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Dermaseptin BI (Dermaseptin B1)

 DMS1_PHYBI              Reviewed;          78 AA.
P80282;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 2.
28-FEB-2018, entry version 69.
RecName: Full=Dermaseptin BI;
AltName: Full=Dermaseptin B1;
Flags: Precursor;
Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae;
Phyllomedusinae; Phyllomedusa.
NCBI_TaxID=8393;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT GLN-75.
TISSUE=Skin;
PubMed=8074751;
Amiche M., Ducancel F., Mor A., Boulain J.-C., Menez A., Nicolas P.;
"Precursors of vertebrate peptide antibiotics dermaseptin b and
adenoregulin have extensive sequence identities with precursors of
opioid peptides dermorphin, dermenkephalin, and deltorphins.";
J. Biol. Chem. 269:17847-17852(1994).
[2]
PROTEIN SEQUENCE OF 45-75.
TISSUE=Skin secretion;
PubMed=8306981; DOI=10.1111/j.1432-1033.1994.tb19924.x;
Mor A., Nicolas P.;
"Isolation and structure of novel defensive peptides from frog skin.";
Eur. J. Biochem. 219:145-154(1994).
-!- FUNCTION: Possesses a potent antimicrobial activity against
bacteria, fungi and protozoa. Probably acts by disturbing membrane
functions with its amphipathic structure.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the skin glands.
-!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
Dermaseptin subfamily. {ECO:0000305}.
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EMBL; X72387; CAA51080.1; -; mRNA.
PIR; A53727; A53727.
PIR; B54897; B54897.
SMR; P80282; -.
TCDB; 1.C.52.1.1; the dermaseptin (dermaseptin) family.
HOVERGEN; HBG096007; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
GO; GO:0031640; P:killing of cells of other organism; IEA:UniProtKB-KW.
InterPro; IPR022731; Dermaseptin.
InterPro; IPR004275; Frog_antimicrobial_propeptide.
InterPro; IPR016322; FSAP.
Pfam; PF12121; DD_K; 1.
Pfam; PF03032; FSAP_sig_propep; 1.
PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
1: Evidence at protein level;
Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
Cleavage on pair of basic residues; Direct protein sequencing;
Fungicide; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 42
/FTId=PRO_0000007089.
PEPTIDE 45 75 Dermaseptin BI.
/FTId=PRO_0000007090.
PROPEP 76 78
/FTId=PRO_0000007091.
MOD_RES 75 75 Glutamine amide.
{ECO:0000303|PubMed:8074751}.
SEQUENCE 78 AA; 8707 MW; EB3B6F03058FEC6F CRC64;
MDILKKSLFL VLFLGLVSLS ICEEEKRENE DEEKQDDEQS EMKRAMWKDV LKKIGTVALH
AGKAALGAVA DTISQGEQ


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Catalog number Product name Quantity
06-271-83186 Dermaseptin - Dermaseptin-1 0.5 mg
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SP2152a [Des Ala20, Gln34] Dermaseptin 1 mg
5-70271 Dermaseptin I, peptide reagents 0.5 mg
5-70272 Dermaseptin I, peptide reagents 1 mg
5-70273 Dermaseptin I, peptide reagents 2.5 mg
SP-52239-1 Dermaseptin I [Ala-Leu-Trp-Lys-Thr-Met-Ley-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His0Ala-Gly-lys-Ala-Leu-Gly-Ala-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln-OH; MW: 3455.08] 0.5 mg
SP2152b [Des Ala20, Gln34] Dermaseptin
abx064475 Synthetic Dermaseptin I Peptide 1 mg
SP2152a [Des Ala20, Gln34] Dermaseptin
SP2152a [Des Ala20, Gln34] Dermaseptin 1mg
SP2152b [Des Ala20, Gln34] Dermaseptin 5mg
SP2152b [Des Ala20, Gln34] Dermaseptin 5 mg
SP-52239-1 Dermaseptin I [Ala-Leu-Trp-Lys-Thr-Met-Ley-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His0Ala-Gly-lys-Ala-Leu-Gly-Ala-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln-OH; MW: 3455.08] Species Reactivity: 0.5 mg Product tipe: Pure Peptide


 

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