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Dermorphin-1 [Cleaved into: Deltorphin (Dermenkephalin); Dermorphin]

 DEM1_PHYSA              Reviewed;         197 AA.
P05422;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-NOV-1988, sequence version 1.
05-OCT-2016, entry version 62.
RecName: Full=Dermorphin-1;
Contains:
RecName: Full=Deltorphin;
AltName: Full=Dermenkephalin;
Contains:
RecName: Full=Dermorphin;
Flags: Precursor;
Phyllomedusa sauvagei (Sauvage's leaf frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae;
Phyllomedusinae; Phyllomedusa.
NCBI_TaxID=8395;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skin;
PubMed=3659910; DOI=10.1126/science.3659910;
Richter K., Egger R., Kreil G.;
"D-alanine in the frog skin peptide dermorphin is derived from L-
alanine in the precursor.";
Science 238:200-202(1987).
[2]
PROTEIN SEQUENCE OF 48-54; 99-111 AND 115-126, D-AMINO ACID AT MET-49,
AND AMIDATION AT ASP-54.
TISSUE=Skin secretion;
PubMed=2007579;
Mor A., Delfaour A., Nicolas P.;
"Identification of a D-alanine-containing polypeptide precursor for
the peptide opioid, dermorphin.";
J. Biol. Chem. 266:6264-6270(1991).
[3]
PROTEIN SEQUENCE OF 48-54, D-AMINO ACID AT MET-49, AMIDATION AT
ASP-54, AND FUNCTION.
TISSUE=Skin secretion;
PubMed=2542051; DOI=10.1016/0014-2999(89)90611-0;
Kreil G., Barra D., Simmaco M., Erspamer V., Erspamer G.F., Negri L.,
Severini C., Corsi R., Melchiorri P.;
"Deltorphin, a novel amphibian skin peptide with high selectivity and
affinity for delta opioid receptors.";
Eur. J. Pharmacol. 162:123-128(1989).
[4]
PROTEIN SEQUENCE OF 80-86; 115-121; 150-156 AND 185-191, D-AMINO ACID
AT ALA-81; ALA-116; ALA-151 AND ALA-186, AMIDATION AT SER-86; SER-121;
SER-156 AND SER-191, FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Skin secretion;
PubMed=7287299;
Montecucchi P.C., de Castiglione R., Piani S., Gozzini L.,
Erspamer V.;
"Amino acid composition and sequence of dermorphin, a novel opiate-
like peptide from the skin of Phyllomedusa sauvagei.";
Int. J. Pept. Protein Res. 17:275-283(1981).
-!- FUNCTION: Dermorphin has a very potent opiate-like activity. It
has high affinity and selectivity for mu-type opioid receptors.
-!- FUNCTION: Deltorphin has a very potent opiate-like activity. It
has high affinity and selectivity for delta-type opioid receptors.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the skin glands.
{ECO:0000269|PubMed:7287299}.
-!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
Dermorphin subfamily. {ECO:0000305}.
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EMBL; M18031; AAA49453.1; -; mRNA.
PIR; A27784; A27784.
PRIDE; P05422; -.
HOVERGEN; HBG005448; -.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0001515; F:opioid peptide activity; IDA:UniProtKB.
GO; GO:0006952; P:defense response; IDA:UniProtKB.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
InterPro; IPR004275; Frog_antimicrobial_propeptide.
Pfam; PF03032; FSAP_sig_propep; 1.
1: Evidence at protein level;
Amidation; Amphibian defense peptide;
Cleavage on pair of basic residues; D-amino acid;
Direct protein sequencing; Endorphin; Opioid peptide; Repeat;
Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 45
/FTId=PRO_0000010233.
PEPTIDE 48 54 Deltorphin.
/FTId=PRO_0000010234.
PROPEP 56 77
/FTId=PRO_0000010235.
PEPTIDE 80 86 Dermorphin.
/FTId=PRO_0000010236.
PROPEP 88 112
/FTId=PRO_0000010237.
PEPTIDE 115 121 Dermorphin.
/FTId=PRO_0000010238.
PROPEP 123 147
/FTId=PRO_0000010239.
PEPTIDE 150 156 Dermorphin.
/FTId=PRO_0000010240.
PROPEP 158 182
/FTId=PRO_0000010241.
PEPTIDE 185 191 Dermorphin.
/FTId=PRO_0000010242.
PROPEP 193 197
/FTId=PRO_0000010243.
MOD_RES 49 49 D-methionine.
{ECO:0000269|PubMed:2007579,
ECO:0000269|PubMed:2542051}.
MOD_RES 54 54 Aspartic acid 1-amide.
{ECO:0000269|PubMed:2007579,
ECO:0000269|PubMed:2542051}.
MOD_RES 81 81 D-alanine (Ala).
{ECO:0000269|PubMed:7287299}.
MOD_RES 86 86 Serine amide.
{ECO:0000269|PubMed:7287299}.
MOD_RES 116 116 D-alanine (Ala).
{ECO:0000269|PubMed:7287299}.
MOD_RES 121 121 Serine amide.
{ECO:0000269|PubMed:7287299}.
MOD_RES 151 151 D-alanine (Ala).
{ECO:0000269|PubMed:7287299}.
MOD_RES 156 156 Serine amide.
{ECO:0000269|PubMed:7287299}.
MOD_RES 186 186 D-alanine (Ala).
{ECO:0000269|PubMed:7287299}.
MOD_RES 191 191 Serine amide.
{ECO:0000269|PubMed:7287299}.
SEQUENCE 197 AA; 23165 MW; 58C6883BC0C9B687 CRC64;
MSFLKKSLLL ILFLGLVSLS VCKEEKRETE EENENEENHE EGSEMKRYMF HLMDGEAKKR
DSEENEIEEN HEEGSEMKRY AFGYPSGEAK KIKRVSEEEN ENEENHEEGS EMKRYAFGYP
SGEAKKIKRE SEEEKEIEEN HEEGSEMKRY AFGYPSGEAK KIKRESEEEN ENEENHEEGS
EMKRYAFGYP SGEAKKM


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