Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Developmental and secondary metabolism regulator veA (Velvet complex subunit A)

 VEA_EMENI               Reviewed;         573 AA.
C8VTV4; O74625;
16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
16-MAR-2016, sequence version 2.
28-MAR-2018, entry version 39.
RecName: Full=Developmental and secondary metabolism regulator veA {ECO:0000305};
AltName: Full=Velvet complex subunit A {ECO:0000305};
Name=veA {ECO:0000303|PubMed:12223191}; ORFNames=ANIA_01052;
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
194 / M139) (Aspergillus nidulans).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=227321;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
Yager L.N., Kennedy P.A.;
"The veA gene is required for light-dependent conidiation in
Emericella (Aspergillus) nidulans.";
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION, FUNCTION, AND
DISRUPTION PHENOTYPE.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=12223191; DOI=10.1016/S1087-1845(02)00029-4;
Kim H.-S., Han K.-Y., Kim K.-J., Han D.-M., Jahng K.-Y., Chae K.-S.;
"The veA gene activates sexual development in Aspergillus nidulans.";
Fungal Genet. Biol. 37:72-80(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
{ECO:0000312|Proteomes:UP000000560};
PubMed=16372000; DOI=10.1038/nature04341;
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A.
fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).
[4]
GENOME REANNOTATION.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
{ECO:0000312|Proteomes:UP000000560};
PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
"The 2008 update of the Aspergillus nidulans genome annotation: a
community effort.";
Fungal Genet. Biol. 46:S2-13(2009).
[5]
FUNCTION.
PubMed=2253875; DOI=10.1101/gad.4.9.1473;
Mooney J.L., Yager L.N.;
"Light is required for conidiation in Aspergillus nidulans.";
Genes Dev. 4:1473-1482(1990).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=2076818;
Mooney J.L., Hassett D.E., Yager L.N.;
"Genetic analysis of suppressors of the veA1 mutation in Aspergillus
nidulans.";
Genetics 126:869-874(1990).
[7]
DISRUPTION PHENOTYPE.
PubMed=9691036;
Yager L.N., Lee H.O., Nagle D.L., Zimmerman J.E.;
"Analysis of fluG mutations that affect light-dependent conidiation in
Aspergillus nidulans.";
Genetics 149:1777-1786(1998).
[8]
FUNCTION.
PubMed=12375102; DOI=10.1007/s00203-002-0463-x;
Jeong H.Y., Song M.H., Back J.H., Han D.M., Wu X., Monnier V.,
Jahng K.Y., Chae K.S.;
"The veA gene is necessary for the inducible expression by fructosyl
amines of the Aspergillus nidulans faoA gene encoding fructosyl amino
acid oxidase (amadoriase, EC 1.5.3).";
Arch. Microbiol. 178:344-350(2002).
[9]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=14665453; DOI=10.1128/EC.2.6.1178-1186.2003;
Kato N., Brooks W., Calvo A.M.;
"The expression of sterigmatocystin and penicillin genes in
Aspergillus nidulans is controlled by veA, a gene required for sexual
development.";
Eukaryot. Cell 2:1178-1186(2003).
[10]
FUNCTION.
PubMed=12620259; DOI=10.1016/S1087-1845(02)00527-3;
Jeong H.Y., Kim H., Han D.M., Jahng K.Y., Chae K.S.;
"Expression of the mnpA gene that encodes the mannoprotein of
Aspergillus nidulans is dependent on fadA and flbA as well as veA.";
Fungal Genet. Biol. 38:228-236(2003).
[11]
FUNCTION.
PubMed=17375284; DOI=10.1007/s00203-007-0224-y;
Sproete P., Brakhage A.A.;
"The light-dependent regulator velvet A of Aspergillus nidulans acts
as a repressor of the penicillin biosynthesis.";
Arch. Microbiol. 188:69-79(2007).
[12]
SUBCELLULAR LOCATION.
PubMed=17163983; DOI=10.1111/j.1365-2958.2006.05506.x;
Stinnett S.M., Espeso E.A., Cobeno L., Araujo-Bazan L., Calvo A.M.;
"Aspergillus nidulans VeA subcellular localization is dependent on the
importin alpha carrier and on light.";
Mol. Microbiol. 63:242-255(2007).
[13]
INTERACTION WITH FPHA.
PubMed=18291652; DOI=10.1016/j.cub.2008.01.061;
Purschwitz J., Mueller S., Kastner C., Schoeser M., Haas H.,
Espeso E.A., Atoui A., Calvo A.M., Fischer R.;
"Functional and physical interaction of blue- and red-light sensors in
Aspergillus nidulans.";
Curr. Biol. 18:255-259(2008).
[14]
FUNCTION.
PubMed=17977758; DOI=10.1016/j.fgb.2007.09.008;
Han K.H., Kim J.H., Moon H., Kim S., Lee S.S., Han D.M., Jahng K.Y.,
Chae K.S.;
"The Aspergillus nidulans esdC (early sexual development) gene is
necessary for sexual development and is controlled by veA and a
heterotrimeric G protein.";
Fungal Genet. Biol. 45:310-318(2008).
[15]
IDENTIFICATION IN THE VELVET COMPLEX, FUNCTION, AND SUBCELLULAR
LOCATION.
PubMed=18556559; DOI=10.1126/science.1155888;
Bayram O., Krappmann S., Ni M., Bok J.W., Helmstaedt K., Valerius O.,
Braus-Stromeyer S., Kwon N.J., Keller N.P., Yu J.H., Braus G.H.;
"VelB/VeA/LaeA complex coordinates light signal with fungal
development and secondary metabolism.";
Science 320:1504-1506(2008).
[16]
INDUCTION.
PubMed=19479257; DOI=10.1007/s00294-009-0253-y;
Kim H.Y., Han K.H., Lee M., Oh M., Kim H.S., Zhixiong X., Han D.M.,
Jahng K.Y., Kim J.H., Chae K.S.;
"The veA gene is necessary for the negative regulation of the veA
expression in Aspergillus nidulans.";
Curr. Genet. 55:391-397(2009).
[17]
SUBCELLULAR LOCATION.
PubMed=19318129; DOI=10.1016/j.fgb.2009.03.006;
Araujo-Bazan L., Dhingra S., Chu J., Fernandez-Martinez J.,
Calvo A.M., Espeso E.A.;
"Importin alpha is an essential nuclear import carrier adaptor
required for proper sexual and asexual development and secondary
metabolism in Aspergillus nidulans.";
Fungal Genet. Biol. 46:506-515(2009).
[18]
INTERACTION WITH FPHA, AND PHOSPHORYLATION.
PubMed=18936976; DOI=10.1007/s00438-008-0390-x;
Purschwitz J., Mueller S., Fischer R.;
"Mapping the interaction sites of Aspergillus nidulans phytochrome
FphA with the global regulator VeA and the White Collar protein
LreB.";
Mol. Genet. Genomics 281:35-42(2009).
[19]
FUNCTION.
PubMed=19210625; DOI=10.1111/j.1365-2958.2009.06606.x;
Bayram O., Sari F., Braus G.H., Irniger S.;
"The protein kinase ImeB is required for light-mediated inhibition of
sexual development and for mycotoxin production in Aspergillus
nidulans.";
Mol. Microbiol. 71:1278-1295(2009).
[20]
SUBCELLULAR LOCATION.
PubMed=20816830; DOI=10.1016/j.fgb.2010.08.007;
Atoui A., Kastner C., Larey C.M., Thokala R., Etxebeste O.,
Espeso E.A., Fischer R., Calvo A.M.;
"Cross-talk between light and glucose regulation controls toxin
production and morphogenesis in Aspergillus nidulans.";
Fungal Genet. Biol. 47:962-972(2010).
[21]
INDUCTION.
PubMed=21152013; DOI=10.1371/journal.pgen.1001226;
Sarikaya Bayram O., Bayram O., Valerius O., Park H.S., Irniger S.,
Gerke J., Ni M., Han K.H., Yu J.H., Braus G.H.;
"LaeA control of velvet family regulatory proteins for light-dependent
development and fungal cell-type specificity.";
PLoS Genet. 6:E1001226-E1001226(2010).
[22]
IDENTIFICATION IN THE VELVET COMPLEX.
PubMed=23065618; DOI=10.1007/978-1-62703-122-6_14;
Bayram O., Bayram O.S., Valerius O., Joehnk B., Braus G.H.;
"Identification of protein complexes from filamentous fungi with
tandem affinity purification.";
Methods Mol. Biol. 944:191-205(2012).
[23]
FUNCTION.
PubMed=23841751; DOI=10.1111/mmi.12326;
Bok J.W., Soukup A.A., Chadwick E., Chiang Y.M., Wang C.C.,
Keller N.P.;
"VeA and MvlA repression of the cryptic orsellinic acid gene cluster
in Aspergillus nidulans involves histone 3 acetylation.";
Mol. Microbiol. 89:963-974(2013).
[24]
SUBCELLULAR LOCATION, AND INTERACTION WITH LLMF.
PubMed=23341778; DOI=10.1371/journal.pgen.1003193;
Palmer J.M., Theisen J.M., Duran R.M., Grayburn W.S., Calvo A.M.,
Keller N.P.;
"Secondary metabolism and development is mediated by LlmF control of
VeA subcellular localization in Aspergillus nidulans.";
PLoS Genet. 9:E1003193-E1003193(2013).
[25]
PHOSPHORYLATION AT THR-167; THR-170; SER-183 AND TYR-254, MUTAGENESIS
OF THR-167; THR-170; SER-183 AND TYR-254, INTERACTION WITH VELB AND
PHPA, SUBCELLULAR LOCATION, DOMAIN, AND INDUCTION.
PubMed=26564476; DOI=10.1111/mmi.13275;
Rauscher S., Pacher S., Hedtke M., Kniemeyer O., Fischer R.;
"A phosphorylation code of the Aspergillus nidulans global regulator
VelvetA (VeA) determines specific functions.";
Mol. Microbiol. 99:909-924(2016).
-!- FUNCTION: Component of the velvet transcription factor complex
that controls sexual/asexual developmental ratio in response to
light, promoting sexual development in the darkness while
stimulating asexual sporulation under illumination
(PubMed:12223191, PubMed:2253875, PubMed:2076818, PubMed:14665453,
PubMed:18556559, PubMed:19210625). The velvet complex acts as a
global regulator for secondary metabolite gene expression
(PubMed:18556559). Controls the expression of the sterigmatocystin
and penicillin gene clusters (PubMed:14665453, PubMed:17375284).
Represses the cryptic ors gene cluster producing orsellinic acid
and its F9775 derivatives in a laeA-independent manner
(PubMed:23841751). Required for full induction of faoA gene
expression by fructosyl amines (PubMed:12375102). Positively
regulates the expression of the early sexual development gene esdC
(PubMed:17977758). Controls the expression of mannoprotein mnpA
(PubMed:12620259). {ECO:0000269|PubMed:12223191,
ECO:0000269|PubMed:12375102, ECO:0000269|PubMed:12620259,
ECO:0000269|PubMed:14665453, ECO:0000269|PubMed:17977758,
ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:19210625,
ECO:0000269|PubMed:2076818, ECO:0000269|PubMed:2253875,
ECO:0000269|PubMed:23841751}.
-!- SUBUNIT: Component of the heterotrimeric velvet complex composed
of laeA, veA and velB; VeA acting as a bridging protein between
laeA and velB (PubMed:18556559). Interacts with the light-sensing
phytochrome fphA (PubMed:18291652, PubMed:18936976). Interacts
with llmF (PubMed:23341778). {ECO:0000269|PubMed:18291652,
ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:18936976,
ECO:0000269|PubMed:23341778}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17163983,
ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:19318129,
ECO:0000269|PubMed:20816830, ECO:0000269|PubMed:23341778}.
Cytoplasm {ECO:0000269|PubMed:17163983,
ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:19318129,
ECO:0000269|PubMed:20816830, ECO:0000269|PubMed:23341778}.
Note=Enriched in the nucleus in the dark (PubMed:17163983,
PubMed:18556559, PubMed:20816830). Migration to the nucleus
depends on the importin alpha carrier protein KapA
(PubMed:17163983, PubMed:19318129). Migration to the nucleus is
also controled by llmF (PubMed:23341778).
{ECO:0000269|PubMed:17163983, ECO:0000269|PubMed:18556559,
ECO:0000269|PubMed:19318129, ECO:0000269|PubMed:23341778}.
-!- INDUCTION: Expressed almost constitutively at an increased level
throughout the asexual and sexual developmental processes
(PubMed:12223191). Negatively regulates its own expression
(PubMed:19479257). Expression is derepressed in light-illuminated
conditions (PubMed:19479257). Expression is regulated by laeA
(PubMed:21152013). Regulates its own expression, depending on its
phosphorylation state (PubMed:26564476).
{ECO:0000269|PubMed:12223191, ECO:0000269|PubMed:19479257,
ECO:0000269|PubMed:21152013, ECO:0000269|PubMed:26564476}.
-!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
glutamic acid, serine and threonine residues that is required for
the light-dependent regulation of development and secondary
metabolism. {ECO:0000269|PubMed:26564476}.
-!- PTM: Phosphorylated at Thr-167, Thr-170, Ser-183 and Tyr-254
(PubMed:26564476). Thr-167 should be phosphorylated and T170 and
S183 should be dephosphorylated to achieve light induction of
conidiation (PubMed:26564476). Phosphorylation of Ser-183 and Tyr-
254 influence sterigmatocystin production in a light-independent
manner (PubMed:26564476). Phosphorylation of Thr-167 and Thr-170
modulates expression of veA (PubMed:26564476).
{ECO:0000269|PubMed:18936976, ECO:0000269|PubMed:26564476}.
-!- DISRUPTION PHENOTYPE: Aboshes light-dependent conidiation,
allowing conidiation to occur in the dark (PubMed:2076818).
Impairs formation of sexual structures, even under conditions
where sexual development preferentially occurs (PubMed:12223191).
Alters the expression of the transcription factors nsdD, steA and
brlA, the penicillin biosynthetic genes ipnA and acvA, as well as
of the sterigmatocystin-specific regulatory gene aflR
(PubMed:14665453). {ECO:0000269|PubMed:12223191,
ECO:0000269|PubMed:14665453, ECO:0000269|PubMed:2076818}.
-!- SIMILARITY: Belongs to the velvet family. VeA subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CBF88249.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U95045; AAC26841.1; -; Genomic_DNA.
EMBL; AF109316; AAD42946.1; -; mRNA.
EMBL; AF335465; AAK21245.1; -; Genomic_DNA.
EMBL; BN001308; CBF88249.1; ALT_SEQ; Genomic_DNA.
STRING; 162425.CADANIAP00001588; -.
iPTMnet; C8VTV4; -.
EnsemblFungi; CADANIAT00001588; CADANIAP00001588; CADANIAG00001588.
InParanoid; C8VTV4; -.
OrthoDB; EOG092C1LNH; -.
Proteomes; UP000000560; Chromosome VIII.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 2.60.40.3960; -; 1.
InterPro; IPR021740; Velvet.
InterPro; IPR037525; Velvet_dom.
InterPro; IPR038491; Velvet_dom_sf.
PANTHER; PTHR33572; PTHR33572; 1.
Pfam; PF11754; Velvet; 2.
PROSITE; PS51821; VELVET; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Nucleus; Phosphoprotein;
Reference proteome; Sporulation; Transcription;
Transcription regulation.
CHAIN 1 573 Developmental and secondary metabolism
regulator veA.
/FTId=PRO_0000435759.
DOMAIN 27 230 Velvet. {ECO:0000255|PROSITE-
ProRule:PRU01165}.
REGION 459 498 PEST. {ECO:0000269|PubMed:26564476}.
MOTIF 41 46 Nuclear localization signal.
{ECO:0000305|PubMed:12223191}.
COMPBIAS 286 363 Pro-rich. {ECO:0000255|PROSITE-
ProRule:PRU00015}.
COMPBIAS 398 491 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
MOD_RES 167 167 Phosphothreonine.
{ECO:0000269|PubMed:26564476}.
MOD_RES 170 170 Phosphothreonine.
{ECO:0000269|PubMed:26564476}.
MOD_RES 183 183 Phosphoserine.
{ECO:0000269|PubMed:26564476}.
MOD_RES 254 254 Phosphotyrosine.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 167 167 T->E: Leads to strong light induction of
conidiation.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 167 167 T->V: Leads to loss of sterigmatocystin
production in darkness.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 170 170 T->E: Leads to an increase of
sterigmatocystin production in darkness.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 170 170 T->V: Leads to strong light induction of
conidiation.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 183 183 S->A: Leads to strong light induction of
conidiation.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 183 183 S->E: Leads to increased production of
sterigmatocystin in darkness and after
illumination.
{ECO:0000269|PubMed:26564476}.
MUTAGEN 254 254 Y->E,F: Leads to increased production of
sterigmatocystin in darkness and after
illumination.
{ECO:0000269|PubMed:26564476}.
SEQUENCE 573 AA; 63113 MW; 584C7639C5E8FC1D CRC64;
MATLAAPPPP LGESGNSNSV SRITREGKKI TYKLNIMQQP KRARACGQGS KSHTDRRPVD
PPPVIELNIF ESDPHDDSNK TDITFVYNAN FFLFATLEPE RPIATGKLMT NQGSPVLTGV
PVAGVAYLDK PNRAGYFIFP DLSVRNEGSY RFSFHLFEQI KDPKDATEGT QPMPSPVPGK
LSSPQEFLEF RLEVISNPFI VYSAKKFPGL TTSTPISRMI AEQGCRVRIR RDVRMRRRGD
KRTEDYDYDN ERGYNNRRPD QYAGSDAYAN APERPRSTSI STNMDPYSYP SRRPSAVEYG
QPIAQPYQRP MASTPAPSST PIPAPIPMPG PVALPPSTPS PASAHAPAPP SVPLAAPPPL
HTPSYQSHLS FGATQTQYPA PQLSHIPQQT TTPTHPYSPR SSISHSRNQS ISEYEPSMGY
PGSQTRLSAE RPSYGQPSQT TSLPPLRHSL EPSVNSRSKT PSNMITSLPP IQSLSELPST
TSQPSSAIGS SPANEPGPRL WETNSMLSKR TYEESFGHDD RPLYNGMRPD SESYPGGMQR
RPSYERSSLL DGPDQMAYKR ANGRMVSKPA TMR


Related products :

Catalog number Product name Quantity
28-027 COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (U 0.1 mg
28-869 COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (U 0.1 mg
28-026 COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (U 0.05 mg
EIAAB32876 11S regulator complex subunit beta,Activator of multicatalytic protease subunit 2,Homo sapiens,Human,PA28b,PA28beta,Proteasome activator 28 subunit beta,Proteasome activator complex subunit 2,PSME2,RE
EIAAB32871 11S regulator complex subunit alpha,Activator of multicatalytic protease subunit 1,Mouse,Mus musculus,PA28a,PA28alpha,Proteasome activator 28 subunit alpha,Proteasome activator complex subunit 1,Psme1
EIAAB32875 11S regulator complex subunit beta,Activator of multicatalytic protease subunit 2,Mouse,Mus musculus,PA28b,Pa28b1,PA28beta,Proteasome activator 28 subunit beta,Proteasome activator complex subunit 2,P
EIAAB32869 11S regulator complex subunit alpha,Activator of multicatalytic protease subunit 1,PA28a,PA28alpha,Proteasome activator 28 subunit alpha,Proteasome activator complex subunit 1,Psme1,Rat,Rattus norvegi
EIAAB32873 11S regulator complex subunit beta,Activator of multicatalytic protease subunit 2,PA28b,PA28beta,Proteasome activator 28 subunit beta,Proteasome activator complex subunit 2,Psme2,Rat,Rattus norvegicus
26-298 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. PSMD8 is a non-ATPase subunit of the 19S regulator. T 0.05 mg
EIAAB38858 BAF170,BAF170,BRG1-associated factor 170,Homo sapiens,Human,SMARCC2,SWI_SNF complex 170 kDa subunit,SWI_SNF complex subunit SMARCC2,SWI_SNF-related matrix-associated actin-dependent regulator of chrom
EIAAB38857 BAF155,BAF155,BRG1-associated factor 155,Homo sapiens,Human,SMARCC1,SWI_SNF complex 155 kDa subunit,SWI_SNF complex subunit SMARCC1,SWI_SNF-related matrix-associated actin-dependent regulator of chrom
EIAAB38859 BAF170,Baf170,BRG1-associated factor 170,Mouse,Mus musculus,Smarcc2,SWI_SNF complex 170 kDa subunit,SWI_SNF complex subunit SMARCC2,SWI_SNF-related matrix-associated actin-dependent regulator of chrom
EIAAB38856 BAF155,Baf155,BRG1-associated factor 155,Mouse,Mus musculus,Smarcc1,Srg3,SWI_SNF complex 155 kDa subunit,SWI_SNF complex subunit SMARCC1,SWI_SNF-related matrix-associated actin-dependent regulator of
EIAAB33312 Complex III subunit 8,Complex III subunit VIII,Cytochrome b-c1 complex subunit 8,Low molecular mass ubiquinone-binding protein,Qpc,Rat,Rattus norvegicus,Ubiquinol-cytochrome c reductase complex 9.5 kD
EIAAB33299 Complex III subunit 10,Complex III subunit XI,Cytochrome b-c1 complex subunit 10,Homo sapiens,Human,Ubiquinol-cytochrome c reductase complex 6.4 kDa protein,UQCR,UQCR11
EIAAB33310 Complex III subunit 7,Complex III subunit VII,Cytochrome b-c1 complex subunit 7,Homo sapiens,Human,QP-C,Ubiquinol-cytochrome c reductase complex 14 kDa protein,UQBP,UQCRB
EIAAB33300 Bos taurus,Bovine,Complex III subunit 10,Complex III subunit XI,Cytochrome b-c1 complex subunit 10,Ubiquinol-cytochrome c reductase complex 6.4 kDa protein,UQCR,UQCR11
EIAAB33298 Complex III subunit 10,Complex III subunit XI,Cytochrome b-c1 complex subunit 10,Mouse,Mus musculus,Ubiquinol-cytochrome c reductase complex 6.4 kDa protein,Uqcr,Uqcr11
25-029 PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. 0.05 mg
EIAAB10234 COB,Complex III subunit 3,Complex III subunit III,CYTB,Cytochrome b,Cytochrome b-c1 complex subunit 3,Homo sapiens,Human,MTCYB,MT-CYB,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
EIAAB33309 Complex III subunit 7,Complex III subunit VII,Cytochrome b-c1 complex subunit 7,Mouse,Mus musculus,Ubiquinol-cytochrome c reductase complex 14 kDa protein,Uqcrb
EIAAB33311 Bos taurus,Bovine,Complex III subunit 7,Complex III subunit VII,Cytochrome b-c1 complex subunit 7,QP-C,Ubiquinol-cytochrome c reductase complex 14 kDa protein,UQCRB
E0291h ELISA C1orf193,C1orf60,Homo sapiens,Human,Int3,Integrator complex subunit 3,INTS3,Sensor of single-strand DNA complex subunit A,Sensor of ssDNA subunit A,SOSS complex subunit A,SOSS-A 96T
E0291h ELISA kit C1orf193,C1orf60,Homo sapiens,Human,Int3,Integrator complex subunit 3,INTS3,Sensor of single-strand DNA complex subunit A,Sensor of ssDNA subunit A,SOSS complex subunit A,SOSS-A 96T
U0291h CLIA C1orf193,C1orf60,Homo sapiens,Human,Int3,Integrator complex subunit 3,INTS3,Sensor of single-strand DNA complex subunit A,Sensor of ssDNA subunit A,SOSS complex subunit A,SOSS-A 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur