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Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (EC 2.4.99.18) (Defender against apoptotic death 1 protein) (Defender against cell death 1) (DAD-1)

 DAD1_ORYSI              Reviewed;         114 AA.
A2XSY1; O50070; Q7F9I2; Q84N35;
10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
20-MAR-2007, sequence version 1.
10-OCT-2018, entry version 60.
RecName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1;
Short=Oligosaccharyl transferase subunit DAD1;
EC=2.4.99.18;
AltName: Full=Defender against apoptotic death 1 protein;
AltName: Full=Defender against cell death 1;
Short=DAD-1;
Name=DAD1; Synonyms=DAD-1; ORFNames=OsI_015174;
Oryza sativa subsp. indica (Rice).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
NCBI_TaxID=39946;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. 93-11;
PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
Samudrala R., Wang J., Wong G.K.-S., Yang H.;
"The genomes of Oryza sativa: a history of duplications.";
PLoS Biol. 3:266-281(2005).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-113.
STRAIN=cv. Taichung native 1;
Chen W.-P., Li P.H.;
"Indica rice dad-1 gene.";
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Essential subunit of the N-oligosaccharyl transferase
(OST) complex which catalyzes the transfer of a high mannose
oligosaccharide from a lipid-linked oligosaccharide donor to an
asparagine residue within an Asn-X-Ser/Thr consensus motif in
nascent polypeptide chains. Possesses cell death-inhibiting
activity. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Dolichyl diphosphooligosaccharide + [protein]-
L-asparagine = dolichyl diphosphate + a glycoprotein with the
oligosaccharide chain attached by N-beta-D-glycosyl linkage to a
protein L-asparagine.
-!- PATHWAY: Protein modification; protein glycosylation.
-!- SUBUNIT: Component of the oligosaccharyltransferase (OST) complex.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the DAD/OST2 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; CM000129; EAY93941.1; -; Genomic_DNA.
EMBL; AY271663; AAP23065.1; -; Genomic_DNA.
SMR; A2XSY1; -.
STRING; 39946.BGIOSGA016310-PA; -.
EnsemblPlants; BGIOSGA016310-TA; BGIOSGA016310-PA; BGIOSGA016310.
Gramene; BGIOSGA016310-TA; BGIOSGA016310-PA; BGIOSGA016310.
eggNOG; KOG1746; Eukaryota.
eggNOG; ENOG4111Q2I; LUCA.
HOGENOM; HOG000211854; -.
OMA; GVCLRLQ; -.
OrthoDB; EOG09360TZX; -.
UniPathway; UPA00378; -.
Proteomes; UP000007015; Chromosome 4.
ExpressionAtlas; A2XSY1; differential.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0008250; C:oligosaccharyltransferase complex; IEA:InterPro.
GO; GO:0004579; F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; IEA:InterPro.
GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
InterPro; IPR003038; DAD/Ost2.
PANTHER; PTHR10705; PTHR10705; 1.
Pfam; PF02109; DAD; 1.
PIRSF; PIRSF005588; DAD; 1.
3: Inferred from homology;
Apoptosis; Complete proteome; Endoplasmic reticulum;
Glycosyltransferase; Membrane; Reference proteome; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 114 Dolichyl-diphosphooligosaccharide--
protein glycosyltransferase subunit DAD1.
/FTId=PRO_0000295012.
TOPO_DOM 1 30 Cytoplasmic. {ECO:0000255}.
TRANSMEM 31 51 Helical. {ECO:0000255}.
TOPO_DOM 52 54 Lumenal. {ECO:0000255}.
TRANSMEM 55 75 Helical. {ECO:0000255}.
TOPO_DOM 76 93 Cytoplasmic. {ECO:0000255}.
TRANSMEM 94 114 Helical. {ECO:0000255}.
CONFLICT 48 48 G -> E (in Ref. 2; AAP23065).
{ECO:0000305}.
CONFLICT 105 105 L -> P (in Ref. 2; AAP23065).
{ECO:0000305}.
SEQUENCE 114 AA; 12379 MW; 0BE69A7E935FA301 CRC64;
MPRATSDAKL LIQSLGKAYA ATPTNLKIID LYVVFAVATA LIQVVYMGIV GSFPFNSFLS
GVLSCIGTAV LAVCLRIQVN KDNKEFKDLP PERAFADFVL CNLVLHLVIM NFLG


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