GENTAUR Molecular Products.

 DPA5A_MOUSE             Reviewed;         118 AA.
 Q9CQS7;
 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
 01-JUN-2003, sequence version 2.
 16-JAN-2019, entry version 116.
 RecName: Full=Developmental pluripotency-associated protein 5A;
          Short=mDppa5;
 AltName: Full=ES cell-associated transcript 2 protein;
 AltName: Full=Embryonal stem cell-specific gene 1 protein;
          Short=ESG-1;
 AltName: Full=Protein pH 34;
 Name=Dppa5a; Synonyms=Dppa5, Ecat2, Esg1, Ph34;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
 PubMed=2044862; DOI=10.1111/j.1432-0436.1991.tb00866.x;
 Astigiano S., Barkai U., Abarzua P., Tan S.C., Harper M.I.,
 Sherman M.I.;
 "Changes in gene expression following exposure of nulli-SCCl murine
 embryonal carcinoma cells to inducers of differentiation:
 characterization of a down-regulated mRNA.";
 Differentiation 46:61-67(1991).
 [2]
 NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
 PubMed=12620990; DOI=10.1242/dev.00366;
 Bortvin A., Eggan K., Skaletsky H., Akutsu H., Berry D.L.,
 Yanagimachi R., Page D.C., Jaenisch R.;
 "Incomplete reactivation of Oct4-related genes in mouse embryos cloned
 from somatic nuclei.";
 Development 130:1673-1680(2003).
 [3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 STRAIN=C57BL/6J; TISSUE=Blastocyst, and Embryonic stem cell;
 PubMed=16141072; DOI=10.1126/science.1112014;
 Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
 Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
 Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
 Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
 Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
 Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
 Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
 Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
 di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
 Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
 Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
 Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
 Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
 Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
 Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
 Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
 Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
 Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
 Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
 Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
 Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
 Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
 Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
 Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
 Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
 Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
 Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
 Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
 Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
 Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
 Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
 Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
 Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
 Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
 Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
 Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
 Hayashizaki Y.;
 "The transcriptional landscape of the mammalian genome.";
 Science 309:1559-1563(2005).
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 STRAIN=C57BL/6J; TISSUE=Embryonic germ cell;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 [5]
 DEVELOPMENTAL STAGE.
 PubMed=8123591;
 Bierbaum P., MacLean-Hunter S., Ehlert F., Moeroey T., Mueller R.;
 "Cloning of embryonal stem cell-specific genes: characterization of
 the transcriptionally controlled gene esg-1.";
 Cell Growth Differ. 5:37-46(1994).
 [6]
 DEVELOPMENTAL STAGE.
 PubMed=12466296; DOI=10.1101/gr.670002;
 Tanaka T.S., Kunath T., Kimber W.L., Jaradat S.A., Stagg C.A.,
 Usuda M., Yokota T., Niwa H., Rossant J., Ko M.S.;
 "Gene expression profiling of embryo-derived stem cells reveals
 candidate genes associated with pluripotency and lineage
 specificity.";
 Genome Res. 12:1921-1928(2002).
 [7]
 INDUCTION, AND DEVELOPMENTAL STAGE.
 PubMed=15790765; DOI=10.1634/stemcells.2004-0245;
 Kim S.-K., Suh M.R., Yoon H.S., Lee J.B., Oh S.K., Moon S.-Y.,
 Moon S.H., Lee J.Y., Hwang J.H., Cho W.J., Kim K.-S.;
 "Identification of developmental pluripotency associated 5 expression
 in human pluripotent stem cells.";
 Stem Cells 23:458-462(2005).
 [8]
 SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
 PubMed=16166252; DOI=10.1634/stemcells.2005-0146;
 Western P., Maldonado-Saldivia J., van den Bergen J., Hajkova P.,
 Saitou M., Barton S., Surani M.A.;
 "Analysis of Esg1 expression in pluripotent cells and the germline
 reveals similarities with Oct4 and Sox2 and differences between human
 pluripotent cell lines.";
 Stem Cells 23:1436-1442(2005).
 [9]
 FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
 PubMed=16504174; DOI=10.1186/1471-213X-6-11;
 Amano H., Itakura K., Maruyama M., Ichisaka T., Nakagawa M.,
 Yamanaka S.;
 "Identification and targeted disruption of the mouse gene encoding
 ESG1 (PH34/ECAT2/DPPA5).";
 BMC Dev. Biol. 6:11-11(2006).
 [10]
 SUBCELLULAR LOCATION, RNA-BINDING, AND DEVELOPMENTAL STAGE.
 PubMed=16872451; DOI=10.1111/j.1440-169X.2006.00875.x;
 Tanaka T.S., Lopez de Silanes I., Sharova L.V., Akutsu H.,
 Yoshikawa T., Amano H., Yamanaka S., Gorospe M., Ko M.S.;
 "Esg1, expressed exclusively in preimplantation embryos, germline, and
 embryonic stem cells, is a putative RNA-binding protein with broad RNA
 targets.";
 Dev. Growth Differ. 48:381-390(2006).
 [11]
 IDENTIFICATION.
 PubMed=17913455; DOI=10.1016/j.ygeno.2007.06.003;
 Pierre A., Gautier M., Callebaut I., Bontoux M., Jeanpierre E.,
 Pontarotti P., Monget P.;
 "Atypical structure and phylogenomic evolution of the new eutherian
 oocyte-and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.";
 Genomics 90:583-594(2007).
 -!- FUNCTION: Involved in the maintenance of embryonic stem (ES) cell
     pluripotency. Dispensable for self-renewal of pluripotent ES cells
     and establishment of germ cells. Associates with specific target
     mRNAs. {ECO:0000269|PubMed:16504174}.
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16166252,
     ECO:0000269|PubMed:16872451}.
 -!- DEVELOPMENTAL STAGE: Pluripotent cell-specific. Expressed in
     zygotes, cleavage-stage embryos and blastocysts, embryonic stem
     (ES) and embryonic germ (EG) cells. Detected in both the
     trophectoderm (TE) and inner cell mass (ICM) of blastocysts. More
     abundant in the ICM than TE at 3.5 dpc blastocyst stage. Expressed
     in primordial germ (PGC) cells from 10.5 to 13.5 dpc. Expressed in
     developing gonads from 11.5 to 15.5 dpc. Progressively
     undetectable in ovary from 13.5 to 15.5 dpc. Undetectable in
     testis after 15.5 dpc. Not expressed in somatic cells at 13.5 dpc
     (at protein level). Expressed in embryonic stem (ES) and embryonic
     carcinoma (EC) cells. Not detected during the differentiation of
     stem cells or midgestation embryos nor in neonatal tissues. Weakly
     expressed or not detected in oocytes and fertilized eggs.
     {ECO:0000269|PubMed:12466296, ECO:0000269|PubMed:12620990,
     ECO:0000269|PubMed:15790765, ECO:0000269|PubMed:16166252,
     ECO:0000269|PubMed:16504174, ECO:0000269|PubMed:16872451,
     ECO:0000269|PubMed:8123591}.
 -!- INDUCTION: Down-regulated by retinoic acid in embryonic carcinoma
     (EC) cells and in developing germ cells.
     {ECO:0000269|PubMed:15790765, ECO:0000269|PubMed:2044862}.
 -!- DISRUPTION PHENOTYPE: Mice develop normally and are fertile. ES
     cells derived from these mice demonstrate normal morphology,
     proliferation and differentiation. {ECO:0000269|PubMed:16504174}.
 -!- SIMILARITY: Belongs to the KHDC1 family. {ECO:0000305}.
 -----------------------------------------------------------------------
 Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 -----------------------------------------------------------------------
 EMBL; AF490349; AAO84507.1; -; mRNA.
 EMBL; AK010519; BAB27001.2; -; mRNA.
 EMBL; AK010584; BAB27045.2; -; mRNA.
 EMBL; AK145761; BAE26633.1; -; mRNA.
 EMBL; BC092353; AAH92353.1; -; mRNA.
 EMBL; BC092354; AAH92354.1; -; mRNA.
 EMBL; BC095979; AAH95979.1; -; mRNA.
 CCDS; CCDS23360.1; -.
 PIR; A55058; A55058.
 RefSeq; NP_079550.2; NM_025274.3.
 UniGene; Mm.139314; -.
 UniGene; Mm.440500; -.
 ProteinModelPortal; Q9CQS7; -.
 STRING; 10090.ENSMUSP00000071881; -.
 iPTMnet; Q9CQS7; -.
 PhosphoSitePlus; Q9CQS7; -.
 REPRODUCTION-2DPAGE; Q9CQS7; -.
 PaxDb; Q9CQS7; -.
 PeptideAtlas; Q9CQS7; -.
 PRIDE; Q9CQS7; -.
 Ensembl; ENSMUST00000071991; ENSMUSP00000071881; ENSMUSG00000060461.
 GeneID; 434423; -.
 KEGG; mmu:434423; -.
 UCSC; uc009qug.2; mouse.
 CTD; 434423; -.
 MGI; MGI:101800; Dppa5a.
 eggNOG; ENOG410IZIS; Eukaryota.
 eggNOG; ENOG4111AYN; LUCA.
 GeneTree; ENSGT00940000154353; -.
 HOGENOM; HOG000081506; -.
 HOVERGEN; HBG107820; -.
 InParanoid; Q9CQS7; -.
 OMA; FAHISTW; -.
 OrthoDB; 1502478at2759; -.
 PhylomeDB; Q9CQS7; -.
 TreeFam; TF338690; -.
 PRO; PR:Q9CQS7; -.
 Proteomes; UP000000589; Chromosome 9.
 Bgee; ENSMUSG00000060461; Expressed in 27 organ(s), highest expression level in embryonic stem cell.
 CleanEx; MM_DPPA5A; -.
 Genevisible; Q9CQS7; MM.
 GO; GO:0005737; C:cytoplasm; IDA:MGI.
 GO; GO:0003729; F:mRNA binding; IDA:MGI.
 GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
 GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
 CDD; cd12795; FILIA_N_like; 1.
 Gene3D; 3.30.1370.10; -; 1.
 InterPro; IPR036612; KH_dom_type_1_sf.
 InterPro; IPR031952; MOEP19_KH-like.
 Pfam; PF16005; MOEP19; 1.
 SUPFAM; SSF54791; SSF54791; 1.
 1: Evidence at protein level;
 Complete proteome; Cytoplasm; Developmental protein;
 Reference proteome; RNA-binding.
 CHAIN         1    118       Developmental pluripotency-associated
                              protein 5A.
                              /FTId=PRO_0000311976.
 DOMAIN       24     86       KH; atypical.
 SEQUENCE   118 AA;  13810 MW;  30233CB5C536AC55 CRC64;
 MMVTLVTRKD IPPWVKVPED LKDPEVFQVQ SLVLKYLFGP QGSRMSHIEQ VSQAMFELKN
 LESPEELIEV FIYGSQNNKI RAKWMLQSMA ERYHLRQQKG VLKLEESMKT LELGQCIE

Related products :