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Dermorphin

 DEM_PHAJA               Reviewed;           7 AA.
P86633;
08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
08-FEB-2011, sequence version 1.
10-MAY-2017, entry version 7.
RecName: Full=Dermorphin {ECO:0000303|PubMed:20932854};
Phasmahyla jandaia (Jandaia leaf frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae;
Phyllomedusinae; Phasmahyla.
NCBI_TaxID=762504;
[1] {ECO:0000305}
PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
SPECTROMETRY, AND AMIDATION AT SER-7.
TISSUE=Skin secretion {ECO:0000269|PubMed:20932854};
PubMed=20932854; DOI=10.1016/j.toxicon.2010.09.010;
Rates B., Silva L.P., Ireno I.C., Leite F.S., Borges M.H.,
Bloch C. Jr., De Lima M.E., Pimenta A.M.;
"Peptidomic dissection of the skin secretion of Phasmahyla jandaia
(Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).";
Toxicon 57:35-52(2011).
-!- FUNCTION: Has a very potent opiate-like activity. It has high
affinity and selectivity for mu-type opioid receptors (By
similarity). {ECO:0000250|UniProtKB:P05422}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20932854}.
-!- TISSUE SPECIFICITY: Expressed by the skin glands.
{ECO:0000269|PubMed:20932854}.
-!- MASS SPECTROMETRY: Mass=802.2; Method=MALDI; Range=1-7;
Evidence={ECO:0000269|PubMed:20932854};
-!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
Dermorphin subfamily. {ECO:0000255}.
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GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
1: Evidence at protein level;
Amidation; Amphibian defense peptide; D-amino acid;
Direct protein sequencing; Endorphin; Opioid peptide; Secreted.
PEPTIDE 1 7 Dermorphin.
{ECO:0000269|PubMed:20932854}.
/FTId=PRO_0000404606.
MOD_RES 2 2 D-alanine (Ala).
{ECO:0000250|UniProtKB:P05422}.
MOD_RES 7 7 Serine amide.
{ECO:0000269|PubMed:20932854}.
SEQUENCE 7 AA; 804 MW; 75A77B5879CDCB30 CRC64;
YAFGYPS


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Catalog number Product name Quantity
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orb70121 [D-Arg2,Sar4]-Dermorphin (1-4) peptide This is [D-Arg2,Sar4]-Dermorphin (1-4) peptide. For research use only. 1 mg
orb70120 [D-Arg2,Lys4]-Dermorphin (1-4) peptide This is [D-Arg2,Lys4]-Dermorphin (1-4) peptide. For research use only. 1 mg
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