Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Dimethylaniline oxidase 1) (Hepatic flavin-containing monooxygenase 1) (FMO 1)

 FMO1_PIG                Reviewed;         532 AA.
P16549;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
12-SEP-2018, entry version 141.
RecName: Full=Dimethylaniline monooxygenase [N-oxide-forming] 1;
EC=1.14.13.8;
AltName: Full=Dimethylaniline oxidase 1;
AltName: Full=Hepatic flavin-containing monooxygenase 1;
Short=FMO 1;
Name=FMO1; Synonyms=FMO-1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 137-151 AND
309-318.
TISSUE=Liver;
PubMed=2322534; DOI=10.1021/bi00453a014;
Gasser R., Tynes R.E., Lawton M.P., Korsmeyer K.K., Ziegler D.M.,
Philpot R.M.;
"The flavin-containing monooxygenase expressed in pig liver: primary
sequence, distribution, and evidence for a single gene.";
Biochemistry 29:119-124(1990).
[2]
PROTEIN SEQUENCE OF 2-14 AND 185-202, ACETYLATION AT ALA-2, AND
IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Liver;
PubMed=2383273; DOI=10.1016/0006-291X(90)92181-X;
Guan S.H., Falick A.M., Cashman J.R.;
"N-terminus determination: FAD and NADP binding domain mapping of hog
liver flavin-containing monooxygenase by tandem mass spectrometry.";
Biochem. Biophys. Res. Commun. 170:937-943(1990).
[3]
PROTEIN SEQUENCE OF 186-208.
TISSUE=Liver;
PubMed=7758472; DOI=10.1111/j.1432-1033.1995.tb20523.x;
Wu R.-F., Ichikawa Y.;
"An essential lysyl residue (Lys208) in the substrate-binding site of
porcine FAD-containing monooxygenase.";
Eur. J. Biochem. 229:749-753(1995).
[4]
GLYCOSYLATION AT ASN-120.
PubMed=9778310; DOI=10.1021/tx980117p;
Korsmeyer K.K., Guan S., Yang Z.C., Falick A.M., Ziegler D.M.,
Cashman J.R.;
"N-glycosylation of pig flavin-containing monooxygenase form 1:
determination of the site of protein modification by mass
spectrometry.";
Chem. Res. Toxicol. 11:1145-1153(1998).
-!- FUNCTION: This protein is involved in the oxidative metabolism of
a variety of xenobiotics such as drugs and pesticides.
-!- CATALYTIC ACTIVITY: N,N-dimethylaniline + NADPH + O(2) = N,N-
dimethylaniline N-oxide + NADP(+) + H(2)O.
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
-!- SUBCELLULAR LOCATION: Microsome membrane
{ECO:0000250|UniProtKB:Q95LA2}; Single-pass membrane protein
{ECO:0000255}. Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q95LA2}; Single-pass membrane protein
{ECO:0000255}.
-!- TISSUE SPECIFICITY: Liver.
-!- SIMILARITY: Belongs to the FMO family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M32031; AAA31033.1; -; mRNA.
PIR; A33768; A33768.
RefSeq; NP_999229.1; NM_214064.1.
RefSeq; XP_005656702.1; XM_005656645.2.
UniGene; Ssc.229; -.
ProteinModelPortal; P16549; -.
SMR; P16549; -.
STRING; 9823.ENSSSCP00000016191; -.
iPTMnet; P16549; -.
PaxDb; P16549; -.
PeptideAtlas; P16549; -.
PRIDE; P16549; -.
Ensembl; ENSSSCT00000016637; ENSSSCP00000016191; ENSSSCG00000015268.
Ensembl; ENSSSCT00000056435; ENSSSCP00000036498; ENSSSCG00000015268.
Ensembl; ENSSSCT00000059500; ENSSSCP00000051826; ENSSSCG00000015268.
GeneID; 397132; -.
KEGG; ssc:397132; -.
CTD; 2326; -.
eggNOG; KOG1399; Eukaryota.
eggNOG; COG2072; LUCA.
GeneTree; ENSGT00760000119232; -.
HOGENOM; HOG000076537; -.
HOVERGEN; HBG002037; -.
InParanoid; P16549; -.
KO; K00485; -.
OMA; DWEVYVW; -.
OrthoDB; EOG091G0465; -.
TreeFam; TF105285; -.
Reactome; R-SSC-217271; FMO oxidises nucleophiles.
SABIO-RK; P16549; -.
Proteomes; UP000008227; Chromosome 9.
Bgee; ENSSSCG00000015268; Expressed in 6 organ(s), highest expression level in liver.
Genevisible; P16549; SS.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IDA:BHF-UCL.
GO; GO:0050661; F:NADP binding; IEA:InterPro.
GO; GO:0017144; P:drug metabolic process; IEA:Ensembl.
GO; GO:0070995; P:NADPH oxidation; IDA:BHF-UCL.
GO; GO:0006082; P:organic acid metabolic process; IDA:BHF-UCL.
GO; GO:0009404; P:toxin metabolic process; IDA:BHF-UCL.
Gene3D; 3.50.50.60; -; 2.
InterPro; IPR036188; FAD/NAD-bd_sf.
InterPro; IPR000960; Flavin_mOase.
InterPro; IPR020946; Flavin_mOase-like.
InterPro; IPR002253; Flavin_mOase_1.
Pfam; PF00743; FMO-like; 1.
PIRSF; PIRSF000332; FMO; 1.
PRINTS; PR00370; FMOXYGENASE.
PRINTS; PR01121; FMOXYGENASE1.
SUPFAM; SSF51905; SSF51905; 3.
1: Evidence at protein level;
Acetylation; Complete proteome; Direct protein sequencing;
Endoplasmic reticulum; FAD; Flavoprotein; Glycoprotein; Membrane;
Microsome; Monooxygenase; NADP; Oxidoreductase; Reference proteome;
Transmembrane; Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:2383273}.
CHAIN 2 532 Dimethylaniline monooxygenase [N-oxide-
forming] 1.
/FTId=PRO_0000147641.
TRANSMEM 511 531 Helical. {ECO:0000255}.
NP_BIND 9 13 FAD. {ECO:0000250|UniProtKB:Q9HFE4}.
NP_BIND 40 41 FAD. {ECO:0000250|UniProtKB:Q9HFE4}.
NP_BIND 60 61 NADP. {ECO:0000250|UniProtKB:Q9HFE4}.
NP_BIND 61 62 FAD. {ECO:0000250|UniProtKB:Q9HFE4}.
NP_BIND 195 198 NADP. {ECO:0000250|UniProtKB:Q9HFE4}.
BINDING 32 32 FAD. {ECO:0000250|UniProtKB:Q9HFE4}.
SITE 208 208 Important for substrate binding.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000269|PubMed:2383273}.
CARBOHYD 120 120 N-linked (GlcNAc...) (high mannose)
asparagine. {ECO:0000269|PubMed:9778310}.
SEQUENCE 532 AA; 59952 MW; 5E475E7F2F3B8A67 CRC64;
MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG RASLYKSVVS
NSCKEMSCYP DFPFPEDYPN YVPNSHFLEY LRMYANQFNL LKCIQFKTKV CSVTKHEDFN
TTGQWDVVTL CEGKQESAVF DAVMVCTGFL TNPYLPLDSF PGINTFKGQY FHSRQYKHPD
IFKDKSVLVV GMGNSGTDIA VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMVFMTRFQ
NMFRNSLPTP IVNWLIAKKM NSWFNHANYG LIPEDRIQLR EPVLNDELPG RIITGKVLIK
PSIKEVKENS VVFNSSPEEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA SLYKYIFPAH
LQKPTLAVIG LIKPLGSLLP TGDTQARWAV RVLKGVNKLP PSSVMIQEVN TRKENKPSGF
GLCYCKALQS DYIAYIDELL TYIDAKPNMF SLLLTDPHLA LTIFFGPCTP YQFRLTGPGK
WEGARNAIMT QWDRTFKVTK TRIVKESPSP FASLLKLFSF LALLVAIFQI FL


Related products :

Catalog number Product name Quantity
E13097h Rat ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 3 96T
FMO4_RAT Rat ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 4 96T
FMO2_RAT Rat ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 2 96T
E12931h Dog ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 1 96T
CSB-EL008746RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 1(FMO1) ELISA kit 96T
CSB-EL008750RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 4(FMO4) ELISA kit 96T
CSB-EL008749DO Dog Dimethylaniline monooxygenase [N-oxide-forming] 3(FMO3) ELISA kit 96T
E0950h Mouse ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 5 96T
PCGF5_HUMAN Mouse ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 2 96T
CSB-EL008748RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 2(FMO2) ELISA kit 96T
CSB-EL008749RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 3(FMO3) ELISA kit 96T
CSB-EL008746DO Dog Dimethylaniline monooxygenase [N-oxide-forming] 1(FMO1) ELISA kit 96T
CSB-EL008751RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 5(FMO5) ELISA kit 96T
E0575p Mouse ELISA Kit FOR Dimethylaniline monooxygenase [N-oxide-forming] 2 96T
CSB-EL008746RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 1(FMO1) ELISA kit SpeciesRat 96T
CSB-EL008750HU Human Dimethylaniline monooxygenase [N-oxide-forming] 4(FMO4) ELISA kit 96T
CSB-EL008749HU Human Dimethylaniline monooxygenase [N-oxide-forming] 3(FMO3) ELISA kit 96T
CSB-EL008748HU Human Dimethylaniline monooxygenase [N-oxide-forming] 2(FMO2) ELISA kit 96T
CSB-EL008746HU Human Dimethylaniline monooxygenase [N-oxide-forming] 1(FMO1) ELISA kit 96T
CSB-EL008751RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 5(FMO5) ELISA kit SpeciesRat 96T
CSB-EL008748RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 2(FMO2) ELISA kit SpeciesRat 96T
CSB-EL008749RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 3(FMO3) ELISA kit SpeciesRat 96T
CSB-EL008746DO Dog Dimethylaniline monooxygenase [N-oxide-forming] 1(FMO1) ELISA kit SpeciesDog 96T
CSB-EL008751HU Human Dimethylaniline monooxygenase [N-oxide-forming] 5(FMO5) ELISA kit 96T
CSB-EL008750RA Rat Dimethylaniline monooxygenase [N-oxide-forming] 4(FMO4) ELISA kit SpeciesRat 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur