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Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4)

 DLL4_HUMAN              Reviewed;         685 AA.
Q9NR61; Q3KP23; Q9NQT9;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
23-MAY-2018, entry version 165.
RecName: Full=Delta-like protein 4;
AltName: Full=Drosophila Delta homolog 4;
Short=Delta4;
Flags: Precursor;
Name=DLL4; ORFNames=UNQ1895/PRO4341;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=10837024;
Shutter J.R., Scully S., Fan W., Richards W.G., Kitajewski J.,
Deblandre G.A., Kintner C.R., Stark K.L.;
"Dll4, a novel Notch ligand expressed in arterial endothelium.";
Genes Dev. 14:1313-1318(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Sakano S.;
"Human Delta-2, Notch ligand gene.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=11134954; DOI=10.1093/oxfordjournals.jbchem.a002832;
Yoneya T., Tahara T., Nagao K., Yamada Y., Yamamoto T., Miyatani S.,
Nishikawa M.;
"Molecular cloning of Delta-4, a new mouse and human Notch ligand.";
J. Biochem. 129:27-34(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 27-41.
PubMed=15340161; DOI=10.1110/ps.04682504;
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally
verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 33-685.
TISSUE=Placenta;
Mailhos C., Modlich U., Lewis J., Harris A., Bicknell R.,
Ish-Horowicz D.;
"A novel Delta gene expressed in embryonic and tumour vasculature.";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[8]
FUNCTION IN NEUROGENESIS.
PubMed=17728344; DOI=10.1242/dev.005868;
Del Barrio M.G., Taveira-Marques R., Muroyama Y., Yuk D.I., Li S.,
Wines-Samuelson M., Shen J., Smith H.K., Xiang M., Rowitch D.,
Richardson W.D.;
"A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1
generates V2a and V2b spinal interneurons from a common progenitor
pool.";
Development 134:3427-3436(2007).
[9]
FUNCTION IN ANGIOGENESIS.
PubMed=20616313; DOI=10.1161/CIRCRESAHA.110.217257;
Brutsch R., Liebler S.S., Wustehube J., Bartol A., Herberich S.E.,
Adam M.G., Telzerow A., Augustin H.G., Fischer A.;
"Integrin cytoplasmic domain-associated protein-1 attenuates sprouting
angiogenesis.";
Circ. Res. 107:592-601(2010).
[10]
INVOLVEMENT IN AOS6, AND VARIANTS AOS6 PRO-121; CYS-186; LEU-195;
THR-267; ARG-390; TYR-390 AND TRP-455.
PubMed=26299364; DOI=10.1016/j.ajhg.2015.07.015;
Meester J.A., Southgate L., Stittrich A.B., Venselaar H.,
Beekmans S.J., den Hollander N., Bijlsma E.K.,
Helderman-van den Enden A., Verheij J.B., Glusman G., Roach J.C.,
Lehman A., Patel M.S., de Vries B.B., Ruivenkamp C., Itin P.,
Prescott K., Clarke S., Trembath R., Zenker M., Sukalo M.,
Van Laer L., Loeys B., Wuyts W.;
"Heterozygous loss-of-function mutations in DLL4 cause Adams-Oliver
syndrome.";
Am. J. Hum. Genet. 97:475-482(2015).
-!- FUNCTION: Involved in the Notch signaling pathway as Notch ligand
(PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in
angiogenesis; negatively regulates endothelial cell proliferation
and migration and angiogenic sprouting (PubMed:20616313).
Essential for retinal progenitor proliferation. Required for
suppressing rod fates in late retinal progenitors as well as for
proper generation of other retinal cell types (By similarity).
During spinal cord neurogenesis, inhibits V2a interneuron fate
(PubMed:17728344). {ECO:0000250|UniProtKB:Q9JI71,
ECO:0000269|PubMed:11134954, ECO:0000269|PubMed:17728344,
ECO:0000269|PubMed:20616313}.
-!- SUBUNIT: Interacts with NOTCH4. Interacts (via N-terminal DSL and
MNNL domains) with NOTCH1 (via EGF-like domains).
{ECO:0000250|UniProtKB:D3ZHH1}.
-!- INTERACTION:
P57105:SYNJ2BP; NbExp=3; IntAct=EBI-11700027, EBI-1049004;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
type I membrane protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in vascular endothelium.
-!- DOMAIN: The Delta-Serrate-Lag2 (DSL) domain is required for
binding to the Notch receptor.
-!- DISEASE: Adams-Oliver syndrome 6 (AOS6) [MIM:616589]: A form of
Adams-Oliver syndrome, a disorder characterized by the congenital
absence of skin (aplasia cutis congenita) in combination with
transverse limb defects. Aplasia cutis congenita can be located
anywhere on the body, but in the vast majority of the cases, it is
present on the posterior parietal region where it is often
associated with an underlying defect of the parietal bones. Limb
abnormalities are typically limb truncation defects affecting the
distal phalanges or entire digits (true ectrodactyly). Only
rarely, metatarsals/metacarpals or more proximal limb structures
are also affected. Apart from transverse limb defects, syndactyly,
most commonly of second and third toes, can also be observed. The
clinical features are highly variable and can also include
cardiovascular malformations, brain abnormalities and vascular
defects such as cutis marmorata and dilated scalp veins.
{ECO:0000269|PubMed:26299364}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
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EMBL; AF253468; AAF76427.1; -; mRNA.
EMBL; AB036931; BAB16085.1; -; mRNA.
EMBL; AB043894; BAB18581.1; -; mRNA.
EMBL; AY358894; AAQ89253.1; -; mRNA.
EMBL; BC106950; AAI06951.1; -; mRNA.
EMBL; AF279305; AAF81912.1; -; mRNA.
CCDS; CCDS45232.1; -.
PIR; JC7570; JC7570.
RefSeq; NP_061947.1; NM_019074.3.
UniGene; Hs.511076; -.
PDB; 5MVX; X-ray; 2.17 A; A=27-325.
PDBsum; 5MVX; -.
ProteinModelPortal; Q9NR61; -.
SMR; Q9NR61; -.
IntAct; Q9NR61; 1.
STRING; 9606.ENSP00000249749; -.
ChEMBL; CHEMBL3712916; -.
iPTMnet; Q9NR61; -.
PhosphoSitePlus; Q9NR61; -.
BioMuta; DLL4; -.
DMDM; 13431490; -.
EPD; Q9NR61; -.
PaxDb; Q9NR61; -.
PeptideAtlas; Q9NR61; -.
PRIDE; Q9NR61; -.
Ensembl; ENST00000249749; ENSP00000249749; ENSG00000128917.
GeneID; 54567; -.
KEGG; hsa:54567; -.
UCSC; uc001zng.3; human.
CTD; 54567; -.
DisGeNET; 54567; -.
EuPathDB; HostDB:ENSG00000128917.6; -.
GeneCards; DLL4; -.
HGNC; HGNC:2910; DLL4.
HPA; HPA023392; -.
MalaCards; DLL4; -.
MIM; 605185; gene.
MIM; 616589; phenotype.
neXtProt; NX_Q9NR61; -.
OpenTargets; ENSG00000128917; -.
PharmGKB; PA27366; -.
eggNOG; KOG1217; Eukaryota.
eggNOG; ENOG410XP6K; LUCA.
GeneTree; ENSGT00810000125346; -.
HOGENOM; HOG000267024; -.
HOVERGEN; HBG007139; -.
InParanoid; Q9NR61; -.
KO; K06051; -.
OMA; FNGATCY; -.
OrthoDB; EOG091G07YQ; -.
PhylomeDB; Q9NR61; -.
TreeFam; TF351835; -.
Reactome; R-HSA-1980150; Signaling by NOTCH4.
Reactome; R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus.
Reactome; R-HSA-2644606; Constitutive Signaling by NOTCH1 PEST Domain Mutants.
Reactome; R-HSA-2660826; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
Reactome; R-HSA-2691232; Constitutive Signaling by NOTCH1 HD Domain Mutants.
Reactome; R-HSA-2894862; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
Reactome; R-HSA-2979096; NOTCH2 Activation and Transmission of Signal to the Nucleus.
Reactome; R-HSA-9013507; NOTCH3 Activation and Transmission of Signal to the Nucleus.
SignaLink; Q9NR61; -.
SIGNOR; Q9NR61; -.
GeneWiki; DLL4; -.
GenomeRNAi; 54567; -.
PRO; PR:Q9NR61; -.
Proteomes; UP000005640; Chromosome 15.
Bgee; ENSG00000128917; -.
CleanEx; HS_DLL4; -.
Genevisible; Q9NR61; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0005112; F:Notch binding; TAS:ProtInc.
GO; GO:0001525; P:angiogenesis; ISS:BHF-UCL.
GO; GO:0008015; P:blood circulation; TAS:ProtInc.
GO; GO:0072554; P:blood vessel lumenization; IEA:Ensembl.
GO; GO:0001974; P:blood vessel remodeling; ISS:BHF-UCL.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISS:BHF-UCL.
GO; GO:0003209; P:cardiac atrium morphogenesis; ISS:BHF-UCL.
GO; GO:0003208; P:cardiac ventricle morphogenesis; ISS:BHF-UCL.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IDA:UniProtKB.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IMP:UniProtKB.
GO; GO:0035912; P:dorsal aorta morphogenesis; ISS:BHF-UCL.
GO; GO:1903588; P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IDA:UniProtKB.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IDA:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
GO; GO:0010596; P:negative regulation of endothelial cell migration; IMP:UniProtKB.
GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
GO; GO:0061314; P:Notch signaling involved in heart development; ISS:BHF-UCL.
GO; GO:0007219; P:Notch signaling pathway; TAS:Reactome.
GO; GO:0003344; P:pericardium morphogenesis; ISS:BHF-UCL.
GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; ISS:UniProtKB.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISS:UniProtKB.
GO; GO:0061074; P:regulation of neural retina development; ISS:UniProtKB.
GO; GO:0050767; P:regulation of neurogenesis; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
GO; GO:0060579; P:ventral spinal cord interneuron fate commitment; IMP:UniProtKB.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; ISS:BHF-UCL.
GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
InterPro; IPR001774; DSL.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR011651; Notch_ligand_N.
Pfam; PF01414; DSL; 1.
Pfam; PF00008; EGF; 5.
Pfam; PF07657; MNNL; 1.
SMART; SM00051; DSL; 1.
SMART; SM00181; EGF; 9.
SMART; SM00179; EGF_CA; 6.
SUPFAM; SSF57184; SSF57184; 1.
PROSITE; PS00010; ASX_HYDROXYL; 1.
PROSITE; PS51051; DSL; 1.
PROSITE; PS00022; EGF_1; 8.
PROSITE; PS01186; EGF_2; 7.
PROSITE; PS50026; EGF_3; 8.
1: Evidence at protein level;
3D-structure; Angiogenesis; Cell membrane; Complete proteome;
Developmental protein; Differentiation; Direct protein sequencing;
Disease mutation; Disulfide bond; EGF-like domain; Glycoprotein;
Membrane; Neurogenesis; Notch signaling pathway; Reference proteome;
Repeat; Sensory transduction; Signal; Transmembrane;
Transmembrane helix; Vision.
SIGNAL 1 26 {ECO:0000269|PubMed:15340161}.
CHAIN 27 685 Delta-like protein 4.
/FTId=PRO_0000007512.
TOPO_DOM 27 529 Extracellular. {ECO:0000255}.
TRANSMEM 530 550 Helical. {ECO:0000255}.
TOPO_DOM 551 685 Cytoplasmic. {ECO:0000255}.
DOMAIN 173 217 DSL. {ECO:0000255|PROSITE-
ProRule:PRU00377}.
DOMAIN 218 251 EGF-like 1. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 252 282 EGF-like 2. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 284 322 EGF-like 3. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 324 360 EGF-like 4. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 362 400 EGF-like 5. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 402 438 EGF-like 6. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 440 476 EGF-like 7. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 480 518 EGF-like 8. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
REGION 185 187 Interaction with Notch1.
{ECO:0000250|UniProtKB:D3ZHH1}.
REGION 191 195 Interaction with Notch1.
{ECO:0000250|UniProtKB:D3ZHH1}.
SITE 110 110 Interaction with Notch1.
{ECO:0000250|UniProtKB:D3ZHH1}.
SITE 216 216 Interaction with Notch1.
{ECO:0000250|UniProtKB:D3ZHH1}.
CARBOHYD 108 108 N-linked (GlcNAc...) asparagine.
{ECO:0000250|UniProtKB:D3ZHH1}.
CARBOHYD 183 183 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 205 205 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 393 393 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 50 54 {ECO:0000250|UniProtKB:D3ZHH1}.
DISULFID 61 74 {ECO:0000250|UniProtKB:D3ZHH1}.
DISULFID 175 184 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00377}.
DISULFID 188 200 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00377}.
DISULFID 208 217 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00377}.
DISULFID 222 233 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 226 239 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 241 250 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 253 264 {ECO:0000250|UniProtKB:D3ZHH1}.
DISULFID 259 270 {ECO:0000250|UniProtKB:D3ZHH1}.
DISULFID 272 281 {ECO:0000250|UniProtKB:D3ZHH1,
ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 288 300 {ECO:0000250}.
DISULFID 294 310 {ECO:0000250}.
DISULFID 312 321 {ECO:0000250}.
DISULFID 328 339 {ECO:0000250}.
DISULFID 333 348 {ECO:0000250}.
DISULFID 350 359 {ECO:0000250}.
DISULFID 366 377 {ECO:0000250}.
DISULFID 371 388 {ECO:0000250}.
DISULFID 390 399 {ECO:0000250}.
DISULFID 406 417 {ECO:0000250}.
DISULFID 411 426 {ECO:0000250}.
DISULFID 428 437 {ECO:0000250}.
DISULFID 444 455 {ECO:0000250}.
DISULFID 449 464 {ECO:0000250}.
DISULFID 466 475 {ECO:0000250}.
DISULFID 484 495 {ECO:0000250}.
DISULFID 489 506 {ECO:0000250}.
DISULFID 508 517 {ECO:0000250}.
VARIANT 121 121 A -> P (in AOS6; dbSNP:rs796065350).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075858.
VARIANT 186 186 R -> C (in AOS6; dbSNP:rs796065348).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075859.
VARIANT 195 195 F -> L (in AOS6; dbSNP:rs796065351).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075860.
VARIANT 267 267 P -> T (in AOS6; dbSNP:rs796065349).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075861.
VARIANT 390 390 C -> R (in AOS6; dbSNP:rs796065347).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075862.
VARIANT 390 390 C -> Y (in AOS6; dbSNP:rs796065346).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075863.
VARIANT 455 455 C -> W (in AOS6; dbSNP:rs796065345).
{ECO:0000269|PubMed:26299364}.
/FTId=VAR_075864.
STRAND 28 38 {ECO:0000244|PDB:5MVX}.
STRAND 51 53 {ECO:0000244|PDB:5MVX}.
STRAND 55 64 {ECO:0000244|PDB:5MVX}.
STRAND 77 80 {ECO:0000244|PDB:5MVX}.
STRAND 85 90 {ECO:0000244|PDB:5MVX}.
STRAND 103 109 {ECO:0000244|PDB:5MVX}.
STRAND 113 123 {ECO:0000244|PDB:5MVX}.
STRAND 125 127 {ECO:0000244|PDB:5MVX}.
TURN 131 133 {ECO:0000244|PDB:5MVX}.
HELIX 136 138 {ECO:0000244|PDB:5MVX}.
STRAND 139 148 {ECO:0000244|PDB:5MVX}.
STRAND 151 153 {ECO:0000244|PDB:5MVX}.
STRAND 156 161 {ECO:0000244|PDB:5MVX}.
STRAND 166 174 {ECO:0000244|PDB:5MVX}.
STRAND 179 181 {ECO:0000244|PDB:5MVX}.
STRAND 191 193 {ECO:0000244|PDB:5MVX}.
STRAND 196 200 {ECO:0000244|PDB:5MVX}.
STRAND 206 208 {ECO:0000244|PDB:5MVX}.
STRAND 212 214 {ECO:0000244|PDB:5MVX}.
TURN 228 230 {ECO:0000244|PDB:5MVX}.
STRAND 245 247 {ECO:0000244|PDB:5MVX}.
STRAND 260 263 {ECO:0000244|PDB:5MVX}.
TURN 278 281 {ECO:0000244|PDB:5MVX}.
STRAND 283 285 {ECO:0000244|PDB:5MVX}.
HELIX 287 291 {ECO:0000244|PDB:5MVX}.
STRAND 299 303 {ECO:0000244|PDB:5MVX}.
TURN 304 306 {ECO:0000244|PDB:5MVX}.
STRAND 307 311 {ECO:0000244|PDB:5MVX}.
STRAND 316 321 {ECO:0000244|PDB:5MVX}.
SEQUENCE 685 AA; 74605 MW; 6CF89D3C220ACC89 CRC64;
MAAASRSASG WALLLLVALW QQRAAGSGVF QLQLQEFINE RGVLASGRPC EPGCRTFFRV
CLKHFQAVVS PGPCTFGTVS TPVLGTNSFA VRDDSSGGGR NPLQLPFNFT WPGTFSLIIE
AWHAPGDDLR PEALPPDALI SKIAIQGSLA VGQNWLLDEQ TSTLTRLRYS YRVICSDNYY
GDNCSRLCKK RNDHFGHYVC QPDGNLSCLP GWTGEYCQQP ICLSGCHEQN GYCSKPAECL
CRPGWQGRLC NECIPHNGCR HGTCSTPWQC TCDEGWGGLF CDQDLNYCTH HSPCKNGATC
SNSGQRSYTC TCRPGYTGVD CELELSECDS NPCRNGGSCK DQEDGYHCLC PPGYYGLHCE
HSTLSCADSP CFNGGSCRER NQGANYACEC PPNFTGSNCE KKVDRCTSNP CANGGQCLNR
GPSRMCRCRP GFTGTYCELH VSDCARNPCA HGGTCHDLEN GLMCTCPAGF SGRRCEVRTS
IDACASSPCF NRATCYTDLS TDTFVCNCPY GFVGSRCEFP VGLPPSFPWV AVSLGVGLAV
LLVLLGMVAV AVRQLRLRRP DDGSREAMNN LSDFQKDNLI PAAQLKNTNQ KKELEVDCGL
DKSNCGKQQN HTLDYNLAPG PLGRGTMPGK FPHSDKSLGE KAPLRLHSEK PECRISAICS
PRDSMYQSVC LISEERNECV IATEV


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15-288-22845 Translocon-associated protein subunit delta - TRAP-delta; Signal sequence receptor subunit delta; SSR-delta Polyclonal 0.05 mg
15-288-22845 Translocon-associated protein subunit delta - TRAP-delta; Signal sequence receptor subunit delta; SSR-delta Polyclonal 0.1 mg
EIAAB12331 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,Cholestenol Delta-isomerase,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,EBP,Emopamil-binding protein,Homo sapiens,Human
EIAAB12332 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,Cholestenol Delta-isomerase,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,Ebp,Emopamil-binding protein,Mouse,Msi,Mus musculus
EIAAB41750 A45,Cct4,Cctd,CCT-delta,Mouse,Mus musculus,T-complex protein 1 subunit delta,TCP-1-delta
EIAAB08605 Archain,Arcn1,Coatomer subunit delta,Copd,Delta-coat protein,Delta-COP,Rat,Rattus norvegicus
EIAAB08603 Archain,ARCN1,Bos taurus,Bovine,Coatomer subunit delta,COPD,Delta-coat protein,Delta-COP
EIAAB08601 Archain,Arcn1,Coatomer subunit delta,Copd,Delta-coat protein,Delta-COP,Mouse,Mus musculus
EIAAB41753 Cct4,CCT-delta,Rat,Rattus norvegicus,T-complex protein 1 subunit delta,TCP-1-delta
EIAAB41752 Bos taurus,Bovine,CCT4,CCT-delta,T-complex protein 1 subunit delta,TCP-1-delta
18-003-42500 T-complex protein 1 subunit delta - TCP-1-delta; CCT-delta; Stimulator of TAR RNA-binding Polyclonal 0.1 mg Protein A
18-003-42500 T-complex protein 1 subunit delta - TCP-1-delta; CCT-delta; Stimulator of TAR RNA-binding Polyclonal 0.05 mg Aff Pur


 

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