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Developmental pluripotency-associated protein 5A (mDppa5) (ES cell-associated transcript 2 protein) (Embryonal stem cell-specific gene 1 protein) (ESG-1) (Protein pH 34)

 DPA5A_MOUSE             Reviewed;         118 AA.
Q9CQS7;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 2.
25-OCT-2017, entry version 113.
RecName: Full=Developmental pluripotency-associated protein 5A;
Short=mDppa5;
AltName: Full=ES cell-associated transcript 2 protein;
AltName: Full=Embryonal stem cell-specific gene 1 protein;
Short=ESG-1;
AltName: Full=Protein pH 34;
Name=Dppa5a; Synonyms=Dppa5, Ecat2, Esg1, Ph34;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
PubMed=2044862; DOI=10.1111/j.1432-0436.1991.tb00866.x;
Astigiano S., Barkai U., Abarzua P., Tan S.C., Harper M.I.,
Sherman M.I.;
"Changes in gene expression following exposure of nulli-SCCl murine
embryonal carcinoma cells to inducers of differentiation:
characterization of a down-regulated mRNA.";
Differentiation 46:61-67(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
PubMed=12620990; DOI=10.1242/dev.00366;
Bortvin A., Eggan K., Skaletsky H., Akutsu H., Berry D.L.,
Yanagimachi R., Page D.C., Jaenisch R.;
"Incomplete reactivation of Oct4-related genes in mouse embryos cloned
from somatic nuclei.";
Development 130:1673-1680(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Blastocyst, and Embryonic stem cell;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryonic germ cell;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
DEVELOPMENTAL STAGE.
PubMed=8123591;
Bierbaum P., MacLean-Hunter S., Ehlert F., Moeroey T., Mueller R.;
"Cloning of embryonal stem cell-specific genes: characterization of
the transcriptionally controlled gene esg-1.";
Cell Growth Differ. 5:37-46(1994).
[6]
DEVELOPMENTAL STAGE.
PubMed=12466296; DOI=10.1101/gr.670002;
Tanaka T.S., Kunath T., Kimber W.L., Jaradat S.A., Stagg C.A.,
Usuda M., Yokota T., Niwa H., Rossant J., Ko M.S.;
"Gene expression profiling of embryo-derived stem cells reveals
candidate genes associated with pluripotency and lineage
specificity.";
Genome Res. 12:1921-1928(2002).
[7]
INDUCTION, AND DEVELOPMENTAL STAGE.
PubMed=15790765; DOI=10.1634/stemcells.2004-0245;
Kim S.-K., Suh M.R., Yoon H.S., Lee J.B., Oh S.K., Moon S.-Y.,
Moon S.H., Lee J.Y., Hwang J.H., Cho W.J., Kim K.-S.;
"Identification of developmental pluripotency associated 5 expression
in human pluripotent stem cells.";
Stem Cells 23:458-462(2005).
[8]
SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=16166252; DOI=10.1634/stemcells.2005-0146;
Western P., Maldonado-Saldivia J., van den Bergen J., Hajkova P.,
Saitou M., Barton S., Surani M.A.;
"Analysis of Esg1 expression in pluripotent cells and the germline
reveals similarities with Oct4 and Sox2 and differences between human
pluripotent cell lines.";
Stem Cells 23:1436-1442(2005).
[9]
FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
PubMed=16504174; DOI=10.1186/1471-213X-6-11;
Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M.,
Yamanaka S.;
"Identification and targeted disruption of the mouse gene encoding
ESG1 (PH34/ECAT2/DPPA5).";
BMC Dev. Biol. 6:11-11(2006).
[10]
SUBCELLULAR LOCATION, RNA-BINDING, AND DEVELOPMENTAL STAGE.
PubMed=16872451; DOI=10.1111/j.1440-169X.2006.00875.x;
Tanaka T.S., Lopez de Silanes I., Sharova L.V., Akutsu H.,
Yoshikawa T., Amano H., Yamanaka S., Gorospe M., Ko M.S.;
"Esg1, expressed exclusively in preimplantation embryos, germline, and
embryonic stem cells, is a putative RNA-binding protein with broad RNA
targets.";
Dev. Growth Differ. 48:381-390(2006).
[11]
IDENTIFICATION.
PubMed=17913455; DOI=10.1016/j.ygeno.2007.06.003;
Pierre A., Gautier M., Callebaut I., Bontoux M., Jeanpierre E.,
Pontarotti P., Monget P.;
"Atypical structure and phylogenomic evolution of the new eutherian
oocyte-and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.";
Genomics 90:583-594(2007).
-!- FUNCTION: Involved in the maintenance of embryonic stem (ES) cell
pluripotency. Dispensable for self-renewal of pluripotent ES cells
and establishment of germ cells. Associates with specific target
mRNAs. {ECO:0000269|PubMed:16504174}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16166252,
ECO:0000269|PubMed:16872451}.
-!- DEVELOPMENTAL STAGE: Pluripotent cell-specific. Expressed in
zygotes, cleavage-stage embryos and blastocysts, embryonic stem
(ES) and embryonic germ (EG) cells. Detected in both the
trophectoderm (TE) and inner cell mass (ICM) of blastocysts. More
abundant in the ICM than TE at 3.5 dpc blastocyst stage. Expressed
in primordial germ (PGC) cells from 10.5 to 13.5 dpc. Expressed in
developing gonads from 11.5 to 15.5 dpc. Progressively
undetectable in ovary from 13.5 to 15.5 dpc. Undetectable in
testis after 15.5 dpc. Not expressed in somatic cells at 13.5 dpc
(at protein level). Expressed in embryonic stem (ES) and embryonic
carcinoma (EC) cells. Not detected during the differentiation of
stem cells or midgestation embryos nor in neonatal tissues. Weakly
expressed or not detected in oocytes and fertilized eggs.
{ECO:0000269|PubMed:12466296, ECO:0000269|PubMed:12620990,
ECO:0000269|PubMed:15790765, ECO:0000269|PubMed:16166252,
ECO:0000269|PubMed:16504174, ECO:0000269|PubMed:16872451,
ECO:0000269|PubMed:8123591}.
-!- INDUCTION: Down-regulated by retinoic acid in embryonic carcinoma
(EC) cells and in developing germ cells.
{ECO:0000269|PubMed:15790765, ECO:0000269|PubMed:2044862}.
-!- DISRUPTION PHENOTYPE: Mice develop normally and are fertile. ES
cells derived from these mice demonstrate normal morphology,
proliferation and differentiation. {ECO:0000269|PubMed:16504174}.
-!- SIMILARITY: Belongs to the KHDC1 family. {ECO:0000305}.
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EMBL; AF490349; AAO84507.1; -; mRNA.
EMBL; AK010519; BAB27001.2; -; mRNA.
EMBL; AK010584; BAB27045.2; -; mRNA.
EMBL; AK145761; BAE26633.1; -; mRNA.
EMBL; BC092353; AAH92353.1; -; mRNA.
EMBL; BC092354; AAH92354.1; -; mRNA.
EMBL; BC095979; AAH95979.1; -; mRNA.
CCDS; CCDS23360.1; -.
PIR; A55058; A55058.
RefSeq; NP_079550.2; NM_025274.3.
UniGene; Mm.139314; -.
UniGene; Mm.440500; -.
ProteinModelPortal; Q9CQS7; -.
STRING; 10090.ENSMUSP00000071881; -.
iPTMnet; Q9CQS7; -.
PhosphoSitePlus; Q9CQS7; -.
REPRODUCTION-2DPAGE; Q9CQS7; -.
PaxDb; Q9CQS7; -.
PeptideAtlas; Q9CQS7; -.
PRIDE; Q9CQS7; -.
Ensembl; ENSMUST00000071991; ENSMUSP00000071881; ENSMUSG00000060461.
GeneID; 434423; -.
KEGG; mmu:434423; -.
UCSC; uc009qug.2; mouse.
CTD; 434423; -.
MGI; MGI:101800; Dppa5a.
eggNOG; ENOG410IZIS; Eukaryota.
eggNOG; ENOG4111AYN; LUCA.
GeneTree; ENSGT00390000011646; -.
HOGENOM; HOG000081506; -.
HOVERGEN; HBG107820; -.
InParanoid; Q9CQS7; -.
OMA; FAHISTW; -.
OrthoDB; EOG091G0VPR; -.
PhylomeDB; Q9CQS7; -.
TreeFam; TF338690; -.
PRO; PR:Q9CQS7; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000060461; -.
CleanEx; MM_DPPA5A; -.
Genevisible; Q9CQS7; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0003729; F:mRNA binding; IDA:MGI.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
CDD; cd12795; FILIA_N_like; 1.
Gene3D; 3.30.1370.10; -; 1.
InterPro; IPR036612; KH_dom_type_1_sf.
InterPro; IPR031952; MOEP19_KH-like.
Pfam; PF16005; MOEP19; 1.
SUPFAM; SSF54791; SSF54791; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Developmental protein;
Reference proteome; RNA-binding.
CHAIN 1 118 Developmental pluripotency-associated
protein 5A.
/FTId=PRO_0000311976.
DOMAIN 24 86 KH; atypical.
SEQUENCE 118 AA; 13810 MW; 30233CB5C536AC55 CRC64;
MMVTLVTRKD IPPWVKVPED LKDPEVFQVQ SLVLKYLFGP QGSRMSHIEQ VSQAMFELKN
LESPEELIEV FIYGSQNNKI RAKWMLQSMA ERYHLRQQKG VLKLEESMKT LELGQCIE


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