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Developmental and secondary metabolism regulator VEL1 (Velvet complex subunit 1)

 VEA_GIBF5               Reviewed;         530 AA.
S0DHV6; E0WDF7;
16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
18-SEP-2013, sequence version 1.
28-MAR-2018, entry version 17.
RecName: Full=Developmental and secondary metabolism regulator VEL1 {ECO:0000305};
AltName: Full=Velvet complex subunit 1 {ECO:0000305};
Name=VEL1 {ECO:0000303|PubMed:20572938}; ORFNames=FFUJ_01649;
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
(Bakanae and foot rot disease fungus) (Fusarium fujikuroi).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
Fusarium; Fusarium fujikuroi species complex.
NCBI_TaxID=1279085;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, SUBCELLULAR LOCATION,
INTERACTION WITH LAEA, AND DISRUPTION PHENOTYPE.
STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
PubMed=20572938; DOI=10.1111/j.1365-2958.2010.07263.x;
Wiemann P., Brown D.W., Kleigrewe K., Bok J.W., Keller N.P.,
Humpf H.U., Tudzynski B.;
"FfVel1 and FfLae1, components of a velvet-like complex in Fusarium
fujikuroi, affect differentiation, secondary metabolism and
virulence.";
Mol. Microbiol. 77:972-994(2010).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K.,
Bald T., Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M.,
Brown D.W., Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U.,
Gueldener U., Tudzynski B.;
"Deciphering the cryptic genome: genome-wide analyses of the rice
pathogen Fusarium fujikuroi reveal complex regulation of secondary
metabolism and novel metabolites.";
PLoS Pathog. 9:E1003475-E1003475(2013).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=24389666; DOI=10.1007/s00253-013-5453-1;
Niehaus E.M., von Bargen K.W., Espino J.J., Pfannmueller A.,
Humpf H.U., Tudzynski B.;
"Characterization of the fusaric acid gene cluster in Fusarium
fujikuroi.";
Appl. Microbiol. Biotechnol. 98:1749-1762(2014).
-!- FUNCTION: Component of the velvet transcription factor complex
that controls sexual/asexual developmental ratio in response to
light, promoting sexual development in the darkness while
stimulating asexual sporulation under illumination
(PubMed:20572938). The velvet complex hat acts as a global
regulator for secondary metabolite gene expression
(PubMed:20572938). Controls positively the expression of the
gibberellins, fumonisins and fusarin C gene clusters
(PubMed:20572938). Controls the expression of the fusaric acid
gene cluster (PubMed:24389666). Controls negatively the expression
of the bikaverin gene cluster (PubMed:20572938). Regulates the
expression of laeA (PubMed:20572938). Plays a crucial role in
virulence (PubMed:20572938). {ECO:0000250|UniProtKB:C8VTV4,
ECO:0000269|PubMed:20572938, ECO:0000269|PubMed:24389666}.
-!- SUBUNIT: Component of the heterotrimeric velvet complex composed
of LAE1, VEL1 and VEL2; VEL1 acting as a bridging protein between
LAE1 and VEL2 (By similarity). Interacts with LAE1
(PubMed:20572938). {ECO:0000250|UniProtKB:C8VQG9,
ECO:0000269|PubMed:20572938}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20572938}.
Cytoplasm {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the
nucleus in the dark (By similarity).
{ECO:0000250|UniProtKB:C8VTV4}.
-!- INDUCTION: Expression is repressed in media containing high
amounts of nitrogen (PubMed:20572938).
{ECO:0000269|PubMed:20572938}.
-!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
glutamic acid, serine and threonine residues that is required for
the light-dependent regulation of development and secondary
metabolism (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
-!- DISRUPTION PHENOTYPE: Impairs the production of gibberellins,
fumonisins and fusarin C (PubMed:20572938). Reduces both the
fusaric acid gene cluster expression and production of fusaric
acid (PubMed:24389666). Affects conidiation associated with
stunted aerial hyphae (PubMed:20572938).
{ECO:0000269|PubMed:20572938, ECO:0000269|PubMed:24389666}.
-!- SIMILARITY: Belongs to the velvet family. VeA subfamily.
{ECO:0000305}.
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EMBL; FN548142; CBE54373.1; -; Genomic_DNA.
EMBL; HF679023; CCT61859.1; -; Genomic_DNA.
EnsemblFungi; CCT61859; CCT61859; FFUJ_01649.
OrthoDB; EOG092C1LNH; -.
Proteomes; UP000016800; Chromosome 1.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 2.60.40.3960; -; 1.
InterPro; IPR021740; Velvet.
InterPro; IPR037525; Velvet_dom.
InterPro; IPR038491; Velvet_dom_sf.
PANTHER; PTHR33572; PTHR33572; 2.
Pfam; PF11754; Velvet; 2.
PROSITE; PS51821; VELVET; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Nucleus; Reference proteome;
Sporulation; Transcription; Transcription regulation.
CHAIN 1 530 Developmental and secondary metabolism
regulator VEL1.
/FTId=PRO_0000435767.
DOMAIN 26 220 Velvet. {ECO:0000255|PROSITE-
ProRule:PRU01165}.
REGION 429 460 PEST. {ECO:0000250|UniProtKB:C8VTV4}.
MOTIF 40 45 Nuclear localization signal.
{ECO:0000250|UniProtKB:C8VTV4}.
COMPBIAS 296 465 Pro-rich. {ECO:0000255|PROSITE-
ProRule:PRU00015}.
SEQUENCE 530 AA; 58837 MW; E70157D51B038E8D CRC64;
MATPSSIPAE PKRDVVNRIH RVTRGNRSLW YQMTVLQQPE RARACGSGSK ANSDRRPVDP
PPVVELRIIE GPSVEEGKDI TFDYNANFFL YASLEHARPL ARGRVNTPAA GNPPILTGVP
ASGMAYLDRP TEAGYFIFPD LSVRHEGLYI LTFSLFETTK EERDFDLEPA DGDLPPGVDY
RMEIKTDPFS VYSAKKFPGL MESTQLSKTV ADQGCQVRIR RDVRMRKRES KPGAGNSNSG
GNGFERREED FGRRRTITPA SEDPHSIRNR SHSNSSEQRT PYTDASRRPS MVDSYPPPPP
PPSYEPAPSA SRHLDFGDSS AAQYPTPRQY AHQPGLQITP GPPSGSYAPT AQSPYSKTDA
PYGYVNRNIP PSCPSPAPSV KHDLYDRRQS TSSYVPPSPS VYSTEGHHRR DSRPSYPPTP
VAAPRPRPMH SQTSLPALKI DQLVSPVSPL PPIEPQTGPA PELPPINVGG KRKHESVFAQ
STRPLHNGQR QVDPHYGRSH RGYSPDHDQG WYSRADGQIS SVQFNRYYDE


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