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Developmental and secondary metabolism regulator veA (Velvet complex subunit A)

 VEA_ASPFU               Reviewed;         570 AA.
E9RCK4; Q4WSK1; Q6MYN4;
16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
05-APR-2011, sequence version 1.
20-JUN-2018, entry version 27.
RecName: Full=Developmental and secondary metabolism regulator veA {ECO:0000305};
AltName: Full=Velvet complex subunit A {ECO:0000305};
Name=veA {ECO:0000303|PubMed:16002655}; ORFNames=AFUA_1G12490;
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
A1100) (Aspergillus fumigatus).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=330879;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
PubMed=14998527; DOI=10.1016/j.fgb.2003.12.003;
Pain A., Woodward J.R., Quail M.A., Anderson M.J., Clark R.,
Collins M., Fosker N., Fraser A., Harris D.E., Larke N., Murphy L.D.,
Humphray S., O'Neil S., Pertea M., Price C., Rabbinowitsch E.,
Rajandream M.A., Salzberg S.L., Saunders D., Seeger K., Sharp S.,
Warren T., Denning D.W., Barrell B.G., Hall N.;
"Insight into the genome of Aspergillus fumigatus: analysis of a 922
kb region encompassing the nitrate assimilation gene cluster.";
Fungal Genet. Biol. 41:443-453(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
PubMed=16372009; DOI=10.1038/nature04332;
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
Machida M., Hall N., Barrell B.G., Denning D.W.;
"Genomic sequence of the pathogenic and allergenic filamentous fungus
Aspergillus fumigatus.";
Nature 438:1151-1156(2005).
[3]
DISRUPTION PHENOTYPE.
PubMed=16002655; DOI=10.1128/EC.4.7.1298-1307.2005;
Krappmann S., Bayram O., Braus G.H.;
"Deletion and allelic exchange of the Aspergillus fumigatus veA locus
via a novel recyclable marker module.";
Eukaryot. Cell 4:1298-1307(2005).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=23087369; DOI=10.1128/EC.00222-12;
Dhingra S., Andes D., Calvo A.M.;
"VeA regulates conidiation, gliotoxin production, and protease
activity in the opportunistic human pathogen Aspergillus fumigatus.";
Eukaryot. Cell 11:1531-1543(2012).
[5]
FUNCTION, DISRUPTION PHENOTYPE, AND IDENTIFICATION IN THE VELVET
COMPLEX.
PubMed=22970834; DOI=10.1111/mmi.12032;
Park H.S., Bayram O., Braus G.H., Kim S.C., Yu J.H.;
"Characterization of the velvet regulators in Aspergillus fumigatus.";
Mol. Microbiol. 86:937-953(2012).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=24116213; DOI=10.1371/journal.pone.0077147;
Dhingra S., Lind A.L., Lin H.C., Tang Y., Rokas A., Calvo A.M.;
"The fumagillin gene cluster, an example of hundreds of genes under
veA control in Aspergillus fumigatus.";
PLoS ONE 8:E77147-E77147(2013).
-!- FUNCTION: Component of the velvet transcription factor complex
that controls sexual/asexual developmental ratio in response to
light, promoting sexual development in the darkness while
stimulating asexual sporulation under illumination (By
similarity). The velvet complex hat acts as a global regulator for
secondary metabolite gene expression (By similarity). Controls the
expression of hundreds of genes, including those comprising more
than a dozen known secondary metabolite gene clusters
(PubMed:24116213). Controls the expression of the gliotoxin gene
cluster (PubMed:23087369). Controls the expression of the
fumagillin, fumitremorgin G, fumigaclavine C and glionitrin gene
clusters (PubMed:24116213). The regulation of the fumagillin gene
cluster and fumagillin production is performed through direct
control of the expression of fumR (PubMed:24116213). Negatively
regulates conidiation (PubMed:22970834, PubMed:23087369). Required
for normal protease activity (PubMed:23087369).
{ECO:0000250|UniProtKB:C8VTV4, ECO:0000269|PubMed:22970834,
ECO:0000269|PubMed:23087369, ECO:0000269|PubMed:24116213}.
-!- SUBUNIT: Component of the heterotrimeric velvet complex composed
of laeA, veA and velB; VeA acting as a bridging protein between
laeA and velB (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}.
Cytoplasm {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the
nucleus in the dark (By similarity).
{ECO:0000250|UniProtKB:C8VTV4}.
-!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
glutamic acid, serine and threonine residues that is required for
the light-dependent regulation of development and secondary
metabolism (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
-!- DISRUPTION PHENOTYPE: Reduces sporulation capacities on nitrate-
containing medium (PubMed:16002655). Results in the abundant
formation of conidiophores (PubMed:22970834). Leads to a reduction
of gliotoxin production (PubMed:23087369). Decreases the
production of fumagillin, fumitremorgin G, fumigaclavine C and
Glionitrin A (PubMed:24116213). Reduces also protease activity
(PubMed:23087369). {ECO:0000269|PubMed:16002655,
ECO:0000269|PubMed:22970834, ECO:0000269|PubMed:23087369,
ECO:0000269|PubMed:24116213}.
-!- SIMILARITY: Belongs to the velvet family. VeA subfamily.
{ECO:0000305}.
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EMBL; BX649605; CAE47975.1; -; Genomic_DNA.
EMBL; AAHF01000004; EAL90581.1; -; Genomic_DNA.
RefSeq; XP_752619.1; XM_747526.1.
SMR; E9RCK4; -.
EnsemblFungi; EAL90581; EAL90581; AFUA_1G12490.
GeneID; 3510437; -.
KEGG; afm:AFUA_1G12490; -.
EuPathDB; FungiDB:Afu1g12490; -.
HOGENOM; HOG000206350; -.
InParanoid; E9RCK4; -.
OMA; RDEMAYK; -.
OrthoDB; EOG092C1LNH; -.
Proteomes; UP000002530; Chromosome 1.
Proteomes; UP000002530; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IDA:AspGD.
GO; GO:0005634; C:nucleus; IDA:AspGD.
GO; GO:0043936; P:asexual sporulation resulting in formation of a cellular spore; IMP:AspGD.
GO; GO:0070787; P:conidiophore development; IMP:AspGD.
GO; GO:0070794; P:negative regulation of conidiophore development; IMP:AspGD.
GO; GO:0043942; P:negative regulation of sexual sporulation resulting in formation of a cellular spore; IMP:AspGD.
GO; GO:0043945; P:positive regulation of asexual sporulation resulting in formation of a cellular spore; IMP:AspGD.
GO; GO:1900691; P:positive regulation of gliotoxin biosynthetic process; IMP:AspGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0009847; P:spore germination; IMP:AspGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 2.60.40.3960; -; 1.
InterPro; IPR021740; Velvet.
InterPro; IPR037525; Velvet_dom.
InterPro; IPR038491; Velvet_dom_sf.
PANTHER; PTHR33572; PTHR33572; 2.
Pfam; PF11754; Velvet; 2.
PROSITE; PS51821; VELVET; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Nucleus; Reference proteome;
Sporulation; Transcription; Transcription regulation.
CHAIN 1 570 Developmental and secondary metabolism
regulator veA.
/FTId=PRO_0000435763.
DOMAIN 25 231 Velvet. {ECO:0000255|PROSITE-
ProRule:PRU01165}.
REGION 454 493 PEST. {ECO:0000250|UniProtKB:C8VTV4}.
MOTIF 39 44 Nuclear localization signal.
{ECO:0000250|UniProtKB:C8VTV4}.
COMPBIAS 354 465 Pro-rich. {ECO:0000255|PROSITE-
ProRule:PRU00015}.
SEQUENCE 570 AA; 63032 MW; 7A6A83213F422021 CRC64;
MATRPPLMPP ANETESSVSR ISREGKKITY KLSVMQQPER ARACGAGAKS SADRRPVDPP
PVVELRIFES DPNDDLHKTD ITFAYNANFF LFATLETARP MAQGRLTGPP TCPVLTGVPV
AGVAYLDRPQ QAGYFIFPDL SVRHEGRYRL SFHLYEEIKD IKDADKDTPM PDLNSSTNLT
KPSAPKAHLN FRLEVKSVPF TVYSAKKFPG LATSTSLSRI IAEQGCRVRI RRDVRMRRRG
EKRTDDYDFD DERAFATRSD RYTTPDMYAA NSAERARSTS ISTTADTSFP YGSDAQRRPS
AGDYGFQGAQ PYQRSMPAAS AAPAPAPVHS PATSAQTSSY QSHLSFGATQ SQYPAPQLPP
TPQSATPTNT YSPHPSYSHS RNPSNGTEYD ATSSGYPYPQ PRLPADRPSY SKAALPPLRL
EPPKAPNMQT STDSRSSDAN AYPTLSQPPV PRAPTPANHV TSLPPLKVLS GEYSHPSQPN
AQSPHHDLGS GKRLLWETNH TLSKRSHEET FGSDERPLHN GMRPDMDQYP SMGRKQPDYG
RLPFYTDSRD EMAYKRANGR MVMKILPALP


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