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Developmental pluripotency-associated protein 2 (Embryonic stem cell-associated transcript 15-2 protein) (ECAT15-2) (Pluripotent embryonic stem cell-related gene 1 protein)

 DPPA2_MOUSE             Reviewed;         301 AA.
Q9CWH0;
30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-JUN-2017, entry version 105.
RecName: Full=Developmental pluripotency-associated protein 2;
AltName: Full=Embryonic stem cell-associated transcript 15-2 protein;
Short=ECAT15-2;
AltName: Full=Pluripotent embryonic stem cell-related gene 1 protein;
Name=Dppa2; Synonyms=Phsecrg1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
PubMed=12620990; DOI=10.1242/dev.00366;
Bortvin A., Eggan K., Skaletsky H., Akutsu H., Berry D.L.,
Yanagimachi R., Page D.C., Jaenisch R.;
"Incomplete reactivation of Oct4-related genes in mouse embryos cloned
from somatic nuclei.";
Development 130:1673-1680(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=15583978;
Du J., Lin G., Nie Z.Y., Lu G.X.;
"Molecular cloning and characterization analysis of HPESCRG1, a novel
gene expressed specifically in human embryonic stem cell.";
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:542-547(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Blastocyst, Egg, and Embryonic stem cell;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
FUNCTION, INTERACTION WITH DPPA4, SUBCELLULAR LOCATION, DEVELOPMENTAL
STAGE, AND DISRUPTION PHENOTYPE.
PubMed=21896782; DOI=10.1128/MCB.05701-11;
Nakamura T., Nakagawa M., Ichisaka T., Shiota A., Yamanaka S.;
"Essential roles of ECAT15-2/Dppa2 in functional lung development.";
Mol. Cell. Biol. 31:4366-4378(2011).
-!- FUNCTION: Binds to target gene promoters, including NKX2-5 and
SYCE1, but not GATA4, and may be involved in the maintenance of
the active epigenetic status of these genes.
{ECO:0000269|PubMed:21896782}.
-!- SUBUNIT: Interacts with DPPA4. {ECO:0000269|PubMed:21896782}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21896782}.
-!- TISSUE SPECIFICITY: Not detected in adult tissues.
{ECO:0000269|PubMed:12620990}.
-!- DEVELOPMENTAL STAGE: Expressed in 4-cell embryo, morula and
blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc,
expressed in the primordial germ cells. Expression decreases at
12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is
restricted to testis. 6 days after birth, still detected in
primitive type A spermatogonia. Expressed in undifferentiated
embryonic stem cells, but expression rapidly decreases upon
differentiation. {ECO:0000269|PubMed:12620990,
ECO:0000269|PubMed:21896782}.
-!- DISRUPTION PHENOTYPE: Mutant animals show survival rates similar
to wild-type until 16.5 dpc. Then mortality increases and no
animals survive beyond weaning age. At 18.5 dpc, the lungs of
mutants mice show a thicker mesenchyme and smaller alveolar space
than those of wild-type animals. {ECO:0000269|PubMed:21896782}.
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EMBL; AF490346; AAO84504.1; -; mRNA.
EMBL; AY561246; AAS68013.1; -; mRNA.
EMBL; AK010743; BAB27153.1; -; mRNA.
EMBL; AK145760; BAE26632.1; -; mRNA.
EMBL; AK145645; BAE26562.1; -; mRNA.
EMBL; AK163375; BAE37324.1; -; mRNA.
EMBL; AK167211; BAE39338.1; -; mRNA.
CCDS; CCDS37350.1; -.
RefSeq; NP_082891.1; NM_028615.1.
UniGene; Mm.27857; -.
SMR; Q9CWH0; -.
STRING; 10090.ENSMUSP00000110183; -.
iPTMnet; Q9CWH0; -.
PhosphoSitePlus; Q9CWH0; -.
MaxQB; Q9CWH0; -.
PaxDb; Q9CWH0; -.
PRIDE; Q9CWH0; -.
Ensembl; ENSMUST00000097175; ENSMUSP00000110183; ENSMUSG00000072419.
GeneID; 73703; -.
KEGG; mmu:73703; -.
UCSC; uc007zjn.1; mouse.
CTD; 151871; -.
MGI; MGI:2157523; Dppa2.
eggNOG; ENOG410IJEN; Eukaryota.
eggNOG; ENOG4111ADR; LUCA.
GeneTree; ENSGT00390000004871; -.
HOGENOM; HOG000060113; -.
HOVERGEN; HBG095578; -.
InParanoid; Q9CWH0; -.
OMA; NDEVPPM; -.
OrthoDB; EOG091G0QL3; -.
PhylomeDB; Q9CWH0; -.
TreeFam; TF338129; -.
PRO; PR:Q9CWH0; -.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000072419; -.
CleanEx; MM_DPPA2; -.
ExpressionAtlas; Q9CWH0; baseline and differential.
Genevisible; Q9CWH0; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003682; F:chromatin binding; IDA:MGI.
GO; GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.
GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:MGI.
GO; GO:0031060; P:regulation of histone methylation; IMP:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0019827; P:stem cell population maintenance; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR025891; Dppa2/4_C_dom.
InterPro; IPR025892; Dppa2/4_central_dom.
Pfam; PF14047; DCR; 1.
Pfam; PF14049; Dppa2_A; 1.
1: Evidence at protein level;
Complete proteome; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 301 Developmental pluripotency-associated
protein 2.
/FTId=PRO_0000239264.
DOMAIN 85 119 SAP.
SEQUENCE 301 AA; 34116 MW; 3DAC9C0EE94984E8 CRC64;
MSYFGLETFN ENQSEENLDE ESVILTLVPF KEEEEPNTDY ATQSNVSSST LDHTPPARSL
VRHAGIKHPT RTIPSTCPPP SLPPIRDVSR NTLREWCRYH NLSTDGKKVE VYLRLRRHSY
SKQECYIPNT SREARMKQGP KKSKIVFRGI GPPSGCQRKK EESGVLEILT SPKESTFAAW
ARIAMRAAQS MSKNRCPLPS NVEAFLPQAT GSRWCVVHGR QLPADKKGWV RLQFLAGQTW
VPDTPQRMNF LFLLPACIIP EPGVEDNLLC PECVHSNKKI LRNFKIRSRA KKNALPPNMP
P


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