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Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac protein) (XSmac)

 DBLOH_XENLA             Reviewed;         244 AA.
A4GZV0;
07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
01-MAY-2007, sequence version 1.
22-NOV-2017, entry version 36.
RecName: Full=Diablo homolog, mitochondrial {ECO:0000250|UniProtKB:Q9NR28, ECO:0000303|PubMed:17336467};
AltName: Full=Direct IAP-binding protein with low pI {ECO:0000250|UniProtKB:Q9NR28};
AltName: Full=Second mitochondria-derived activator of caspase {ECO:0000250|UniProtKB:Q9NR28};
Short=Smac protein {ECO:0000312|EMBL:CAJ19268.1};
Short=XSmac {ECO:0000303|PubMed:17336467};
Flags: Precursor;
Name=diablo; Synonyms=smac {ECO:0000312|EMBL:CAJ19268.1};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000312|EMBL:CAJ19268.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=17336467; DOI=10.1016/j.gene.2006.12.010;
Montesanti A., Deignan K., Hensey C.;
"Cloning and characterization of Xenopus laevis Smac/DIABLO.";
Gene 392:187-195(2007).
-!- FUNCTION: Acts by opposing the inhibitory activity of inhibitor of
apoptosis proteins (IAP) (By similarity). Promotes apoptosis.
{ECO:0000250, ECO:0000269|PubMed:17336467}.
-!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9NR28}.
-!- SUBCELLULAR LOCATION: Mitochondrion
{ECO:0000250|UniProtKB:Q9NR28}. Note=Released into the cytosol
when cells undergo apoptosis. {ECO:0000250|UniProtKB:Q9NR28}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed throughout embryonic development.
{ECO:0000269|PubMed:17336467}.
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EMBL; AM050817; CAJ19268.1; -; mRNA.
RefSeq; NP_001091439.1; NM_001097970.1.
UniGene; Xl.76004; -.
ProteinModelPortal; A4GZV0; -.
SMR; A4GZV0; -.
GeneID; 100049147; -.
KEGG; xla:100049147; -.
CTD; 100049147; -.
Xenbase; XB-GENE-5915587; diablo.
KO; K10522; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
InterPro; IPR009062; Smac/DIABLO-like_sf.
InterPro; IPR015142; Smac_DIABLO.
PANTHER; PTHR32247; PTHR32247; 1.
Pfam; PF09057; Smac_DIABLO; 1.
SUPFAM; SSF46984; SSF46984; 1.
2: Evidence at transcript level;
Apoptosis; Mitochondrion; Transit peptide.
TRANSIT 1 57 Mitochondrion. {ECO:0000255}.
CHAIN 58 244 Diablo homolog, mitochondrial.
{ECO:0000255}.
/FTId=PRO_0000379493.
MOTIF 50 54 IAP-binding. {ECO:0000255}.
SEQUENCE 244 AA; 26969 MW; 1E4039ED8AB3B674 CRC64;
MASLPRRLLW SVSYIVRESF PIVSKRNCVS LLQGSWRKVL SVGVGTSLCA IPVGQRSEPT
LSSESLIKRA ASLVADSSST FLSQTTYALV ESLTEYTTAV YTLISLQQKY SSLLDKINSN
EESAIWQVII GARVQINQLK EQYMKYESSW QRAVSLSEMA AEAAYQSGAD QASMTVRNHI
QIVQTQVQGA RDQAHMAEVQ LAASQTEEIK RTITEDKGNP PSGGSPRNSL SEEEDIPEAY
LRED


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