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Divalent metal cation transporter MntH

 MNTH_ECOLI              Reviewed;         412 AA.
P0A769; P77145;
07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
07-JUN-2005, sequence version 1.
25-OCT-2017, entry version 101.
RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; Synonyms=yfeP;
OrderedLocusNames=b2392, JW2388;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=K12 / MM1955;
PubMed=10844693; DOI=10.1046/j.1365-2958.2000.01922.x;
Kehres D.G., Zaharik M.L., Finlay B.B., Maguire M.E.;
"The NRAMP proteins of Salmonella typhimurium and Escherichia coli are
selective manganese transporters involved in the response to reactive
oxygen.";
Mol. Microbiol. 36:1085-1100(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=9205837; DOI=10.1093/dnares/4.2.91;
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
Yamagata S., Horiuchi T.;
"Construction of a contiguous 874-kb sequence of the Escherichia coli-
K12 genome corresponding to 50.0-68.8 min on the linkage map and
analysis of its sequence features.";
DNA Res. 4:91-113(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
FUNCTION.
STRAIN=K12;
PubMed=10712688; DOI=10.1046/j.1365-2958.2000.01774.x;
Makui H., Roig E., Cole S.T., Helmann J.D., Gros P., Cellier M.F.M.;
"Identification of the Escherichia coli K-12 Nramp orthologue (MntH)
as a selective divalent metal ion transporter.";
Mol. Microbiol. 35:1065-1078(2000).
[6]
SUBCELLULAR LOCATION, AND TOPOLOGY.
PubMed=14607838; DOI=10.1074/jbc.M309913200;
Courville P., Chaloupka R., Veyrier F., Cellier M.F.M.;
"Determination of transmembrane topology of the Escherichia coli
natural resistance-associated macrophage protein (Nramp) ortholog.";
J. Biol. Chem. 279:3318-3326(2004).
[7]
MUTAGENESIS OF ASP-34; PRO-35; GLY-36; ASN-37; GLU-102; ASP-109;
GLU-112; GLY-115; GLU-154 AND ASP-238.
PubMed=15630547; DOI=10.1007/s00232-004-0711-x;
Haemig H.A., Brooker R.J.;
"Importance of conserved acidic residues in mntH, the Nramp homolog of
Escherichia coli.";
J. Membr. Biol. 201:97-107(2004).
[8]
TOPOLOGY [LARGE SCALE ANALYSIS].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=15919996; DOI=10.1126/science.1109730;
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
"Global topology analysis of the Escherichia coli inner membrane
proteome.";
Science 308:1321-1323(2005).
-!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
Involved in manganese and iron uptake. Can also transport cadmium,
cobalt, zinc and to a lesser extent nickel and copper. Involved in
response to reactive oxygen. {ECO:0000255|HAMAP-Rule:MF_00221,
ECO:0000269|PubMed:10712688, ECO:0000269|PubMed:10844693}.
-!- INTERACTION:
P09372:grpE; NbExp=3; IntAct=EBI-551337, EBI-547441;
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
Rule:MF_00221, ECO:0000269|PubMed:14607838}; Multi-pass membrane
protein {ECO:0000255|HAMAP-Rule:MF_00221,
ECO:0000269|PubMed:14607838}.
-!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
Rule:MF_00221}.
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EMBL; AF161318; AAD46617.1; -; Genomic_DNA.
EMBL; U00096; AAC75451.1; -; Genomic_DNA.
EMBL; AP009048; BAA16262.1; -; Genomic_DNA.
PIR; E65013; E65013.
RefSeq; NP_416893.1; NC_000913.3.
RefSeq; WP_000186369.1; NZ_LN832404.1.
ProteinModelPortal; P0A769; -.
BioGrid; 4259183; 8.
DIP; DIP-48004N; -.
IntAct; P0A769; 1.
STRING; 316385.ECDH10B_2556; -.
TCDB; 2.A.55.3.1; the metal ion (mn(2+)-iron) transporter (nramp) family.
PaxDb; P0A769; -.
PRIDE; P0A769; -.
EnsemblBacteria; AAC75451; AAC75451; b2392.
EnsemblBacteria; BAA16262; BAA16262; BAA16262.
GeneID; 946899; -.
KEGG; ecj:JW2388; -.
KEGG; eco:b2392; -.
PATRIC; fig|1411691.4.peg.4337; -.
EchoBASE; EB3909; -.
EcoGene; EG14157; mntH.
eggNOG; ENOG4105C56; Bacteria.
eggNOG; COG1914; LUCA.
HOGENOM; HOG000152205; -.
InParanoid; P0A769; -.
KO; K03322; -.
PhylomeDB; P0A769; -.
BioCyc; EcoCyc:YFEP-MONOMER; -.
BioCyc; MetaCyc:YFEP-MONOMER; -.
PRO; PR:P0A769; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0016021; C:integral component of membrane; IMP:EcoliWiki.
GO; GO:0005886; C:plasma membrane; IDA:EcoliWiki.
GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IMP:EcoliWiki.
GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IMP:EcoliWiki.
GO; GO:0005384; F:manganese ion transmembrane transporter activity; IMP:EcoliWiki.
GO; GO:0015293; F:symporter activity; IDA:EcoliWiki.
GO; GO:0015292; F:uniporter activity; IMP:EcoliWiki.
GO; GO:0015691; P:cadmium ion transport; IDA:EcoliWiki.
GO; GO:0006824; P:cobalt ion transport; IMP:EcoliWiki.
GO; GO:0015684; P:ferrous iron transport; IMP:EcoliWiki.
GO; GO:0006826; P:iron ion transport; IMP:EcoliWiki.
GO; GO:0006828; P:manganese ion transport; IMP:EcoCyc.
GO; GO:0030001; P:metal ion transport; IMP:EcoliWiki.
HAMAP; MF_00221; NRAMP; 1.
InterPro; IPR001046; NRAMP_fam.
PANTHER; PTHR11706; PTHR11706; 1.
Pfam; PF01566; Nramp; 1.
PRINTS; PR00447; NATRESASSCMP.
TIGRFAMs; TIGR01197; nramp; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome; Ion transport;
Iron; Manganese; Membrane; Reference proteome; Symport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 412 Divalent metal cation transporter MntH.
/FTId=PRO_0000212617.
TOPO_DOM 1 19 Cytoplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 20 39 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 40 51 Periplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 52 71 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 72 95 Cytoplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 96 118 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 119 125 Periplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 126 145 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 146 155 Cytoplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 156 175 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 176 196 Periplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 197 220 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 221 238 Cytoplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 239 258 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 259 276 Periplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 277 297 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 298 327 Cytoplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 328 344 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 345 350 Periplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 351 370 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 371 387 Cytoplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TRANSMEM 388 406 Helical. {ECO:0000255|HAMAP-
Rule:MF_00221}.
TOPO_DOM 407 412 Periplasmic. {ECO:0000255|HAMAP-
Rule:MF_00221}.
MUTAGEN 34 34 D->E,N: Loss of function.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 35 35 P->N,Q: Loss of function.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 36 36 G->P: Loss of function.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 37 37 N->D: Loss of function.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 102 102 E->D,Q: Loss of function.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 109 109 D->E,N: Transports manganese to a very
low level. {ECO:0000269|PubMed:15630547}.
MUTAGEN 112 112 E->D,Q: Transports manganese to a very
low level. {ECO:0000269|PubMed:15630547}.
MUTAGEN 115 115 G->A,P: Loss of function.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 154 154 E->Q: Transports manganese to a level
half of that of wild-type.
{ECO:0000269|PubMed:15630547}.
MUTAGEN 238 238 D->N: Transports manganese to a very low
level. {ECO:0000269|PubMed:15630547}.
SEQUENCE 412 AA; 44194 MW; 7D77FEAEA00411FB CRC64;
MTNYRVESSS GRAARKMRLA LMGPAFIAAI GYIDPGNFAT NIQAGASFGY QLLWVVVWAN
LMAMLIQILS AKLGIATGKN LAEQIRDHYP RPVVWFYWVQ AEIIAMATDL AEFIGAAIGF
KLILGVSLLQ GAVLTGIATF LILMLQRRGQ KPLEKVIGGL LLFVAAAYIV ELIFSQPNLA
QLGKGMVIPS LPTSEAVFLA AGVLGATIMP HVIYLHSSLT QHLHGGSRQQ RYSATKWDVA
IAMTIAGFVN LAMMATAAAA FHFSGHTGVA DLDEAYLTLQ PLLSHAAATV FGLSLVAAGL
SSTVVGTLAG QVVMQGFIRF HIPLWVRRTV TMLPSFIVIL MGLDPTRILV MSQVLLSFGI
ALALVPLLIF TSDSKLMGDL VNSKRVKQTG WVIVVLVVAL NIWLLVGTAL GL


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