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Dihydrofolate reductase (EC 1.5.1.3)

 A0A0N9NL43_AERSO        Unreviewed;       165 AA.
A0A0N9NL43;
20-JAN-2016, integrated into UniProtKB/TrEMBL.
20-JAN-2016, sequence version 1.
05-DEC-2018, entry version 13.
RecName: Full=Dihydrofolate reductase {ECO:0000256|PIRNR:PIRNR000194};
EC=1.5.1.3 {ECO:0000256|PIRNR:PIRNR000194};
Aeromonas sobria.
Plasmid pASCH21 {ECO:0000313|EMBL:ALG88032.1}.
Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
Aeromonadaceae; Aeromonas.
NCBI_TaxID=646 {ECO:0000313|EMBL:ALG88032.1};
[1] {ECO:0000313|EMBL:ALG88032.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ASCH21 {ECO:0000313|EMBL:ALG88032.1};
PLASMID=pASCH21 {ECO:0000313|EMBL:ALG88032.1};
Dolejska M., Dobiasova H.;
"Complete sequences of IncU plasmids harbouring quinolone resistance
genes qnrS2 and aac(6')-Ib-cr in Aeromonas spp. from ornamental
fish.";
Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Key enzyme in folate metabolism. Catalyzes an essential
reaction for de novo glycine and purine synthesis, and for DNA
precursor synthesis. {ECO:0000256|PIRNR:PIRNR000194}.
-!- CATALYTIC ACTIVITY:
Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-
dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009,
ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453,
ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3;
Evidence={ECO:0000256|PIRNR:PIRNR000194};
-!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis;
5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
{ECO:0000256|PIRNR:PIRNR000194}.
-!- SIMILARITY: Belongs to the dihydrofolate reductase family.
{ECO:0000256|PIRNR:PIRNR000194, ECO:0000256|RuleBase:RU004474}.
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EMBL; KT315928; ALG88032.1; -; Genomic_DNA.
UniPathway; UPA00077; UER00158.
GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
GO; GO:0050661; F:NADP binding; IEA:InterPro.
GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
CDD; cd00209; DHFR; 1.
Gene3D; 3.40.430.10; -; 1.
InterPro; IPR012259; DHFR.
InterPro; IPR024072; DHFR-like_dom_sf.
InterPro; IPR017925; DHFR_CS.
InterPro; IPR001796; DHFR_dom.
PANTHER; PTHR22778:SF16; PTHR22778:SF16; 1.
Pfam; PF00186; DHFR_1; 1.
PIRSF; PIRSF000194; DHFR; 1.
SUPFAM; SSF53597; SSF53597; 1.
PROSITE; PS00075; DHFR_1; 1.
PROSITE; PS51330; DHFR_2; 1.
3: Inferred from homology;
NADP {ECO:0000256|PIRNR:PIRNR000194};
One-carbon metabolism {ECO:0000256|PIRNR:PIRNR000194};
Oxidoreductase {ECO:0000256|PIRNR:PIRNR000194};
Plasmid {ECO:0000313|EMBL:ALG88032.1}.
DOMAIN 7 162 DHFR. {ECO:0000259|PROSITE:PS51330}.
SEQUENCE 165 AA; 17755 MW; F89CD5BFF7902BD4 CRC64;
MNPESVRIYL VAAMGANRVI GNGPDIPWNI PGEQKIFRRL TEGKVVVMGR KTFESIGKPL
PNRRTVVLSR QASYSAAGCA VVSTLSQAIA IAAEHGKELY VAGGAEVYAL ALPRADGVFL
SEVHQTFEGD AFFPVLDAAE FDVVSAETVQ ATITYTHSVY ARRNG


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