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Diuretic hormone class 1 (DH(46)) (Diuretic hormone class I) (Diuretic peptide) (DP)

 DIUH_DIPPU              Reviewed;          46 AA.
P82373;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 1.
10-MAY-2017, entry version 57.
RecName: Full=Diuretic hormone class 1;
AltName: Full=DH(46);
AltName: Full=Diuretic hormone class I;
AltName: Full=Diuretic peptide;
Short=DP;
Diploptera punctata (Pacific beetle cockroach).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Polyneoptera; Dictyoptera; Blattodea;
Blaberoidea; Blaberidae; Diplopterinae; Diploptera.
NCBI_TaxID=6984;
[1]
PROTEIN SEQUENCE, FUNCTION, AMIDATION AT ILE-46, AND MASS
SPECTROMETRY.
TISSUE=Brain, and Corpora cardiaca;
PubMed=10841553; DOI=10.1073/pnas.97.12.6469;
Furuya K., Milchak R.J., Schegg K.M., Zhang J., Tobe S.S., Coast G.M.,
Schooley D.A.;
"Cockroach diuretic hormones: characterization of a calcitonin-like
peptide in insects.";
Proc. Natl. Acad. Sci. U.S.A. 97:6469-6474(2000).
-!- FUNCTION: Regulation of fluid secretion. Stimulates primary urine
secretion by Malpighian tubules and causes a dose-dependent
stimulation of cAMP levels in the tubules. Has a greater effect on
the transport of Na(+) then K(+) ions. In vitro, has synergistic
effects with the smaller diuretic hormone DH(31) which co-occurs
with it. {ECO:0000269|PubMed:10841553}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- MASS SPECTROMETRY: Mass=5322; Mass_error=0.1; Method=Electrospray;
Range=1-46; Evidence={ECO:0000269|PubMed:10841553};
-!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
factor/urotensin I family. {ECO:0000305}.
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SMR; P82373; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR018446; Corticotropin-releasing_fac_CS.
InterPro; IPR000187; CRF.
Pfam; PF00473; CRF; 1.
SMART; SM00039; CRF; 1.
PROSITE; PS00511; CRF; 1.
1: Evidence at protein level;
Amidation; Direct protein sequencing; Hormone; Secreted.
CHAIN 1 46 Diuretic hormone class 1.
/FTId=PRO_0000221017.
MOD_RES 46 46 Isoleucine amide.
{ECO:0000269|PubMed:10841553}.
SEQUENCE 46 AA; 5322 MW; 693CD9A16E47F67E CRC64;
TGTGPSLSIV NPLDVLRQRL LLEIARRRMR QTQNMIQANR DFLESI


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