Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase)

 DLDH_CAEEL              Reviewed;         495 AA.
O17953; D3YT81;
06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 2.
22-NOV-2017, entry version 134.
RecName: Full=Dihydrolipoyl dehydrogenase, mitochondrial;
EC=1.8.1.4;
AltName: Full=Dihydrolipoamide dehydrogenase;
Flags: Precursor;
Name=dld-1; ORFNames=LLC1.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
-!- CATALYTIC ACTIVITY: Protein N(6)-(dihydrolipoyl)lysine + NAD(+) =
protein N(6)-(lipoyl)lysine + NADH.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Note=Binds 1 FAD per subunit. {ECO:0000250};
-!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=a;
IsoId=O17953-1; Sequence=Displayed;
Name=b;
IsoId=O17953-2; Sequence=VSP_045381;
-!- MISCELLANEOUS: The active site is a redox-active disulfide bond.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
oxidoreductase family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; Z82277; CAB05249.2; -; Genomic_DNA.
EMBL; Z82277; CBK19462.1; -; Genomic_DNA.
PIR; T23632; T23632.
RefSeq; NP_001255810.1; NM_001268881.1. [O17953-1]
RefSeq; NP_001255811.1; NM_001268882.1. [O17953-2]
UniGene; Cel.8993; -.
ProteinModelPortal; O17953; -.
SMR; O17953; -.
IntAct; O17953; 1.
STRING; 6239.LLC1.3a.1; -.
EPD; O17953; -.
PaxDb; O17953; -.
PeptideAtlas; O17953; -.
PRIDE; O17953; -.
EnsemblMetazoa; LLC1.3a; LLC1.3a; WBGene00010794. [O17953-1]
GeneID; 178387; -.
KEGG; cel:CELE_LLC1.3; -.
UCSC; LLC1.3.1; c. elegans. [O17953-1]
CTD; 178387; -.
WormBase; LLC1.3a; CE31971; WBGene00010794; dld-1. [O17953-1]
WormBase; LLC1.3b; CE44593; WBGene00010794; dld-1. [O17953-2]
eggNOG; KOG1335; Eukaryota.
eggNOG; COG1249; LUCA.
GeneTree; ENSGT00550000074844; -.
HOGENOM; HOG000276708; -.
InParanoid; O17953; -.
KO; K00382; -.
OMA; TMSEAVM; -.
OrthoDB; EOG091G05AA; -.
PhylomeDB; O17953; -.
Reactome; R-CEL-204174; Regulation of pyruvate dehydrogenase (PDH) complex.
Reactome; R-CEL-389661; Glyoxylate metabolism and glycine degradation.
Reactome; R-CEL-5362517; Signaling by Retinoic Acid.
Reactome; R-CEL-6783984; Glycine degradation.
Reactome; R-CEL-70268; Pyruvate metabolism.
Reactome; R-CEL-70895; Branched-chain amino acid catabolism.
Reactome; R-CEL-71064; Lysine catabolism.
Reactome; R-CEL-71403; Citric acid cycle (TCA cycle).
PRO; PR:O17953; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00010794; -.
GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
GO; GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
Gene3D; 3.30.390.30; -; 1.
InterPro; IPR036188; FAD/NAD-bd_sf.
InterPro; IPR023753; FAD/NAD-binding_dom.
InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
InterPro; IPR006258; Lipoamide_DH.
InterPro; IPR001100; Pyr_nuc-diS_OxRdtase.
InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
InterPro; IPR012999; Pyr_OxRdtase_I_AS.
Pfam; PF07992; Pyr_redox_2; 1.
Pfam; PF02852; Pyr_redox_dim; 1.
PIRSF; PIRSF000350; Mercury_reductase_MerA; 1.
SUPFAM; SSF51905; SSF51905; 1.
SUPFAM; SSF55424; SSF55424; 1.
TIGRFAMs; TIGR01350; lipoamide_DH; 1.
PROSITE; PS00076; PYRIDINE_REDOX_1; 1.
3: Inferred from homology;
Alternative splicing; Complete proteome; Disulfide bond; FAD;
Fatty acid biosynthesis; Fatty acid metabolism; Flavoprotein;
Lipid biosynthesis; Lipid metabolism; Mitochondrion; NAD;
Oxidoreductase; Redox-active center; Reference proteome;
Transit peptide.
TRANSIT 1 ? Mitochondrion. {ECO:0000255}.
CHAIN ? 495 Dihydrolipoyl dehydrogenase,
mitochondrial.
/FTId=PRO_0000421278.
NP_BIND 59 68 FAD. {ECO:0000250}.
NP_BIND 169 171 FAD. {ECO:0000250}.
NP_BIND 206 213 NAD. {ECO:0000250}.
NP_BIND 346 349 FAD. {ECO:0000250}.
ACT_SITE 472 472 Proton acceptor. {ECO:0000250}.
BINDING 77 77 FAD. {ECO:0000250}.
BINDING 229 229 NAD. {ECO:0000250}.
BINDING 264 264 NAD; via amide nitrogen and carbonyl
oxygen. {ECO:0000250}.
BINDING 299 299 NAD; via amide nitrogen. {ECO:0000250}.
BINDING 340 340 FAD. {ECO:0000250}.
DISULFID 68 73 Redox-active. {ECO:0000250}.
VAR_SEQ 1 345 Missing (in isoform b). {ECO:0000305}.
/FTId=VSP_045381.
SEQUENCE 495 AA; 52633 MW; 77EB4A2FA935F0F6 CRC64;
MSLSRTTQLP FAKRQFFQVL ARNYSNTQDA DLVVIGGGPG GYVAAIKAAQ LGMKTVCVEK
NATLGGTCLN VGCIPSKALL NNSHYLHMAQ HDFAARGIDC TASLNLPKMM EAKSNSVKQL
TGGIKQLFKA NKVGHVEGFA TIVGPNTVQA KKNDGSVETI NARNILIASG SEVTPFPGIT
IDEKQIVSST GALSLGQVPK KMVVIGAGVI GLELGSVWQR LGAEVTAVEF LGHVGGMGID
GEVSKNFQRS LTKQGFKFLL NTKVMGASQN GSTITVEVEG AKDGKKQTLE CDTLLVSVGR
RPYTEGLGLS NVQIDLDNRG RVPVNERFQT KVPSIFAIGD VIEGPMLAHK AEDEGILCVE
GIAGGPVHID YNCVPSVVYT HPEVAWVGKA EEQLKQEGVA YKIGKFPFVA NSRAKTNNDQ
EGFVKVLADK QTDRMLGVHI IGPNAGEMIA EATLAMEYGA SAEDVARVCH PHPTLSEAFR
EANLAAYCGK AINNV


Related products :

Catalog number Product name Quantity
EIAAB11371 Dihydrolipoamide dehydrogenase,Dihydrolipoyl dehydrogenase, mitochondrial,Dld,Mouse,Mus musculus
EIAAB11375 Dihydrolipoamide dehydrogenase,Dihydrolipoyl dehydrogenase, mitochondrial,Dld,Rat,Rattus norvegicus
EIAAB11374 Dihydrolipoamide dehydrogenase,Dihydrolipoyl dehydrogenase, mitochondrial,DLD,LAD,Pig,Sus scrofa
EIAAB11372 Dihydrolipoamide dehydrogenase,Dihydrolipoyl dehydrogenase, mitochondrial,DLD,GCSL,Glycine cleavage system L protein,Homo sapiens,Human,LAD,PHE3
EIAAB11373 Canis familiaris,Canis lupus familiaris,Dihydrolipoamide dehydrogenase,Dihydrolipoyl dehydrogenase, mitochondrial,DLD,Dog
27-169 DLD is the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketogl 0.05 mg
18-783-77883 RABBIT ANTI PORCINE LIPOAMIDE DEHYDROGENASE - EC 1.8.1.4; Dihydrolipoamide dehydrogenase; Pyruvate dehydrogenase complex E3 subunit; PDC-E3; E3; Glycine cleavage system L protein Polyclonal 1 ml
LF-PA40331 anti-Dihydrolipoamide Dehydrogenase (DLD), Rabbit polyclonal to Dihydrolipoamide Dehydrogenase (DLD), Isotype IgG, Host Rabbit 50 ul
15-288-22844 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. mitochondrial - EC 2.3.1.12; Pyruvate dehydrogenase complex E2 subunit; PDCE2; E2; Dihydrolipoamide S-acetylt 0.05 mg
15-288-22844 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. mitochondrial - EC 2.3.1.12; Pyruvate dehydrogenase complex E2 subunit; PDCE2; E2; Dihydrolipoamide S-acetylt 0.1 mg
18-003-43720 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. mitochondrial - EC 2.3.1.12; Pyruvate dehydrogenase complex E2 subunit; PDCE2; E2; Dihydrolipoamide S-acetylt 0.1 mg Protein A
CSB-EL006928DO Dog Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit 96T
ER555 Dihydrolipoyl dehydrogenase, mitochondrial Elisa Kit 96T
CSB-EL006928RA Rat Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit 96T
CSB-EL006928RA Rat Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit SpeciesRat 96T
CSB-EL006928DO Dog Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit SpeciesDog 96T
CSB-EL006928HU Human Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit 96T
CSB-EL006928PI Pig Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit SpeciesPig 96T
CSB-EL006928MO Mouse Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit 96T
EIAAB28692 Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex,Lipoyl-containing pyruvate dehydrogenase complex component X,Mouse,Mus musculus,Pdhx,Pyruvate dehydrogenase protein X c
CSB-EL006928MO Mouse Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit SpeciesMouse 96T
CSB-EL006928HU Human Dihydrolipoyl dehydrogenase, mitochondrial(DLD) ELISA kit SpeciesHuman 96T
DLDH_HUMAN ELISA Kit FOR Dihydrolipoyl dehydrogenase, mitochondrial; organism: Human; gene name: DLD 96T
DLDH_MOUSE ELISA Kit FOR Dihydrolipoyl dehydrogenase, mitochondrial; organism: Mouse; gene name: Dld 96T
EIAAB28681 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex,Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial,Dlat,Mouse,Mus m


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur