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Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase)

 DHPS_NEIMB              Reviewed;         285 AA.
Q51161; Q51157; Q51158; Q51159; Q51160; Q57214; Q60395;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
08-DEC-2000, sequence version 2.
25-OCT-2017, entry version 124.
RecName: Full=Dihydropteroate synthase;
Short=DHPS;
EC=2.5.1.15;
AltName: Full=Dihydropteroate pyrophosphorylase;
Name=folP; Synonyms=dhpS; OrderedLocusNames=NMB1691;
Neisseria meningitidis serogroup B (strain MC58).
Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
Neisseriaceae; Neisseria.
NCBI_TaxID=122586;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=952 / Serogroup B / Serotype NT,
BT490 / Serogroup B / Serotype 15, and
MO035 / Serogroup B / Serotype 15;
PubMed=1400191; DOI=10.1128/jb.174.20.6386-6393.1992;
Raadstroem P., Fermer C., Kristiansen B.-E., Jenkins A., Skoeld O.,
Swedberg G.;
"Transformational exchanges in the dihydropteroate synthase gene of
Neisseria meningitidis: a novel mechanism for acquisition of
sulfonamide resistance.";
J. Bacteriol. 174:6386-6393(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=3976 / Serogroup B / Serotype NT;
PubMed=7642493; DOI=10.1128/jb.177.16.4669-4675.1995;
Fermer C., Kristiansen B.E., Skoeld O., Swedberg G.;
"Sulfonamide resistance in Neisseria meningitidis as defined by site-
directed mutagenesis could have its origin in other species.";
J. Bacteriol. 177:4669-4675(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58;
PubMed=10710307; DOI=10.1126/science.287.5459.1809;
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C.,
Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F.,
Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D.,
Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D.,
Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E.,
Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M.,
Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M.,
Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R.,
Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain
MC58.";
Science 287:1809-1815(2000).
-!- FUNCTION: Catalyzes the condensation of para-aminobenzoate (pABA)
with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to
form 7,8-dihydropteroate (H2Pte), the immediate precursor of
folate derivatives. {ECO:0000250|UniProtKB:P0AC13}.
-!- CATALYTIC ACTIVITY: 6-hydroxymethyl-7,8-dihydropterin diphosphate
+ 4-aminobenzoate = diphosphate + dihydropteroate.
{ECO:0000250|UniProtKB:P0AC13}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000250|UniProtKB:P0AC13};
-!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis;
7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-
dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
-!- SUBUNIT: Homodimer.
-!- SIMILARITY: Belongs to the DHPS family. {ECO:0000305}.
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EMBL; X68062; CAA48199.1; -; Genomic_DNA.
EMBL; X68066; CAA48203.1; -; Genomic_DNA.
EMBL; X68069; CAA48206.1; -; Genomic_DNA.
EMBL; X87405; CAA60855.1; -; Genomic_DNA.
EMBL; AE002098; AAF42039.1; -; Genomic_DNA.
PIR; A57423; A57423.
PIR; S25611; S25611.
PIR; S65832; S65832.
PIR; S65839; S65839.
RefSeq; NP_274695.1; NC_003112.2.
RefSeq; WP_002224358.1; NC_003112.2.
ProteinModelPortal; Q51161; -.
SMR; Q51161; -.
STRING; 122586.NMB1691; -.
PaxDb; Q51161; -.
EnsemblBacteria; AAF42039; AAF42039; NMB1691.
GeneID; 903415; -.
KEGG; nme:NMB1691; -.
PATRIC; fig|122586.8.peg.2174; -.
eggNOG; ENOG4105EEI; Bacteria.
eggNOG; COG0294; LUCA.
KO; K00796; -.
OMA; WAVRVHD; -.
OrthoDB; POG091H00BJ; -.
UniPathway; UPA00077; UER00156.
Proteomes; UP000000425; Chromosome.
GO; GO:0004156; F:dihydropteroate synthase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
CDD; cd00739; DHPS; 1.
Gene3D; 3.20.20.20; -; 2.
InterPro; IPR006390; DHP_synth.
InterPro; IPR011005; Dihydropteroate_synth-like.
InterPro; IPR000489; Pterin-binding_dom.
Pfam; PF00809; Pterin_bind; 1.
SUPFAM; SSF51717; SSF51717; 1.
TIGRFAMs; TIGR01496; DHPS; 1.
PROSITE; PS00792; DHPS_1; 1.
PROSITE; PS50972; PTERIN_BINDING; 1.
3: Inferred from homology;
Complete proteome; Folate biosynthesis; Magnesium; Metal-binding;
Reference proteome; Transferase.
CHAIN 1 285 Dihydropteroate synthase.
/FTId=PRO_0000168218.
DOMAIN 18 276 Pterin-binding. {ECO:0000255|PROSITE-
ProRule:PRU00334}.
REGION 264 266 6-hydroxymethyl-7,8-dihydropterin
diphosphate binding.
{ECO:0000250|UniProtKB:P0AC13}.
METAL 25 25 Magnesium.
{ECO:0000250|UniProtKB:P9WND1}.
BINDING 66 66 6-hydroxymethyl-7,8-dihydropterin
diphosphate.
{ECO:0000250|UniProtKB:P0AC13}.
BINDING 99 99 6-hydroxymethyl-7,8-dihydropterin
diphosphate.
{ECO:0000250|UniProtKB:P0AC13}.
BINDING 119 119 6-hydroxymethyl-7,8-dihydropterin
diphosphate.
{ECO:0000250|UniProtKB:P0AC13}.
BINDING 190 190 6-hydroxymethyl-7,8-dihydropterin
diphosphate.
{ECO:0000250|UniProtKB:P0AC13}.
BINDING 229 229 6-hydroxymethyl-7,8-dihydropterin
diphosphate.
{ECO:0000250|UniProtKB:P0AC13}.
VARIANT 2 4 ARH -> VGC (in strain: 3976 / Serogroup B
/ Serotype NT).
VARIANT 31 31 F -> L (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 36 36 V -> A (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 42 42 Q -> R (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 50 50 Q -> R (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 68 68 S -> P (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 69 69 G -> C (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 84 84 P -> S (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 96 96 I -> V (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 102 102 R -> H (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 105 105 I -> V (in strain: 952 / Serogroup B /
Serotype NT and 3976 / Serogroup B /
Serotype NT).
VARIANT 125 125 N -> T (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 130 130 V -> L (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 135 135 R -> C (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 137 137 A -> T (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 147 147 Q -> R (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 151 151 K -> E (in strain: BT490 / Serogroup B /
Serotype 15 and 952 / Serogroup B /
Serotype NT).
VARIANT 152 152 T -> N (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 172 172 A -> T (in strain: 952 / Serogroup B /
Serotype NT).
VARIANT 174 174 S -> A (in strain: BT490 / Serogroup B /
Serotype 15 and 3976 / Serogroup B /
Serotype NT).
VARIANT 175 178 AECI -> ETCV (in strain: 952 / Serogroup
B / Serotype NT).
VARIANT 188 188 I -> T (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 194 195 Missing (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 196 196 G -> C (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 200 200 P -> T (in strain: 952 / Serogroup B /
Serotype NT and 3976 / Serogroup B /
Serotype NT).
VARIANT 206 206 A -> T (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 208 208 M -> V (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 220 220 F -> Y (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 230 230 S -> R (in strain: 952 / Serogroup B /
Serotype NT and BT490 / Serogroup B /
Serotype 15).
VARIANT 231 231 T -> M (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 232 232 I -> V (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 239 239 A -> S (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 239 239 A -> T (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 240 240 N -> D (in strain: BT490 / Serogroup B /
Serotype 15, 952 / Serogroup B / Serotype
NT and 3976 / Serogroup B / Serotype NT).
VARIANT 243 243 E -> A (in strain: BT490 / Serogroup B /
Serotype 15 and 3976 / Serogroup B /
Serotype NT).
VARIANT 245 245 V -> G (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 253 253 L -> V (in strain: BT490 / Serogroup B /
Serotype 15).
VARIANT 255 255 S -> A (in strain: BT490 / Serogroup B /
Serotype 15 and 3976 / Serogroup B /
Serotype NT).
VARIANT 261 261 Q -> K (in strain: 3976 / Serogroup B /
Serotype NT).
VARIANT 277 277 V -> A (in strain: 3976 / Serogroup B /
Serotype NT).
SEQUENCE 285 AA; 30313 MW; C56518F61CF98A4E CRC64;
MARHVWQAGR FEIGLDKPKI MGIVNLTPDS FSDGGVYSQN AQTALAHAEQ LLKEGADILD
IGGESTRSGA DYVSPEEEWA RVEPVLAEVA GWGVPISLDT RRTVIMEKAL ALGGIDIIND
VAALNDEGAV ELLARQADTG ICLMHMQGLP KTMQINPKYQ DVVGEVARYL KARSAECIAA
GIAPQRIILD PGFGSGFGKP LQHNIALMRH LPELMAETGF PLLIGVSRKS TIGELTGEAN
AAERVHGSVA AALASVARGA QIVRVHDVKA TADALKVWEA LGINL


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