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Disease resistance protein RPP8 (Resistance to Peronospora parasitica protein 8)

 RPP8_ARATH              Reviewed;         908 AA.
Q8W4J9; Q8GWG5; Q9M5A1; Q9ZSY3; Q9ZSY4;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
11-APR-2003, sequence version 2.
25-OCT-2017, entry version 127.
RecName: Full=Disease resistance protein RPP8;
AltName: Full=Resistance to Peronospora parasitica protein 8;
Name=RPP8; Synonyms=HRT; OrderedLocusNames=At5g43470;
ORFNames=MWF20.19;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, MUTANTS RPP8-1; RPP8-2
AND RPP8-3, AND VARIANTS.
STRAIN=cv. Columbia, and cv. Landsberg erecta;
PubMed=9811794; DOI=10.1105/tpc.10.11.1861;
McDowell J.M., Dhandaydham M., Long T.A., Aarts M.G.M., Goff S.,
Holub E.B., Dangl J.L.;
"Intragenic recombination and diversifying selection contribute to the
evolution of downy mildew resistance at the RPP8 locus of
Arabidopsis.";
Plant Cell 10:1861-1874(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
STRAIN=cv. Di-17;
PubMed=10810142; DOI=10.1105/tpc.12.5.663;
Cooley M.B., Pathirana S., Wu H.-J., Kachroo P., Klessig D.F.;
"Members of the Arabidopsis HRT/RPP8 family of resistance genes confer
resistance to both viral and oomycete pathogens.";
Plant Cell 12:663-676(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10718197; DOI=10.1093/dnares/7.1.31;
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
features of the regions of 3,076,755 bp covered by sixty P1 and TAC
clones.";
DNA Res. 7:31-63(2000).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[7]
INTERACTION WITH TIP.
PubMed=11041886; DOI=10.1105/tpc.12.10.1917;
Ren T., Qu F., Morris T.J.;
"HRT gene function requires interaction between a NAC protein and
viral capsid protein to confer resistance to turnip crinkle virus.";
Plant Cell 12:1917-1926(2000).
[8]
INTERACTION WITH MORC1/CRT1.
PubMed=18191794; DOI=10.1016/j.chom.2007.11.006;
Kang H.-G., Kuhl J.C., Kachroo P., Klessig D.F.;
"CRT1, an Arabidopsis ATPase that interacts with diverse resistance
proteins and modulates disease resistance to turnip crinkle virus.";
Cell Host Microbe 3:48-57(2008).
[9]
INTERACTION WITH MORC1/CRT1.
PubMed=20332379; DOI=10.1105/tpc.109.071662;
Kang H.-G., Oh C.-S., Sato M., Katagiri F., Glazebrook J.,
Takahashi H., Kachroo P., Martin G.B., Klessig D.F.;
"Endosome-associated CRT1 functions early in resistance gene-mediated
defense signaling in Arabidopsis and tobacco.";
Plant Cell 22:918-936(2010).
[10]
INDUCTION BY HYALOPERONOSPORA ARABIDOPSIDIS; BTH; WOUNDING AND
SALICYLIC ACID, AND TISSUE SPECIFICITY.
STRAIN=cv. Columbia;
PubMed=20831409; DOI=10.1094/MPMI-01-10-0022;
Mohr T.J., Mammarella N.D., Hoff T., Woffenden B.J., Jelesko J.G.,
McDowell J.M.;
"The Arabidopsis downy mildew resistance gene RPP8 is induced by
pathogens and salicylic acid and is regulated by W box cis elements.";
Mol. Plant Microbe Interact. 23:1303-1315(2010).
[11]
SUBCELLULAR LOCATION, REGULATION BY BLUE-LIGHT AND DARKNESS, AND
INTERACTION WITH COP1.
PubMed=20624951; DOI=10.1073/pnas.1004529107;
Jeong R.-D., Chandra-Shekara A.C., Barman S.R., Navarre D.,
Klessig D.F., Kachroo A., Kachroo P.;
"Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated
viral defense by negatively regulating an E3 ubiquitin ligase.";
Proc. Natl. Acad. Sci. U.S.A. 107:13538-13543(2010).
[12]
FUNCTION, AND INDUCTION BY SALICYLIC ACID.
PubMed=22072959; DOI=10.1371/journal.ppat.1002318;
Zhu S., Jeong R.-D., Venugopal S.C., Lapchyk L., Navarre D.,
Kachroo A., Kachroo P.;
"SAG101 forms a ternary complex with EDS1 and PAD4 and is required for
resistance signaling against turnip crinkle virus.";
PLoS Pathog. 7:E1002318-E1002318(2011).
-!- FUNCTION: Disease resistance protein. Resistance proteins guard
the plant against pathogens that contain an appropriate avirulence
protein via an indirect interaction with this avirulence protein.
That triggers a defense system including the hypersensitive
response, which restricts the pathogen growth. The interaction
with TIP (TCV-interacting protein) may be essential for the
recognition of the avirulence proteins, and the triggering of the
defense response. Triggers resistance to turnip crinkle virus
(TCV) via a SAG101-dependent pathway.
{ECO:0000269|PubMed:22072959, ECO:0000269|PubMed:9811794}.
-!- SUBUNIT: Interacts with the NAC protein TIP (PubMed:11041886).
Interacts with MORC1/CRT1 (PubMed:18191794, PubMed:20332379).
Interacts with COP1 and is subsequently degraded in a 26s
proteasome dependent manner (PubMed:20624951).
{ECO:0000269|PubMed:11041886, ECO:0000269|PubMed:18191794,
ECO:0000269|PubMed:20332379, ECO:0000269|PubMed:20624951}.
-!- INTERACTION:
P43254:COP1; NbExp=2; IntAct=EBI-15865035, EBI-301649;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20624951}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8W4J9-1; Sequence=Displayed;
Name=2;
IsoId=Q8W4J9-2; Sequence=VSP_007171, VSP_007172;
Note=Has been shown to exist only in cv. Columbia so far.;
-!- TISSUE SPECIFICITY: Mostly expressed in leaves, and, to a lower
extent, in roots. {ECO:0000269|PubMed:20831409}.
-!- INDUCTION: By salicylic acid (SA) (PubMed:22072959,
PubMed:20831409). Induced by Hyaloperonospora arabidopsidis,
benzothiadiazole (BTH) and wounding (PubMed:20831409). Degraded in
darkness and in blue-light (PubMed:20624951).
{ECO:0000269|PubMed:20624951, ECO:0000269|PubMed:20831409,
ECO:0000269|PubMed:22072959}.
-!- DOMAIN: The LRR repeats probably act as specificity determinant of
pathogen recognition. {ECO:0000269|PubMed:10810142}.
-!- POLYMORPHISM: The strong polymorphisms present in cv. Di-17 and
cv. Columbia are probably due to an unequal crossing-over between
the highly related RPP8 and RPH8A genes present in cv. Landsberg
erecta. Such variations probably modify the specificity of
pathogen recognition.
-!- MISCELLANEOUS: In cv. Columbia and cv. Landsberg erecta, RPP8
specifically recognizes the Emco5 avirulence protein from
Hyaloperonospora parasitica, while it is not the case in cv. Di-
17, where it confers resistance to Turnip Crinkle Virus upon
recognition of the viral capsid protein.
-!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
RPP8/HRT subfamily. {ECO:0000305}.
-!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative
genomics of disease resistance gene homologs;
URL="http://niblrrs.ucdavis.edu";
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EMBL; AF089710; AAC83165.1; -; Genomic_DNA.
EMBL; AF089711; AAC78631.1; -; Genomic_DNA.
EMBL; AF234174; AAF36987.1; -; Genomic_DNA.
EMBL; AB025638; BAA97426.1; -; Genomic_DNA.
EMBL; CP002688; AED94967.1; -; Genomic_DNA.
EMBL; CP002688; AED94968.1; -; Genomic_DNA.
EMBL; CP002688; ANM71032.1; -; Genomic_DNA.
EMBL; CP002688; ANM71033.1; -; Genomic_DNA.
EMBL; AK118862; BAC43449.1; -; mRNA.
EMBL; AY062514; AAL32592.1; -; mRNA.
PIR; T48898; T48898.
PIR; T48899; T48899.
RefSeq; NP_001318736.1; NM_001344485.1. [Q8W4J9-1]
RefSeq; NP_001332592.1; NM_001344486.1. [Q8W4J9-1]
RefSeq; NP_199160.1; NM_123713.4. [Q8W4J9-1]
RefSeq; NP_851124.1; NM_180793.1. [Q8W4J9-1]
UniGene; At.47555; -.
UniGene; At.49144; -.
UniGene; At.66702; -.
ProteinModelPortal; Q8W4J9; -.
BioGrid; 19617; 8.
DIP; DIP-59355N; -.
IntAct; Q8W4J9; 2.
STRING; 3702.AT5G43470.1; -.
PaxDb; Q8W4J9; -.
PRIDE; Q8W4J9; -.
EnsemblPlants; AT5G43470.1; AT5G43470.1; AT5G43470. [Q8W4J9-1]
EnsemblPlants; AT5G43470.2; AT5G43470.2; AT5G43470. [Q8W4J9-1]
EnsemblPlants; AT5G43470.3; AT5G43470.3; AT5G43470. [Q8W4J9-1]
EnsemblPlants; AT5G43470.4; AT5G43470.4; AT5G43470. [Q8W4J9-1]
GeneID; 834367; -.
Gramene; AT5G43470.1; AT5G43470.1; AT5G43470.
Gramene; AT5G43470.2; AT5G43470.2; AT5G43470.
Gramene; AT5G43470.3; AT5G43470.3; AT5G43470.
Gramene; AT5G43470.4; AT5G43470.4; AT5G43470.
KEGG; ath:AT5G43470; -.
Araport; AT5G43470; -.
TAIR; locus:2176486; AT5G43470.
eggNOG; KOG4658; Eukaryota.
eggNOG; COG4886; LUCA.
InParanoid; Q8W4J9; -.
OMA; QFINCDQ; -.
OrthoDB; EOG093605YG; -.
PhylomeDB; Q8W4J9; -.
PRO; PR:Q8W4J9; -.
Proteomes; UP000006548; Chromosome 5.
Genevisible; Q8W4J9; AT.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0043531; F:ADP binding; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0000166; F:nucleotide binding; ISS:TAIR.
GO; GO:0071446; P:cellular response to salicylic acid stimulus; IEP:UniProtKB.
GO; GO:0006952; P:defense response; TAS:TAIR.
GO; GO:0051607; P:defense response to virus; IMP:UniProtKB.
GO; GO:0009626; P:plant-type hypersensitive response; IMP:TAIR.
GO; GO:0002230; P:positive regulation of defense response to virus by host; IDA:UniProtKB.
GO; GO:0009646; P:response to absence of light; IEP:UniProtKB.
GO; GO:0009637; P:response to blue light; IEP:UniProtKB.
GO; GO:0009416; P:response to light stimulus; IMP:TAIR.
GO; GO:0002239; P:response to oomycetes; IEP:UniProtKB.
GO; GO:0051707; P:response to other organism; IMP:TAIR.
GO; GO:0009751; P:response to salicylic acid; IEP:UniProtKB.
GO; GO:0009611; P:response to wounding; IEP:UniProtKB.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR032675; L_dom-like.
InterPro; IPR002182; NB-ARC.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00931; NB-ARC; 1.
SUPFAM; SSF52058; SSF52058; 1.
SUPFAM; SSF52540; SSF52540; 1.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Cell membrane; Coiled coil;
Complete proteome; Hypersensitive response; Leucine-rich repeat;
Membrane; Nucleotide-binding; Plant defense; Reference proteome;
Repeat.
CHAIN 1 908 Disease resistance protein RPP8.
/FTId=PRO_0000212719.
DOMAIN 146 459 NB-ARC. {ECO:0000255}.
REPEAT 575 600 LRR 1. {ECO:0000255}.
REPEAT 601 623 LRR 2. {ECO:0000255}.
REPEAT 648 673 LRR 3. {ECO:0000255}.
REPEAT 693 718 LRR 4. {ECO:0000255}.
REPEAT 722 746 LRR 5. {ECO:0000255}.
REPEAT 748 770 LRR 6. {ECO:0000255}.
REPEAT 793 820 LRR 7. {ECO:0000255}.
REPEAT 842 867 LRR 8. {ECO:0000255}.
REPEAT 882 905 LRR 9. {ECO:0000255}.
NP_BIND 192 199 ATP. {ECO:0000255}.
COILED 15 57 {ECO:0000255}.
VAR_SEQ 294 308 WKMLLTSRNEGVGIH -> ELLWYIHEALFLLNS (in
isoform 2).
{ECO:0000303|PubMed:11910074}.
/FTId=VSP_007171.
VAR_SEQ 309 908 Missing (in isoform 2).
{ECO:0000303|PubMed:11910074}.
/FTId=VSP_007172.
VARIANT 27 31 IDGQL -> VDEQI (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 29 29 G -> E (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 85 87 SGK -> RGE (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 88 91 GKGV -> EKGI (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 100 100 C -> R (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 121 121 E -> D (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 129 129 F -> L (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 133 133 Q -> QQ (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 138 138 G -> V (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 173 173 K -> T (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 177 177 G -> C (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 253 253 Y -> S (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 257 257 R -> P (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 265 265 A -> T (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 267 267 R -> K (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 270 270 V -> L (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 283 283 V -> R (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 369 369 A -> V (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 387 387 F -> S (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 399 399 W -> C (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 426 426 C -> R (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 429 429 N -> F (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 436 446 DSEISTYSLFY -> YSKISAYDLFN (in strain:
cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 438 443 EISTYS -> KITTQE (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 450 450 A -> V (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 460 460 E -> Q (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 480 486 DNYLSWQ -> NKYLRVH (in strain: cv. Di-
17). {ECO:0000269|PubMed:10810142}.
VARIANT 480 481 DN -> NR (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 485 486 WQ -> SH (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 489 489 Y -> N (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 514 514 I -> K (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 518 518 C -> S (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 519 519 T -> I (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 528 528 S -> R (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 537 537 S -> R (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 542 542 H -> Q (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 543 543 I -> L (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 547 550 KNKT -> RNNA (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 549 549 K -> N (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 558 565 PRFEEDYW -> WDEDFG (in strain: cv.
Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 558 560 PRF -> SRFK (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 564 564 Y -> F (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 584 584 S -> Y (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 595 595 C -> S (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 609 612 YEAK -> FLAG (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 630 635 NLRVDT -> DLSVHE (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 632 636 RVDTE -> SVNNK (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 650 650 Q -> E (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 653 654 YL -> HI (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 659 659 Missing (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 660 660 M -> K (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 676 678 YLY -> FLF (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 678 679 YG -> FR (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 692 692 R -> H (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 697 697 R -> Q (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 700 700 A -> G (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 724 724 T -> S (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 726 727 NF -> YV (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 730 731 SL -> TP (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 731 734 LETY -> PEIF (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 752 752 Q -> E (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 768 768 F -> L (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 773 781 VHLFLIYCG -> AQIYICNCR (in strain: cv.
Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 773 781 VHLFLIYCG -> THIHLLFCR (in strain: cv.
Di-17). {ECO:0000269|PubMed:10810142}.
VARIANT 800 807 RLARKAFL -> QLTDEAFV (in strain: cv. Di-
17). {ECO:0000269|PubMed:10810142}.
VARIANT 800 803 RLAR -> KLTF (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 807 809 LGS -> AGR (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 819 819 P -> T (in strain: cv. Landsberg erecta).
{ECO:0000269|PubMed:9811794}.
VARIANT 823 824 VI -> AL (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 825 825 E -> D (in strain: cv. Di-17).
{ECO:0000269|PubMed:10810142}.
VARIANT 828 829 KE -> EQ (in strain: cv. Landsberg
erecta). {ECO:0000269|PubMed:9811794}.
VARIANT 851 851 D -> H (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
VARIANT 854 854 K -> E (in strain: cv. Di-17 and cv.
Landsberg erecta).
{ECO:0000269|PubMed:10810142,
ECO:0000269|PubMed:9811794}.
MUTAGEN 418 418 D->N: In rpp8-1; loss of function.
{ECO:0000269|PubMed:9811794}.
MUTAGEN 553 553 R->K: In rpp8-2; loss of function.
{ECO:0000269|PubMed:9811794}.
MUTAGEN 830 830 S->L: In rpp8-1; loss of function.
{ECO:0000269|PubMed:9811794}.
CONFLICT 83 83 K -> R (in Ref. 6; AAL32592).
{ECO:0000305}.
CONFLICT 686 686 S -> G (in Ref. 6; AAL32592).
{ECO:0000305}.
CONFLICT 835 835 W -> R (in Ref. 6; AAL32592).
{ECO:0000305}.
SEQUENCE 908 AA; 104682 MW; 1BFA35BB6B0CB5CD CRC64;
MAEAFVSFGL EKLWDLLSRE SERLQGIDGQ LDGLKRQLRS LQSLLKDADA KKHGSDRVRN
FLEDVKDLVF DAEDIIESYV LNKLSGKGKG VKKHVRRLAC FLTDRHKVAS DIEGITKRIS
EVIGEMQSFG IQQIIDGGRS LSLQERQRVQ REIRQTYPDS SESDLVGVEQ SVKELVGHLV
ENDVHQVVSI AGMGGIGKTT LARQVFHHDL VRRHFDGFAW VCVSQQFTQK HVWQRILQEL
QPHDGDILQM DEYALQRKLF QLLEAGRYLV VLDDVWKKED WDVIKAVFPR KRGWKMLLTS
RNEGVGIHAD PTCLTFRASI LNPEESWKLC ERIVFPRRDE TEVRLDEEME AMGKEMVTHC
GGLPLAVKAL GGLLANKHTV PEWKRVFDNI GSQIVGGSWL DDNSLNSVYR ILSLSYEDLP
THLKHCFLNL AHFPEDSEIS TYSLFYYWAA EGIYDGSTIE DSGEYYLEEL VRRNLVIADD
NYLSWQSKYC QMHDMMREVC LSKAKEENFL QIIIDPTCTS TINAQSPSRS RRLSIHSGKA
FHILGHKNKT KVRSLIVPRF EEDYWIRSAS VFHNLTLLRV LDLSWVKFEG GKLPCSIGGL
IHLRYLSLYE AKVSHLPSTM RNLKLLLYLN LRVDTEEPIH VPNVLKEMIQ LRYLSLPLKM
DDKTKLELGD LVNLEYLYGF STQHSSVTDL LRMTKLRYLA VSLSERCNFE TLSSSLRELR
NLETLNFLFS LETYMVDYMG EFVLDHFIHL KQLGLAVRMS KIPDQHQFPP HLVHLFLIYC
GMEEDPMPIL EKLLHLKSVR LARKAFLGSR MVCSKGGFPQ LCVIEISKES ELEEWIVEEG
SMPCLRTLTI DDCKKLKELP DGLKYITSLK ELKIEGMKRE WKEKLVPGGE DYYKVQHIPD
VQFINCDQ


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