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Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD)

 DNSL3_HUMAN             Reviewed;         305 AA.
Q13609; B2R8B1; B7Z707; O75803;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
07-NOV-2018, entry version 171.
RecName: Full=Deoxyribonuclease gamma;
Short=DNase gamma;
EC=3.1.21.-;
AltName: Full=DNase I homolog protein DHP2;
AltName: Full=Deoxyribonuclease I-like 3;
Short=DNase I-like 3;
AltName: Full=Liver and spleen DNase;
Short=LS-DNase;
Short=LSD;
Flags: Precursor;
Name=DNASE1L3 {ECO:0000312|HGNC:HGNC:2959}; Synonyms=DHP2, DNAS1L3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=9205125; DOI=10.1006/geno.1997.4748;
Rodriguez A.M., Rodin D., Nomura H., Morton C.C., Weremowicz S.,
Schneider M.C.;
"Identification, localization, and expression of two novel human genes
similar to deoxyribonuclease I.";
Genomics 42:507-513(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
PubMed=9070308; DOI=10.1006/bbrc.1996.5923;
Zeng Z., Parmelee D., Hyaw H., Coleman T.A., Su K., Zhang J.,
Gentz R., Ruben S., Rosen C., Li Y.;
"Cloning and characterization of a novel human DNase.";
Biochem. Biophys. Res. Commun. 231:499-504(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND SUBCELLULAR
LOCATION.
PubMed=9714828; DOI=10.1016/S0378-1119(98)00281-9;
Baron W.F., Pan C.Q., Spencer S.A., Ryan A.M., Lazarus R.A.,
Baker K.P.;
"Cloning and characterization of an actin-resistant DNase I-like
endonuclease secreted by macrophages.";
Gene 215:291-301(1998).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND VARIANT LYS-96.
TISSUE=Spleen;
PubMed=14646506; DOI=10.1023/A:1009692807692;
Shiokawa D., Hirai M., Tanuma S.;
"cDNA cloning of human DNase gamma: chromosomal localization of its
gene and enzymatic properties of recombinant protein.";
Apoptosis 3:89-95(1998).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Spleen;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16641997; DOI=10.1038/nature04728;
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
FUNCTION, COFACTOR, AND ADP-RIBOSYLATION.
PubMed=10807908; DOI=10.1074/jbc.M001087200;
Yakovlev A.G., Wang G., Stoica B.A., Boulares H.A., Spoonde A.Y.,
Yoshihara K., Smulson M.E.;
"A role of the Ca2+/Mg2+-dependent endonuclease in apoptosis and its
inhibition by poly(ADP-ribose) polymerase.";
J. Biol. Chem. 275:21302-21308(2000).
[10]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=11141064; DOI=10.1021/bi001041a;
Shiokawa D., Tanuma S.;
"Characterization of human DNase I family endonucleases and activation
of DNase gamma during apoptosis.";
Biochemistry 40:143-152(2001).
[11]
INVOLVEMENT IN SLEB16, AND VARIANT CYS-206.
PubMed=22019780; DOI=10.1038/ng.975;
Al-Mayouf S.M., Sunker A., Abdwani R., Abrawi S.A., Almurshedi F.,
Alhashmi N., Al Sonbul A., Sewairi W., Qari A., Abdallah E.,
Al-Owain M., Al Motywee S., Al-Rayes H., Hashem M., Khalak H.,
Al-Jebali L., Alkuraya F.S.;
"Loss-of-function variant in DNASE1L3 causes a familial form of
systemic lupus erythematosus.";
Nat. Genet. 43:1186-1188(2011).
[12]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=23229555; DOI=10.1074/jbc.M112.423061;
Errami Y., Naura A.S., Kim H., Ju J., Suzuki Y., El-Bahrawy A.H.,
Ghonim M.A., Hemeida R.A., Mansy M.S., Zhang J., Xu M., Smulson M.E.,
Brim H., Boulares A.H.;
"Apoptotic DNA fragmentation may be a cooperative activity between
caspase-activated deoxyribonuclease and the poly(ADP-ribose)
polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized
endonuclease that translocates to the nucleus during apoptosis.";
J. Biol. Chem. 288:3460-3468(2013).
[13]
FUNCTION.
PubMed=24312463; DOI=10.1371/journal.pone.0080223;
Mizuta R., Araki S., Furukawa M., Furukawa Y., Ebara S., Shiokawa D.,
Hayashi K., Tanuma S., Kitamura D.;
"DNase gamma is the effector endonuclease for internucleosomal DNA
fragmentation in necrosis.";
PLoS ONE 8:E80223-E80223(2013).
[14]
FUNCTION, AND CHARACTERIZATION OF VARIANT CYS-206.
PubMed=27293190; DOI=10.1016/j.cell.2016.05.034;
Sisirak V., Sally B., D'Agati V., Martinez-Ortiz W., Oezcakar Z.B.,
David J., Rashidfarrokhi A., Yeste A., Panea C., Chida A.S.,
Bogunovic M., Ivanov I.I., Quintana F.J., Sanz I., Elkon K.B.,
Tekin M., Yalcinkaya F., Cardozo T.J., Clancy R.M., Buyon J.P.,
Reizis B.;
"Digestion of chromatin in apoptotic cell microparticles prevents
autoimmunity.";
Cell 166:88-101(2016).
[15]
VARIANTS [LARGE SCALE ANALYSIS] VAL-19; ARG-82 AND SER-117.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
[16]
VARIANT CYS-206, AND CHARACTERIZATION OF VARIANT CYS-206.
PubMed=19559017; DOI=10.1016/j.cca.2009.06.022;
Ueki M., Takeshita H., Fujihara J., Iida R., Yuasa I., Kato H.,
Panduro A., Nakajima T., Kominato Y., Yasuda T.;
"Caucasian-specific allele in non-synonymous single nucleotide
polymorphisms of the gene encoding deoxyribonuclease I-like 3,
potentially relevant to autoimmunity, produces an inactive enzyme.";
Clin. Chim. Acta 407:20-24(2009).
[17]
VARIANTS ARG-82 AND MET-243, AND CHARACTERIZATION OF VARIANT ARG-82.
PubMed=21692081; DOI=10.1002/elps.201100064;
Ueki M., Fujihara J., Takeshita H., Kimura-Kataoka K., Iida R.,
Yuasa I., Kato H., Yasuda T.;
"Global genetic analysis of all single nucleotide polymorphisms in
exons of the human deoxyribonuclease I-like 3 gene and their effect on
its catalytic activity.";
Electrophoresis 32:1465-1472(2011).
-!- FUNCTION: Has DNA hydrolytic activity. Is capable of both
single- and double-stranded DNA cleavage, producing DNA fragments
with 3'-OH ends (By similarity). Can cleave chromatin to
nucleosomal units and cleaves nucleosomal and liposome-coated DNA
(PubMed:9070308, PubMed:9714828, PubMed:14646506, PubMed:10807908,
PubMed:27293190). Acts in internucleosomal DNA fragmentation
(INDF) during apoptosis and necrosis (PubMed:23229555,
PubMed:24312463). The role in apoptosis includes myogenic and
neuronal differentiation, and BCR-mediated clonal deletion of
self-reactive B cells (By similarity). Is active on chromatin in
apoptotic cell-derived membrane-coated microparticles and thus
suppresses anti-DNA autoimmunity (PubMed:27293190). Together with
DNASE1, plays a key role in degrading neutrophil extracellular
traps (NETs) (By similarity). NETs are mainly composed of DNA
fibers and are released by neutrophils to bind pathogens during
inflammation (By similarity). Degradation of intravascular NETs by
DNASE1 and DNASE1L3 is required to prevent formation of clots that
obstruct blood vessels and cause organ damage following
inflammation (By similarity). {ECO:0000250|UniProtKB:O55070,
ECO:0000250|UniProtKB:O89107, ECO:0000269|PubMed:10807908,
ECO:0000269|PubMed:14646506, ECO:0000269|PubMed:23229555,
ECO:0000269|PubMed:24312463, ECO:0000269|PubMed:27293190,
ECO:0000269|PubMed:9070308, ECO:0000269|PubMed:9714828}.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Evidence={ECO:0000269|PubMed:10807908};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:10807908};
-!- ACTIVITY REGULATION: Inhibited by zinc.
{ECO:0000250|UniProtKB:O89107}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
pH dependence:
Optimum pH is about 7.2.;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11141064,
ECO:0000269|PubMed:23229555}. Endoplasmic reticulum
{ECO:0000269|PubMed:23229555}. Secreted
{ECO:0000269|PubMed:9714828}. Note=Translocates from the
endoplasmic reticulum to the nucleus during apoptosis
(PubMed:23229555). Contradictory reports exist about the
subcellular localization under normal physiological conditions.
Under conditions of cell death, may diffuse and/or be actively
transported to the nucleus. {ECO:0000269|PubMed:23229555,
ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q13609-1; Sequence=Displayed;
Name=2;
IsoId=Q13609-2; Sequence=VSP_047251;
Note=Gene prediction based on EST data.;
-!- TISSUE SPECIFICITY: Liver and spleen.
-!- PTM: Poly-ADP-ribosylated by PARP1. ADP-ribosylation negatively
regulates enzymatic activity during apoptosis.
{ECO:0000305|PubMed:10807908}.
-!- DISEASE: Systemic lupus erythematosus 16 (SLEB16) [MIM:614420]: A
rare autosomal recessive form of systemic lupus erythematosus with
childhood onset, characterized by high frequency of anti-
neutrophil cytoplasmic antibodies and lupus nephritis. Systemic
lupus erythematosus is a chronic, relapsing, inflammatory, and
often febrile multisystemic disorder of connective tissue,
characterized principally by involvement of the skin, joints,
kidneys and serosal membranes. It is of unknown etiology, but is
thought to represent a failure of the regulatory mechanisms of the
autoimmune system. The disease is marked by a wide range of system
dysfunctions, an elevated erythrocyte sedimentation rate, and the
formation of LE cells in the blood or bone marrow.
{ECO:0000269|PubMed:22019780}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the DNase I family. {ECO:0000305}.
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EMBL; U56814; AAB63967.1; -; mRNA.
EMBL; AF047354; AAC35752.1; -; mRNA.
EMBL; U75744; AAC23652.1; -; mRNA.
EMBL; AK301263; BAH13443.1; -; mRNA.
EMBL; AK313303; BAG36108.1; -; mRNA.
EMBL; AC137936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471055; EAW65358.1; -; Genomic_DNA.
EMBL; BC015831; AAH15831.1; -; mRNA.
CCDS; CCDS2886.1; -. [Q13609-1]
CCDS; CCDS58836.1; -. [Q13609-2]
PIR; JC5361; JC5361.
RefSeq; NP_001243489.1; NM_001256560.1. [Q13609-2]
RefSeq; NP_004935.1; NM_004944.3. [Q13609-1]
UniGene; Hs.476453; -.
ProteinModelPortal; Q13609; -.
SMR; Q13609; -.
IntAct; Q13609; 3.
MINT; Q13609; -.
STRING; 9606.ENSP00000316193; -.
BindingDB; Q13609; -.
ChEMBL; CHEMBL1649048; -.
iPTMnet; Q13609; -.
PhosphoSitePlus; Q13609; -.
BioMuta; DNASE1L3; -.
DMDM; 2494173; -.
EPD; Q13609; -.
PaxDb; Q13609; -.
PeptideAtlas; Q13609; -.
PRIDE; Q13609; -.
ProteomicsDB; 59596; -.
DNASU; 1776; -.
Ensembl; ENST00000394549; ENSP00000378053; ENSG00000163687. [Q13609-1]
Ensembl; ENST00000486455; ENSP00000419052; ENSG00000163687. [Q13609-2]
GeneID; 1776; -.
KEGG; hsa:1776; -.
UCSC; uc003djo.3; human. [Q13609-1]
CTD; 1776; -.
DisGeNET; 1776; -.
EuPathDB; HostDB:ENSG00000163687.13; -.
GeneCards; DNASE1L3; -.
HGNC; HGNC:2959; DNASE1L3.
HPA; HPA019955; -.
MalaCards; DNASE1L3; -.
MIM; 602244; gene.
MIM; 614420; phenotype.
neXtProt; NX_Q13609; -.
OpenTargets; ENSG00000163687; -.
Orphanet; 300345; Autosomal systemic lupus erythematosus.
Orphanet; 36412; Hypocomplementemic urticarial vasculitis.
PharmGKB; PA27430; -.
eggNOG; ENOG410IHHA; Eukaryota.
eggNOG; ENOG410ZR9A; LUCA.
GeneTree; ENSGT00390000013146; -.
HOGENOM; HOG000059570; -.
HOVERGEN; HBG051368; -.
InParanoid; Q13609; -.
KO; K11995; -.
OMA; KIIKRCD; -.
OrthoDB; EOG091G0I0B; -.
PhylomeDB; Q13609; -.
TreeFam; TF329541; -.
ChiTaRS; DNASE1L3; human.
GeneWiki; DNASE1L3; -.
GenomeRNAi; 1776; -.
PRO; PR:Q13609; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000163687; Expressed in 164 organ(s), highest expression level in visceral pleura.
CleanEx; HS_DNASE1L3; -.
ExpressionAtlas; Q13609; baseline and differential.
Genevisible; Q13609; HS.
GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
GO; GO:0004536; F:deoxyribonuclease activity; IBA:GO_Central.
GO; GO:0004530; F:deoxyribonuclease I activity; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0006309; P:apoptotic DNA fragmentation; IDA:UniProtKB.
GO; GO:0006308; P:DNA catabolic process; IBA:GO_Central.
GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IBA:GO_Central.
GO; GO:0006259; P:DNA metabolic process; TAS:ProtInc.
GO; GO:0002283; P:neutrophil activation involved in immune response; ISS:UniProtKB.
GO; GO:0010623; P:programmed cell death involved in cell development; IBA:GO_Central.
GO; GO:0002673; P:regulation of acute inflammatory response; ISS:UniProtKB.
GO; GO:0070948; P:regulation of neutrophil mediated cytotoxicity; ISS:UniProtKB.
Gene3D; 3.60.10.10; -; 1.
InterPro; IPR018057; Deoxyribonuclease-1_AS.
InterPro; IPR016202; DNase_I.
InterPro; IPR033125; DNASE_I_2.
InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
InterPro; IPR005135; Endo/exonuclease/phosphatase.
Pfam; PF03372; Exo_endo_phos; 1.
PIRSF; PIRSF000988; DNase_I_euk; 1.
PRINTS; PR00130; DNASEI.
SMART; SM00476; DNaseIc; 1.
SUPFAM; SSF56219; SSF56219; 1.
PROSITE; PS00919; DNASE_I_1; 1.
PROSITE; PS00918; DNASE_I_2; 1.
1: Evidence at protein level;
ADP-ribosylation; Alternative splicing; Apoptosis; Calcium;
Complete proteome; Disulfide bond; Endonuclease;
Endoplasmic reticulum; Hydrolase; Necrosis; Nuclease; Nucleus;
Polymorphism; Reference proteome; Secreted; Signal;
Systemic lupus erythematosus.
SIGNAL 1 20 {ECO:0000250}.
CHAIN 21 305 Deoxyribonuclease gamma.
/FTId=PRO_0000007288.
REGION 284 305 Not required for free DNA-nuclease
activity but required for activity
towards liposome-coated DNA.
{ECO:0000250|UniProtKB:O55070}.
MOTIF 35 51 Bipartite nuclear localization signal.
{ECO:0000255}.
MOTIF 296 304 Nuclear localization signal.
{ECO:0000255}.
ACT_SITE 100 100 {ECO:0000250|UniProtKB:P00639}.
ACT_SITE 155 155 {ECO:0000250|UniProtKB:P00639}.
DISULFID 194 231 Essential for enzymatic activity.
{ECO:0000250|UniProtKB:O55070}.
VAR_SEQ 78 107 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_047251.
VARIANT 19 19 L -> V (in a breast cancer sample;
somatic mutation; dbSNP:rs763778721).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036079.
VARIANT 82 82 G -> R (in a breast cancer sample;
somatic mutation; diminishes enzymatic
activity; dbSNP:rs74350392).
{ECO:0000269|PubMed:16959974,
ECO:0000269|PubMed:21692081}.
/FTId=VAR_036080.
VARIANT 96 96 N -> K (in dbSNP:rs12491947).
{ECO:0000269|PubMed:14646506}.
/FTId=VAR_059249.
VARIANT 117 117 Y -> S (in a colorectal cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036081.
VARIANT 206 206 R -> C (abolishes enzymatic activity;
dbSNP:rs35677470).
{ECO:0000269|PubMed:19559017,
ECO:0000269|PubMed:22019780,
ECO:0000269|PubMed:27293190}.
/FTId=VAR_076797.
VARIANT 243 243 I -> M (in dbSNP:rs76440799).
{ECO:0000269|PubMed:19559017}.
/FTId=VAR_061137.
SEQUENCE 305 AA; 35504 MW; BAB9F1A0341E6048 CRC64;
MSRELAPLLL LLLSIHSALA MRICSFNVRS FGESKQEDKN AMDVIVKVIK RCDIILVMEI
KDSNNRICPI LMEKLNRNSR RGITYNYVIS SRLGRNTYKE QYAFLYKEKL VSVKRSYHYH
DYQDGDADVF SREPFVVWFQ SPHTAVKDFV IIPLHTTPET SVKEIDELVE VYTDVKHRWK
AENFIFMGDF NAGCSYVPKK AWKNIRLRTD PRFVWLIGDQ EDTTVKKSTN CAYDRIVLRG
QEIVSSVVPK SNSVFDFQKA YKLTEEEALD VSDHFPVEFK LQSSRAFTNS KKSVTLRKKT
KSKRS


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