Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)

 DBLOH_MOUSE             Reviewed;         237 AA.
Q9JIQ3; Q542V8; Q9CZD1; Q9DCD3;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
07-NOV-2018, entry version 146.
RecName: Full=Diablo homolog, mitochondrial;
AltName: Full=Direct IAP-binding protein with low pI;
AltName: Full=Second mitochondria-derived activator of caspase;
Short=Smac;
Flags: Precursor;
Name=Diablo; Synonyms=Smac;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
STRAIN=BALB/cJ; TISSUE=Kidney;
PubMed=10929712; DOI=10.1016/S0092-8674(00)00009-X;
Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M.,
Reid G.E., Moritz R.L., Simpson R.J., Vaux D.L.;
"Identification of DIABLO, a mammalian protein that promotes apoptosis
by binding to and antagonizing IAP proteins.";
Cell 102:43-53(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
INTERACTION WITH BEX3.
PubMed=15178455; DOI=10.1016/j.bbrc.2004.05.043;
Yoon K., Jang H.D., Lee S.Y.;
"Direct interaction of Smac with NADE promotes TRAIL-induced
apoptosis.";
Biochem. Biophys. Res. Commun. 319:649-654(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Promotes apoptosis by activating caspases in the
cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the
inhibitory activity of inhibitor of apoptosis proteins (IAP).
Inhibits the activity of BIRC6/bruce by inhibiting its binding to
caspases (By similarity). {ECO:0000250,
ECO:0000269|PubMed:10929712}.
-!- SUBUNIT: Homodimer. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2,
XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Interacts with the
monomeric and dimeric form of BIRC5/survivin (By similarity).
Interacts with BEX3. {ECO:0000250, ECO:0000269|PubMed:15178455}.
-!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10929712}.
Note=Released into the cytosol when cells undergo apoptosis.
-!- TISSUE SPECIFICITY: Highest expression found in heart, liver,
kidney and testis. {ECO:0000269|PubMed:10929712}.
-!- DOMAIN: The mature N-terminus mediates interaction with
XIAP/BIRC4. {ECO:0000250}.
-!- PTM: Ubiquitinated by BIRC7/livin. {ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF203914; AAF82190.1; -; mRNA.
EMBL; AK012760; BAB28450.1; -; mRNA.
EMBL; AK002887; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AK077198; BAC36676.1; -; mRNA.
EMBL; AK133194; BAE21552.1; -; mRNA.
EMBL; AC157931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS39270.1; -.
RefSeq; NP_075721.3; NM_023232.3.
UniGene; Mm.46716; -.
ProteinModelPortal; Q9JIQ3; -.
SMR; Q9JIQ3; -.
BioGrid; 211579; 2.
IntAct; Q9JIQ3; 2.
MINT; Q9JIQ3; -.
STRING; 10090.ENSMUSP00000107214; -.
iPTMnet; Q9JIQ3; -.
PhosphoSitePlus; Q9JIQ3; -.
EPD; Q9JIQ3; -.
MaxQB; Q9JIQ3; -.
PaxDb; Q9JIQ3; -.
PeptideAtlas; Q9JIQ3; -.
PRIDE; Q9JIQ3; -.
Ensembl; ENSMUST00000111587; ENSMUSP00000107214; ENSMUSG00000029433.
Ensembl; ENSMUST00000125652; ENSMUSP00000115045; ENSMUSG00000029433.
GeneID; 66593; -.
KEGG; mmu:66593; -.
UCSC; uc008znx.1; mouse.
CTD; 56616; -.
MGI; MGI:1913843; Diablo.
eggNOG; ENOG410IHTM; Eukaryota.
eggNOG; ENOG4111KJ0; LUCA.
GeneTree; ENSGT00390000007237; -.
HOGENOM; HOG000217916; -.
HOVERGEN; HBG051315; -.
InParanoid; Q9JIQ3; -.
KO; K10522; -.
OMA; DAVWQVI; -.
OrthoDB; EOG091G0L3E; -.
PhylomeDB; Q9JIQ3; -.
TreeFam; TF102048; -.
Reactome; R-MMU-111457; Release of apoptotic factors from the mitochondria.
Reactome; R-MMU-111463; SMAC binds to IAPs.
Reactome; R-MMU-111464; SMAC-mediated dissociation of IAP:caspase complexes.
ChiTaRS; Diablo; mouse.
PRO; PR:Q9JIQ3; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000029433; Expressed in 276 organ(s), highest expression level in testis.
CleanEx; MM_DIABLO; -.
ExpressionAtlas; Q9JIQ3; baseline and differential.
Genevisible; Q9JIQ3; MM.
GO; GO:0035631; C:CD40 receptor complex; IDA:BHF-UCL.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:BHF-UCL.
GO; GO:0005758; C:mitochondrial intermembrane space; ISO:MGI.
GO; GO:0005739; C:mitochondrion; IDA:MGI.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:MGI.
GO; GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:UniProtKB.
GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IDA:MGI.
GO; GO:0051402; P:neuron apoptotic process; IDA:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
InterPro; IPR009062; Smac/DIABLO-like_sf.
InterPro; IPR015142; Smac_DIABLO.
PANTHER; PTHR32247; PTHR32247; 1.
Pfam; PF09057; Smac_DIABLO; 1.
SUPFAM; SSF46984; SSF46984; 1.
1: Evidence at protein level;
Apoptosis; Complete proteome; Mitochondrion; Phosphoprotein;
Reference proteome; Transit peptide; Ubl conjugation.
TRANSIT 1 53 Mitochondrion. {ECO:0000250}.
CHAIN 54 237 Diablo homolog, mitochondrial.
/FTId=PRO_0000021073.
MOTIF 54 58 IAP-binding. {ECO:0000255}.
MOD_RES 222 222 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CONFLICT 64 64 Q -> H (in Ref. 1; AAF82190).
{ECO:0000305}.
SEQUENCE 237 AA; 26820 MW; 6961A7E76C780AC5 CRC64;
MAALRSWVTR SVCSLFRYRQ RFPVLANSKK RCFSELIKPW HKTVLTGFGM TLCAVPIAQK
SEPQSLSNEA LMRRAVSLVT DSTSTFLSQT TYALIEAITE YTKAVYTLVS LYRQYTSLLG
KMNSQEEDEV WQVIIGARVE MTSKQQEYLK LETTWMTAVG LSEMAAEAAY QTGADQASIT
ARNHIQLVKS QVQEVRQLSQ KAETKLAEAQ TKELHQKAQE VSDEGADQEE EAYLRED


Related products :

Catalog number Product name Quantity
EIAAB10476 Diablo,Diablo homolog, mitochondrial,Direct IAP-binding protein with low pI,Mouse,Mus musculus,Second mitochondria-derived activator of caspase,Smac,Smac
EIAAB10477 DIABLO,Diablo homolog, mitochondrial,Direct IAP-binding protein with low pI,Homo sapiens,Human,Second mitochondria-derived activator of caspase,Smac,SMAC
18-661-15112 Diablo homolog. mitochondrial - Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI Polyclonal 0.1 mg
18-661-15111 Diablo homolog. mitochondrial - Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI Polyclonal 0.1 mg
18-272-195968 Smac _ Diablo - Rabbit polyclonal to Smac _ Diablo; Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI Polyclonal 0.1 mg
18-272-195275 Smac _ Diablo - Rabbit polyclonal to Smac _ Diablo; Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI Polyclonal 0.05 mg
18-272-197105 Smac - Rabbit polyclonal to Smac; Second mitochondria-derived activator of caspase; Smac protein; Direct IAP-binding protein with low pI Polyclonal 1 ml
GWB-F49F64 Second Mitochondria-derived Activator Of Caspase (SMAC DIABLO) Rabbit anti-Mouse Polyclonal (aa222-237) Antibody
H-6656.0001 Smac_N7 Peptide Salt Trifluoroacetate Binding _ Synonym Mitochondrial Diablo Homolog (1_7) (human, mouse), Second Mitochondria_derived Activator of Caspase (1_7) (human, mouse), Smac Protein (1_7) 1.0 mg
H-6656.0005 Smac_N7 Peptide Salt Trifluoroacetate Binding _ Synonym Mitochondrial Diablo Homolog (1_7) (human, mouse), Second Mitochondria_derived Activator of Caspase (1_7) (human, mouse), Smac Protein (1_7) 5.0 mg
H-6656.0001 Smac_N7 Peptide Salt Trifluoroacetate Binding _ Synonym Mitochondrial Diablo Homolog (1_7) (human, mouse), Second Mitochondria_derived Activator of Caspase (1_7) (human, mouse), Smac Protein (1_7) 1.0 mg
H-6656.0005 Smac_N7 Peptide Salt Trifluoroacetate Binding _ Synonym Mitochondrial Diablo Homolog (1_7) (human, mouse), Second Mitochondria_derived Activator of Caspase (1_7) (human, mouse), Smac Protein (1_7) 5.0 mg
E02S0013 Rat Second mitochondrial-derived activator of caspase ELISA , Smac 96 Tests/kit
E02S0013 Rat Second mitochondrial-derived activator of caspase ELISA , Smac
E09S0013 Monkey Second mitochondrial-derived activator of caspase ELISA , Smac
E07S0013 Porcine Second mitochondrial-derived activator of caspase ELISA , Smac
E11S0013 Bovine Second mitochondrial-derived activator of caspase ELISA , Smac
E06S0013 Goat Second mitochondrial-derived activator of caspase ELISA , Smac
E05S0013 Guinea pig Second mitochondrial-derived activator of caspase ELISA , Smac
E04S0013 Rabbit Second mitochondrial-derived activator of caspase ELISA , Smac 96 Tests/kit
E07S0013 Porcine Second mitochondrial-derived activator of caspase ELISA , Smac 96 Tests/kit
E12S0013 Chicken Second mitochondrial-derived activator of caspase ELISA , Smac 96 Tests/kit
E08S0013 Canine Second mitochondrial-derived activator of caspase ELISA , Smac 96 Tests/kit
E01S0013 Human Second mitochondrial-derived activator of caspase ELISA , Smac
E08S0013 Canine Second mitochondrial-derived activator of caspase ELISA , Smac


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur