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Diuretic hormone 1 (DH-1) (DH(41)) (Diuretic peptide 1) (DP-1)

 DIUH1_HYLLI             Reviewed;          41 AA.
P82014;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 1.
27-SEP-2017, entry version 60.
RecName: Full=Diuretic hormone 1;
Short=DH-1;
AltName: Full=DH(41);
AltName: Full=Diuretic peptide 1;
Short=DP-1;
Hyles lineata (White-lined sphinx moth).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
Bombycoidea; Sphingidae; Macroglossinae; Macroglossini; Hyles.
NCBI_TaxID=103890;
[1]
PROTEIN SEQUENCE, FUNCTION, AMIDATION AT ILE-41, AND MASS
SPECTROMETRY.
TISSUE=Head;
PubMed=10696588; DOI=10.1016/S0965-1748(99)00106-X;
Furuya K., Harper M.A., Schegg K.M., Shooley D.A.;
"Isolation and characterization of CRF-related diuretic hormones from
the whitelined sphinx moth Hyles lineata.";
Insect Biochem. Mol. Biol. 30:127-133(2000).
-!- FUNCTION: Regulation of fluid secretion. May stimulate primary
urine secretion by Malpighian tubules and causes a dose-dependent
stimulation of cAMP levels in the tubules.
{ECO:0000269|PubMed:10696588}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- MASS SPECTROMETRY: Mass=4722; Method=MALDI; Range=1-41;
Evidence={ECO:0000269|PubMed:10696588};
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
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SMR; P82014; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
Pfam; PF00473; CRF; 1.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
1: Evidence at protein level;
Amidation; Direct protein sequencing; Hormone; Secreted.
CHAIN 1 41 Diuretic hormone 1.
/FTId=PRO_0000221018.
MOD_RES 41 41 Isoleucine amide.
{ECO:0000269|PubMed:10696588}.
SEQUENCE 41 AA; 4724 MW; FC23DD22EA0AD5B7 CRC64;
RMPSLSIDLP MSVLRQKLSL EKERKVQALR AAANRNFLND I


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