biol. Cell 19:833-842(2008).
-!- FUNCTION: Delta(6) fatty acid desaturase that acts on a range of
substrates. Catalyzes the desaturation of linoleic acid
(Delta(9,12)-18:2, or C18:2(n-6)) to gamma-linolenic acid
(Delta(6,9,12)-18:3, or C18:3(n-6)) (PubMed:11972048,
PubMed:9480865). Plays a role in synaptic vesicle recycling by
regulating synaptojanin unc-26 localization at synapses
(PubMed:18094048). {ECO:0000269|PubMed:11972048,
ECO:0000269|PubMed:18094048, ECO:0000269|PubMed:9480865}.
-!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid
biosynthesis. {ECO:0000269|PubMed:11972048,
ECO:0000269|PubMed:9480865}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=a;
IsoId=Q23221-1; Sequence=Displayed;
Name=b;
IsoId=Q23221-2; Sequence=VSP_047787;
Name=c;
IsoId=Q23221-3; Sequence=VSP_047786;
-!- DISRUPTION PHENOTYPE: Impaired synaptic vesicle (SV) recycling
characterized by the presence of enlarged SV and the formation of
abnormal endocytic membrane-bound structures at synapses. The
number of SVs is reduced by 37 percent although SV production in
neuron cell body and their transport to release sites are normal.
{ECO:0000269|PubMed:18094048}.
-!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
{ECO:0000305}.
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EMBL; AF031477; AAC15586.1; -; mRNA.
EMBL; Z70271; CAA94233.2; -; Genomic_DNA.
EMBL; Z70271; CBZ01799.1; -; Genomic_DNA.
EMBL; Z70271; CBZ01800.1; -; Genomic_DNA.
PIR; T26280; T26280.
RefSeq; NP_001255426.1; NM_001268497.1. [Q23221-1]
RefSeq; NP_001255427.1; NM_001268498.1. [Q23221-2]
RefSeq; NP_001255428.1; NM_001268499.1. [Q23221-3]
UniGene; Cel.17880; -.
ProteinModelPortal; Q23221; -.
BioGrid; 42924; 1.
DIP; DIP-27071N; -.
IntAct; Q23221; 1.
STRING; 6239.W08D2.4a; -.
SwissLipids; SLP:000000267; -.
EPD; Q23221; -.
PaxDb; Q23221; -.
PeptideAtlas; Q23221; -.
PRIDE; Q23221; -.
EnsemblMetazoa; W08D2.4a; W08D2.4a; WBGene00001395. [Q23221-1]
EnsemblMetazoa; W08D2.4b.1; W08D2.4b.1; WBGene00001395. [Q23221-2]
EnsemblMetazoa; W08D2.4b.2; W08D2.4b.2; WBGene00001395. [Q23221-2]
EnsemblMetazoa; W08D2.4c; W08D2.4c; WBGene00001395. [Q23221-3]
GeneID; 177820; -.
KEGG; cel:CELE_W08D2.4; -.
CTD; 177820; -.
WormBase; W08D2.4a; CE25153; WBGene00001395; fat-3. [Q23221-1]
WormBase; W08D2.4b; CE45719; WBGene00001395; fat-3. [Q23221-2]
WormBase; W08D2.4c; CE45812; WBGene00001395; fat-3. [Q23221-3]
eggNOG; KOG4232; Eukaryota.
eggNOG; ENOG410XVSZ; LUCA.
GeneTree; ENSGT00940000153379; -.
HOGENOM; HOG000017168; -.
InParanoid; Q23221; -.
OMA; SIGWWKS; -.
OrthoDB; EOG091G0E0W; -.
PhylomeDB; Q23221; -.
Reactome; R-CEL-2046105; Linoleic acid (LA) metabolism.
Reactome; R-CEL-2046106; alpha-linolenic acid (ALA) metabolism.
UniPathway; UPA00658; -.
PRO; PR:Q23221; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00001395; Expressed in 5 organ(s), highest expression level in adult organism.
GO; GO:0016021; C:integral component of membrane; IC:WormBase.
GO; GO:0098793; C:presynapse; IEA:GOC.
GO; GO:0004768; F:stearoyl-CoA 9-desaturase activity; IDA:WormBase.
GO; GO:0014055; P:acetylcholine secretion, neurotransmission; IMP:WormBase.
GO; GO:0040002; P:collagen and cuticulin-based cuticle development; IMP:WormBase.
GO; GO:0030421; P:defecation; IMP:WormBase.
GO; GO:0032456; P:endocytic recycling; IMP:WormBase.
GO; GO:0040011; P:locomotion; IMP:WormBase.
GO; GO:0035264; P:multicellular organism growth; IMP:WormBase.
GO; GO:0006936; P:muscle contraction; IMP:WormBase.
GO; GO:0018991; P:oviposition; IMP:WormBase.
GO; GO:0043050; P:pharyngeal pumping; IMP:WormBase.
GO; GO:0008104; P:protein localization; IMP:WormBase.
GO; GO:0045088; P:regulation of innate immune response; IMP:WormBase.
GO; GO:0001820; P:serotonin secretion; IMP:WormBase.
GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IMP:WormBase.
InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
InterPro; IPR005804; FA_desaturase_dom.
InterPro; IPR012171; Fatty_acid_desaturase.
Pfam; PF00487; FA_desaturase; 1.
PIRSF; PIRSF015921; FA_sphinglp_des; 1.
SUPFAM; SSF55856; SSF55856; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Fatty acid biosynthesis;
Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane;
Oxidoreductase; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN 1 443 Delta(6)-fatty-acid desaturase fat-3.
/FTId=PRO_0000423385.
TRANSMEM 136 156 Helical. {ECO:0000255}.
TRANSMEM 296 316 Helical. {ECO:0000255}.
TRANSMEM 318 338 Helical. {ECO:0000255}.
DOMAIN 1 71 Cytochrome b5 heme-binding.
VAR_SEQ 1 366 Missing (in isoform c). {ECO:0000305}.
/FTId=VSP_047786.
VAR_SEQ 1 258 Missing (in isoform b). {ECO:0000305}.
/FTId=VSP_047787.
MUTAGEN 186 186 S->F: In wa22; Impaired synaptic vesicle
recycling characterized by a partially
diffused localization of synaptic vesicle
protein snb-1 along the dorsal nerve cord
and the formation of enlarged synaptic
vesicles. snb-1 diffused localization is
increased in a unc-57 (ok310) mutant
background but not in a unc-26 (s1710)
mutant background. Severe depletion of
unc-26 at release sites in the dorsal
nerve cord and increased
phosphatidylinositol 4,5-bisphosphate
levels at release sites and at the axonal
plasma membrane. Impaired locomotion.
{ECO:0000269|PubMed:18094048}.
CONFLICT 401 401 M -> V (in Ref. 1; AAC15586).
{ECO:0000305}.
SEQUENCE 443 AA; 51773 MW; 9513D611ECB99A06 CRC64;
MVVDKNASGL RMKVDGKWLY LSEELVKKHP GGAVIEQYRN SDATHIFHAF HEGSSQAYKQ
LDLLKKHGEH DEFLEKQLEK RLDKVDINVS AYDVSVAQEK KMVESFEKLR QKLHDDGLMK
ANETYFLFKA ISTLSIMAFA FYLQYLGWYI TSACLLALAW QQFGWLTHEF CHQQPTKNRP
LNDTISLFFG NFLQGFSRDW WKDKHNTHHA ATNVIDHDGD IDLAPLFAFI PGDLCKYKAS
FEKAILKIVP YQHLYFTAML PMLRFSWTGQ SVQWVFKENQ MEYKVYQRNA FWEQATIVGH
WAWVFYQLFL LPTWPLRVAY FIISQMGGGL LIAHVVTFNH NSVDKYPANS RILNNFAALQ
ILTTRNMTPS PFIDWLWGGL NYQIEHHLFP TMPRCNLNAC MKYVKEWCKE NNLPYLVDDY
FDGYAMNLQQ LKNMAEHIQA KAA


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