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Dethiobiotin synthetase (DTB synthetase) (EC 6.3.3.3) (Dethiobiotin synthase) (DTBS)

 BIOD_YEAST              Reviewed;         237 AA.
P53630; D6W1N2;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
28-MAR-2018, entry version 146.
RecName: Full=Dethiobiotin synthetase;
Short=DTB synthetase;
EC=6.3.3.3;
AltName: Full=Dethiobiotin synthase;
Short=DTBS;
Name=BIO4; OrderedLocusNames=YNR057C; ORFNames=N3506;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=ATCC 28383 / FL100 / VTT C-80102;
PubMed=10333520; DOI=10.1016/S0378-1119(99)00117-1;
Phalip V., Kuhn I., Lemoine Y., Jeltsch J.-M.;
"Characterization of the biotin biosynthesis pathway in Saccharomyces
cerevisiae and evidence for a cluster containing BIO5, a novel gene
involved in vitamer uptake.";
Gene 232:43-51(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169873;
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F.,
Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M.,
Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N.,
Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D.,
Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A.,
Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A.,
Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C.,
Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M.,
Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J.,
Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L.,
Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M.,
Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P.,
Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A.,
Wambutt R., Wedler H., Zollner A., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications.";
Nature 387:93-98(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=17322287; DOI=10.1101/gr.6037607;
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-
encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
-!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
phosphate + dethiobiotin.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
-!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
7,8-diaminononanoate: step 1/2.
-!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
{ECO:0000305}.
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EMBL; U53467; AAB63971.1; -; Genomic_DNA.
EMBL; Z71672; CAA96339.1; -; Genomic_DNA.
EMBL; AY558424; AAS56750.1; -; Genomic_DNA.
EMBL; BK006947; DAA10598.1; -; Genomic_DNA.
PIR; S63389; S63389.
RefSeq; NP_014455.1; NM_001183234.1.
PDB; 1M3T; Model; -; A=1-237.
PDBsum; 1M3T; -.
ProteinModelPortal; P53630; -.
SMR; P53630; -.
BioGrid; 35883; 49.
IntAct; P53630; 2.
STRING; 4932.YNR057C; -.
MaxQB; P53630; -.
PaxDb; P53630; -.
PRIDE; P53630; -.
EnsemblFungi; YNR057C; YNR057C; YNR057C.
GeneID; 855794; -.
KEGG; sce:YNR057C; -.
EuPathDB; FungiDB:YNR057C; -.
SGD; S000005340; BIO4.
HOGENOM; HOG000275033; -.
InParanoid; P53630; -.
KO; K01935; -.
OMA; DYWKPIQ; -.
OrthoDB; EOG092C4YDH; -.
BioCyc; YEAST:YNR057C-MONOMER; -.
UniPathway; UPA00078; UER00161.
PRO; PR:P53630; -.
Proteomes; UP000002311; Chromosome XIV.
GO; GO:0005737; C:cytoplasm; ISS:SGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004141; F:dethiobiotin synthase activity; IDA:SGD.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0009102; P:biotin biosynthetic process; IDA:SGD.
HAMAP; MF_00336; BioD; 1.
InterPro; IPR004472; DTB_synth_BioD.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR43210; PTHR43210; 1.
PIRSF; PIRSF006755; DTB_synth; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00347; bioD; 1.
3: Inferred from homology;
3D-structure; ATP-binding; Biotin biosynthesis; Complete proteome;
Ligase; Magnesium; Nucleotide-binding; Reference proteome.
CHAIN 1 237 Dethiobiotin synthetase.
/FTId=PRO_0000188006.
NP_BIND 18 26 ATP. {ECO:0000250}.
SEQUENCE 237 AA; 26257 MW; F1147BF18DA40735 CRC64;
MNSKSQQQEQ QPIVFVTGTD TDVGKTFVST LLVHKWKAAY WKPVQTGIES DQGDSETLKN
FKIAASTWQP PIFTPTYALQ KPLSPLQAME YEPNVDIRLL DFVVPEEWSA ENPLVVEGAG
GVCVPITRKL EITTDLIKHL IETSGHPVYV VVVARSGLGT LNHTLLTWNH LCDNGLRSHL
FGVILNGEPN EGNVQALKKF GVNIMAQVAQ CTTAHDQDME LHELPSVESL MTQQDVE


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