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DfrA5 (Dihydrofolate reductase) (EC 1.5.1.3) (Dihydrofolate reductase type V) (Trimethoprim-resistant dihydrofolate reductase DfrA1)

 Q546J2_ECOLX            Unreviewed;       157 AA.
Q546J2;
24-MAY-2005, integrated into UniProtKB/TrEMBL.
24-MAY-2005, sequence version 1.
07-NOV-2018, entry version 85.
SubName: Full=DfrA5 {ECO:0000313|EMBL:ACX70182.1};
SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:CAD11596.1};
EC=1.5.1.3 {ECO:0000313|EMBL:CAD11596.1};
SubName: Full=Dihydrofolate reductase type V {ECO:0000313|EMBL:ACT83768.1};
SubName: Full=Trimethoprim-resistant dihydrofolate reductase DfrA1 {ECO:0000313|EMBL:OOK22804.1};
SubName: Full=Trimethoprim-resistant dihydrofolate reductase DfrA5 {ECO:0000313|EMBL:RBX08417.1};
Name=dfrV {ECO:0000313|EMBL:CAD11596.1};
Synonyms=dfrA {ECO:0000313|EMBL:RBX08417.1},
dfrA5 {ECO:0000313|EMBL:ACL98091.1},
drfA5 {ECO:0000313|EMBL:AEC47396.1};
ORFNames=BMT91_25905 {ECO:0000313|EMBL:OOK22804.1},
DS980_26295 {ECO:0000313|EMBL:RBX08417.1},
DTL41_27680 {ECO:0000313|EMBL:RCY11478.1},
DTM10_28610 {ECO:0000313|EMBL:RCZ41464.1};
Escherichia coli.
Plasmid pO111-CRL-115 {ECO:0000313|EMBL:AGW45026.1}, and
Plasmid pO26-CRL-125 {ECO:0000313|EMBL:AGW45160.1}.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=562 {ECO:0000313|EMBL:CAD11596.1};
[1] {ECO:0000313|EMBL:CAD11596.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Vy2a {ECO:0000313|EMBL:CAD11596.1};
Schwarz S.P.;
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:CAD11596.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Vy2a {ECO:0000313|EMBL:CAD11596.1};
PubMed=12493806; DOI=10.1093/jac/dkf253;
Waturangi D.E., Suwanto A., Schwarz S., Erdelen W.;
"Identification of class 1 integrons-associated gene cassettes in
Escherichia coli isolated from Varanus spp. in Indonesia.";
J. Antimicrob. Chemother. 51:175-177(2003).
[3] {ECO:0000313|EMBL:BAD99255.1}
NUCLEOTIDE SEQUENCE.
STRAIN=831 {ECO:0000313|EMBL:BAD99255.1};
Fujihara K., Ramamurthy T., Yamasaki S.;
"Direct Submission.";
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ACL98091.1}
NUCLEOTIDE SEQUENCE.
STRAIN=EC_423-1 {ECO:0000313|EMBL:ACL98091.1};
Laroche E., Pawlak B., Berthe T., Skurnik D., Petit F.;
"Occurrence of antibiotic resistance and class 1, 2 and 3 integrons in
Escherichia coli isolated from a densely populated estuary (Seine,
France).";
FEMS Microbiol. Ecol. 68:118-130(2009).
[5] {ECO:0000313|EMBL:ACX70182.1}
NUCLEOTIDE SEQUENCE.
STRAIN=K-202 {ECO:0000313|EMBL:ACX70182.1};
Pryamchuk S.D., Fursova N.K., Abaev I.V., Pecherskikh E.I.,
Shishkova N.A., Korobova O.V.;
"Escherichia coli variable region of class 1 integron containing dfrA5
and ereA2 cassettes.";
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:ACT83768.1}
NUCLEOTIDE SEQUENCE.
STRAIN=59 {ECO:0000313|EMBL:ACT83775.1}, and
D22 {ECO:0000313|EMBL:ACT83768.1};
PubMed=20856797; DOI=10.1371/journal.pone.0012754;
Dawes F.E., Kuzevski A., Bettelheim K.A., Hornitzky M.A.,
Djordjevic S.P., Walker M.J.;
"Distribution of class 1 integrons with IS26-mediated deletions in
their 3'-conserved segments in Escherichia coli of human and animal
origin.";
PLoS ONE 5:E12754-E12754(2010).
[7] {ECO:0000313|EMBL:AEC47396.1}
NUCLEOTIDE SEQUENCE.
STRAIN=NF707518 {ECO:0000313|EMBL:AEC47472.1}, and
NF908182 {ECO:0000313|EMBL:AEC47396.1};
Wu K., Wang F., Sun J., Rui Y.;
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:AGW45026.1}
NUCLEOTIDE SEQUENCE.
PLASMID=pO111-CRL-115 {ECO:0000313|EMBL:AGW45026.1}, and
pO26-CRL-125 {ECO:0000313|EMBL:AGW45160.1};
PubMed=24223859;
Venturini C., Hassan K.A., Roy Chowdhury P., Paulsen I.T.,
Walker M.J., Djordjevic S.P.;
"Sequences of Two Related Multiple Antibiotic Resistance Virulence
Plasmids Sharing a Unique IS26-Related Molecular Signature Isolated
from Different Escherichia coli Pathotypes from Different Hosts.";
PLoS ONE 8:E78862-E78862(2013).
[9] {ECO:0000313|EMBL:AHB39761.1}
NUCLEOTIDE SEQUENCE.
STRAIN=1260183 {ECO:0000313|EMBL:AHB39761.1};
Christopher M.A.;
"Integrons & their impact on the mobility of antibiotic resistance in
clinical environments.";
Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AIV43491.1}
NUCLEOTIDE SEQUENCE.
STRAIN=APp10310_3_26.1 {ECO:0000313|EMBL:AIV43491.1};
Ramos Madrigal J., Vinuesa P.;
"Distribution and prevalence of antibiotic resistant Enterobacteria in
two rivers sharing the same origin but contrasting degree of
contamination.";
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
[11] {ECO:0000313|EMBL:AIM47175.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BMO 645 {ECO:0000313|EMBL:AIM47175.1};
PubMed=25167818;
Kotlarska E., Luczkiewicz A., Pisowacka M., Burzynski A.;
"Antibiotic resistance and prevalence of class 1 and 2 integrons in
Escherichia coli isolated from two wastewater treatment plants, and
their receiving waters (Gulf of Gdansk, Baltic Sea, Poland).";
Environ. Sci. Pollut. Res. Int. 0:0-0(2014).
[12] {ECO:0000313|EMBL:AGW45026.1}
NUCLEOTIDE SEQUENCE.
PLASMID=pO111-CRL-115 {ECO:0000313|EMBL:AGW45026.1}, and
pO26-CRL-125 {ECO:0000313|EMBL:AGW45160.1};
Venturini C., Bhattacharya P., Hassan K.A., Paulsen I.T., Walker M.J.,
Djordjevic S.P.;
"Derivate Tn3 family transposons play a central role in the evolution
of multiple antibiotic resistance on virulence plasmids in
enterohemorrhagic Escherichia coli.";
Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
[13] {ECO:0000313|EMBL:ALL53120.1}
NUCLEOTIDE SEQUENCE.
STRAIN=D2S {ECO:0000313|EMBL:ALL53120.1}, and
G30 {ECO:0000313|EMBL:ALL53122.1};
PubMed=26483759; DOI=10.3389/fmicb.2015.00977;
Ghaderpour A., Ho W.S., Chew L.L., Bong C.W., Chong V.C., Thong K.L.,
Chai L.C.;
"Diverse and abundant multi-drug resistant E. coli in Matang mangrove
estuaries, Malaysia.";
Front. Microbiol. 6:977-977(2015).
[14] {ECO:0000313|EMBL:OOK22804.1, ECO:0000313|Proteomes:UP000188855}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2.3-R4 {ECO:0000313|EMBL:OOK22804.1,
ECO:0000313|Proteomes:UP000188855};
Moran R.A., Anantham S., Nigro S.J., Holt K.E., Hall R.M.;
"Whole genome sequences of antibiotic resistant commensal Escherichia
coli from healthy Australian adults.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[15] {ECO:0000313|Proteomes:UP000252138, ECO:0000313|Proteomes:UP000252576, ECO:0000313|Proteomes:UP000253589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AVC154 {ECO:0000313|EMBL:RCZ41464.1,
ECO:0000313|Proteomes:UP000252138},
AVC209 {ECO:0000313|EMBL:RCY11478.1,
ECO:0000313|Proteomes:UP000253589}, and
AVC65 {ECO:0000313|EMBL:RBX08417.1,
ECO:0000313|Proteomes:UP000252576};
Cummins M.L., Reid C.J., Roy Chowdhury P., Bushell R., Esbert N.,
Tivendale K.A., Noormohammadi A.H., Islam S., Marenda M.S.,
Browning G.F., Markham P.F., Djordjevic S.P.;
"Whole Genome Sequence Analysis of Avian Pathogenic E. coli - An
Australian Perspective.";
Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the dihydrofolate reductase family.
{ECO:0000256|RuleBase:RU004474}.
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EMBL; FJ591050; ACL98091.1; -; Genomic_DNA.
EMBL; EU914098; ACT83768.1; -; Genomic_DNA.
EMBL; EU914100; ACT83775.1; -; Genomic_DNA.
EMBL; GQ924768; ACX70182.1; -; Genomic_DNA.
EMBL; HQ880248; AEC47396.1; -; Genomic_DNA.
EMBL; HQ880285; AEC47472.1; -; Genomic_DNA.
EMBL; KC340959; AGW45026.1; -; Genomic_DNA.
EMBL; KC340960; AGW45160.1; -; Genomic_DNA.
EMBL; KF534912; AHB39761.1; -; Genomic_DNA.
EMBL; KJ192426; AIM47175.1; -; Genomic_DNA.
EMBL; KF914303; AIV43491.1; -; Genomic_DNA.
EMBL; KR952341; ALL53120.1; -; Genomic_DNA.
EMBL; KR952343; ALL53122.1; -; Genomic_DNA.
EMBL; AB188269; BAD99255.1; -; Genomic_DNA.
EMBL; AJ419169; CAD11596.1; -; Genomic_DNA.
EMBL; MPAF01000117; OOK22804.1; -; Genomic_DNA.
EMBL; QODV01000074; RBX08417.1; -; Genomic_DNA.
EMBL; QOFM01000097; RCY11478.1; -; Genomic_DNA.
EMBL; QOGI01000085; RCZ41464.1; -; Genomic_DNA.
RefSeq; WP_001317507.1; NZ_UIMZ01000083.1.
RefSeq; YP_008864016.1; NC_022992.1.
RefSeq; YP_008864683.1; NC_022996.1.
GeneID; 17824297; -.
GeneID; 17824432; -.
PATRIC; fig|562.7000.peg.5597; -.
Proteomes; UP000188855; Unassembled WGS sequence.
Proteomes; UP000252138; Unassembled WGS sequence.
Proteomes; UP000252576; Unassembled WGS sequence.
Proteomes; UP000253589; Unassembled WGS sequence.
GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
GO; GO:0050661; F:NADP binding; IEA:InterPro.
GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
CDD; cd00209; DHFR; 1.
Gene3D; 3.40.430.10; -; 1.
InterPro; IPR012259; DHFR.
InterPro; IPR024072; DHFR-like_dom_sf.
InterPro; IPR017925; DHFR_CS.
InterPro; IPR001796; DHFR_dom.
PANTHER; PTHR22778:SF16; PTHR22778:SF16; 1.
Pfam; PF00186; DHFR_1; 1.
SUPFAM; SSF53597; SSF53597; 1.
PROSITE; PS00075; DHFR_1; 1.
PROSITE; PS51330; DHFR_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000188855,
ECO:0000313|Proteomes:UP000252138, ECO:0000313|Proteomes:UP000252576,
ECO:0000313|Proteomes:UP000253589};
Oxidoreductase {ECO:0000313|EMBL:CAD11596.1};
Plasmid {ECO:0000313|EMBL:AGW45026.1}.
DOMAIN 2 156 DHFR. {ECO:0000259|PROSITE:PS51330}.
SEQUENCE 157 AA; 17531 MW; 04B968163A25EFF4 CRC64;
MKVSLMAAKA KNGVIGCGPH IPWSAKGEQL LFKALTYNQW LLVGRKTFES MGALPNRKYA
VVTRSAWTAD NDNVIVFPSI EEAMYGLAEL TDHVIVSGGG EIYRETLPMA STLHISTIDI
EPEGDVFFPN IPNTFEVVFE QHFSSNINYC YQIWQKG


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